Abstracts tagged "cartilage"

Abstract Number: 2010 • 2015 ACR/ARHP Annual Meeting
Adenosine A2A Receptor, but Not A2B Receptor, Deletion Leads to Development of Osteoarthritis (OA) in Mice and Administration of a Liposomal Suspension of Adenosine Prevents/Treats Osteoarthritis in Rats
CARMEN CORCIULO¹, MATIN Lendhey², AUSTIN RAMME², Tuere Wilder³, ORAN KENNEDY² and Bruce Cronstein⁴, ¹Medicine, NYU-School of Medicine, New York, NY, ²Department of Orthopaedic Surgery, NYU-School of Medicine, New York, NY, ³Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ⁴Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: Adenosine, acting at its receptors, regulates chondrocyte function and inflammation, two components of OA. Mice lacking adenosine A2A receptors (A2AR) have increasing difficulty walking…
Abstract Number: 1127 • 2014 ACR/ARHP Annual Meeting
Mass Spectrometry Imaging Revealed Potential Lipid Chondrogenic Biomarkers for Cell-Based Therapy in Cartilage
Beatriz Rocha¹, Berta Cillero-Pastor², Gert Eijkel², Valentina Calamia¹, Lucia Lourido¹, Carolina Fernández-Costa¹, Patricia Fernandez-Puente¹, Jesus Mateos¹, Cristina Ruiz-Romero^1,3, Ron MA Heeren² and Francisco J. Blanco Garcia¹, ¹Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ²1Biomolecular Imaging Mass Spectrometry (BIMS) Molecular Nanophotonics Department, AMOLF, Amsterdam, Netherlands, ³CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain
Background/Purpose: Recent studies highlight the importance of lipid metabolism in the modulation of chondrogenesis. Specifically, the positive chondrogenic effect of acid ceramidase, which is necessary…
Abstract Number: 1034 • 2014 ACR/ARHP Annual Meeting
Therapeutic Potential of Targeting Sialic Acid Modified Receptors in Osteoarthritis
Maria Dolores Mayan^1,2, Paula Carpintero-Fernández¹, Raquel Gago-Fuentes¹, Marta Varela-Eirin¹, Gary S. Goldberg³ and Francisco Javier Blanco^1,4,5, ¹Cartilage Biology Research Group, Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Email: [email protected], A Coruña, Spain, ³Rowan University, Department of Molecular Biology, School of Osteopathic Medicine, Stratford, NJ, ⁴Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁵Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
Background/Purpose: Glycosylated proteins are essential components of the extracellular matrix (ECM) of cartilage and contribute to the maintenance of its function. A shift from a-2,6-…
Abstract Number: 1026 • 2014 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate Crystals Induces the Expression of Ihh and MMP-13 in ATDC5 Cells: Implications in Osteoarthritis (OA) Development.
Melissa Ramirez¹, Josh Potvin¹, Diana Ramirez² and Anthony M. Reginato³, ¹Division of Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Department of Orthopaedic Surgery, The Warren Alpert School of Medicine at Brown University, Providence, RI, ³Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI
Background/Purpose: Cartilage damage is often observed in affected joints with advance gout1. Musculoskeletal ultrasound studies have highlighted the close relationship between monosodium urate (MSU) crystals…
Abstract Number: 1011 • 2014 ACR/ARHP Annual Meeting
Fibroblast Growth Factor-2 and Its Receptor Antagonists in Osteoarthritis
Elina Nummenmaa¹, Mari Hamalainen¹, Teemu Moilanen^1,2, Katriina Vuolteenaho¹ and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: The fibroblast growth factor (FGF) family represents an interesting group of molecules which are involved in the regulation of connective tissue development and metabolism.…
Abstract Number: 1004 • 2014 ACR/ARHP Annual Meeting
Elevated Levels of BMP2 Compensate for Loss of TGF-Beta in Articular Cartilage during Experimental Osteoarthritis
Esmeralda Blaney Davidson¹, Arjan van Caam¹, Arjen Blom², Elly Vitters², Miranda Bennink¹, Wim van den Berg², Fons van de Loo³ and Peter van der Kraan⁴, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ³Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose: We have demonstrated that TGF-beta signaling via Smad2/3 is drastically reduced in articular cartilage (AC) with age and loss of Smad2/3-signaling predisposed AC for…
Abstract Number: 1005 • 2014 ACR/ARHP Annual Meeting
Histone Lysine Demethylase KDM6A Mediates Joint Destruction in Osteoarthritic Knees By Epigenetic Disturbance of SOX9 Promoter and Histone H3K27
Feng-Sheng Wang¹, Pe-Chin Chuang¹, Yi-Chih Sun¹, Yu-Shan Chen¹ and Jih-Yang Ko², ¹Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: Intensive articular cartilage deterioration and synovial fibrosis in joints are prominently pathogenic features of osteoarthritic (OA) knees. Epigenetic reactions in joint microenvironments are linked…
Abstract Number: 1003 • 2014 ACR/ARHP Annual Meeting
Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis
Raquel Gago-Fuentes¹, Patricia Fernández-Puente^2,3, Paula Carpintero-Fernández¹, Jesus Mateos^2,3, Maria Dolores Mayan¹ and Francisco Javier Blanco^2,3, ¹Cartilage Biology Research Group, Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ³Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
Background/Purpose: We have previously reported that articular chondrocytes in tissue contain long cytoplasmic arms that physically connect two distant cells. Cell-to-cell communication occurs through connexin…
Abstract Number: 1019 • 2014 ACR/ARHP Annual Meeting
Targeting the Bone-Driven Metabolic OA Phenotype By a Novel Dual Amylin Calcitonin Receptor Agonist, KBP-056
Ditte Reker, Sara Toftegaard Hjuler, Kim Andreassen, Morten Asser Karsdal, Kim Henriksen and Anne C. Bay-Jensen, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose: Osteoarthritis (OA) may be segregated into different disease phenotypes based on disease drivers; cartilage damage, joint inflammation or subchondral bone remodelling. Each phenotype may…
Abstract Number: 629 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Chondrocyte Activity Are Increased in Psoriasis Arthritis and Spondyloarthritis
Natasja Stæhr Gudman¹, Heidi Lausten Munk², Anne Friesgaard Christensen³, Leif Ejstrup⁴, Grith Lykke Sørensen⁵, Anne Gitte Loft³, Morten A. Karsdal⁶, Anne C. Bay-Jensen⁷, Yi He⁸, Anne Sofie Siebuhr⁹ and Peter Junker², ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Department of Rheumatology, Odense University Hospital, Odense, Denmark, ³Department of Rheumatology, Vejle Hospital, Vejle, Denmark, ⁴Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark, ⁵Cardiovascular and Renal Research, Institute of Molecular Medicin, University of Southern Denmark, Odense, Denmark, ⁶Research & Development, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁷Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁸Nordic Bioscience, Herlev, Denmark, ⁹Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose: Psoriasis arthritis (PsA) and spondyloarthritis (SpA) are both inflammatory joint diseases in which the pathogenesis is not fully understood. However, both pathologies are associated…
Abstract Number: 541 • 2014 ACR/ARHP Annual Meeting
Collagen II Neo-Epitopes in Spondyloarthritis.
Heidi Lausten Munk¹, Natasja Staehr Gudmann², Anne Friesgaard Christensen³, Leif Ejstrup⁴, Grith Lykke Sørensen⁵, Anne Gitte Loft³, Anne C. Bay-Jensen², Anne Sofie Siebuhr² and Peter Junker¹, ¹Department of Rheumatology, Odense University Hospital, Odense, Denmark, ²Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Department of Rheumatology, Vejle Hospital, Vejle, Denmark, ⁴Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark, ⁵Cardiovascular and Renal Research, Institute of Molecular Medicin, University of Southern Denmark, Odense, Denmark
Background/Purpose Spondyloarthritis (SpA) is characterized by aseptic inflammation of the axial skeleton which may ultimately lead to irreversible deformities due to bony ankylosis. Occasionally, peripheral…
Abstract Number: 436 • 2014 ACR/ARHP Annual Meeting
Increasing Cartilage Turnover in Smokers Developing Rheumatoid Arthritis Is Associated with High Disease Activity in Early Disease
Carl Turesson¹, Christina Book², Ulf Bergström², Lennart Jacobsson^2,3 and Tore Saxne⁴, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, ⁴Dept of Rheumatology, Dept of Clinical Sciences Lund, Section of Rheumatology, Lund, Sweden
Background/Purpose Autoantibodies and other biomarkers of rheumatoid arthritis (RA) that may be detected years before disease onset in a subset of investigated individuals could be…
Abstract Number: 218 • 2014 ACR/ARHP Annual Meeting
Surface Area and Fatty Infiltration of Vastus Medialis Measured By Magnetic Resonance Imaging Are Risk Factors for the Progression of Knee Osteoarthritis and Discriminate Two Osteoarthritis Phenotypes
Johanne Martel-Pelletier¹, Jean-Pierre Raynauld¹, François Abram², Marc Dorais³, Yuanyuan Wang⁴, Jessica Fairley⁴, Flavia Cicuttini⁴ and Jean-Pierre Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³StatSciences Inc., Notre-Dame de l’Île Perrot, QC, Canada, ⁴Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Osteoarthritis (OA) is the most common arthritic condition but its treatment still remains symptomatic. Understanding factors affecting the progression of this disease may enable…
Abstract Number: 2951 • 2014 ACR/ARHP Annual Meeting
Syndecan-4 Regulates Chondrocyte Phenotype and Cartilage Homeostasis Via the WNT Signaling Pathway
Charlotte Kimberley Clarke¹, Annelena Held¹, Richard Stange², Uwe Hansen³, Lars Godmann⁴, Jessica Bertrand⁵, Thomas Pap⁶, Giovanna Nalesso⁷, Frank Echtermeyer⁸, Francesco Dell'Accio⁹ and Joanna Sherwood⁷, ¹University Hospital Muenster, Institute of Experimental Musculoskeletal Medicine (IEMM), Muenster, 48149, Germany, ²Dept. of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany, ³Institute for Physiological Chemistry & Pathobiochemistry, University Hospital Münster, Münster, Germany, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁵Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ⁶Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁷Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom, ⁸Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Hannover, Hanover, Germany, ⁹William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
Background/Purpose Syndecan-4 (Sdc4), family member of type I transmembrane heparan sulfate proteoglycans (HSPGs), is a regulator of various cartilage-related processes including osteoarthritis (OA). Blockade of…
Abstract Number: 209 • 2014 ACR/ARHP Annual Meeting
Physical Performance and Obesity Measures Are Associated with Tibial Cartilage Volume and Explains the Sex Difference in Cartilage Volume
Benny Samuel Eathakkattu Antony¹, Alison Venn², Flavia Cicutinni³, Lyn March⁴, Leigh Blizzard⁵, Terry Dwyer⁶, Marita Cross⁷, Graeme Jones⁸ and Changhai Ding⁸, ¹Musculoskeletal, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, ²Epidemiology, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ³Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia, ⁴Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁵Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁶Director, Murdoch Children's Research Institute, Melbourne, Australia, ⁷University of Sydney Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia, ⁸Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia
Background/Purpose The factors associated with knee cartilage volume in younger population are insufficiently explored. The aims of this study were to describe the associations between…

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