Abstract Number: 988 • 2012 ACR/ARHP Annual Meeting
Zone-Specific Protein Profiles in Human Cartilage Unraveled by a Quantitative Proteomic Approach
Background/Purpose: Articular cartilage consists of a single type of cells called chondrocytes, which comprise 2-5% of total tissue mass and an extracellular matrix (ECM) mainly…Abstract Number: 22 • 2012 ACR/ARHP Annual Meeting
Protective Properties of Conditioned Media From Adipose Stem Cells On Osteoarthritic Chondrocytes
Background/Purpose: Adipose-derived mesenchymal stem cells (ASC) exhibit a high potential for cell therapy and they might also act as a cellular source for supplying soluble…Abstract Number: 993 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide DNA Methylation Analysis Reveals Different Methylation Patterns in the OA Disease
Background/Purpose: DNA methylation is a basic mechanism involved in epigenetic regulation that affects gene transcription by the addition of a methyl group to the cytosine…Abstract Number: 25 • 2012 ACR/ARHP Annual Meeting
Activation of the Canonical Wnt Signaling Pathway Is Tissue Dependent in Osteoarthritic Joints: Distinct Mechanisms of Regulation by Wnt Antagonists
Background/Purpose: Wnt signaling pathway is a major regulator of bone and cartilage remodeling. Modulation of this pathway has lead to controversial results on joint cartilage…Abstract Number: 994 • 2012 ACR/ARHP Annual Meeting
The Genome-Wide Expression of Human Osteoarthritic Cartilage Shows A Differential Pattern Between Two Subgroups of OA Patients
Background/Purpose: Many genes, many of them still unknown, are involved in the etiology and development of OA. Today, different tools are available to try to…Abstract Number: 250 • 2012 ACR/ARHP Annual Meeting
Incident and Worsening Cartilage Damage in the Lateral Compartment and Multiple Subregions Worsening in the Medial Compartment Increase the Risk for Knee Replacement – Data From the Osteoarthritis Initiative
Background/Purpose: Knee joint replacement (KR) is a cost-effective procedure with good long-term outcomes. However, at present there is no clear consensus on indications for KR.…Abstract Number: 111 • 2012 ACR/ARHP Annual Meeting
Ultrasound Measurement of Metacarpal Cartilage Thickness Correlates with Joint Space Narrowing in the Metacarphalangeal Joints of Patients with Rheumatoid Arthritis
Background/Purpose: To correlate cartilage thickness as measured by ultrasound (US) with joint space narrowing as measured by conventional radiography in the metacarpophalangeal (MCP) joints of…Abstract Number: 48 • 2012 ACR/ARHP Annual Meeting
Tissue Engineering for Articular Cartilage Repair, Culturing Bone Marrow Mesenchymal Stem Cells On Collagen and Heparan Sulphate Scaffolds
Background/Purpose: The aim of this study was to evaluate the chondrogenic potential of bone marrow mesenchymal stem cells (BM-MSCs) grown on type I collagen and…Abstract Number: 28 • 2012 ACR/ARHP Annual Meeting
Role of Microrna 455 Networks in Mesenchymal Cell Differentiation and Osteoarthritis
Background/Purpose: The objectives of this study were to identify cartilage specific microRNAs (miRNAs, miR-) that are regulated by SOX9 and are increased in chondrogenesis, to…Abstract Number: 2519 • 2012 ACR/ARHP Annual Meeting
IL-1β and TNF-α Regulate the Global and Locus-Specific hydroxymethylation of Genomic DNA by Modulating the Expression and Activity of Tet-1 in Human OA Chondrocytes
Background/Purpose: 5-hydroxymethylcytosine (5-hmC), which is formed by the oxidation of 5-methylcytosine (5-mC), is a recently discovered epigenetic mark and is highest in brain and in…Abstract Number: 35 • 2012 ACR/ARHP Annual Meeting
Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis
Background/Purpose: The destabilisation of the medial meniscus (DMM) mouse osteoarthritis (OA) model is commonly used to study OA joint degeneration. In DMM-OA, the knee is…Abstract Number: 2520 • 2012 ACR/ARHP Annual Meeting
Suppressor of Cytokine Signaling 3 Is Reduced in Obese Patients with Osteoarthritis and Regulates Leptin Responses in Chondrocytes
Background/Purpose: Leptin is an adipokine whose concentrations in circulation are proportional to body fat stores and body mass index (BMI). Initially leptin was discovered to…Abstract Number: 40 • 2012 ACR/ARHP Annual Meeting
Syndecan-4 Regulates Activation of WNT Signaling in Chondrocytes
Background/Purpose: Blockade of syndecan-4 (Sdc4) signaling protects mice from cartilage degradation in experimentally induced osteoarthritis (OA). Cartilage damage results in changes of chondrocyte phenotype induced…Abstract Number: 2467 • 2012 ACR/ARHP Annual Meeting
Tissue Lesions in Osteoarthritis Initiative Participants with Normal X-Rays and Risk Factors for Incident Cartilage Damage
Background/Purpose: Understanding factors underlying initial development of knee OA is crucial to effective prevention strategy design. Our goals were to: 1) determine extent of tissue…Abstract Number: 41 • 2012 ACR/ARHP Annual Meeting
Long-Distance Physical Connections Between Chondrocytes; Cell-to-Cell Communication within Articular Cartilage
Background/Purpose: It is believed that chondrocytes in cartilage do not connect each other, as they are isolated inside their lacunae separated from each other by…