Abstract Number: 1638 • 2012 ACR/ARHP Annual Meeting
Synovial Fibroblast Migration Is Modulated by the Focal Contact Protein Lasp-1
Background/Purpose: RA synovial fibroblasts (SF) have been suggested to contribute to the spreading of disease through their ability to leave cartilage destruction sites, migrate via…Abstract Number: 9 • 2012 ACR/ARHP Annual Meeting
Function of the Chondrocyte PI-3 Kinase Akt Signaling Pathway Is Stimulus Dependent
Background/Purpose: Previous studies have shown that activation of the chondrocyte PI-3K-Akt signaling pathway by IGF-1 promotes chondrocyte survival and matrix synthesis. However, other studies have…Abstract Number: 1119 • 2012 ACR/ARHP Annual Meeting
Prediction of MRI-Detected Cartilage Loss Over 30 Months Using Simplified Radiographic and Clinical Stratification: The MOST Study
Background/Purpose: MRI-detected cartilage loss is the main structural outcome measure in large studies of knee OA. Definition of subjects at high risk for cartilage loss…Abstract Number: 10 • 2012 ACR/ARHP Annual Meeting
Fibronectin Fragment Induces Procatabolic Effects Through TLR-2 Signaling Pathway in Human Articular Chondrocytes
Background/Purpose: Fibronectin fragments (FN-fs) are increased in the synovial fluid of osteoarthritis patients and have a potent chondrolytic effect. However, little is known about the…Abstract Number: 1059 • 2012 ACR/ARHP Annual Meeting
Endogenous Complement Factor H Plays an Important Role in Controlling Immune Complex-Induced Inflammatory Arthritis
Background/Purpose: The complement system, a major component of innate immunity, likely plays an important role in the pathogenesis of rheumatoid arthritis (RA). Factor H (fH)…Abstract Number: 11 • 2012 ACR/ARHP Annual Meeting
Cartilage Tissue Engineering Using Collagen Scaffolds and Human Mesenchymal Stem Cells
Background/Purpose: The aim of this study was to obtain cartilage-like constructs by chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) grown on different…Abstract Number: 1019 • 2012 ACR/ARHP Annual Meeting
Visualization of Cartilage in High-Resolution Magnetic Resonance Imaging Is a New Imaging Biomarker for the Quantification of Joint Damage in Rheumatoid Arthritis
Background/Purpose: Recent achievements in Magnetic Resonance Imaging (MRI) have been the gradient-echo-based T1-delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) focussing on the detection of proteoglycan content…Abstract Number: 12 • 2012 ACR/ARHP Annual Meeting
Articular Cartilage Expresses the IL-15 Receptor Alpha-Chain and Responds to IL-15 with Increased Matrix Metalloproteinase Release
Background/Purpose: IL-15, known for its effects on survival of lymphocyte subsets, plays a role in synovitis of Rheumatoid Arthritis. We reported that IL-15 is also…Abstract Number: 1027 • 2012 ACR/ARHP Annual Meeting
Frequency of MRI-Detected Hip Osteoarthritis Features in Persons with Chronic Hip Pain and the Diagnostic Performance of Radiography Using MRI As the Reference
Background/Purpose: Conventional radiography has been the standard imaging tool to diagnose and grade the severity of hip OA. However, radiography cannot visualize the bone marrow,…Abstract Number: 17 • 2012 ACR/ARHP Annual Meeting
Synovial Overexpression of Wnt and Wnt-1-Induced Secreted Protein 1 Induces Cartilage Damage by Skewing of TGF-Beta Signaling and Reduction of the Anti-Hypertrophy Factor Sox9
Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. We found highly increased expression of canonical Wnts 2b and 16…
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