Abstracts tagged "cartilage"

Abstract Number: 2520 • 2012 ACR/ARHP Annual Meeting
Suppressor of Cytokine Signaling 3 Is Reduced in Obese Patients with Osteoarthritis and Regulates Leptin Responses in Chondrocytes
Anna Koskinen¹, Katriina Vuolteenaho¹, Riku Korhonen¹, Teemu Moilanen² and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: Leptin is an adipokine whose concentrations in circulation are proportional to body fat stores and body mass index (BMI). Initially leptin was discovered to…
Abstract Number: 40 • 2012 ACR/ARHP Annual Meeting
Syndecan-4 Regulates Activation of WNT Signaling in Chondrocytes
Jessica Bertrand¹, Richard Stange², Giovanna Nalesso³, Joanna Sherwood³, Lars Godmann⁴, Frank Echtermeyer⁵, Francesco Dell'Accio⁶ and Thomas Pap⁴, ¹Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, ²Dept. of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany, ³Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁵Dept. of Anaesthesiology and Intensive Care Medicine, University hospital Hanover, Hanover, Germany, ⁶William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
Background/Purpose: Blockade of syndecan-4 (Sdc4) signaling protects mice from cartilage degradation in experimentally induced osteoarthritis (OA). Cartilage damage results in changes of chondrocyte phenotype induced…
Abstract Number: 2467 • 2012 ACR/ARHP Annual Meeting
Tissue Lesions in Osteoarthritis Initiative Participants with Normal X-Rays and Risk Factors for Incident Cartilage Damage
Leena Sharma¹, Ali Guermazi², Orit Almagor¹, Michel Crema², Dorothy D. Dunlop³, Frank Roemer⁴, Marc C. Hochberg⁵, Charles Eaton⁶, Joan M. Bathon⁷, Rebecca D. Jackson⁸, W.J. Mysiw⁸, C. Kent Kwoh⁹, Michael C. Nevitt¹⁰ and Joan S. Chmiel¹, ¹Northwestern University, Chicago, IL, ²Boston University, Boston, MA, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Klinikum Augsburg, Augsburg, Germany, ⁵Department of Medicine, University of Maryland, Baltimore, MD, ⁶Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁷Columbia University, New York, NY, ⁸Ohio State University, Columbus, OH, ⁹School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁰Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA
Background/Purpose: Understanding factors underlying initial development of knee OA is crucial to effective prevention strategy design. Our goals were to: 1) determine extent of tissue…
Abstract Number: 41 • 2012 ACR/ARHP Annual Meeting
Long-Distance Physical Connections Between Chondrocytes; Cell-to-Cell Communication within Articular Cartilage
Maria Dolores Mayan¹, Raquel Gago-Fuentes¹, Paula Carpintero-Fernandez², Patricia Fernandez-Puente², Purificacion Filgueira-Fernandez¹, Virgin Valiunas³, Peter Brink³, Gary Goldberg⁴ and Francisco J. Blanco Garcia⁵, ¹Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, Xubias de Arriba 84, 15006, A Coruña, Spain, ²Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, As Xubias de Arriba 84, 15006, A Coruña, Spain, ³Department of Physiology and Biophysics. State University of New York, Stony Brook, New York, SC, ⁴Department of Molecular Biology. Medical Center Drive, University of Medicine and Dentistry of New Jersey, Stratford, NJ, ⁵Grupo de Bioingeniería Tisular y Terapia Celular (CBTTC-CHUAC). CIBER-BBN/ISCIII. Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de Coruña (CHUAC). SERGAS. Universidade de A Coruña, A Coruña, Spain
Background/Purpose: It is believed that chondrocytes in cartilage do not connect each other, as they are isolated inside their lacunae separated from each other by…
Abstract Number: 1638 • 2012 ACR/ARHP Annual Meeting
Synovial Fibroblast Migration Is Modulated by the Focal Contact Protein Lasp-1
Adelheid Korb-Pap¹, Jan Hillen¹, Marianne Heitzmann¹, Catherine S. Chew², Stefan Butz³, Dietmar Vestweber⁴, Hermann Pavenstädt⁵ and Thomas Pap¹, ¹Institute of Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, ³Max Planck Institute of Molecular Biomedicine, Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁴Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁵Internal Medicine D, Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany
Background/Purpose: RA synovial fibroblasts (SF) have been suggested to contribute to the spreading of disease through their ability to leave cartilage destruction sites, migrate via…
Abstract Number: 9 • 2012 ACR/ARHP Annual Meeting
Function of the Chondrocyte PI-3 Kinase Akt Signaling Pathway Is Stimulus Dependent
Richard F. Loeser and Meredith Greene, Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC
Background/Purpose: Previous studies have shown that activation of the chondrocyte PI-3K-Akt signaling pathway by IGF-1 promotes chondrocyte survival and matrix synthesis. However, other studies have…
Abstract Number: 1119 • 2012 ACR/ARHP Annual Meeting
Prediction of MRI-Detected Cartilage Loss Over 30 Months Using Simplified Radiographic and Clinical Stratification: The MOST Study
Frank Roemer¹, David T. Felson², Jingbo Niu³, Yuqing Zhang², Michael C. Nevitt⁴, Michel Crema⁵, Cora E. Lewis⁶, James Torner⁷ and Ali Guermazi⁵, ¹Klinikum Augsburg, Augsburg, Germany, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁵Boston University, Boston, MA, ⁶Preventive Medicine, University of Alabama, Birmingham, Birmingham, AL, ⁷Epidemiology, University of Iowa, Iowa City, Iowa City, IA
Background/Purpose: MRI-detected cartilage loss is the main structural outcome measure in large studies of knee OA. Definition of subjects at high risk for cartilage loss…
Abstract Number: 10 • 2012 ACR/ARHP Annual Meeting
Fibronectin Fragment Induces Procatabolic Effects Through TLR-2 Signaling Pathway in Human Articular Chondrocytes
Su Jin Park¹, Eun-Jeong Cheon² and Hyun Ah Kim³, ¹Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ²Department of internal medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Hallym university, Kyunggi, South Korea
Background/Purpose: Fibronectin fragments (FN-fs) are increased in the synovial fluid of osteoarthritis patients and have a potent chondrolytic effect. However, little is known about the…
Abstract Number: 1059 • 2012 ACR/ARHP Annual Meeting
Endogenous Complement Factor H Plays an Important Role in Controlling Immune Complex-Induced Inflammatory Arthritis
Nirmal K. Banda¹, Gaurav Mehta², Viviana P. Ferreira³, Claudio Cortes³, Michael K. Pangburn⁴, William P. Arend² and V. Michael Holers², ¹University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Department of Medical Microbiology and Immunology, University of Toledo Health Science Campus, Toledo, OH, ⁴Department of Biochemistry, University of Texas Health Sciences Center, Tyler, TX
Background/Purpose: The complement system, a major component of innate immunity, likely plays an important role in the pathogenesis of rheumatoid arthritis (RA). Factor H (fH)…
Abstract Number: 11 • 2012 ACR/ARHP Annual Meeting
Cartilage Tissue Engineering Using Collagen Scaffolds and Human Mesenchymal Stem Cells
Clara Sanjurjo-Rodriguez¹, Adela Helvia Martinez-Sanchez¹, Silvia Diaz-Prado², Emma Muiños-Lopez¹, Isaac M. Fuentes-Boquete², Francisco J. De Toro² and Francisco J. Blanco¹, ¹Osteoarticular and Aging Res. Lab. CIBER-BBN. Rheumatology Div. INIBIC-Complejo Hosp. Univ. A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain
Background/Purpose: The aim of this study was to obtain cartilage-like constructs by chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) grown on different…
Abstract Number: 1019 • 2012 ACR/ARHP Annual Meeting
Visualization of Cartilage in High-Resolution Magnetic Resonance Imaging Is a New Imaging Biomarker for the Quantification of Joint Damage in Rheumatoid Arthritis
Barbara Herz¹, Stephanie Finzel¹, Andreas Albrecht¹, Juergen Rech², Matthias Englbrecht¹, Goetz Welsch³ and Georg Schett¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Traumatic Surgery, Department of Traumatic Surgery, University Clinic of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Recent achievements in Magnetic Resonance Imaging (MRI) have been the gradient-echo-based T1-delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) focussing on the detection of proteoglycan content…
Abstract Number: 12 • 2012 ACR/ARHP Annual Meeting
Articular Cartilage Expresses the IL-15 Receptor Alpha-Chain and Responds to IL-15 with Increased Matrix Metalloproteinase Release
Anjali Nair¹, Michael Huvard², Madeline Rollins³, Arnavaz Hakimiyan⁴, Lev Rappaport⁴, Arkady Margulis⁴, Susanna Chubinskaya⁵ and Carla R. Scanzello⁶, ¹Section of Rheumatology, Rush University Medical Center, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Rush University Medical Center, Chicago, IL, ⁵Biochemistry, Rush University Medical Center, Chicago, IL, ⁶Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: IL-15, known for its effects on survival of lymphocyte subsets, plays a role in synovitis of Rheumatoid Arthritis. We reported that IL-15 is also…
Abstract Number: 1027 • 2012 ACR/ARHP Annual Meeting
Frequency of MRI-Detected Hip Osteoarthritis Features in Persons with Chronic Hip Pain and the Diagnostic Performance of Radiography Using MRI As the Reference
Li Xu¹, Daichi Hayashi¹, Ali Guermazi², David J. Hunter³, Anton Winterstein⁴, Ling Li⁵, Klaus Bohndorf⁴ and Frank Roemer⁶, ¹Department of Radiology, Boston University School of Medicine, Boston, MA, ²Boston University, Boston, MA, ³Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁴Department of Radiology, Klinikum Augsburg, Augsburg, Germany, ⁵Division of Research, New England Baptist Hospital, Boston, MA, ⁶Klinikum Augsburg, Augsburg, Germany
Background/Purpose: Conventional radiography has been the standard imaging tool to diagnose and grade the severity of hip OA. However, radiography cannot visualize the bone marrow,…
Abstract Number: 17 • 2012 ACR/ARHP Annual Meeting
Synovial Overexpression of Wnt and Wnt-1-Induced Secreted Protein 1 Induces Cartilage Damage by Skewing of TGF-Beta Signaling and Reduction of the Anti-Hypertrophy Factor Sox9
Martijn H. van den Bosch¹, Arjen B. Blom¹, Peter L. van Lent², Henk M. van Beuningen¹, Fons A. van de Loo³, Esmeralda N. Blaney Davidson¹, Peter M. van der Kraan¹ and Wim B. van den Berg⁴, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. We found highly increased expression of canonical Wnts 2b and 16…
Abstract Number: 1029 • 2012 ACR/ARHP Annual Meeting
Frequency of Mediopatellar Plica in Persons with Chronic Knee Pain and Its Cross-Sectional Association with Patellofemoral Cartilage Damage and Bone Marrow Lesions: Data From the Joints On Glucosamine Study
Li Xu¹, Daichi Hayashi¹, Ali Guermazi², C. Kent Kwoh³, Michael J. Hannon⁴, Mohamed Jarraya¹, Carolyn E. Moore⁵, John M. Jakicic⁶, Stephanie M. Green⁷ and Frank Roemer⁸, ¹Department of Radiology, Boston University School of Medicine, Boston, MA, ²Boston University, Boston, MA, ³School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁵Department of Nutrition and Food Science, Texas Women's University, Houston, TX, ⁶University of Pittsburgh, PA, ⁷Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁸Klinikum Augsburg, Augsburg, Germany
Background/Purpose: Osteoarthritis (OA) commonly occurs in the patellofemoral joint (PFJ) and knee pain in subjects with knee OA often emanates from the PFJ rather than…

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