Abstracts tagged "chondrocytes"

Abstract Number: 1006 • 2014 ACR/ARHP Annual Meeting
Interleukin-4 As Promising, Anti-Inflammatory Transgene for Gene Therapeutic Application in Joint Diseases
Annemarie Lang¹, Johannes Neuhaus², Moritz Pfeiffenberger³, Erik Schroeder⁴, Frank Buttgereit⁵, Michael F. G. Schmidt³ and Timo Gaber⁶, ¹Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany, ²Department of Veterinary Medicine, Research Center of Medical Technology and Biotechnology, Bad Langensalza, Germany, ³Department of Veterinary Medicine, Institute of Immunology, Freie Universität Berlin, Berlin, Germany, ⁴Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁵Charité University Hospital, Berlin, Germany, ⁶Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany
Background/Purpose Interleukin- 4 (IL-4), a Th2-cell released immunomodulatory factor, has potent chondroprotective and anti-inflammatory properties able to inhibit the synthesis of IL-1β and TNFα, and…
Abstract Number: 1018 • 2014 ACR/ARHP Annual Meeting
Monolayer Culture Induced the Expression of Zyxin-Related Protein 1 (ZRP-1), α_vβ₃integrin Complex and Leptin in Human Articular Chondrocytes
Edith Charlier¹, Olivier Malaise¹, Mustapha Zeddou², Sophie Neuville³, Gaël Cobraiville³, Philippe Gillet⁴, William Kurth⁴, Dominique de Seny¹, Biserka Relic¹ and Michel G. Malaise¹, ¹Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ²Department of Biology, Faculty of Sciences, University Mohamed I, Oujda, Morocco, ³GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ⁴Orthopedic Surgery Unit-CHU of Liège, Liège, Belgium
Background/Purpose During Osteoarthritis (OA), chondrocytes loose their initial anabolic properties, undergoing morphological and biochemical modifications similar to those encountered during chondrocyte dedifferentiation. However, the molecular…
Abstract Number: 616 • 2014 ACR/ARHP Annual Meeting
In Situ Analysis of Mechanisms of New Bone Formation in Zygapophyseal Joints from Patients with Ankylosing Spondylitis
Janine Bleil¹, Joachim Sieper², Rene Maier³, Uwe Schlichting⁴, Axel Hempfing⁵, Heiner Appel⁶ and Uta Syrbe⁷, ¹Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Deutsches Rheumaforschungszentrum, Berlin, Germany, ⁴Department of Pathology, Charite, Berlin, Germany, ⁵Werner-Wicker-Klinik, Bad Wildungen, Germany, ⁶Rheumatology and Nephrology Practice, Hamm, Germany, ⁷Charité, Berlin, Germany
Background/Purpose Osteoproliferation leading to joint ankylosis is a characteristic feature of ankylosing spondylitis (AS). In general, there are two ways of bone formation: a) endochondral…
Abstract Number: 1026 • 2014 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate Crystals Induces the Expression of Ihh and MMP-13 in ATDC5 Cells: Implications in Osteoarthritis (OA) Development.
Melissa Ramirez¹, Josh Potvin¹, Diana Ramirez² and Anthony M. Reginato³, ¹Division of Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Department of Orthopaedic Surgery, The Warren Alpert School of Medicine at Brown University, Providence, RI, ³Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI
Background/Purpose: Cartilage damage is often observed in affected joints with advance gout1. Musculoskeletal ultrasound studies have highlighted the close relationship between monosodium urate (MSU) crystals…
Abstract Number: 1014 • 2014 ACR/ARHP Annual Meeting
Harpagide, a Low Molecular Weight Natural Product, Suppresses IL-1â-Induced IL-6 Expression By Blocking the Activation of p38 MAPK and Transcription Factors CEBPâ and AP-1 in Primary Human Osteoarthritis Chondrocytes
Abdul Haseeb¹ and Tariq Haqqi², ¹Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: There is growing evidence that shows the involvement of IL-6 in cartilage degradation during OA. Significant correlation between IL-6 levels in serum as well…
Abstract Number: 1837 • 2013 ACR/ARHP Annual Meeting
Three-Dimension Culture Of Mesenchymal Stem Cells With Nano-Fiber Scaffold Induces Chondrogenesis and Osteogenesis
Kunihiro Yamaoka¹, Koshiro Sonomoto¹, Xiangmei Zhang¹, Masahiro Kondo¹, Shunsuke Fukuyo¹, Makoto Satake², Hiroaki Kaneko², Kazuhisa Nakano¹, Yosuke Okada¹ and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The Third Laboratory, Integrative Technology Research Institute, Teijin Limited, Tokyo, Japan
Background/Purpose: Development of biologics has made remission a realistic treatment goal in treatment of rheumatoid arthritis (RA). However, once bone or cartilage is destructed treatment…
Abstract Number: 770 • 2013 ACR/ARHP Annual Meeting
Suppressor Of Cytokine Signaling-3 Is a Critical Regulator Of gp130 Cytokine Signaling In Articular Chondrocytes
Xiao Liu^1,2, Kate E Lawlor^1,2, Ben A Croker¹ and Ian P Wicks^1,2,3, ¹Inflammation Division, Walter & Eliza Hall Institute of Medical Research, Parkville, Australia, ²Department of Medical Biology, University of Melbourne, Parkville, Australia, ³Department of Rheumatology, The Royal Melbourne Hospital, Melbourne, Australia
Background/Purpose: Cartilage damage is a key feature of inflammatory and degenerative arthritis and an important determinant of patient outcomes. Chondrocytes are the only cells in…
Abstract Number: 67 • 2013 ACR/ARHP Annual Meeting
Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF) As a Potential Mediator In Osteoarthritis
Richard F. Loeser¹ and David A. Long², ¹Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, ²Section Of Molecular Medicine, Wake Forest University, Winston-Salem, NC
Background/Purpose: We recently reported changes in gene expression in knee joint tissue from 12 week-old and 12 month-old mice after OA was induced by surgical…
Abstract Number: 63 • 2013 ACR/ARHP Annual Meeting
Investigations On The Role Of Delta/Notch Like EGF-Related Receptor In The Pathogenesis Of Osteoarthritis
Lucija Berninger¹, Anna Balkenhol¹, Clemens Baier², Stefan Rehart³, Markus Rickert⁴, Ulf Müller-Ladner¹, Elena Neumann⁵ and Matthias Geyer¹, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Orthopaedic surgery, University of Regensburg, Bad Abbach, Germany, ³Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁴Dept of Orthopedics and Orthopedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, ⁵Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: Delta/Notch like EGF-related receptor (DNER) is a single-pass transmembrane protein with characteristic EGF-like repeats in the extracellular domain, similar to those of the Notch…
Abstract Number: 66 • 2013 ACR/ARHP Annual Meeting
Follistatin-Like Protein 1 Is An Important Regulator Of Chondrogenesis
Yury Chaly¹, Sonja Smith², Daniel Bushnell³, Brian Campfield⁴, Harry Blair⁵ and Raphael Hirsch⁶, ¹Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ²University of Iowa Carver College of Medicine, Iowa City, IA, ³Division of Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁴Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁵University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁶Department of Pediatrics,, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Chondrocytes play a pivotal role in osteoarthritis (OA) because they are the only cells in the articular cartilage that are responsible for maintenance of…
Abstract Number: 68 • 2013 ACR/ARHP Annual Meeting
Autophagy Activation Protects From Mitochondrial Dysfunction In Human Chondrocytes
Beatriz Caramés¹, Paloma López de Figueroa², Martin Lotz³ and Francisco J. Blanco⁴, ¹Osteoarticular and Aging Research Lab, INIBIC–Complejo Hospitalario Universitario A Coruña, SPAIN, A Coruña, Spain, ²Cartilage Biology group. Rheumatology Division, INIBIC-A Coruña, Spain, A Coruña, Spain, ³The Scripps Research Institute, La Jolla, USA, La Jolla, CA, ⁴Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain
Background/Purpose: A common feature of aging-related diseases, such as osteoarthritis (OA), is the progressive accumulation of damaged macromolecules leading to cell dysfunction and death. Autophagy,…
Abstract Number: 76 • 2013 ACR/ARHP Annual Meeting
Protective Effect Of Intra-Articular Injection Of Alginate-Chitosan Beads In An Hydrogel Against The Development Of Experimental Osteoarthritis Lesions In Rabbit
Frédéric Oprenyeszk¹, Mickael Chausson², Véronique Maquet², Jean-Emile Dubuc³ and Yves Henrotin¹, ¹University of Liège, Bone and Cartilage Research Unit, Liège, Belgium, ²Parc industriel des Haut-Sarts, KitoZyme SA, Herstal, Belgium, ³Clinical University Saint Luc, Orthopaedic Department, Bruxelles, Belgium
Background/Purpose: Today, there is no treatment to cure osteoarthritis (OA) or to delay effectively its progression. Current treatments are mainly based on the alleviation of…
Abstract Number: 58 • 2013 ACR/ARHP Annual Meeting
Saturated Fatty Acids Act Synergistically With Interleukin 1 Beta To Increase Inflammation, Endoplasmic Reticulum Stress and Cell Death In Human Articular Chondrocytes
Oscar Alvarez-Garcia¹, Nicole H Rogers², Roy G Smith³ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²California Institute for Biomedical Research (Calibr), La Jolla, CA, ³Department of Metabolism and Aging, Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL
Background/Purpose: Obesity is a major risk factor for the development of osteoarthritis (OA). Altered biomechanics have been postulated as the main causative mechanism, but recent…
Abstract Number: 44 • 2013 ACR/ARHP Annual Meeting
Suppressor Of Cytokine Signaling 3 Negatively Modulates Leptin-Mediated Catabolic and Proinflammatory Effects In Cartilage – New Potential Mechanism To Target Obesity-Induced Osteoarthritis
Anna Koskinen¹, Katriina Vuolteenaho¹, Riku Korhonen¹, Teemu Moilanen^1,2 and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: Adipocytokine leptin has been suggested to link obesity and osteoarthritis (OA). Initially leptin was found to regulate energy metabolism through central nervous system. More…
Abstract Number: 47 • 2013 ACR/ARHP Annual Meeting
Exogenous Hydrogen Sulfide Donors Show Anti-Catabolic and Anti-Inflammatory Properties But Limited Anti-Oxidant Capability On Human Articular Osteoarthritic Chondrocytes
Elena F. Burguera^1,2, Angela Vela-Anero^2,3, Rosa Meijide-Failde² and Francisco J. Blanco^1,4, ¹Rheumatology Service, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Universidade da Coruña (UDC)., Grupo de Bioingeniería Tisular y Terapia Celular (CBTTC-CHUAC). CIBER-BBN/ISCIII., A Coruña, Spain, ³Department of Medicine, University of A Coruña, A Coruña, Spain, ⁴Tissue Engineering and Cellular Therapy Group (CBTTC-CHUAC), CIBER BBN/ISCIII, A Coruña, Spain
Background/Purpose: Osteoarthritis (OA) is characterized by an imbalance between catabolism and anabolism, higher than normal levels of matrix metalloproteinases (MMPs), an increase in inflammatory markers…

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