ACR Meeting Abstracts

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Abstracts tagged "chemokines"

  • Abstract Number: 0915 • ACR Convergence 2023

    IL-16+ Is Abundantly Expressed by Kidney-infiltrating Myeloid and Lymphoid Cells in Lupus Nephritis: A Spatially Resolved Multiplexed Approach

    Alessandra Ida Celia1, Xiaoping Yang2, Hana Minsky2, Silvia Malvica2, Michelle Petri3, the Accelerating Medicines Partnership in RA/SLE4, Avi Rosenberg5 and Andrea Fava2, 1John Hopkins University of Medicine, Rome, Italy, 2Johns Hopkins University, Baltimore, MD, 3Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 4Multiple, Multiple, 5Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: We previously discovered that IL-16 is the urinary protein most strongly correlated with histological activity in lupus nephritis (LN), followed by neutrophil degranulation products…
  • Abstract Number: 1124 • ACR Convergence 2023

    A Double-blind, Placebo-parallel Controlled Phase III Clinical Study of the Efficacy and Safety of Hemay005 Tablets in Patients with Moderate to Severe Chronic Plaque Psoriasis in China

    Charles Jones1, Jianzhong Zhang2, Lihua Wang3, Xunyi Dai4, Huimin Wang5, Xiadong Bi6, Xinsuo Duan7, Zudong Meng8, Zhongwei Tian9, Aie Xu10, Bin Yang11, Shuping Guo12, Wei Li13, Qingchun Diao14, Hong Fang15, Yongjun Liu16, Juanli Fan17, Min Yan18, Sensen Lin19, Mingfei Zhu20, xianjun Hu20, Jinfeng Lin20 and Mingye Bi21, 1Hemay Pharmaceuticals, Tianjin, China, 2Peking University People’s Hospital, Beijing, China, 3Jinan Central Hospital, Jinan, China, 4Wuxi Second People's Hospital, Wuxi, China, 5Jinzhong First People's Hospital, Jinzhong, China, 6Nanyang First People's Hospital, Nanyang, China, 7Chengde Medical College Affiliated Hospital, Chengde, China, 8Shiyan City People's Hospital, Shiyan, China, 9The First Affiliated Hospital of Xinxiang Medical College, Weihui, China, 10Hangzhou Third People's Hospital, Hangzhou, China, 11Skin Disease Hospital of Southern Medical University, Guangzhou, China, 12The First Hospital of Shanxi Medical University, Taiyuan, China, 13West China Hospital of Sichuan University, Chengdu, China, 14Chongqing Traditional Chinese Medicine Hospital, Chongqing, China, 15The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 16Qiqihar Traditional Chinese Medicine Hospital, Qiqihar, China, 17Yuncheng Central Hospital, Yuncheng, China, 18Shengli Oilfield Central Hospital, Dongying, China, 19Hangzhou Tigermed, Hangzhou, China, 20Clinical Department, Tianjin Hemay Pharmaceutical Co., Ltd., Tianjin, China, 21Wuxi People's Hospital, Wuxi, China

    Background/Purpose: Hemay005 is an orally active selective PDE4 inhibitor under clinical development for treating chronic inflammatory diseases. Hemay005 significantly inhibits the activation of T lymphocytes,…
  • Abstract Number: 2176 • ACR Convergence 2023

    Cellular and Proteomic Changes Following Administration of Peresolimab, in a Phase 2a Trial in Rheumatoid Arthritis

    Robert J. Benschop1, Jay Tuttle1, Paul Emery2, Christoph Preuss1, Mark Daniels1, Veavi Ching-Yun Chan1, Pia Yachi1 and Ajay Nirula1, 1Eli Lilly and Company, Indianapolis, IN, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Peresolimab is a humanized immunoglobulin G1 monoclonal antibody that stimulates human programmed cell death protein 1 (PD-1). Peresolimab demonstrated superiority to placebo in Disease…
  • Abstract Number: 2206 • ACR Convergence 2023

    Increased Frequency of Activated MAIT Cells Expressing the Gut Homing Receptor CCR9 in Patients with Radiographic Axial Spondyloarthritis

    Eric Toussirot1, Caroline Laheurte2, Eléonore Gravelin2, Charline Vauchy3, Marc Puyraveau3 and Philippe Saas4, 1University Hospital of Besancon, Besançon, France, 2INSERM UMR1098, plateforme de biomonitoring, EFS Bourgogne-Franche-Comté, Besançon, France, 3INSERM CIC-1431, Besançon, France, 4INSERM UMR1098, EFS Bourgogne-Franche-Comté, Besançon, France

    Background/Purpose: MAIT (mucosal associated invariant T) cells are involved in mucosa defense against bacteria. This cellular subset is characterized by a semi-invariant αβ TCR and…
  • Abstract Number: 2352 • ACR Convergence 2023

    High Serum C-X-C Motif Chemokine Ligand 10 (CXCL10) Potentially Predicts New Onset of Systemic Sclerosis-Interstitial Lung Disease

    Yehya Al-Adwi, Isabella Atzeni, Berber Doornbos-van der Meer, Marcel J van der Leij, Bart-Jan Kroesen, Alja Stel, Wim Timens, C.Tji Gan, Harry van Goor, Johanna Westra and Douwe J Mulder, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Systemic sclerosis-interstitial lung disease (SSc-ILD) is the leading cause of death in SSc patients. There is an unmet need for predictive biomarkers of ILD…
  • Abstract Number: 2357 • ACR Convergence 2023

    The Involvement of CCR3-CCL24 Axis in Endothelial to Mesenchymal Transition Process and Pulmonary Arterial Hypertension in Systemic Sclerosis Patients

    Itzchak Amoyal1, Tzipi Hornik-Lurie2, Tali Zitman-Gal1, Hilit Levy3, Ilan Vaknin3, Liat Drucker4, Ishai Heusler5, Yair Levy1 and Shelly Tartakover Matalon1, 1Meir Medical Center, Autoimmune Research Laboratory, Kfar-Saba, Israel, 2Meir Medical Center, Data Research Department, Kfar-Saba, Israel, 3Chemomab Ltd, Tel Aviv, Israel, 4Meir Medical Center, Oncogenetics Laboratory, Kfar Saba, Israel, 5Meir Medical Center, Department of Obstetric and Genecology, Kfar-Saba, Israel

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and extensive tissue fibrosis of the skin and internal organs. Endothelial cells (ECs),…
  • Abstract Number: 2519 • ACR Convergence 2023

    A Phase II Clinical Study to Investigate the Efficacy and Safety of Hemay005 Tablets in Patients with Active Behçet`sDisease

    Charles Jones1, Zhanguo Li2, Zhuoli Zhang3, Jian Wu4, Guixiu Shi5, Wenjie Zheng6, Jianping Tang7, Xiaobing Wang8, Lie Dai9, Lin Chen10, Yasong Li11, Ling Wu12, Yongfu Wang13, Shengyun Liu14, Yao Ke15, Jin Lin16, Zhenchun Zhang17, Jiankang Hu18, Wantai Dang19, Songlou Yin20, Xin Tang21, Mingfei Zhu22, Jinfeng Lin22, Richard Jones22, Weiguo Wan23 and xianjun Hu22, 1Hemay Pharmaceuticals, Tianjin, China, 2Peking University Health Science Center, Department of Rheumatology and Immunology, People's Hospital, Beijing, China, 3Peking University First Hospital, Rheumatology and Immunology Department, Beijing, China, 4Suzhou University Affiliated First Hospital, Suzhou, China, 5the First Affiliated Hospital of Xiamen University, Xiamen, China, 6Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, 7Shanghai Tongji Hospital, Shanghai, China, 8The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, 9Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, 10Jilin Provincial People's Hospital, Changchun, China, 1111Zhejiang Provincial People's Hospital, Hangzhou, China, 12University of Hong Kong Shenzhen Hospital, Shenzhen, China, 13The First Affiliated Hospital of Baotou Medical College, Baotou, China, 14The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 15Jiangsu Provincial People's Hospital, Nanjing, China, 16The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 17Linyi People's Hospital, Linyi, China, 18Pingxiang People’s Hospital, PingXiang, China, 19The First Affiliated Hospital of Chengdu Medical College, Chengdu, China, 20Xuzhou Medical University Affiliated Hospital, Xuzhou, China, 21Bestudy (Shanghai) Medical Technology Co., Ltd, Shanghai, China, 22Clinical Department, Tianjin Hemay Pharmaceutical Co., Ltd., Tianjin, China, 23Huashan Hospital Affiliated to Fudan University, Shanghai, China

    Background/Purpose: Behçet's disease (BD) is a chronic and recurrent vascular inflammatory disease with major manifestations including oral ulcers, genital ulcers, skin damage and ophthalmitis, and…
  • Abstract Number: 2554 • ACR Convergence 2023

    Validation of a Flare Risk Index Informed by Select Immune Mediators in Systemic Lupus Erythematosus in a Confirmatory Cohort

    Melissa Munroe1, Derek Blankenship2, Daniele DeFreese2, Adrian Holloway2, Mohan Purushothaman2, Wade DeJager3, Susan Macwana3, Joel Guthridge3, Stan Kamp3, Nancy Redinger3, Teresa Aberle3, Eliza Chakravarty3, Cristina Arriens4, Yanfeng Li5, Hu Zeng5, Stephanie Dezzutti6, Peter Izmirly7, Uma Thanarajasingam5, Diane L. Kamen6, Jill Buyon8, Judith James3 and Eldon Jupe2, 1Oklahoma Medical Research Foundation; Progentec Diagnostics, Inc., Oklahoma City, OK, 2Progentec Diagnostics, Inc., Oklahoma City, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, Department of Arthritis & Clinical Immunology, Oklahoma City, OK, 5Mayo Clinic, Rochester, MN, 6Medical University of South Carolina, Charleston, SC, 7New York University School of Medicine, New York, NY, 8NYU Grossman School of Medicine, New York, NY

    Background/Purpose: SLE is marked by immune dysregulation linked to varied clinical disease activity. Using a unique confirmatory cohort of SLE patients, this study seeks to…
  • Abstract Number: 1682 • ACR Convergence 2022

    Peptidyl Arginine Deiminase Expression and Macrophage Polarization Following Stimulation with Citrullinated and Malondialdehyde-acetaldehyde Modified Fibrinogen

    nozima Aripova1, Michael Duryee1, carlos hunter1, Bryant England1, Debra Romberger1, James O'Dell1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Post-translational modifications (PTM) of extracellular matrix proteins, such as fibrinogen, have been implicated in the pathogenesis of rheumatoid arthritis (RA). Citrullination, a type of…
  • Abstract Number: 2160 • ACR Convergence 2022

    The Role of CCL21 in Serum Samples from Systemic Sclerosis Patients

    Henriette Didriksen1, Øyvind Molberg2, Adi Mehta3, Suzana Jordan4, Håvard Fretheim3, Einar Gude3, Thor Ueland3, Cathrine Brunborg3, Vyacheslav Palchevskiy5, Torhild Garen3, Øyvind Midtvedt3, Arne Andreassen3, Fridtjof Lund-Johansen3, Oliver Distler4, John Belperio5 and Anna-Maria Hoffmann-Vold3, 1Oslo University Hospital, Moss, Norway, 2Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 3Oslo University Hospital, Oslo, Norway, 4Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 5University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Chemokines appear to be important for the pathogenesis of autoimmune diseases. Humans may generate antibodies targeting chemokines leading to inhibition of signaling and driving…
  • Abstract Number: 0012 • ACR Convergence 2022

    Role of Type L IFN Signaling on B Cell Pathogenicity in Early Sjögren’s Disease in Mouse Model

    Merri-Grace Allred and Scott Lieberman, University of Iowa, Iowa City, IA

    Background/Purpose: Sjogren's disease is a chronic autoimmune disease autoimmune disease characterized by foci of inflammation of the lacrimal and salivary glands. As disease progresses, B…
  • Abstract Number: 0013 • ACR Convergence 2022

    Binding of CXCL13 with Heparan Sulfate of Syndecan-1 Plays an Important Role in Pathogenesis of Sjögren’s Syndrome

    Eon Jeong Nam1, Na Ri Kim1 and Gun Woo Kim2, 1Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea, 2Daegu Fatima Hospital, Daegu, Republic of Korea

    Background/Purpose: Sjögren's syndrome (SS) is a chronic autoimmune disorder with lymphocytic infiltration in exocrine and non-exocrine epithelia, in which epithelial cells play a critical role…
  • Abstract Number: 0266 • ACR Convergence 2022

    Expression of Cytokine and Chemokine Genes in Patients with Clinically Suspect Arthralgia; A Longitudinal Study During Progression to Inflammatory Arthritis or Non-Progression

    Judith Heutz1, Cleo Rogier2, Ellis Niemantsverdriet3, Susan van den Eeden4, Pascal de Jong5, Annemieke Geluk6 and Annette van der Helm-van Mil7, 1Erasmus Medical Center, Rotterdam, Netherlands, 2Erasmus MC, Rotterdam, Netherlands, 3LUMC, Leiden, Netherlands, 4Leiden University Medical Center (LUMC), Leiden, Netherlands, 5ErasmusMC, Hendrik Ido Ambacht, Netherlands, 6Leiden University Medical Center (LUMC), Leiden, Zuid-Holland, Netherlands, 7Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands

    Background/Purpose: Autoantibody responses rise years before onset of inflammatory arthritis (IA) and are stable during transitioning from clinically suspect arthralgia (CSA) to IA (1). Cytokine…
  • Abstract Number: 0586 • ACR Convergence 2022

    Transcription Factor Fli-1 Impacts CXCL13 Expression and Renal Inflammation in Lupus-like Nephritis of Adult MRL/lpr Mouse

    Shuzo Sato1, Xian Zhang2, Naoki Matsuoka1, Yuya Sumichika1, Kenji Saito1, Shuhei Yoshida1, Haruki Matsumoto1, Jumpei Temmoku1, Yuya Fujita1, Tomoyuki Asano1, Hiroshi Watanabe1 and Kiyoshi Migita1, 1Fukushima Medical University, Fukushima, Japan, 2Medical University of South Carolina, Charleston, SC

    Background/Purpose: Friend leukemia virus integration 1 (Fli-1) belongs to the Ets family of transcription factors and plays an important role in the development of lupus…
  • Abstract Number: 0614 • ACR Convergence 2022

    Post-translationally Modified Fibrinogen Activated Macrophages Drive the Expression of Fibrotic Genes in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

    nozima Aripova1, Michael Duryee1, carlos hunter1, Eric Daubach1, Evan Ryan1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Cellular interactions between synovial macrophages and human fibroblast-like synoviocytes (HFLS) contribute to articular inflammation and fibrosis in rheumatoid arthritis (RA), leading to subsequent joint…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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