ACR Meeting Abstracts

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Abstracts tagged "cartilage"

  • Abstract Number: 1147 • 2015 ACR/ARHP Annual Meeting

    TGFß1 Blocks Chondrocyte Hypertrophy and Increases Cell Viability in Cultured Cartilage Explants but Does Not Protect Against Proteoglycan Loss

    Arjan van Caam, Wojciech Madej, Henk van Beuningen, Esmeralda Blaney Davidson and Peter van der Kraan, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: In osteoarthritis, cartilage degradation is partly due to chondrocytes gaining a hypertrophy-like phenotype. TGFβ1 is considered to be a protective factor for articular cartilage by blocking…
  • Abstract Number: 629 • 2014 ACR/ARHP Annual Meeting

    Biomarkers of Chondrocyte Activity Are Increased in Psoriasis Arthritis and Spondyloarthritis

    Natasja Stæhr Gudman1, Heidi Lausten Munk2, Anne Friesgaard Christensen3, Leif Ejstrup4, Grith Lykke Sørensen5, Anne Gitte Loft3, Morten A. Karsdal6, Anne C. Bay-Jensen7, Yi He8, Anne Sofie Siebuhr9 and Peter Junker2, 1Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 2Department of Rheumatology, Odense University Hospital, Odense, Denmark, 3Department of Rheumatology, Vejle Hospital, Vejle, Denmark, 4Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark, 5Cardiovascular and Renal Research, Institute of Molecular Medicin, University of Southern Denmark, Odense, Denmark, 6Research & Development, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 7Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 8Nordic Bioscience, Herlev, Denmark, 9Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark

    Background/Purpose: Psoriasis arthritis (PsA) and spondyloarthritis (SpA) are both inflammatory joint diseases in which the pathogenesis is not fully understood. However, both pathologies are associated…
  • Abstract Number: 541 • 2014 ACR/ARHP Annual Meeting

    Collagen II Neo-Epitopes in Spondyloarthritis.

    Heidi Lausten Munk1, Natasja Staehr Gudmann2, Anne Friesgaard Christensen3, Leif Ejstrup4, Grith Lykke Sørensen5, Anne Gitte Loft3, Anne C. Bay-Jensen2, Anne Sofie Siebuhr2 and Peter Junker1, 1Department of Rheumatology, Odense University Hospital, Odense, Denmark, 2Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 3Department of Rheumatology, Vejle Hospital, Vejle, Denmark, 4Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark, 5Cardiovascular and Renal Research, Institute of Molecular Medicin, University of Southern Denmark, Odense, Denmark

    Background/Purpose Spondyloarthritis (SpA) is characterized by aseptic inflammation of the axial skeleton which may ultimately lead to irreversible deformities due to bony ankylosis. Occasionally, peripheral…
  • Abstract Number: 436 • 2014 ACR/ARHP Annual Meeting

    Increasing Cartilage Turnover in Smokers Developing Rheumatoid Arthritis Is Associated with High Disease Activity in Early Disease

    Carl Turesson1, Christina Book2, Ulf Bergström2, Lennart Jacobsson2,3 and Tore Saxne4, 1Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 2Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 3Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, 4Dept of Rheumatology, Dept of Clinical Sciences Lund, Section of Rheumatology, Lund, Sweden

    Background/Purpose Autoantibodies and other biomarkers of rheumatoid arthritis (RA) that may be detected years before disease onset in a subset of investigated individuals could be…
  • Abstract Number: 218 • 2014 ACR/ARHP Annual Meeting

    Surface Area and Fatty Infiltration of Vastus Medialis Measured By Magnetic Resonance Imaging Are Risk Factors for the Progression of Knee Osteoarthritis and Discriminate Two Osteoarthritis Phenotypes

    Johanne Martel-Pelletier1, Jean-Pierre Raynauld1, François Abram2, Marc Dorais3, Yuanyuan Wang4, Jessica Fairley4, Flavia Cicuttini4 and Jean-Pierre Pelletier1, 1Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 2Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, 3StatSciences Inc., Notre-Dame de l’Île Perrot, QC, Canada, 4Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia

    Background/Purpose: Osteoarthritis (OA) is the most common arthritic condition but its treatment still remains symptomatic. Understanding factors affecting the progression of this disease may enable…
  • Abstract Number: 2951 • 2014 ACR/ARHP Annual Meeting

    Syndecan-4 Regulates Chondrocyte Phenotype and Cartilage Homeostasis Via the WNT Signaling Pathway

    Charlotte Kimberley Clarke1, Annelena Held1, Richard Stange2, Uwe Hansen3, Lars Godmann4, Jessica Bertrand5, Thomas Pap6, Giovanna Nalesso7, Frank Echtermeyer8, Francesco Dell'Accio9 and Joanna Sherwood7, 1University Hospital Muenster, Institute of Experimental Musculoskeletal Medicine (IEMM), Muenster, 48149, Germany, 2Dept. of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany, 3Institute for Physiological Chemistry & Pathobiochemistry, University Hospital Münster, Münster, Germany, 4Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, 5Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, 6Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, 7Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom, 8Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Hannover, Hanover, Germany, 9William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom

    Background/Purpose Syndecan-4 (Sdc4), family member of type I transmembrane heparan sulfate proteoglycans (HSPGs), is a regulator of various cartilage-related processes including osteoarthritis (OA). Blockade of…
  • Abstract Number: 209 • 2014 ACR/ARHP Annual Meeting

    Physical Performance and Obesity Measures Are Associated with Tibial Cartilage Volume and Explains the Sex Difference in Cartilage Volume

    Benny Samuel Eathakkattu Antony1, Alison Venn2, Flavia Cicutinni3, Lyn March4, Leigh Blizzard5, Terry Dwyer6, Marita Cross7, Graeme Jones8 and Changhai Ding8, 1Musculoskeletal, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, 2Epidemiology, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, 3Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia, 4Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, 5Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, 6Director, Murdoch Children's Research Institute, Melbourne, Australia, 7University of Sydney Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia, 8Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia

    Background/Purpose The factors associated with knee cartilage volume in younger population are insufficiently explored. The aims of this study were to describe the associations between…
  • Abstract Number: 2796 • 2014 ACR/ARHP Annual Meeting

    A Novel Mouse Model of Osteochondromagenesis By Deleting NFATc1 in Mesenchymal Progenitors and Postnatal Chondrocytes

    Xian-Peng Ge1, Susan Y. Ritter2, Julia F. Charles3, Kelly Tsang2 and Antonios O. Aliprantis2, 1Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Osteochondromas are the most common benign bone tumor and are characterized by cartilage-capped bony projections from the external surface of bone. These lesions may…
  • Abstract Number: 208 • 2014 ACR/ARHP Annual Meeting

    Correlates of Knee Bone Marrow Lesions in Younger Adults

    Benny Samuel Eathakkattu Antony1, Graeme Jones2, Alison Venn3, Lyn March4, Flavia Cicutinni5, Andrew Halliday6, Leigh Blizzard7, Marita Cross8, Terry Dwyer9 and Changhai Ding2, 1Musculoskeletal, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, 2Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, 3Epidemiology, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, 4Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, 5Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia, 6Radiology, Royal Hobart Hospital, Australia, Hobart, Australia, 7Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, 8University of Sydney Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia, 9Director, Murdoch Children's Research Institute, Melbourne, Australia

    Background/Purpose: Bone marrow lesions (BMLs) of the knee joint are a key player in osteoarthritis of the knee. However, little is known of their determinants,…
  • Abstract Number: 2465 • 2014 ACR/ARHP Annual Meeting

    Cyclic Phosphatidic Acid (cPA) Suppresses MMP-3, a Disintegrin and Metalloproteinase with Thrombospondin Motifs(ADAMTS)-4, -5 and Stimulates HAS2 Expression in Inflammatory Rheumatoid Synovial Fibroblasts Induced with IL-1β and/or TNF-α

    Ikuko Masuda1,2, Kodo Okada3, Hisashi Yamanaka4 and Shigeki Momohara4, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Rheumatology, Jyujyo Takeda Rehabilitation Hospital, Kyoto, Japan, 3SANSHO, Co. Ltd., Tokyo, Japan, 4Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan

    Background/Purpose Cyclic phosphatidic acid (cPA) is one of bioactive lipid, has been implicated as an mediator of various biological effects including i) antiproliferative effect on…
  • Abstract Number: 205 • 2014 ACR/ARHP Annual Meeting

    Natural History and Clinical Significance of Meniscal Tears over 8 Years in a Largely Non-Osteoarthritic Cohort

    Hussain Ijaz Khan1, Dawn Aitken1, Changhai Ding2, Leigh Blizzard3, Jean-Pierre Pelletier4, Johanne Martel-Pelletier4, Flavia Cicutinni5 and Graeme Jones2, 1Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, 2Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, 3Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, 4Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 5Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia

    Background/Purpose: Meniscal tears are a key player in knee osteoarthritis (OA) and family history of the disease has been shown to play an important role.…
  • Abstract Number: 1135 • 2014 ACR/ARHP Annual Meeting

    Genes Involved in Cartilage Synthesis and Risk to Knee Osteoarthritis

    Abhishek Mishra Sr., Rajeshwar Srivastava II, Divya Sanghi III, Ajai Singh IV and Devendra Parmar V, Deptt of Orthopaedic Surgery, King George's Medical University,, Lucknow, India

    Background/Purpose  Osteoarthritis (OA), characterized by gradual loss of articular cartilage in the joint, is a leading cause of disability among the elderly people. Though the…
  • Abstract Number: 127 • 2014 ACR/ARHP Annual Meeting

    Metacarpophalangeal Cartilage Loss in Rheumatoid Arthritis. a Simple and Fast Ultrasonographic Assessment Comparing Patients and Healthy Controls

    Tomas Cazenave1, Christian A. Waimann2, Marwin Gutierrez3, Emilio Filippucci4, Gustavo Citera5 and Marcos G. Rosemffet1, 1Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 2Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 3Università Politecnica delle Marche, Jesi, Italy, 4Department of Rheumatology, University of Ancona, Jesi, Italy, 5Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina

    Background/Purpose There is evidence supporting the use of ultrasonography (US) as a valid and reliable imaging tool to evaluate cartilage in patients with arthritis. The…
  • Abstract Number: 1127 • 2014 ACR/ARHP Annual Meeting

    Mass Spectrometry Imaging Revealed Potential Lipid Chondrogenic Biomarkers for Cell-Based Therapy in Cartilage

    Beatriz Rocha1, Berta Cillero-Pastor2, Gert Eijkel2, Valentina Calamia1, Lucia Lourido1, Carolina Fernández-Costa1, Patricia Fernandez-Puente1, Jesus Mateos1, Cristina Ruiz-Romero1,3, Ron MA Heeren2 and Francisco J. Blanco Garcia1, 1Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, 21Biomolecular Imaging Mass Spectrometry (BIMS) Molecular Nanophotonics Department, AMOLF, Amsterdam, Netherlands, 3CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain

    Background/Purpose: Recent studies highlight the importance of lipid metabolism in the modulation of chondrogenesis. Specifically, the positive chondrogenic effect of acid ceramidase, which is necessary…
  • Abstract Number: 1034 • 2014 ACR/ARHP Annual Meeting

    Therapeutic Potential of Targeting Sialic Acid Modified Receptors in Osteoarthritis

    Maria Dolores Mayan1,2, Paula Carpintero-Fernández1, Raquel Gago-Fuentes1, Marta Varela-Eirin1, Gary S. Goldberg3 and Francisco Javier Blanco1,4,5, 1Cartilage Biology Research Group, Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 2Email: [email protected], A Coruña, Spain, 3Rowan University, Department of Molecular Biology, School of Osteopathic Medicine, Stratford, NJ, 4Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 5Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain

    Background/Purpose: Glycosylated proteins are essential components of the extracellular matrix (ECM) of cartilage and contribute to the maintenance of its function. A shift from a-2,6-…
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