Abstracts tagged "citrullination"

Abstract Number: 581 • 2016 ACR/ARHP Annual Meeting
Cell-Mediated Neutrophil Lysis-a Mechanism Promoting Hypercitrullination in Rheumatoid Arthritis?
Tal Gazitt¹, Christian Lood¹, Xizhang Sun², David Feith³, Jeffrey Ledbetter², Gordon Starkebaum¹, Thomas Loughran Jr.⁴ and Keith B. Elkon¹, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Seattle, WA, ³Hematology and Oncology, University of Virginia, Charlottesville, VA, ⁴Hematology Oncology, University of Virginia, Charlottesville, VA
BACKGROUND/PURPOSE:Protein citrullination, the post-translational conversion of arginine to citrulline, mediated by peptidylarginine deiminase (PAD) enzymes, is considered a likely mechanism for the stimulation of anti-citrullinated…
Abstract Number: 913 • 2016 ACR/ARHP Annual Meeting
Aggregatibacter Actinomycetemcomitans-Induced Hypercitrullination Links Periodontal Infection to Autoimmunity in Rheumatoid Arthritis
Maximilian F. Konig^1,2, Loreto Abusleme³, Jesper Reinholdt⁴, Robert J. Palmer³, Kevon Sampson¹, Ricardo P. Teles⁵, Peter A. Nigrovic⁶, Antony Rosen¹, Jeremy Sokolove⁷, Jon T. Giles⁸, Niki M. Moutsopoulos³ and Felipe Andrade¹, ¹Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ⁴Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁵Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁸Columbia University, College of Physicians and Surgeons, Division of Rheumatology, New York, NY
Background/Purpose: A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of modern germ theory. Recent studies implicate mucosal surfaces as sites…
Abstract Number: 1461 • 2016 ACR/ARHP Annual Meeting
Modification of Proteins with Malondialdehyde-Acetaldehyde and Citrulline Elicit Antibody Responses in DBA/1J Mice
Peter M. Maloley¹, Michael J. Duryee², Carlos D. Hunter², James R. O'Dell³, Daniel R. Anderson¹, Ted R Mikuls⁴, Geoffrey M. Thiele¹ and Lynell W. Klassen³, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Previous studies have shown that proteins modified with malondialdehyde-acetaldehyde (MAA) and/or citrulline (CIT) co-localize in rheumatoid arthritis (RA) synovial tissues, are pro-inflammatory, and promote…
Abstract Number: 521 • 2015 ACR/ARHP Annual Meeting
Targeted Quantitative Analysis to Identify Citrullinated Peptides in the Synovial Fluid of Patients with Rheumatoid Arthritis
Min Jueng Kang¹, Ji Soo Kim², Eugene C. Yi¹ and Eun Young Lee², ¹Molecular Medicine and Biopharmaceutical Sciences, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: The protein/peptide citrullination is a post-translational modification and the citrullinated peptide epitopes are recognized by anti-citrullinated protein/peptide antibody (ACPA), which is a major diagnostic…
Abstract Number: 528 • 2015 ACR/ARHP Annual Meeting
RA33 Challenges the Paradigm of Autoantigen Selection in Rheumatoid Arthritis
Maximilian F. Konig¹, Jon Giles², Peter A. Nigrovic³ and Felipe Andrade¹, ¹Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Columbia University Medical Center, NY, NY, ³Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Antibodies against citrullinated proteins (ACPAs) are the autoimmune hallmark of rheumatoid arthritis (RA), and can precede the onset of symptomatic disease by years. By…
Abstract Number: 530 • 2015 ACR/ARHP Annual Meeting
Immunomodulation of Naïve RA Patients PBMCs with a Multi-Epitope Peptide Derived from Citrullinated Autoantigens
Smadar Gertel¹, Yehuda Shoenfeld² and Howard Amital³, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²Head Dept of Medicine B, Sheba Medical Center, Ramat-Gan, Israel, ³Sheba Medical Center, Tel-Hashomer, Israel
Background/Purpose: Citrullinated peptides are major targets of disease-specific autoantibodies in rheumatoid arthritis (RA). We generated a multi-epitope citrullinated peptide (Cit-ME), derived from major prevalent citrullinated…
Abstract Number: 905 • 2015 ACR/ARHP Annual Meeting
Citrullinated Epithelial-Derived Neutrophil-Activating Peptide 78 (ENA-78/CXCL5) Induces Monocyte Migration Via JNK and NFκB Signaling Pathways
Ray A. Ohara¹, Nicholas Lepore², W. Alexander Stinson³, Gautam Edhayan³, Phillip L. Campbell¹, Sarah Arwani¹, Rachel Morgan¹, Jeffrey H. Ruth¹, Alisa E. Koch^1,4, David A. Fox¹ and M. Asif Amin¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by monocyte (MN) infiltration into the synovium. Citrullination is a post-translational modification of arginine to…
Abstract Number: 1034 • 2015 ACR/ARHP Annual Meeting
Immunomodulation By a Second-Generation Peptidyl Arginine Deiminase Inhibitor Abrogates Collagen-Induced Arthritis in a Therapeutic Protocol
Anne-Marie Quirke¹, Joanna Kawalkowska², Fatemeh Ghari³, Venkataraman Subramaniam⁴, Paul Thompson⁵, Richard O. Williams¹, Nick La Thangue³ and Patrick J. Venables¹, ¹Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ²Kennedy Institute for Rheumatology, University of Oxford, Oxford, United Kingdom, ³Department of Oncology, University of Oxford, Oxford, United Kingdom, ⁴Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, ⁵University of Massachusetts, Worcester, MA
Background/Purpose: Citrullination is a post translational modification of arginine catalysed by peptidyl arginine deiminases (PADs) and may be important in generating pathogenic autoantibodies to citrullinated…
Abstract Number: 1038 • 2015 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Alpha and Peptidylarginine Deiminase 4 in Lung and Joint Inflammation
Mandar Bawadekar¹, Annette Gendron-Fitzpatrick², Thomas F. Warner³, Lennart K.A. Lundblad⁴, Paul Thompson⁵ and Miriam A. Shelef^1,6, ¹Medicine, University of Wisconsin, Madison, WI, ²Comparative Pathology Laboratory of the Research Animal Resources Center and Pathobiological Sciences, University of Wisconsin, Madison, WI, ³Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, ⁴Medicine, The University of Vermont, Burlington, VT, ⁵University of Massachusetts, Worcester, MA, ⁶Medicine, William S. Middleton Memorial Veterans Hospital, Madison, WI
Background/Purpose: The relationship between lung and joint inflammation in rheumatoid arthritis is poorly understood. About 10% of people with rheumatoid arthritis develop interstitial lung disease…
Abstract Number: 1371 • 2015 ACR/ARHP Annual Meeting
Complement-Mediated Neutrophil Lysis-a Mechanism Promoting Hypercitrullination in Rheumatoid Arthritis?
Tal Gazitt¹, Christian Lood², Jeffrey Ledbetter³ and Keith B. Elkon³, ¹Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Lund, Sweden, ³Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Protein citrullination, the post-translational conversion of arginine to citrulline, mediated by peptidylarginine deiminase (PAD) enzymes, is considered a likely mechanism for the stimulation of…
Abstract Number: 1510 • 2015 ACR/ARHP Annual Meeting
The Association Between HDL Cholesterol Efflux Capacity, Citrullinated ApoA1 and Anti-Citrullinated ApoA1 Antibodies in Rheumatoid Arthritis
Katherine Liao¹, Jing Cui¹, Christopher Rhodes², Lauren J. Lahey², Martin Playford³, I-Hsin Kuo¹, Michelle Frits¹, Christine Iannaccone¹, Jonathan S. Coblyn⁴, Michael Weinblatt¹, Nancy Shadick⁵, Nehal N. Mehta³ and Jeremy Sokolove², ¹Division of Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Boston, MA, ²Medicine, VA Palo Alto HealthCare System and Stanford University, Palo Alto, CA, ³NHLBI, National Institutes of Health, Bethesda, MD, ⁴Brigham & Women's Hospital, Boston, MA, ⁵Division of Rheumatology, Immunology & Allergy, Brigham & Women's Hospital, Boston, MA
Background/Purpose: High density lipoprotein (HDL) cholesterol efflux capacity measures how well HDL particles remove cholesterol from lipid-laden macrophages, such as those found in atherosclerotic plaques. …
Abstract Number: 1617 • 2015 ACR/ARHP Annual Meeting
Evidence for Citrullinated Inhibitor of DNA Binding 1 (Id1) As a Novel Autoantigen Candidate in Rheumatoid Arthritis
Ray A. Ohara¹, Gautam Edhayan¹, W. Alexander Stinson², Phillip L. Campbell¹, Henriette A. Remmer³, M. Asif Amin¹, David A. Fox¹ and Jeffrey H. Ruth¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Biomedical Research Core Facilities, Proteomics & Peptide Synthesis Core, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Inhibitor of DNA-binding 1 (Id1) is a nuclear transcription factor actively transcribed in endothelial progenitor cells and in cells that exhibit hyperproliferative responses such…
Abstract Number: 1769 • 2015 ACR/ARHP Annual Meeting
Role of Topical Administration of Peptidylarginine Deiminase Inhibitors in Murine Lupus
Erica Moore¹, Huw Lewis², Carolyne K. Smith¹, Venkataraman Subramaniam³, Victoria Hoffmann⁴, Paul Thompson⁵ and Mariana J. Kaplan¹, ¹Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Immuno Inflammation, GSK, Stevenage, United Kingdom, ³University of Massachusetts, Boston, MA, ⁴ORS, National Institutes of Health, Bethesda, MD, ⁵University of Massachusetts, Worcester, MA
Background/Purpose: Peptidylarginine deiminases (PADs), specifically PAD4, have recently been implicated in the pathogenesis of systemic lupus erythematosus (SLE) through their role in citrullinating histones in…
Abstract Number: 1946 • 2015 ACR/ARHP Annual Meeting
A Novel HLA-DRB1*10:01 Restricted T Cell Epitope from Citrullinated Type II Collagen Relevant for Rheumatoid Arthritis
Karine Chemin¹, Sabrina Pollastro², Eddie James³, Changrong Ge⁴, Inka Albrecht⁵, Jessica Herrath⁶, Christina Gerstner⁷, Thais Rizzi², Karolina Tandre⁸, Lars Rönnblom⁸, Anca I Catrina⁹, Rikard Holmdahl¹⁰, L. Klareskog¹¹, Niek De Vries¹² and Vivianne Malmström¹¹, ¹Medicine, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical Immunology and Rheumatology, Amsterdam, Netherlands, ³Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁴Department of Medical Biochemistry and Biophysics, Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden, ⁵Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁶Department of Medicine,, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁷Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden, ⁸Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁹Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ¹⁰Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, ¹¹Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹²Dept. of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Antibodies against citrullinated collagen type II (Cit-CII) are common in sera and synovial fluids of Rheumatoid Arthritis (RA) patients, whereas the known CII T-cell…
Abstract Number: 359 • 2014 ACR/ARHP Annual Meeting
14-3-3η Cit:Arg Antibody Ratios: Are We Overlooking the Prognostic Utility of Citrullinated Antibodies By Only Looking at Titers?
Anthony Marotta¹, Samina Turk², Mairead Murphy³, Walter P. Maksymowych⁴ and Dirkjan van Schaardenburg⁵, ¹1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada, ²Reade, Amsterdam, Netherlands, ³Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Dr Jan van Breemenstraat 2, Reade, Amsterdam, Netherlands
Background/Purpose Citrullination is a post-translational modification whereby arginine (Arg) is deiminated by PAD enzymes to form citrulline (Cit). In RA, there are auto-antibodies (AAb) to…

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