Abstracts tagged "cartilage"

Abstract Number: 48 • 2012 ACR/ARHP Annual Meeting
Tissue Engineering for Articular Cartilage Repair, Culturing Bone Marrow Mesenchymal Stem Cells On Collagen and Heparan Sulphate Scaffolds
Adela Helvia Martinez-Sanchez¹, Clara Sanjurjo-Rodriguez¹, Silvia Diaz-Prado², Emma Muiños¹, Isaac M. Fuentes², Francisco J. De Toro², Julia Bujan³ and Francisco J. Blanco¹, ¹Osteoarticular and Aging Res. Lab. CIBER-BBN. Rheumatology Div. INIBIC-Complejo Hosp. Univ. A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC-University of A Coruña, A Coruña, Spain, ³Department of Medical Specialties. University of Alcala de Henares, Madrid, Spain
Background/Purpose: The aim of this study was to evaluate the chondrogenic potential of bone marrow mesenchymal stem cells (BM-MSCs) grown on type I collagen and…
Abstract Number: 28 • 2012 ACR/ARHP Annual Meeting
Role of Microrna 455 Networks in Mesenchymal Cell Differentiation and Osteoarthritis
Fumiaki Ayabe¹, Shigeru Miyaki², Diana Brinson¹, Satoshi Yamashita³, Hiroyuki Nakahara¹, Koji Otabe¹, Stuart Duffy¹, Shawn Grogan⁴, Shuji Takada³, Martin K. Lotz¹ and Hiroshi Asahara⁵, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Department of Orthopaedic Surgery, Hiroshima University, Hiroshima, Japan, ³Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan, ⁴The Scripps Research Institute, La Jolla, CA, ⁵Molecular & Experimental Med, The Scripps Research Institute, La Jolla, CA
Background/Purpose: The objectives of this study were to identify cartilage specific microRNAs (miRNAs, miR-) that are regulated by SOX9 and are increased in chondrogenesis, to…
Abstract Number: 2519 • 2012 ACR/ARHP Annual Meeting
IL-1β and TNF-α Regulate the Global and Locus-Specific hydroxymethylation of Genomic DNA by Modulating the Expression and Activity of Tet-1 in Human OA Chondrocytes
Abdul Haseeb¹ and Tariq M. Haqqi², ¹Medicine/Rheumatology, Case Western Reserve University, Cleveland, OH, ²Medicine/Rheumatology/Haman 586, Metro Health Medical Center, Cleveland, OH
Background/Purpose: 5-hydroxymethylcytosine (5-hmC), which is formed by the oxidation of 5-methylcytosine (5-mC), is a recently discovered epigenetic mark and is highest in brain and in…
Abstract Number: 35 • 2012 ACR/ARHP Annual Meeting
Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis
Brett A. Tonkin¹, Evange Romas², Natalie A. Sims¹ and Nicole C. Walsh¹, ¹St Vincent's Institute of Medical Research, Melbourne, Australia, ²Dept. of Rheumatology, St Vincent's Hospital, Melbourne, Australia
Background/Purpose: The destabilisation of the medial meniscus (DMM) mouse osteoarthritis (OA) model is commonly used to study OA joint degeneration. In DMM-OA, the knee is…
Abstract Number: 2520 • 2012 ACR/ARHP Annual Meeting
Suppressor of Cytokine Signaling 3 Is Reduced in Obese Patients with Osteoarthritis and Regulates Leptin Responses in Chondrocytes
Anna Koskinen¹, Katriina Vuolteenaho¹, Riku Korhonen¹, Teemu Moilanen² and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: Leptin is an adipokine whose concentrations in circulation are proportional to body fat stores and body mass index (BMI). Initially leptin was discovered to…
Abstract Number: 40 • 2012 ACR/ARHP Annual Meeting
Syndecan-4 Regulates Activation of WNT Signaling in Chondrocytes
Jessica Bertrand¹, Richard Stange², Giovanna Nalesso³, Joanna Sherwood³, Lars Godmann⁴, Frank Echtermeyer⁵, Francesco Dell'Accio⁶ and Thomas Pap⁴, ¹Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, ²Dept. of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany, ³Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁵Dept. of Anaesthesiology and Intensive Care Medicine, University hospital Hanover, Hanover, Germany, ⁶William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
Background/Purpose: Blockade of syndecan-4 (Sdc4) signaling protects mice from cartilage degradation in experimentally induced osteoarthritis (OA). Cartilage damage results in changes of chondrocyte phenotype induced…
Abstract Number: 2467 • 2012 ACR/ARHP Annual Meeting
Tissue Lesions in Osteoarthritis Initiative Participants with Normal X-Rays and Risk Factors for Incident Cartilage Damage
Leena Sharma¹, Ali Guermazi², Orit Almagor¹, Michel Crema², Dorothy D. Dunlop³, Frank Roemer⁴, Marc C. Hochberg⁵, Charles Eaton⁶, Joan M. Bathon⁷, Rebecca D. Jackson⁸, W.J. Mysiw⁸, C. Kent Kwoh⁹, Michael C. Nevitt¹⁰ and Joan S. Chmiel¹, ¹Northwestern University, Chicago, IL, ²Boston University, Boston, MA, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Klinikum Augsburg, Augsburg, Germany, ⁵Department of Medicine, University of Maryland, Baltimore, MD, ⁶Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁷Columbia University, New York, NY, ⁸Ohio State University, Columbus, OH, ⁹School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁰Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA
Background/Purpose: Understanding factors underlying initial development of knee OA is crucial to effective prevention strategy design. Our goals were to: 1) determine extent of tissue…
Abstract Number: 41 • 2012 ACR/ARHP Annual Meeting
Long-Distance Physical Connections Between Chondrocytes; Cell-to-Cell Communication within Articular Cartilage
Maria Dolores Mayan¹, Raquel Gago-Fuentes¹, Paula Carpintero-Fernandez², Patricia Fernandez-Puente², Purificacion Filgueira-Fernandez¹, Virgin Valiunas³, Peter Brink³, Gary Goldberg⁴ and Francisco J. Blanco Garcia⁵, ¹Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, Xubias de Arriba 84, 15006, A Coruña, Spain, ²Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, As Xubias de Arriba 84, 15006, A Coruña, Spain, ³Department of Physiology and Biophysics. State University of New York, Stony Brook, New York, SC, ⁴Department of Molecular Biology. Medical Center Drive, University of Medicine and Dentistry of New Jersey, Stratford, NJ, ⁵Grupo de Bioingeniería Tisular y Terapia Celular (CBTTC-CHUAC). CIBER-BBN/ISCIII. Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de Coruña (CHUAC). SERGAS. Universidade de A Coruña, A Coruña, Spain
Background/Purpose: It is believed that chondrocytes in cartilage do not connect each other, as they are isolated inside their lacunae separated from each other by…
Abstract Number: 1638 • 2012 ACR/ARHP Annual Meeting
Synovial Fibroblast Migration Is Modulated by the Focal Contact Protein Lasp-1
Adelheid Korb-Pap¹, Jan Hillen¹, Marianne Heitzmann¹, Catherine S. Chew², Stefan Butz³, Dietmar Vestweber⁴, Hermann Pavenstädt⁵ and Thomas Pap¹, ¹Institute of Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, ³Max Planck Institute of Molecular Biomedicine, Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁴Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁵Internal Medicine D, Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany
Background/Purpose: RA synovial fibroblasts (SF) have been suggested to contribute to the spreading of disease through their ability to leave cartilage destruction sites, migrate via…
Abstract Number: 9 • 2012 ACR/ARHP Annual Meeting
Function of the Chondrocyte PI-3 Kinase Akt Signaling Pathway Is Stimulus Dependent
Richard F. Loeser and Meredith Greene, Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC
Background/Purpose: Previous studies have shown that activation of the chondrocyte PI-3K-Akt signaling pathway by IGF-1 promotes chondrocyte survival and matrix synthesis. However, other studies have…
Abstract Number: 1119 • 2012 ACR/ARHP Annual Meeting
Prediction of MRI-Detected Cartilage Loss Over 30 Months Using Simplified Radiographic and Clinical Stratification: The MOST Study
Frank Roemer¹, David T. Felson², Jingbo Niu³, Yuqing Zhang², Michael C. Nevitt⁴, Michel Crema⁵, Cora E. Lewis⁶, James Torner⁷ and Ali Guermazi⁵, ¹Klinikum Augsburg, Augsburg, Germany, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁵Boston University, Boston, MA, ⁶Preventive Medicine, University of Alabama, Birmingham, Birmingham, AL, ⁷Epidemiology, University of Iowa, Iowa City, Iowa City, IA
Background/Purpose: MRI-detected cartilage loss is the main structural outcome measure in large studies of knee OA. Definition of subjects at high risk for cartilage loss…
Abstract Number: 10 • 2012 ACR/ARHP Annual Meeting
Fibronectin Fragment Induces Procatabolic Effects Through TLR-2 Signaling Pathway in Human Articular Chondrocytes
Su Jin Park¹, Eun-Jeong Cheon² and Hyun Ah Kim³, ¹Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ²Department of internal medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Hallym university, Kyunggi, South Korea
Background/Purpose: Fibronectin fragments (FN-fs) are increased in the synovial fluid of osteoarthritis patients and have a potent chondrolytic effect. However, little is known about the…
Abstract Number: 1059 • 2012 ACR/ARHP Annual Meeting
Endogenous Complement Factor H Plays an Important Role in Controlling Immune Complex-Induced Inflammatory Arthritis
Nirmal K. Banda¹, Gaurav Mehta², Viviana P. Ferreira³, Claudio Cortes³, Michael K. Pangburn⁴, William P. Arend² and V. Michael Holers², ¹University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Department of Medical Microbiology and Immunology, University of Toledo Health Science Campus, Toledo, OH, ⁴Department of Biochemistry, University of Texas Health Sciences Center, Tyler, TX
Background/Purpose: The complement system, a major component of innate immunity, likely plays an important role in the pathogenesis of rheumatoid arthritis (RA). Factor H (fH)…
Abstract Number: 11 • 2012 ACR/ARHP Annual Meeting
Cartilage Tissue Engineering Using Collagen Scaffolds and Human Mesenchymal Stem Cells
Clara Sanjurjo-Rodriguez¹, Adela Helvia Martinez-Sanchez¹, Silvia Diaz-Prado², Emma Muiños-Lopez¹, Isaac M. Fuentes-Boquete², Francisco J. De Toro² and Francisco J. Blanco¹, ¹Osteoarticular and Aging Res. Lab. CIBER-BBN. Rheumatology Div. INIBIC-Complejo Hosp. Univ. A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain
Background/Purpose: The aim of this study was to obtain cartilage-like constructs by chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) grown on different…
Abstract Number: 1019 • 2012 ACR/ARHP Annual Meeting
Visualization of Cartilage in High-Resolution Magnetic Resonance Imaging Is a New Imaging Biomarker for the Quantification of Joint Damage in Rheumatoid Arthritis
Barbara Herz¹, Stephanie Finzel¹, Andreas Albrecht¹, Juergen Rech², Matthias Englbrecht¹, Goetz Welsch³ and Georg Schett¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Traumatic Surgery, Department of Traumatic Surgery, University Clinic of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Recent achievements in Magnetic Resonance Imaging (MRI) have been the gradient-echo-based T1-delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) focussing on the detection of proteoglycan content…

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