Abstracts tagged "cartilage"

Abstract Number: 19 • 2012 ACR/ARHP Annual Meeting
Stress-Induced Cartilage Degradation Does Not Depend On NLRP3-Inflammasome in Osteoarthritis
Carole Bougault¹, Marjolaine Gosset², Xavier Houard³, Colette Salvat⁴, Lars Godmann⁵, Thomas Pap⁵, Claire Jacques¹ and Francis Berenbaum⁶, ¹Ur-4, Pierre et Marie Curie University Paris VI, Paris, France, ²EA 2496, Paris Descartes University, Montrouge, France, ³Sorbonne Universités, UPMC Univ Paris 06, UMRS 938 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France, ⁴UR4, University Pierre and Marie Curie, Paris, France, ⁵Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁶Rheumatology, AP-HP, St Antoine Hospital, Paris, France
Background/Purpose: The cartilage matrix breakdown in osteoarthritis (OA) is due to both abnormal mechanical stress and activation of catabolic processes involving metalloproteinases (MMPs). Currently, IL-1beta…
Abstract Number: 988 • 2012 ACR/ARHP Annual Meeting
Zone-Specific Protein Profiles in Human Cartilage Unraveled by a Quantitative Proteomic Approach
Patricia Fernandez-Puente¹, Lucia Lourido², Valentina Calamia², Jesus Mateos³, Cristina Ruiz-Romero⁴, Martin K. Lotz⁵ and Francisco J. Blanco⁶, ¹Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, As Xubias de Arriba 84, 15006, A Coruña, Spain, ²Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ³Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, ⁴Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain, ⁵Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁶Rheumatology Division, Proteomics Group/ProteoRed-ISCIII, INIBIC-C. Hospitalario, A Coruña, Spain
Background/Purpose: Articular cartilage consists of a single type of cells called chondrocytes, which comprise 2-5% of total tissue mass and an extracellular matrix (ECM) mainly…
Abstract Number: 22 • 2012 ACR/ARHP Annual Meeting
Protective Properties of Conditioned Media From Adipose Stem Cells On Osteoarthritic Chondrocytes
Maria Isabel Guillén¹, Julia Platas¹, Vicente Mirabet², Miguel Angel Castejón³, Francisco Gomar⁴ and Maria Jose Alcaraz¹, ¹Pharmacology, University of Valencia, Burjasot, Valencia, Spain, ²Generalitat Valenciana, Valencia, Spain, ³De la Ribera University Hospital, Alzira, Spain, ⁴Surgery, University of Valencia and University Hospital, Valencia, Spain
Background/Purpose: Adipose-derived mesenchymal stem cells (ASC) exhibit a high potential for cell therapy and they might also act as a cellular source for supplying soluble…
Abstract Number: 993 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide DNA Methylation Analysis Reveals Different Methylation Patterns in the OA Disease
Ignacio Rego-Pérez¹, Juan Fernandez-Tajes², Mercedes Fernandez-Moreno², Maria Tamayo Novas³, Alejandro Mosquera Rey³, Natividad Oreiro², Carlos Fernandez-Lopez², Jose Luis Fernandez Garcia³ and Francisco J. Blanco², ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³INIBIC-Hospital Universitario A Coruña. Genetic Deparment., A Coruña, Spain
Background/Purpose: DNA methylation is a basic mechanism involved in epigenetic regulation that affects gene transcription by the addition of a methyl group to the cytosine…
Abstract Number: 25 • 2012 ACR/ARHP Annual Meeting
Activation of the Canonical Wnt Signaling Pathway Is Tissue Dependent in Osteoarthritic Joints: Distinct Mechanisms of Regulation by Wnt Antagonists
Thomas Funck-Brentano¹, Wafa Bouaziz¹, Hilene Lin¹, Valerie Geoffroy¹, Eric Hay¹ and Martine Cohen-Solal², ¹INSERM U606 Paris 7 university, Paris, France, ²Rhumatologie A, INSERM U606 Hôpital Lariboisière, Centre Viggo Petersen, Paris, France
Background/Purpose: Wnt signaling pathway is a major regulator of bone and cartilage remodeling. Modulation of this pathway has lead to controversial results on joint cartilage…
Abstract Number: 994 • 2012 ACR/ARHP Annual Meeting
The Genome-Wide Expression of Human Osteoarthritic Cartilage Shows A Differential Pattern Between Two Subgroups of OA Patients
Ignacio Rego-Perez¹, Juan Fernandez-Tajes¹, Angel Soto-Hermida², Mercedes Fernandez Moreno¹, Maria Eugenia Vazquez Mosquera³, Natividad Oreiro¹, Carlos Fernandez-Lopez¹, Estefania Cortes Pereira¹, Sara Relaño-Fernandez¹ and Francisco J. Blanco¹, ¹INIBIC-Hospital Universitario A Coruña. Genomic Group. Rheumatology Division., A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose: Many genes, many of them still unknown, are involved in the etiology and development of OA. Today, different tools are available to try to…
Abstract Number: 250 • 2012 ACR/ARHP Annual Meeting
Incident and Worsening Cartilage Damage in the Lateral Compartment and Multiple Subregions Worsening in the Medial Compartment Increase the Risk for Knee Replacement – Data From the Osteoarthritis Initiative
Frank Roemer¹, C. Kent Kwoh², Michael J. Hannon³, Robert M. Boudreau⁴, Felix Eckstein⁵, David J. Hunter⁶, Zhijie Wang³, Markus R. John⁷ and Ali Guermazi⁸, ¹Klinikum Augsburg, Augsburg, Germany, ²School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁵Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ⁶Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁷Novartis Pharma AG, Basel, Switzerland, ⁸Boston University, Boston, MA
Background/Purpose: Knee joint replacement (KR) is a cost-effective procedure with good long-term outcomes. However, at present there is no clear consensus on indications for KR.…
Abstract Number: 111 • 2012 ACR/ARHP Annual Meeting
Ultrasound Measurement of Metacarpal Cartilage Thickness Correlates with Joint Space Narrowing in the Metacarphalangeal Joints of Patients with Rheumatoid Arthritis
Peter Mandl¹, Helga Radner², Gabriela Supp³, Peter V. Balint⁴, Daniel Aletaha³ and Josef S. Smolen⁵, ¹Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Internal Medicine III; Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ⁵Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: To correlate cartilage thickness as measured by ultrasound (US) with joint space narrowing as measured by conventional radiography in the metacarpophalangeal (MCP) joints of…
Abstract Number: 48 • 2012 ACR/ARHP Annual Meeting
Tissue Engineering for Articular Cartilage Repair, Culturing Bone Marrow Mesenchymal Stem Cells On Collagen and Heparan Sulphate Scaffolds
Adela Helvia Martinez-Sanchez¹, Clara Sanjurjo-Rodriguez¹, Silvia Diaz-Prado², Emma Muiños¹, Isaac M. Fuentes², Francisco J. De Toro², Julia Bujan³ and Francisco J. Blanco¹, ¹Osteoarticular and Aging Res. Lab. CIBER-BBN. Rheumatology Div. INIBIC-Complejo Hosp. Univ. A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC-University of A Coruña, A Coruña, Spain, ³Department of Medical Specialties. University of Alcala de Henares, Madrid, Spain
Background/Purpose: The aim of this study was to evaluate the chondrogenic potential of bone marrow mesenchymal stem cells (BM-MSCs) grown on type I collagen and…
Abstract Number: 28 • 2012 ACR/ARHP Annual Meeting
Role of Microrna 455 Networks in Mesenchymal Cell Differentiation and Osteoarthritis
Fumiaki Ayabe¹, Shigeru Miyaki², Diana Brinson¹, Satoshi Yamashita³, Hiroyuki Nakahara¹, Koji Otabe¹, Stuart Duffy¹, Shawn Grogan⁴, Shuji Takada³, Martin K. Lotz¹ and Hiroshi Asahara⁵, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Department of Orthopaedic Surgery, Hiroshima University, Hiroshima, Japan, ³Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan, ⁴The Scripps Research Institute, La Jolla, CA, ⁵Molecular & Experimental Med, The Scripps Research Institute, La Jolla, CA
Background/Purpose: The objectives of this study were to identify cartilage specific microRNAs (miRNAs, miR-) that are regulated by SOX9 and are increased in chondrogenesis, to…

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