Abstracts tagged "cartilage"

Abstract Number: 906 • 2017 ACR/ARHP Annual Meeting
Anp32a Is a Critical Regulator of Oxidative Stress in Cartilage and Protects Against Osteoarthritis
Frederique Cornelis¹, Silvia Monteagudo¹, Wouter den Hollander², Tine Peeters³, Laura-An Guns¹, Lies Storms¹, Ingrid Meulenbelt² and Rik Lories¹, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Skeletal Biology and Engineering Research Center, KU Leuven, 3000, Belgium
Background/Purpose: We described an association between polymorphisms in the ANP32a gene and osteoarthritis. Osteoarthritis is one of the most common chronic musculoskeletal disorders and a…
Abstract Number: 969 • 2017 ACR/ARHP Annual Meeting
Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage
Cecilie F. Kjelgaard-Petersen^1,2, Neha Sharma^1,3, Ashref Kayed^4,5, Britt Christensen¹, Morten Karsdal⁶, Anne-C. Bay-Jensen⁷ and Christian S. Thudium¹, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Bioengineering, Technical University of Denmark, Kgs. Lyngby, Denmark, ³Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, ⁴Research and Biomarkers, Nordic Bioscience, Herlev, Denmark, ⁵Biomolecular Sciences, University of Copenhagen, Copenhagen, Denmark, ⁶Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ⁷Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Several inflammatory cytokines and intracellular signaling pathways have been targeted in drug development with varying clinical results. Improved understanding of the intracellular signaling’s modulation…
Abstract Number: 1928 • 2017 ACR/ARHP Annual Meeting
Fibroblast-like Synovial Cell Production of ED-a Fibronectin Contributes to Inflammation in Osteoarthritis
Tue Wenzel Kragstrup^1,2,3, Dong Hyun Sohn⁴, Christin Lepus³, Kazuhiro Onuma⁵, Qian Wang³, William H. Robinson³ and Jeremy Sokolove³, ¹Randers Regional Hospital, Randers, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁴Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Korea, Republic of (South), ⁵VA Palo Alto Healthcare System and Stanford University, Stanford, CA
Background/Purpose: The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Wear and tear leads to tissue degradation followed by…
Abstract Number: 1929 • 2017 ACR/ARHP Annual Meeting
Sustained Efficacy of Intra-Articular SB-061, a Novel Matrix Regulator Inspired By Aggrecan, in a Rat Model of Osteoarthritis
Kate Stuart¹, Julia Chen¹, Sharmi Saha¹, Harsha Kabra¹, Athene Chan¹, Kamal Egodoge¹, Jennifer Oskins², Chaohua Lin², Morten Karsdal³, Mark Chambers² and John Paderi¹, ¹Symic Bio, Emeryville, CA, ²Lilly Research Laboratories, Indianapolis, IN, ³Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark
Background/Purpose: No therapy for osteoarthritis (OA) has yet to deliver both structural and symptomatic benefits. Symic is approaching this unmet clinical need with a novel…
Abstract Number: 1945 • 2017 ACR/ARHP Annual Meeting
Repositioning Suramin As a Cartilage-Protective Drug
Laura-An Guns¹, Silvia Monteagudo¹, Maryna Kvasnytsia¹, Greet Kerckhofs¹, Jennifer Vandooren², Ghislain Opdenakker², Frederic Cailotto^1,3 and Rik Lories⁴, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Rega Institute, KU Leuven, Leuven, Belgium, ³University of Lorraine, Nancy, France, ⁴Rheumatology, UZ Leuven, Leuven, Belgium
Background/Purpose: Drug repositioning is a recent pharmaceutical strategy to discover new uses for market-approved drugs with known safety profiles that can provide quick transition from…
Abstract Number: 2896 • 2017 ACR/ARHP Annual Meeting
Human Cartilage Influences the Crystallization of Monosodium Urate; Understanding the Link between Gout and Osteoarthritis
Ashika Chhana¹, Bregina Pool², Ally Choi¹, Ryan Gao¹, Mark Zhu¹, Jillian Cornish², Jacob Munro³ and Nicola Dalbeth⁴, ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Orthopaedics, Auckland City Hospital, Auckland, New Zealand, ⁴University of Auckland, Auckland, New Zealand
Background/Purpose: Monosodium urate (MSU) crystal deposition and gout flares frequently affect joints that have been damaged or are affected by osteoarthritis. The aim of…
Abstract Number: 48 • 2017 ACR/ARHP Annual Meeting
Modulation of Subchondral Bone Turnover Is Associated with Alteration of Cartilage Tissue Quality
Cedric Lavet, Isabelle Badoud and Patrick Ammann, Division of Bone Diseases, Geneva, Switzerland
Background/Purpose: Osteochondral unit is a bio composite responsible for an optimal distribution of load during movements and axial compression of a joint. Any alteration of…
Abstract Number: 62 • 2017 ACR/ARHP Annual Meeting
Convergence of Joint Repair and Pain Pathways Via Nerve Growth Factor and p75 Expressing Mesenchymal Stem Cells in Established Osteoarthritis
Thomas Baboolal¹, Sumaiya Al Hinai², Elena Jones², Jill Reckless³, Martyn Foster⁴, Rachel Doyle⁵, Kerry af Forselles⁴, Simon Westbrook⁴ and Dennis McGonagle², ¹PhD, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Rxcelerate Ltd, Cambridge, United Kingdom, ⁴Levicept Ltd, Ramsgate, United Kingdom, ⁵Tetrad Discovery Ltd, Ramsgate, United Kingdom
Background/Purpose: Nerve growth factor (NGF) is a key regulator of pain and anti-NGF therapy reduces osteoarthritis (OA) associated pain. However, anti-NGF therapy is associated with…
Abstract Number: 240 • 2017 ACR/ARHP Annual Meeting
Finger Joint Cartilage Thickness Evaluated By Semiquantitative Ultrasound Score in Patients with Rheumatoid Arthritis
Takehisa Ogura¹, Ayako Hirata¹, Sayaka Takenaka², Hideki Ito², Yuki Inoue¹, Chihiro Imaizumi², Yuto Takakura², Kennosuke Mizushina¹, Takaharu Katagiri², Norihide Hayashi², Rie Kujime¹, Munetugu Imamura² and Hideto Kameda³, ¹Department of Rheumatology, Toho University Ohashi Medical Center, Tokyo, Japan, ²Toho University Ohashi Medical Center, Tokyo, Japan, ³Division of Rheumatology, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Background/Purpose: Joint destruction in rheumatoid arthritis (RA) includes both bone and cartilage lesions. By X-ray examination, cartilage destruction is evaluated as the joint space narrowing…
Abstract Number: 305 • 2017 ACR/ARHP Annual Meeting
Ultrasonographic Evaluation of the Femoral Cartilage, Achilles Tendon and Plantar Fascia in Young Women Wearing High-Heeled Shoes
Ayşen Akinci¹, Kamal Mezian², Ayşe Merve Ata¹, Murat Kara¹, Şule Şahin Onat³, Eda Gürçay⁴, Aslı Çalışkan¹, Maria Ines Taboas Simoes⁵ and Levent Özçakar¹, ¹Hacettepe University Medical School Department of Physical Medicine and Rehabilitation, Ankara, Turkey, ²Czech Technical University in Prague, Faculty of Biomedical Engineering, Department of Health Care Disciplines and Population Protection, Kladno, Czech Republic, ³Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey, ⁴Gaziler Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey, ⁵PMR hospitalar assistant in Centro Hospitalar Entre Douro e Vouga, E.P.E, Portugal
Background/Purpose: Wearing high-heeled shoes (HHS) may include structural and functional abnormalities due to repetitive stress particularly in the knee and forefoot. The aim of this…
Abstract Number: 903 • 2017 ACR/ARHP Annual Meeting
Increased Expression of CCN4/WISP1 in Osteoarthritic Articular Cartilage Is Epigenetically Regulated and Disrupts Cartilage Homeostasis
Martijn H. van den Bosch¹, Yolande F. Ramos², Wouter den Hollander², Nils Bömer², Rob G. Nelissen³, Judith V. Bovée⁴, Peter L. van Lent¹, Arjen B. Blom¹, Peter M. van der Kraan¹ and Ingrid Meulenbelt², ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Orthopedics, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Pathology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Previously, we described increased expression of Wnt-1-induced signaling protein 1 (Wisp1) in murine synovium and cartilage after induction of experimental osteoarthritis (OA) models. WISP1…
Abstract Number: 2121 • 2016 ACR/ARHP Annual Meeting
Identification of microRNA-181a-5p and microRNA-4454 As Mediators of Facet Cartilage Degeneration
Akihiro Nakamura^1,2, Y. Raja Rampersaud^3,4, Anirudh Sharma^1,2, Stephen J. Lewis^3,5, Brian Wu^1,2, Poulami Datta^1,2, Kala Sundararajan⁶, Helal Endisha^1,2, Evgeny Rossomacha^1,2, Jason S Rockel^1,2, Igor Jurisica⁷ and Mohit kapoor^1,2,8, ¹Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, University Health Netwok, Toronto, ON, Canada, ³Orthopaedic Surgery and Neurosurgery, Arthritis Program, University Health Network, Toronto, ON, Canada, ⁴Orthopaedics, Toronto Western Hospital, Toronto, ON, Canada, ⁵Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, ON, Canada, ⁶Orthopaedic Research Department, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁷Medical Biophysics and Computer Science, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, ⁸Surgery, Laboratory Medicine, and Pathobiology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) of spine (facet joints, FJ) is one of the major causes of severe low back pain and disability worldwide. However, specific mechanisms…
Abstract Number: 2124 • 2016 ACR/ARHP Annual Meeting
Maintenance of Chondrocyte Phenotypic Stability By TRPC6 Calcium Channel Activity
Joanna Sherwood¹, Jessica Bertrand², Francesco Dell'Accio³ and Thomas Pap⁴, ¹Institute for Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ²Department of Orthopedic Surgery, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany, ³William Harvey Research Institute,, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁴Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: The ELR+ CXC chemokine CXCL6 is produced by healthy articular chondrocytes and retained within the cartilage matrix via interactions with heparan sulphate proteoglycans. There,…
Abstract Number: 2125 • 2016 ACR/ARHP Annual Meeting
Aggrecan Degradation Is Not Just Aggrecan Degradation:a Study of the Neo-Epitopes Tege and Args Released from Cartilage upon Aggrecanase Activity
Anne Sofie Siebuhr¹, Yi He², Yunyun Lou², Sabine Hoielt³, Morten Asser Karsdal¹ and Anne C. Bay-Jensen¹, ¹Rheumatology, Nordic Bioscience, Herlev, Denmark, ²Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Rheumatology, Nordic Bioscience, Biomarkers and Research, 2730, Denmark
Background/Purpose: Cartilage degradation is a hallmark of arthritic disease. The main constituents of cartilage is aggrecan and type II collagen. Previous studies have shown that…
Abstract Number: 2126 • 2016 ACR/ARHP Annual Meeting
Cytokine Dependent Effects of Anti-Inflammatory Inhibitors Targeting JAK and p38 on Cartilage Turnover
Christian S. Thudium¹, Cecilie F. Kjelgaard-Petersen^1,2, Britt Christensen¹, Morten Asser Karsdal³ and Anne C. Bay-Jensen³, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark, ³Rheumatology, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Rheumatoid arthritis (RA) and inflammatory subtypes of osteoarthritis (iOA) are degenerative joint diseases with an inflammatory component allowing for potential anti-inflammatory treatment benefit. A…

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