Abstracts tagged "cartilage"

Abstract Number: 1162 • 2015 ACR/ARHP Annual Meeting
IL37 Reduces Pro-Inflammatory Cytokine and Catabolic Enzyme Production in Human Chondrocytes: A Protective Role in Osteoarthritis?
Ellen van Geffen¹, Arjan van Caam², Elly Vitters², Henk van Beuningen², Esmeralda Blaney Davidson² and Peter M. van der Kraan², ¹Experimential Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Osteoarthritis (OA) is the most common joint disease, primarily characterized by progressive articular cartilage degradation. Cartilage destruction is assumed to be mediated by pro-inflammatory…
Abstract Number: 2951 • 2014 ACR/ARHP Annual Meeting
Syndecan-4 Regulates Chondrocyte Phenotype and Cartilage Homeostasis Via the WNT Signaling Pathway
Charlotte Kimberley Clarke¹, Annelena Held¹, Richard Stange², Uwe Hansen³, Lars Godmann⁴, Jessica Bertrand⁵, Thomas Pap⁶, Giovanna Nalesso⁷, Frank Echtermeyer⁸, Francesco Dell'Accio⁹ and Joanna Sherwood⁷, ¹University Hospital Muenster, Institute of Experimental Musculoskeletal Medicine (IEMM), Muenster, 48149, Germany, ²Dept. of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany, ³Institute for Physiological Chemistry & Pathobiochemistry, University Hospital Münster, Münster, Germany, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁵Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ⁶Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁷Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom, ⁸Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Hannover, Hanover, Germany, ⁹William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
Background/Purpose Syndecan-4 (Sdc4), family member of type I transmembrane heparan sulfate proteoglycans (HSPGs), is a regulator of various cartilage-related processes including osteoarthritis (OA). Blockade of…
Abstract Number: 209 • 2014 ACR/ARHP Annual Meeting
Physical Performance and Obesity Measures Are Associated with Tibial Cartilage Volume and Explains the Sex Difference in Cartilage Volume
Benny Samuel Eathakkattu Antony¹, Alison Venn², Flavia Cicutinni³, Lyn March⁴, Leigh Blizzard⁵, Terry Dwyer⁶, Marita Cross⁷, Graeme Jones⁸ and Changhai Ding⁸, ¹Musculoskeletal, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, ²Epidemiology, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ³Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia, ⁴Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁵Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁶Director, Murdoch Children's Research Institute, Melbourne, Australia, ⁷University of Sydney Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia, ⁸Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia
Background/Purpose The factors associated with knee cartilage volume in younger population are insufficiently explored. The aims of this study were to describe the associations between…
Abstract Number: 2796 • 2014 ACR/ARHP Annual Meeting
A Novel Mouse Model of Osteochondromagenesis By Deleting NFATc1 in Mesenchymal Progenitors and Postnatal Chondrocytes
Xian-Peng Ge¹, Susan Y. Ritter², Julia F. Charles³, Kelly Tsang² and Antonios O. Aliprantis², ¹Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Osteochondromas are the most common benign bone tumor and are characterized by cartilage-capped bony projections from the external surface of bone. These lesions may…
Abstract Number: 208 • 2014 ACR/ARHP Annual Meeting
Correlates of Knee Bone Marrow Lesions in Younger Adults
Benny Samuel Eathakkattu Antony¹, Graeme Jones², Alison Venn³, Lyn March⁴, Flavia Cicutinni⁵, Andrew Halliday⁶, Leigh Blizzard⁷, Marita Cross⁸, Terry Dwyer⁹ and Changhai Ding², ¹Musculoskeletal, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Epidemiology, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁴Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁵Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia, ⁶Radiology, Royal Hobart Hospital, Australia, Hobart, Australia, ⁷Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁸University of Sydney Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia, ⁹Director, Murdoch Children's Research Institute, Melbourne, Australia
Background/Purpose: Bone marrow lesions (BMLs) of the knee joint are a key player in osteoarthritis of the knee. However, little is known of their determinants,…
Abstract Number: 2465 • 2014 ACR/ARHP Annual Meeting
Cyclic Phosphatidic Acid (cPA) Suppresses MMP-3, a Disintegrin and Metalloproteinase with Thrombospondin Motifs(ADAMTS)-4, -5 and Stimulates HAS2 Expression in Inflammatory Rheumatoid Synovial Fibroblasts Induced with IL-1β and/or TNF-α
Ikuko Masuda^1,2, Kodo Okada³, Hisashi Yamanaka⁴ and Shigeki Momohara⁴, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Rheumatology, Jyujyo Takeda Rehabilitation Hospital, Kyoto, Japan, ³SANSHO, Co. Ltd., Tokyo, Japan, ⁴Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose Cyclic phosphatidic acid (cPA) is one of bioactive lipid, has been implicated as an mediator of various biological effects including i) antiproliferative effect on…
Abstract Number: 205 • 2014 ACR/ARHP Annual Meeting
Natural History and Clinical Significance of Meniscal Tears over 8 Years in a Largely Non-Osteoarthritic Cohort
Hussain Ijaz Khan¹, Dawn Aitken¹, Changhai Ding², Leigh Blizzard³, Jean-Pierre Pelletier⁴, Johanne Martel-Pelletier⁴, Flavia Cicutinni⁵ and Graeme Jones², ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁴Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁵Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia
Background/Purpose: Meniscal tears are a key player in knee osteoarthritis (OA) and family history of the disease has been shown to play an important role.…
Abstract Number: 1135 • 2014 ACR/ARHP Annual Meeting
Genes Involved in Cartilage Synthesis and Risk to Knee Osteoarthritis
Abhishek Mishra Sr., Rajeshwar Srivastava II, Divya Sanghi III, Ajai Singh IV and Devendra Parmar V, Deptt of Orthopaedic Surgery, King George's Medical University,, Lucknow, India
Background/Purpose Osteoarthritis (OA), characterized by gradual loss of articular cartilage in the joint, is a leading cause of disability among the elderly people. Though the…
Abstract Number: 127 • 2014 ACR/ARHP Annual Meeting
Metacarpophalangeal Cartilage Loss in Rheumatoid Arthritis. a Simple and Fast Ultrasonographic Assessment Comparing Patients and Healthy Controls
Tomas Cazenave¹, Christian A. Waimann², Marwin Gutierrez³, Emilio Filippucci⁴, Gustavo Citera⁵ and Marcos G. Rosemffet¹, ¹Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ²Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ³Università Politecnica delle Marche, Jesi, Italy, ⁴Department of Rheumatology, University of Ancona, Jesi, Italy, ⁵Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina
Background/Purpose There is evidence supporting the use of ultrasonography (US) as a valid and reliable imaging tool to evaluate cartilage in patients with arthritis. The…
Abstract Number: 1127 • 2014 ACR/ARHP Annual Meeting
Mass Spectrometry Imaging Revealed Potential Lipid Chondrogenic Biomarkers for Cell-Based Therapy in Cartilage
Beatriz Rocha¹, Berta Cillero-Pastor², Gert Eijkel², Valentina Calamia¹, Lucia Lourido¹, Carolina Fernández-Costa¹, Patricia Fernandez-Puente¹, Jesus Mateos¹, Cristina Ruiz-Romero^1,3, Ron MA Heeren² and Francisco J. Blanco Garcia¹, ¹Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ²1Biomolecular Imaging Mass Spectrometry (BIMS) Molecular Nanophotonics Department, AMOLF, Amsterdam, Netherlands, ³CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain
Background/Purpose: Recent studies highlight the importance of lipid metabolism in the modulation of chondrogenesis. Specifically, the positive chondrogenic effect of acid ceramidase, which is necessary…
Abstract Number: 1034 • 2014 ACR/ARHP Annual Meeting
Therapeutic Potential of Targeting Sialic Acid Modified Receptors in Osteoarthritis
Maria Dolores Mayan^1,2, Paula Carpintero-Fernández¹, Raquel Gago-Fuentes¹, Marta Varela-Eirin¹, Gary S. Goldberg³ and Francisco Javier Blanco^1,4,5, ¹Cartilage Biology Research Group, Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Email: [email protected], A Coruña, Spain, ³Rowan University, Department of Molecular Biology, School of Osteopathic Medicine, Stratford, NJ, ⁴Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁵Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
Background/Purpose: Glycosylated proteins are essential components of the extracellular matrix (ECM) of cartilage and contribute to the maintenance of its function. A shift from a-2,6-…
Abstract Number: 1026 • 2014 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate Crystals Induces the Expression of Ihh and MMP-13 in ATDC5 Cells: Implications in Osteoarthritis (OA) Development.
Melissa Ramirez¹, Josh Potvin¹, Diana Ramirez² and Anthony M. Reginato³, ¹Division of Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Department of Orthopaedic Surgery, The Warren Alpert School of Medicine at Brown University, Providence, RI, ³Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI
Background/Purpose: Cartilage damage is often observed in affected joints with advance gout1. Musculoskeletal ultrasound studies have highlighted the close relationship between monosodium urate (MSU) crystals…
Abstract Number: 1011 • 2014 ACR/ARHP Annual Meeting
Fibroblast Growth Factor-2 and Its Receptor Antagonists in Osteoarthritis
Elina Nummenmaa¹, Mari Hamalainen¹, Teemu Moilanen^1,2, Katriina Vuolteenaho¹ and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: The fibroblast growth factor (FGF) family represents an interesting group of molecules which are involved in the regulation of connective tissue development and metabolism.…
Abstract Number: 1004 • 2014 ACR/ARHP Annual Meeting
Elevated Levels of BMP2 Compensate for Loss of TGF-Beta in Articular Cartilage during Experimental Osteoarthritis
Esmeralda Blaney Davidson¹, Arjan van Caam¹, Arjen Blom², Elly Vitters², Miranda Bennink¹, Wim van den Berg², Fons van de Loo³ and Peter van der Kraan⁴, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ³Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose: We have demonstrated that TGF-beta signaling via Smad2/3 is drastically reduced in articular cartilage (AC) with age and loss of Smad2/3-signaling predisposed AC for…
Abstract Number: 1005 • 2014 ACR/ARHP Annual Meeting
Histone Lysine Demethylase KDM6A Mediates Joint Destruction in Osteoarthritic Knees By Epigenetic Disturbance of SOX9 Promoter and Histone H3K27
Feng-Sheng Wang¹, Pe-Chin Chuang¹, Yi-Chih Sun¹, Yu-Shan Chen¹ and Jih-Yang Ko², ¹Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: Intensive articular cartilage deterioration and synovial fibrosis in joints are prominently pathogenic features of osteoarthritic (OA) knees. Epigenetic reactions in joint microenvironments are linked…

« Previous Page
1
…
8
9
10
11
12
…
15
Next Page »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].