Abstracts tagged "cartilage"

Abstract Number: 12 • 2012 ACR/ARHP Annual Meeting
Articular Cartilage Expresses the IL-15 Receptor Alpha-Chain and Responds to IL-15 with Increased Matrix Metalloproteinase Release
Anjali Nair¹, Michael Huvard², Madeline Rollins³, Arnavaz Hakimiyan⁴, Lev Rappaport⁴, Arkady Margulis⁴, Susanna Chubinskaya⁵ and Carla R. Scanzello⁶, ¹Section of Rheumatology, Rush University Medical Center, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Rush University Medical Center, Chicago, IL, ⁵Biochemistry, Rush University Medical Center, Chicago, IL, ⁶Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: IL-15, known for its effects on survival of lymphocyte subsets, plays a role in synovitis of Rheumatoid Arthritis. We reported that IL-15 is also…
Abstract Number: 1027 • 2012 ACR/ARHP Annual Meeting
Frequency of MRI-Detected Hip Osteoarthritis Features in Persons with Chronic Hip Pain and the Diagnostic Performance of Radiography Using MRI As the Reference
Li Xu¹, Daichi Hayashi¹, Ali Guermazi², David J. Hunter³, Anton Winterstein⁴, Ling Li⁵, Klaus Bohndorf⁴ and Frank Roemer⁶, ¹Department of Radiology, Boston University School of Medicine, Boston, MA, ²Boston University, Boston, MA, ³Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁴Department of Radiology, Klinikum Augsburg, Augsburg, Germany, ⁵Division of Research, New England Baptist Hospital, Boston, MA, ⁶Klinikum Augsburg, Augsburg, Germany
Background/Purpose: Conventional radiography has been the standard imaging tool to diagnose and grade the severity of hip OA. However, radiography cannot visualize the bone marrow,…
Abstract Number: 17 • 2012 ACR/ARHP Annual Meeting
Synovial Overexpression of Wnt and Wnt-1-Induced Secreted Protein 1 Induces Cartilage Damage by Skewing of TGF-Beta Signaling and Reduction of the Anti-Hypertrophy Factor Sox9
Martijn H. van den Bosch¹, Arjen B. Blom¹, Peter L. van Lent², Henk M. van Beuningen¹, Fons A. van de Loo³, Esmeralda N. Blaney Davidson¹, Peter M. van der Kraan¹ and Wim B. van den Berg⁴, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. We found highly increased expression of canonical Wnts 2b and 16…
Abstract Number: 1029 • 2012 ACR/ARHP Annual Meeting
Frequency of Mediopatellar Plica in Persons with Chronic Knee Pain and Its Cross-Sectional Association with Patellofemoral Cartilage Damage and Bone Marrow Lesions: Data From the Joints On Glucosamine Study
Li Xu¹, Daichi Hayashi¹, Ali Guermazi², C. Kent Kwoh³, Michael J. Hannon⁴, Mohamed Jarraya¹, Carolyn E. Moore⁵, John M. Jakicic⁶, Stephanie M. Green⁷ and Frank Roemer⁸, ¹Department of Radiology, Boston University School of Medicine, Boston, MA, ²Boston University, Boston, MA, ³School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁵Department of Nutrition and Food Science, Texas Women's University, Houston, TX, ⁶University of Pittsburgh, PA, ⁷Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁸Klinikum Augsburg, Augsburg, Germany
Background/Purpose: Osteoarthritis (OA) commonly occurs in the patellofemoral joint (PFJ) and knee pain in subjects with knee OA often emanates from the PFJ rather than…
Abstract Number: 19 • 2012 ACR/ARHP Annual Meeting
Stress-Induced Cartilage Degradation Does Not Depend On NLRP3-Inflammasome in Osteoarthritis
Carole Bougault¹, Marjolaine Gosset², Xavier Houard³, Colette Salvat⁴, Lars Godmann⁵, Thomas Pap⁵, Claire Jacques¹ and Francis Berenbaum⁶, ¹Ur-4, Pierre et Marie Curie University Paris VI, Paris, France, ²EA 2496, Paris Descartes University, Montrouge, France, ³Sorbonne Universités, UPMC Univ Paris 06, UMRS 938 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France, ⁴UR4, University Pierre and Marie Curie, Paris, France, ⁵Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁶Rheumatology, AP-HP, St Antoine Hospital, Paris, France
Background/Purpose: The cartilage matrix breakdown in osteoarthritis (OA) is due to both abnormal mechanical stress and activation of catabolic processes involving metalloproteinases (MMPs). Currently, IL-1beta…
Abstract Number: 988 • 2012 ACR/ARHP Annual Meeting
Zone-Specific Protein Profiles in Human Cartilage Unraveled by a Quantitative Proteomic Approach
Patricia Fernandez-Puente¹, Lucia Lourido², Valentina Calamia², Jesus Mateos³, Cristina Ruiz-Romero⁴, Martin K. Lotz⁵ and Francisco J. Blanco⁶, ¹Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, As Xubias de Arriba 84, 15006, A Coruña, Spain, ²Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ³Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, ⁴Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain, ⁵Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁶Rheumatology Division, Proteomics Group/ProteoRed-ISCIII, INIBIC-C. Hospitalario, A Coruña, Spain
Background/Purpose: Articular cartilage consists of a single type of cells called chondrocytes, which comprise 2-5% of total tissue mass and an extracellular matrix (ECM) mainly…
Abstract Number: 22 • 2012 ACR/ARHP Annual Meeting
Protective Properties of Conditioned Media From Adipose Stem Cells On Osteoarthritic Chondrocytes
Maria Isabel Guillén¹, Julia Platas¹, Vicente Mirabet², Miguel Angel Castejón³, Francisco Gomar⁴ and Maria Jose Alcaraz¹, ¹Pharmacology, University of Valencia, Burjasot, Valencia, Spain, ²Generalitat Valenciana, Valencia, Spain, ³De la Ribera University Hospital, Alzira, Spain, ⁴Surgery, University of Valencia and University Hospital, Valencia, Spain
Background/Purpose: Adipose-derived mesenchymal stem cells (ASC) exhibit a high potential for cell therapy and they might also act as a cellular source for supplying soluble…
Abstract Number: 993 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide DNA Methylation Analysis Reveals Different Methylation Patterns in the OA Disease
Ignacio Rego-Pérez¹, Juan Fernandez-Tajes², Mercedes Fernandez-Moreno², Maria Tamayo Novas³, Alejandro Mosquera Rey³, Natividad Oreiro², Carlos Fernandez-Lopez², Jose Luis Fernandez Garcia³ and Francisco J. Blanco², ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³INIBIC-Hospital Universitario A Coruña. Genetic Deparment., A Coruña, Spain
Background/Purpose: DNA methylation is a basic mechanism involved in epigenetic regulation that affects gene transcription by the addition of a methyl group to the cytosine…
Abstract Number: 25 • 2012 ACR/ARHP Annual Meeting
Activation of the Canonical Wnt Signaling Pathway Is Tissue Dependent in Osteoarthritic Joints: Distinct Mechanisms of Regulation by Wnt Antagonists
Thomas Funck-Brentano¹, Wafa Bouaziz¹, Hilene Lin¹, Valerie Geoffroy¹, Eric Hay¹ and Martine Cohen-Solal², ¹INSERM U606 Paris 7 university, Paris, France, ²Rhumatologie A, INSERM U606 Hôpital Lariboisière, Centre Viggo Petersen, Paris, France
Background/Purpose: Wnt signaling pathway is a major regulator of bone and cartilage remodeling. Modulation of this pathway has lead to controversial results on joint cartilage…
Abstract Number: 994 • 2012 ACR/ARHP Annual Meeting
The Genome-Wide Expression of Human Osteoarthritic Cartilage Shows A Differential Pattern Between Two Subgroups of OA Patients
Ignacio Rego-Perez¹, Juan Fernandez-Tajes¹, Angel Soto-Hermida², Mercedes Fernandez Moreno¹, Maria Eugenia Vazquez Mosquera³, Natividad Oreiro¹, Carlos Fernandez-Lopez¹, Estefania Cortes Pereira¹, Sara Relaño-Fernandez¹ and Francisco J. Blanco¹, ¹INIBIC-Hospital Universitario A Coruña. Genomic Group. Rheumatology Division., A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose: Many genes, many of them still unknown, are involved in the etiology and development of OA. Today, different tools are available to try to…

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