Abstracts tagged "cartilage"

Abstract Number: 55 • 2018 ACR/ARHP Annual Meeting
Adipose Derived Stem Cell Suppressed Synovial Inflammation and Repaired Cartilage Destruction in Rheumatoid Arthritis Model Mice
Tadashi Okano¹, Kentaro Inui², Hideki Ueyama³, Kumi Orita³, Tatsuya Koike⁴ and Hiroaki Nakamura², ¹Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ²Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ³Osaka City University Graduate School of Medicine, Osaka, Japan, ⁴Center for Senile Degenerative Disorders, Osaka City University Graduate School of Medicine, Osaka, Japan
Background/Purpose: Adipose derived stem cell (ADSC) is one of the stem cells produced by adipose tissue which can be collected easily and in large quantities.…
Abstract Number: 2005 • 2018 ACR/ARHP Annual Meeting
Identification of a Human Cartilage Microbial DNA Signature and Characterization of Distinct Microbiome Profiles Associated with Osteoarthritis
Chris Dunn^1,2, Cassandra Velasco^1,3, Alexander Rivas⁴, Madison Andrews^3,5, Paul Jacob⁶ and Matlock A. Jeffries^2,7, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴University of Arkansas for Medical Sciences, Little Rock, AR, ⁵Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Oklahoma Sport Science and Orthopedics, Oklahoma City, OK, ⁷Department of Medicine, Division of Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Osteoarthritis (OA) is both the most common form of arthritis and a leading cause of chronic disability. Bacterial products, including lipopolysaccharide (LPS), have been…
Abstract Number: 304 • 2018 ACR/ARHP Annual Meeting
Dynamic MRI in Rheumatoid Arthritis for the Assessment of Synovitis Promoting Cartilage Loss
Philipp Sewerin¹, Anja Mueller-Lutz², Matthias Schneider³, Christoph Schleich⁴, Benedikt Ostendorf¹ and Stefan Vordenbäumen⁵, ¹Department and Hiller-Research-Unit for Rheumatology, Heinrich-Heine University, Düsseldorf, Germany, ²Department for diagnostic and interventional Radiology, Heinrich-Heine University, Düsseldorf, Germany, ³Department and Hiller-Research-Unit for Rheumatology, Heinrich-Heine University, Duesseldorf, Germany, ⁴Department for diagnostic and interventional Radiology, Heinrich-Heine University, Duesseldorf, Germany, ⁵Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany
Background/Purpose: To investigate the local inflammatory activity of the synovium by using dynamic magnetic resonance imaging (MRI) and cartilage biochemical composition of the MCP-joints 2…
Abstract Number: 2006 • 2018 ACR/ARHP Annual Meeting
Murine Ear Wound Cartilage Superhealer Trait Is Associated with Gut Microbiota Changes and Is Transferable to Non-Healer Mice By Gut Microbiome Transplant
Chris Dunn^1,2, Cassandra Velasco^1,3, Madison Andrews^3,4, Alexander Rivas⁵ and Matlock A. Jeffries^2,6, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵University of Arkansas for Medical Sciences, Little Rock, AR, ⁶Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. Previous studies…
Abstract Number: 436 • 2018 ACR/ARHP Annual Meeting
Structural Effects of Intra-Articular Sprifermin in Symptomatic Radiographic Knee Osteoarthritis: A Post-Hoc Analysis of Cartilage Morphology over the 2-Year Treatment-Period of a 5-Year Randomized, Placebo-Controlled, Phase II Study
Ali Guermazi¹, Jeffrey Kraines², Aida Aydemir², Stephen Wax³, Michel Crema⁴, Marc C. Hochberg⁵ and Frank Roemer^1,6, ¹Radiology, Boston University School of Medicine, Boston, MA, ²EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ³EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), BIllerica, MA, ⁴Boston University School of Medicine, Boston, MA, ⁵University of Maryland School of Medicine, Baltimore, MD, ⁶Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Sprifermin, a recombinant human fibroblast growth factor 18, is currently being investigated as a potential disease-modifying OA drug. Sprifermin treatment leads to a dose-dependent…
Abstract Number: 439 • 2018 ACR/ARHP Annual Meeting
Articular Cartilage from Osteoarthritis Patients Shows Extracellular Matrix Remodeling over the Course of Treatment with Sprifermin (Recombinant human fibroblast growth factor 18)
Ditte Reker¹, Christian S. Thudium², Anne Sofie Siebuhr³, Thorbjørn Gantzel⁴, Christoph Ladel⁵, Martin Michaelis⁵, Morten A. Karsdal², Anne Gigout⁵ and Anne C. Bay-Jensen², ¹Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁴cOrthopedic Surgery Unit, Gentofte Hospital, Hellerup, Denmark, ⁵Merck KGaA, Darmstadt, Germany
Background/Purpose: Sprifermin, a truncated form of human fibroblast growth factor 18 (FGF18), is being investigated as a potential cartilage and disease-modifying OA drug. In vitro,…
Abstract Number: 848 • 2018 ACR/ARHP Annual Meeting
A2A Adenosine Receptor Stimulation Switches TGF-β Signaling to Promote Chondrocyte Proliferation and Cartilage Regeneration
Carmen Corciulo¹, Cristina Castro², Samson Jacob³, David Fenyo³, Oran Kennedy⁴ and Bruce N. Cronstein⁵, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Medicine, NYU School of Medicine, New York, NY, ³Institute for Systems Genetics, NYU School of Medicine, New York, NY, ⁴Department of Anatomy, Royal College of Surgeons, Dublin, Ireland, ⁵Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: We previously found that intra-articular injections of liposomal preparations of adenosine completely prevent progression and reverse cartilage loss in post-traumatic OA. TGF-β signaling plays…
Abstract Number: 850 • 2018 ACR/ARHP Annual Meeting
Long Term Efficacy of Cartilage Repair Induced By scSOX9 in Situ with Bone Marrow-Derived Mesenchymal Stem Cells
Xiaowei Zhang^1,2, Shili Wu³, Yong Zhu³ and Cong-Qiu Chu^4,5, ¹Oregon Health & Science University, Portland, OR, ²VA Portland Health Care System, Portland, OR, ³VivoScript, Inc, Costa Mesa, CA, ⁴Rheumatology, Oregon Health & Science University, Portland, OR, ⁵Rheumatology, VA Portland Health Care System, Portland, OR
Background/Purpose: Microfracture induces fibrocartilage or fibro-hyaline cartilage both are biomechanically inferior to hyaline cartilage. We reported previously that a super positively charged SOX9 (scSOX9) improved…
Abstract Number: 912 • 2018 ACR/ARHP Annual Meeting
Association of Adiposity Measures in Childhood and Adulthood with Knee Cartilage Thickness, Volume and Bone Area in Young Adults
Tao Meng¹, Alison Venn¹, Felix Eckstein^2,3, Wolfgang Wirth^2,3, Flavia Cicuttini⁴, Lyn March⁵, Terence Dwyer^1,6, Marita Cross⁵, Laura Laslett¹, Graeme Jones¹, Changhai Ding^1,7 and Benny Samuel Eathakkattu Antony¹, ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Chondrometrics GmbH, Ainring, Germany, ³Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria, ⁴Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ⁵Institute of Bone and Joint Research, University of Sydney, Sydney, Australia, ⁶The George Institute for Global Health, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford, United Kingdom, ⁷Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Background/Purpose: Adiposity is associated with increased risk of knee osteoarthritis; cartilage thickness, cartilage volume and subchondral bone area are established biomarkers in knee osteoarthritis. We…
Abstract Number: 954 • 2018 ACR/ARHP Annual Meeting
A New Way to Think about Composite Magnetic Resonance Imaging Scores to Measure Osteoarthritis Severity and Progression
Lori Lyn Price^1,2, Jeffrey B. Driban³, Grace H. Lo⁴, Ming Zhang⁵, Michael P. LaValley⁶ and Timothy E. McAlindon⁷, ¹Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ²Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ³Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁴Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ⁵Tufts Medical Center, Boston, MA, ⁶Biostatistics, Boston University School of Public Health, Boston, MA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: For some rheumatologic diseases (e.g. lupus), separate scores evaluate cumulative damage and disease activity. No such strategy exists for osteoarthritis (OA). The prevailing approach…
Abstract Number: 1035 • 2018 ACR/ARHP Annual Meeting
Different Cartilage-Bone Unit in Patients with Primary Osteoarthritis and Secondary Osteoarthritis Caused By Rheumatoid Arthritis
Rasmus Klose-Jensen¹, Anne Friesgaard Christensen², Kresten Krarup Keller³ and Ellen-Margrethe Hauge^3,4, ¹Department of Rheumatology, Aarhus University Hospital, Aarhus, Aarhus C, Denmark, ²Department of Internal Medicine, Lillebaelt Hospital, Vejle, Vejle, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Aarhus, Denmark, ⁴Clinical medicine, Department of Clinical Medicine, Aarhus University Hospital, Århus N, Denmark
Background/Purpose: Despite distinct aetiologies of joint diseases, the osteoarthritic end-stage of primary osteoarthritis (OA) and rheumatoid arthritis (RA) are described using similar radiological features. However,…
Abstract Number: 1041 • 2018 ACR/ARHP Annual Meeting
The Anti-Adamts-5 Nanobody®, M6495, Protects Against Cartilage Breakdown in Cartilage and Synovial Joint Tissue Explant Models
Anne Sofie Siebuhr¹, Anne C. Bay-Jensen², Christian S. Thudium², Morten A. Karsdal², Benedikte Serruys³, Daniela Werkmann⁴, Martin Michaelis⁴, Christoph Ladel⁴ and Sven Lindemann⁴, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Ablynx NV, Zwijnaarde, Belgium, ⁴Merck KGaA, Darmstadt, Germany
Background/Purpose: Osteoarthritis (OA) is associated with cartilage breakdown, where degradation of aggrecan by ADAMTS-5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) is thought to…
Abstract Number: 1042 • 2018 ACR/ARHP Annual Meeting
Development of a Neo-Epitope Specific Assay for Serological Assessment of Type X Collagen Degradation and Its Potential Diagnostic Value for Knee Osteoarthritis
Yi He¹, Tina Manon-Jensen², Lars Arendt-Nielsen^3,4, Kristian Petersen³, Thorbjørn Gantzel⁵, Jonathan Samuels⁶, Steven B. Abramson⁷, Morten A. Karsdal⁸, Mukundan Attur⁹ and Anne C. Bay-Jensen⁸, ¹Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, ⁴C4Pain, Aalborg, Denmark, ⁵cOrthopedic Surgery Unit, Gentofte Hospital, Hellerup, Denmark, ⁶Department of Medicine, Divison of Rheumatology, NYU Langone Health, New York, NY, ⁷Dept of Medicine, NYU Langone Health, New York, NY, ⁸Nordic Bioscience, Herlev, Denmark, ⁹Rheumatology Research, NYU Langone Orthopedic Hospital, New York, NY
Background/Purpose: Phenotypic changes of chondrocytes toward hypertrophy might be fundamental in the pathogenesis of OA, of which type X collagen is a well-known marker. The…
Abstract Number: 969 • 2017 ACR/ARHP Annual Meeting
Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage
Cecilie F. Kjelgaard-Petersen^1,2, Neha Sharma^1,3, Ashref Kayed^4,5, Britt Christensen¹, Morten Karsdal⁶, Anne-C. Bay-Jensen⁷ and Christian S. Thudium¹, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Bioengineering, Technical University of Denmark, Kgs. Lyngby, Denmark, ³Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, ⁴Research and Biomarkers, Nordic Bioscience, Herlev, Denmark, ⁵Biomolecular Sciences, University of Copenhagen, Copenhagen, Denmark, ⁶Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ⁷Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Several inflammatory cytokines and intracellular signaling pathways have been targeted in drug development with varying clinical results. Improved understanding of the intracellular signaling’s modulation…
Abstract Number: 1928 • 2017 ACR/ARHP Annual Meeting
Fibroblast-like Synovial Cell Production of ED-a Fibronectin Contributes to Inflammation in Osteoarthritis
Tue Wenzel Kragstrup^1,2,3, Dong Hyun Sohn⁴, Christin Lepus³, Kazuhiro Onuma⁵, Qian Wang³, William H. Robinson³ and Jeremy Sokolove³, ¹Randers Regional Hospital, Randers, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁴Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Korea, Republic of (South), ⁵VA Palo Alto Healthcare System and Stanford University, Stanford, CA
Background/Purpose: The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Wear and tear leads to tissue degradation followed by…

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