Abstracts tagged "Cell therapy"

Abstract Number: 1995 • 2019 ACR/ARP Annual Meeting
Gingival-Derived Mesenchymal Stem Cells Alleviate Cartilage Damage in Collagen-Induced Arthritis via Suppressing Activities of Inflamed Synovial Fibroblast
Ximei Zhang¹, Julie Wang ², Nancy Olsen ³, Wael Jarjour ⁴ and Song Guo Zheng ⁴, ¹Ohio State College of Medicine, Columbus, ²Ohio State University, columbus, ³Penn State University, Hershey, PA, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: Dysfunction of immunology and inflammatory responses is crucial in initiating and promoting bone/cartilage destruction in rheumatic arthritis (RA). Inflamed synovial fibroblast cells (ISFs) are…
Abstract Number: 2007 • 2018 ACR/ARHP Annual Meeting
Generation of Human Induced Pluripotent Stem Cell Lines from Patients with Hand Osteoarthritis
Rocío Castro-Viñuelas¹, Clara Sanjurjo-Rodríguez², María Piñeiro-Ramil², Tamara Hermida-Gómez³, Francisco Javier De Toro Santos⁴, Francisco J Blanco⁵, Isaac Fuentes-Boquete² and Silvia María Díaz-Prado², ¹Cell Therapy and Regenerative Medicine research group. Dept. Physiotherapy, Medicine and Biomedical Sciences. University of A Coruña. Institute of Biomedical Research of A Coruña (INIBIC), A Coruña, Spain., A Coruña, Spain, ²Cell Therapy and Regenerative Medicine research group. Dept. Physiotherapy, Medicine and Biomedical Sciences. University of A Coruña. Institute of Biomedical Research of A Coruña (INIBIC), A Coruña, Spain., A CORUÑA, Spain, ³Grupo de Bioingeniería Tisular y Terapia Celular (CBTTC-CHUAC). CIBER-BBN/ISCIII. Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de Coruña (CHUAC). SERGAS. Universidade de A Coruña, A Coruña, Spain, ⁴Cell Therapy and Regenerative Medicine research group. Dept. Physiotherapy, Medicine and Biomedical Sciences. University of A Coruña. Institute of Biomedical Research of A Coruña (INIBIC), A Coruña, Spain., La Coruña, Spain, ⁵Grupo de Investigación en Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose: Although hand osteoarthritis (OA) is a worldwide burden, there is no treatment able to cure it. Induced pluripotent stem cells (iPSCs) are considered ideal…
Abstract Number: 177 • 2016 ACR/ARHP Annual Meeting
Treatment with Dexamethasone and Monophosphoryl Lipid a Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers the Ability to Modulate CD4+ T Cell Responses
Paulina García-González^1,2, Oscar Neira³, Katina Schinnerling^1,2, Alejandro Sepúlveda-Gutiérrez⁴, Jaxaira Maggy^1,2, Lorena Hoyos^1,2, Rodrigo Morales^1,2, Gabriela Ubilla-Olguín^1,2, Ahmed Mehdi⁵, Hendrik Nel⁶, Lilian Soto^1,7, Bárbara Pesce^1,2, María Carmen Molina¹, Miguel Cuchacovich⁸, Milton Larrondo⁹, Diego Catalán^1,2, Catharien M. Hilkens¹⁰, Ranjeny Thomas¹¹, Ricardo Verdugo⁴ and Juan C. Aguillón^1,2, ¹Programa Disciplinario de Inmunología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile, Santiago, Chile, ²Millennium Institute on Immunology and Immunotherapy, Santiago, Chile, Santiago, Chile, ³Rheumatology Unit, Hospital del Salvador. Facultad de Medicina. Universidad de Chile, Santiago, Chile, ⁴Programa de Genética Humana, ICBM, Universidad de Chile, Santiago, Chile, Santiago, Chile, ⁵Diamantina Institute, The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia, ⁶The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ⁷Unidad de Dolor, Hospital Clínico de la Universidad de Chile, Santiago, Chile, Santiago, Chile, ⁸Sección de Reumatología, Departamento de Medicina, Hospital Clínico de la Universidad de Chile, Santiago, Chile, ⁹Banco de Sangre, Hospital Clínico Universidad de Chile, Santiago, Chile, Santiago, Chile, ¹⁰Institute of Cellular Medicine, Musculoskeletal Research Group, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Newcastle upon Tyne,, United Kingdom, ¹¹The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia
Background/Purpose: Tolerogenic dendritic cells (TolDCs) are promising tools for therapy of autoimmune diseases such as rheumatoid arthritis (RA). Here we characterise TolDCs from RA patients…
Abstract Number: 2890 • 2016 ACR/ARHP Annual Meeting
Feasibility of Same Day Adipose Tissue Harvest, Cell Processing and Subcutaneous Delivery of Adipose Derived Regenerative Cells into Fingers of Scleroderma Patients within a Randomized Double Blind Clinical Trial
Dinesh Khanna¹, Maureen D Mayes², Robert W. Simms³, Virginia D. Steen⁴, Steven Cohen⁵, Paul Caldron⁶, Richard Martin⁷, Suzanne Kafaja⁸, Ankoor Shah⁹, Shadi Shahouri¹⁰, Robert F. Spiera¹¹, John Ervin¹², Vivien Hsu¹³, Robyn T. Domsic¹⁴, Laura K. Hummers¹⁵, John Yocum¹⁶, Soumya Chatterjee¹⁷, Chris T. Derk¹⁸, John Varga¹⁹, Mark Adams²⁰, Eve M. Taylor²¹, Steven Kesten²¹ and Daniel E. Furst²², ¹University of Michigan, Ann Arbor, MI, ²Rheumatology, University of Texas Medical School at Houston, Houston, TX, ³Rheumatology, Boston University School of Medicine, Boston, MA, ⁴Rheumatology, Georgetown University Medical Center, Washington, DC, ⁵FacesPlus, San Diego, CA, ⁶Arizona Arthritis and Rheumatology Associates, Phoenix, AZ, ⁷West Michigan Rheumatology, Grand Rapids, MI, ⁸Rheumatology, University of California Los Angeles, Los Angeles, CA, ⁹Medicine, Duke University Medical Center, Durham, NC, ¹⁰Heartland Research Associates, Wichitas, KS, ¹¹Rheumatology, Hospital for Special Surgery, New York, NY, ¹²Center for Pharmaceutical Research, Kansas City, MO, ¹³RWJ Medical School, New Brunswick, NJ, ¹⁴Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ¹⁵Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁶Baptist Health Center for Clinical Research, Little Rock, AR, ¹⁷Rheumatic and Immunologic Ds, Cleveland Clinic, Cleveland, OH, ¹⁸Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁹Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ²⁰Central Kentucky Research, Lexington, KY, ²¹Cytori Therapeutics, Inc., San Diego, CA, ²²Arthritis Associates of Southern California, Los Angeles, CA
Background/Purpose: Current medical therapy to improve hand function has had very limited benefit in patients with systemic sclerosis (SSc). Cells present within a person’s own…
Abstract Number: 2999 • 2016 ACR/ARHP Annual Meeting
Autologous Osteoblastic Cells Versus Concentrated Bone Marrow Implantation in Osteonecrosis of the Femoral Head: A Randomized Controlled Single Blind Study
Valérie Gangji¹, Michel Toungouz², Chantal Lechanteur³, Yves Beguin³, Etienne Baudoux³, Michel Malaise⁴, Viviane De maertelaer⁵, Sanjiva Pather⁶, Julia Ino⁷ and Jean-Philippe Hauzeur⁴, ¹Rheumatology, Hôpital Erasme, brussels, Belgium, ²Hemobiology and Transfusion Dept, Hôpital Erasme, brussels, Belgium, ³Hematology & Laboratory of Cell Therapy,, Sart Tilman, Liège, Belgium, ⁴Rheumatology, Sart Tilman, Liège, Belgium, ⁵Faculty of Medicine, Université Libre de Bruxelles, brussels, Belgium, ⁶Radiology, Hopital Erasme, Brussels, Belgium, ⁷Bone Therapeutics, Gosselies, Belgium
Background/Purpose: Non traumatic osteonecrosis (ON) of the femoral head is characterized by epiphyseal necrosis leading to femoral head collapse and eventually hip replacement. The physiopathology…
Abstract Number: 1726 • 2014 ACR/ARHP Annual Meeting
Therapeutic Efficacy of Mesenchymal Stem Cells in Diffuse Murine Hypochlorite-Induced Systemic Sclerosis
Alexandre Maria¹, Claire Bony², Karine Toupet², Christian Jorgensen³, Philippe Guilpain⁴ and Daniele Noel⁵, ¹U844, Inserm, Montpellier, France, ²Inserm, Montpellier, France, ³Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Lapeyronie., Montpellier, France, ⁴Department of Internal Medicine, Montpellier, France, ⁵Inserm U844, UM1, Montpellier, France
Background/Purpose Systemic sclerosis (SSc) is a rare intractable disease with unmet medical need and fibrosis-related mortality. Absence of efficient treatments has prompted to develop novel…
Abstract Number: 1530 • 2014 ACR/ARHP Annual Meeting
Autologous Tolerogenic Dendritic Cells for Rheumatoid and Inflammatory Arthritis
Gillian Bell¹, Amy E. Anderson¹, Julie Diboll¹, Rachel Harry¹, Elaine McColl², Anne Dickinson³, Catharien Hilkens¹ and John D Isaacs¹, ¹Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ²Clinical Trials Unit, Institute of Health and Society, NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ³Institute of Cellular Medicine (Haematological Sciences), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom
Background/Purpose Rheumatoid arthritis (RA) is a chronic autoimmune disease which results from a breakdown of immune tolerance. Despite their efficacy current RA therapeutics, including biologic…
Abstract Number: 2644 • 2013 ACR/ARHP Annual Meeting
Phase IB/Iia Study On Intravenous Administration Of Expanded Allogeneic Adipose-Derived Mesenchymal Stem Cells In Refractory Rheumatoid Arthritis Patients
JM Alvaro-Gracia¹, Juan A. Jover², Rosario Garcia-Vicuña³, Luis Carreño⁴, Alberto Alonso⁵, Sara Marsal⁶, Francisco J. Blanco⁷, Víctor M. Martínez-Taboada⁸, Peter C. Taylor⁹, Federico Díaz-González¹⁰ and Lydia Dorrego¹¹, ¹Unidad de Terapias Biológicas. Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain, ²Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ³Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁴Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, ⁵Hospital de Cruces, Bilbao, Spain, ⁶Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ⁷INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ⁸Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV., Santander, Spain, ⁹NDORMS, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ¹⁰Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, ¹¹TiGenix, Tres Cantos, Spain
Background/Purpose: Expanded adipose-derived stem cells (eASCs) are shown to have immune-modulatory effects both in vitro and in animal models of arthritis. eASCs are currently under…
Abstract Number: 1286 • 2013 ACR/ARHP Annual Meeting
Anti-Inflammatory Effects Of Tyrosine-Hydroxylase(TH)-Positive Catecholamine Producing Cells In Chronic Arthritis
Zsuzsa Jenei-Lanzl¹, Silvia Capellino², Frieder Kees³ and Rainer H. Straub⁴, ¹Department of Internal Medicine, University Hospital Regensburg, 1Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Regensburg, Germany, ²2Department of Pediatrics, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA., Baltimore, MD, ³Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany, ⁴Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: In previous studies we have shown that inflammatory processes in experimental arthritis are strongly affected by the sympathetic nervous system (SNS): In the early…

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