Abstracts tagged "cartilage"

Abstract Number: 62 • 2017 ACR/ARHP Annual Meeting
Convergence of Joint Repair and Pain Pathways Via Nerve Growth Factor and p75 Expressing Mesenchymal Stem Cells in Established Osteoarthritis
Thomas Baboolal¹, Sumaiya Al Hinai², Elena Jones², Jill Reckless³, Martyn Foster⁴, Rachel Doyle⁵, Kerry af Forselles⁴, Simon Westbrook⁴ and Dennis McGonagle², ¹PhD, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Rxcelerate Ltd, Cambridge, United Kingdom, ⁴Levicept Ltd, Ramsgate, United Kingdom, ⁵Tetrad Discovery Ltd, Ramsgate, United Kingdom
Background/Purpose: Nerve growth factor (NGF) is a key regulator of pain and anti-NGF therapy reduces osteoarthritis (OA) associated pain. However, anti-NGF therapy is associated with…
Abstract Number: 240 • 2017 ACR/ARHP Annual Meeting
Finger Joint Cartilage Thickness Evaluated By Semiquantitative Ultrasound Score in Patients with Rheumatoid Arthritis
Takehisa Ogura¹, Ayako Hirata¹, Sayaka Takenaka², Hideki Ito², Yuki Inoue¹, Chihiro Imaizumi², Yuto Takakura², Kennosuke Mizushina¹, Takaharu Katagiri², Norihide Hayashi², Rie Kujime¹, Munetugu Imamura² and Hideto Kameda³, ¹Department of Rheumatology, Toho University Ohashi Medical Center, Tokyo, Japan, ²Toho University Ohashi Medical Center, Tokyo, Japan, ³Division of Rheumatology, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Background/Purpose: Joint destruction in rheumatoid arthritis (RA) includes both bone and cartilage lesions. By X-ray examination, cartilage destruction is evaluated as the joint space narrowing…
Abstract Number: 305 • 2017 ACR/ARHP Annual Meeting
Ultrasonographic Evaluation of the Femoral Cartilage, Achilles Tendon and Plantar Fascia in Young Women Wearing High-Heeled Shoes
Ayşen Akinci¹, Kamal Mezian², Ayşe Merve Ata¹, Murat Kara¹, Şule Şahin Onat³, Eda Gürçay⁴, Aslı Çalışkan¹, Maria Ines Taboas Simoes⁵ and Levent Özçakar¹, ¹Hacettepe University Medical School Department of Physical Medicine and Rehabilitation, Ankara, Turkey, ²Czech Technical University in Prague, Faculty of Biomedical Engineering, Department of Health Care Disciplines and Population Protection, Kladno, Czech Republic, ³Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey, ⁴Gaziler Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey, ⁵PMR hospitalar assistant in Centro Hospitalar Entre Douro e Vouga, E.P.E, Portugal
Background/Purpose: Wearing high-heeled shoes (HHS) may include structural and functional abnormalities due to repetitive stress particularly in the knee and forefoot. The aim of this…
Abstract Number: 903 • 2017 ACR/ARHP Annual Meeting
Increased Expression of CCN4/WISP1 in Osteoarthritic Articular Cartilage Is Epigenetically Regulated and Disrupts Cartilage Homeostasis
Martijn H. van den Bosch¹, Yolande F. Ramos², Wouter den Hollander², Nils Bömer², Rob G. Nelissen³, Judith V. Bovée⁴, Peter L. van Lent¹, Arjen B. Blom¹, Peter M. van der Kraan¹ and Ingrid Meulenbelt², ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Orthopedics, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Pathology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Previously, we described increased expression of Wnt-1-induced signaling protein 1 (Wisp1) in murine synovium and cartilage after induction of experimental osteoarthritis (OA) models. WISP1…
Abstract Number: 905 • 2017 ACR/ARHP Annual Meeting
Regenerating Cartilage and Reversing Osteoarthritis (OA) Stimulation of Adenosine A2A Receptors (A2AR) Increases Cartilage Volume and Matrix in Vitro and In Vivo
Carmen Corciulo¹, Cristina Castro², Thomas Coughlin³, Tuere Wilder¹, Oran Kennedy⁴ and Bruce Cronstein⁵, ¹Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Medicine, NYU School of Medicine, New York, NY, ³Orthopaedic Surgery, NYU School of Medicine, New York, NY, ⁴Department of Anatomy, Royal College of Surgeons, Dublin, Ireland, ⁵Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: We have recently reported that endogenously produced adenosine, interacting with A2AR, is a critical autocrine factor for maintenance of chondrocyte and cartilage homeostasis and…
Abstract Number: 906 • 2017 ACR/ARHP Annual Meeting
Anp32a Is a Critical Regulator of Oxidative Stress in Cartilage and Protects Against Osteoarthritis
Frederique Cornelis¹, Silvia Monteagudo¹, Wouter den Hollander², Tine Peeters³, Laura-An Guns¹, Lies Storms¹, Ingrid Meulenbelt² and Rik Lories¹, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Skeletal Biology and Engineering Research Center, KU Leuven, 3000, Belgium
Background/Purpose: We described an association between polymorphisms in the ANP32a gene and osteoarthritis. Osteoarthritis is one of the most common chronic musculoskeletal disorders and a…
Abstract Number: 969 • 2017 ACR/ARHP Annual Meeting
Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage
Cecilie F. Kjelgaard-Petersen^1,2, Neha Sharma^1,3, Ashref Kayed^4,5, Britt Christensen¹, Morten Karsdal⁶, Anne-C. Bay-Jensen⁷ and Christian S. Thudium¹, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Bioengineering, Technical University of Denmark, Kgs. Lyngby, Denmark, ³Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, ⁴Research and Biomarkers, Nordic Bioscience, Herlev, Denmark, ⁵Biomolecular Sciences, University of Copenhagen, Copenhagen, Denmark, ⁶Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ⁷Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Several inflammatory cytokines and intracellular signaling pathways have been targeted in drug development with varying clinical results. Improved understanding of the intracellular signaling’s modulation…
Abstract Number: 1928 • 2017 ACR/ARHP Annual Meeting
Fibroblast-like Synovial Cell Production of ED-a Fibronectin Contributes to Inflammation in Osteoarthritis
Tue Wenzel Kragstrup^1,2,3, Dong Hyun Sohn⁴, Christin Lepus³, Kazuhiro Onuma⁵, Qian Wang³, William H. Robinson³ and Jeremy Sokolove³, ¹Randers Regional Hospital, Randers, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁴Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Korea, Republic of (South), ⁵VA Palo Alto Healthcare System and Stanford University, Stanford, CA
Background/Purpose: The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Wear and tear leads to tissue degradation followed by…
Abstract Number: 1929 • 2017 ACR/ARHP Annual Meeting
Sustained Efficacy of Intra-Articular SB-061, a Novel Matrix Regulator Inspired By Aggrecan, in a Rat Model of Osteoarthritis
Kate Stuart¹, Julia Chen¹, Sharmi Saha¹, Harsha Kabra¹, Athene Chan¹, Kamal Egodoge¹, Jennifer Oskins², Chaohua Lin², Morten Karsdal³, Mark Chambers² and John Paderi¹, ¹Symic Bio, Emeryville, CA, ²Lilly Research Laboratories, Indianapolis, IN, ³Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark
Background/Purpose: No therapy for osteoarthritis (OA) has yet to deliver both structural and symptomatic benefits. Symic is approaching this unmet clinical need with a novel…
Abstract Number: 1945 • 2017 ACR/ARHP Annual Meeting
Repositioning Suramin As a Cartilage-Protective Drug
Laura-An Guns¹, Silvia Monteagudo¹, Maryna Kvasnytsia¹, Greet Kerckhofs¹, Jennifer Vandooren², Ghislain Opdenakker², Frederic Cailotto^1,3 and Rik Lories⁴, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Rega Institute, KU Leuven, Leuven, Belgium, ³University of Lorraine, Nancy, France, ⁴Rheumatology, UZ Leuven, Leuven, Belgium
Background/Purpose: Drug repositioning is a recent pharmaceutical strategy to discover new uses for market-approved drugs with known safety profiles that can provide quick transition from…
Abstract Number: 2896 • 2017 ACR/ARHP Annual Meeting
Human Cartilage Influences the Crystallization of Monosodium Urate; Understanding the Link between Gout and Osteoarthritis
Ashika Chhana¹, Bregina Pool², Ally Choi¹, Ryan Gao¹, Mark Zhu¹, Jillian Cornish², Jacob Munro³ and Nicola Dalbeth⁴, ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Orthopaedics, Auckland City Hospital, Auckland, New Zealand, ⁴University of Auckland, Auckland, New Zealand
Background/Purpose: Monosodium urate (MSU) crystal deposition and gout flares frequently affect joints that have been damaged or are affected by osteoarthritis. The aim of…
Abstract Number: 2134 • 2016 ACR/ARHP Annual Meeting
Bone Replaces Cartilage in Non-Weight Bearing Regions of Immobilized Knees
T Mark Campbell¹, Katherine Reilly², Odette Laneuville³, Hans Uhthoff⁴ and Guy Trudel⁵, ¹Physical Medicine and Rehabilitation, Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa, ON, Canada, ³Biology, University of Ottawa, Ottawa, ON, Canada, ⁴Surgery, The Ottawa Hospital, Ottawa, ON, Canada, ⁵Medicine, The Ottawa Hospital Rehabilitation Centre, Ottawa, ON, Canada
Bone Replaces Cartilage In Non-Weight Bearing Regions Of Immobilized KneesBackground/Purpose: Osteoarthritis causes pain, restricts joint range of motion, reduces function, is highly prevalent worldwide and…
Abstract Number: 139 • 2016 ACR/ARHP Annual Meeting
Reliability of Ultrasound in Detecting Cartilage Change in Patients with Rheumatoid Arthritis: A Study By Omeract Ultrasound Task Force
Peter Mandl¹, Emilio Filippucci², Farideh Alasti¹, Artur Bachta³, Marina Backhaus⁴, David Bong⁵, George A. W. Bruyn⁶, Paz Collado⁷, Nemanja Damjanov⁸, Christian Dejaco⁹, Andrea Delle Sedie¹⁰, Christina Duftner¹¹, Marwin Gutierrez¹², Hilde B. Hammer¹³, Cristina Hernandez-Diaz¹⁴, Annamaria Iagnocco¹⁵, Kei Ikeda¹⁶, David Kane¹⁷, Helen I. Keen¹⁸, Stephen Kelly¹⁹, Eszter Kővári²⁰, Eugenio De Miguel²¹, Ingrid Möller²², Uffe Møller Døhn²³, Esperanza Naredo²⁴, Juan Carlos Nieto²⁵, Carlos Pineda²⁶, Ana Rodriguez²⁷, Wolfgang A. Schmidt²⁸, Marcin Szkudlarek²⁹, Ralf G. Thiele³⁰, Lene Terslev³¹, Richard J. Wakefield³², Daniel Windschall³³, Maria Antonietta D'Agostino³⁴ and Peter Balint³⁵, ¹Department of Internal Medicine III; Division of Rheumatology, Medical University Vienna, Vienna, Austria, ²Università Politecnica delle Marche, Jesi, Italy, ³Military Medical Institute, Warsaw, Poland, ⁴Rheumatology, Park-Klinik Weissensee, Berlin, Germany, ⁵Rheumatology, Instituto Poal de Reumatologia, Barcelona, Spain, ⁶Rheumatology, MC Groep, Loenga, Netherlands, ⁷Rheumatology, Pediatric Rheumatology Unit, Hospital Universitario Severo Ochoa, Madrid, Spain, ⁸Institute of Rheumatology, University of Belgrade Medical School, Belgrade, Serbia, ⁹Rheumatology and Immunology, Medical University Graz, Graz, Austria, ¹⁰Department Rheumatology, University of Pisa, Pisa, Italy, ¹¹Medical University Innsbruck, Innsbruck, Austria, ¹²Instituto Nacional de Rehabilitación, Mexico, Mexico, ¹³Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, ¹⁴Instituto Nacional de Rehabilitación, Mexico City, Mexico, ¹⁵Sapienza Università Di Roma,, Roma, Italy, ¹⁶Chiba University Hospital, Chiba, Japan, ¹⁷Rheumatology, Adelaide, Meath hospital Dublin (incorporating the National Children's hospital), Dublin 24, Ireland, ¹⁸School of Medicine and Pharmacology, University of Western Australia, Perth, Australia, ¹⁹18Mile End Hospital, Barts Health NHS Trust, London, United Kingdom, ²⁰III Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ²¹Hospital Universitario La Paz, Madrid, Spain, ²²Instituto Poal de Reumatologia, Barcelona, Spain, ²³Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Glostrup, Denmark, ²⁴Rheumatology, Hospital General Universitario Gregorio Marañón and Universidad Complutense, Madrid, Spain, ²⁵Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain, ²⁶Instituto Nacional de Rehabilitation, Mexico, Mexico, ²⁷Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, ²⁸Immanuel Krankenhaus Berlin, Med Ctr for Rheumatology Berlin-Buch, Berlin, Germany, ²⁹Copenhagen University Hospital at Køge, Køge, Denmark, ³⁰Medicine, University of Rochester Medical Center, Rochester, NY, ³¹Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, ³²University of Leeds, Leeds, United Kingdom, ³³Pediatric Clinic, Asklepios Hospital Weissenfels, Weissenfels, Germany, ³⁴Rheumatology, Versailles-Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ³⁵Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary
Background/Purpose: The assessment of cartilage and bone damage in rheumatoid arthritis (RA) has traditionally relied on radiographical analyses in which joint space loss served as…
Abstract Number: 2281 • 2016 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate (MSU) Crystals Induces Cartilage Degeneration By Accelerating Hypertrophy and Mineralization.
Nicole Yang¹, Anthony M. Reginato² and Changqi Sun³, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ²Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ³Division of Rheumatology, Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI
Background/Purpose: Previous studies have shown that abnormal loads induce meniscus cell damage and matrix degradation both in-vivo and in-vitro1,2. Monosodium urate (MSU) crystal is considered…
Abstract Number: 306 • 2016 ACR/ARHP Annual Meeting
MRI-Detected Cartilage Damage, Meniscal Damage, and Meniscal Extrusion Prior to Incident Radiographic Osteoarthritis and the Subsequent Trajectory of Joint Space Loss
C. Kent Kwoh¹, Frank Roemer^2,3, Erin L. Ashbeck⁴, Charles Ratzlaff⁴, Jeffrey Duryea⁵ and Ali Guermazi⁶, ¹1501 N. Campbell Avenue, Room 8303, The University of Arizona Arthritis Center, Tucson, AZ, ²Department of Radiology, Boston University School of Medicine, Boston, MA, ³Radiology, University of Erlangen, Erlangen, Germany, ⁴The University of Arizona Arthritis Center, Tucson, AZ, ⁵Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁶Boston University School of Medicine, Boston, MA
Background/Purpose: Loss of joint space width (JSW) on x-ray is the recommended standard to define osteoarthritis progression. However, both cartilage and meniscal damage contribute to…

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