Abstracts tagged "calcinosis"

Abstract Number: 2053 • 2017 ACR/ARHP Annual Meeting
Computed Tomography Dependent Diagnosis of Crowned Dens Syndrome; A Cervical Manifestation of Patients with Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
Ammar Haikal¹, Brian Everist², Pim Jetanalin³ and Mehrdad Maz³, ¹Department Internal Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, ²Department of Radiology (MSK), Department of Radiology (MSK), University of Kansas Medical Center, Kansas City, KS, ³Allergy, Clinical Immunology, and Rheumatology, Division of Allergy, Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Crowned Dens Syndrome (CDS), a variation of Calcium Pyrophosphate Deposition Disease (CPPD), is a radiologic-clinical entity defined by the association of radiological calcifications around…
Abstract Number: 2137 • 2017 ACR/ARHP Annual Meeting
Clinical Factors Associated with Long-Term Damage and Calcinosis in an Adult-Age Referral Population of Juvenile Myositis Patients
Vladislav Tsaltskan¹, Annette Aldous², Sam Serafi¹, Heidi Sami¹, Gulnara Mamyrova¹, Frederick W Miller³, Sam Simmens², Rodolfo Curiel¹, Olcay Y. Jones⁴ and Lisa G Rider³, ¹Department of Rheumatology, George Washington University, Washington, DC, ²Department of Epidemiology and Biostatistics, George Washington University Milken Institute School of Public Health, Washington, DC, ³Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ⁴Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD
Background/Purpose: Juvenile idiopathic inflammatory myopathies (JIIM) are rare, autoimmune chronic muscle diseases of childhood with significant potential long-term morbidity. In this study we investigate associations…
Abstract Number: 1898 • 2016 ACR/ARHP Annual Meeting
The Lack of Association of Osteoporosis with Proton Pump Inhibitor in Scleroderma: A UK Single Centre Cohort Experience
Ana Afonso¹, Svetlana Nihtyanova², Christopher Denton³ and Voon H. Ong⁴, ¹Internal Medicine, Hospital Pedro Hispano, EPE, Porto, Portugal, ²Centre for Rheumatology and Connective Tissue Diseases, University College London Medical School, Royal Free Hospital, London, United Kingdom, ³Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁴Rheumatology, UCL Division of Medicine, London, United Kingdom
Background/Purpose: Recent studies suggest that proton pump inhibitor (PPI) use is variably associated with risk of osteoporosis. The aim of this study was to investigate…
Abstract Number: 836 • 2016 ACR/ARHP Annual Meeting
Comprehensive Characterization of Calcinosis in a Multicenter International Cohort of Patients with Systemic Sclerosis
Antonia Valenzuela^1,2, Jessica K. Gordon³, Tatiana Sofia Rodriguez-Reyna⁴, Susanna Proudman^5,6, Murray Baron⁷, Monique Hinchcliff⁸, Dinesh Khanna⁹, Amber Young¹⁰, Flavia V. Castelino¹¹, Sara R. Schoenfeld¹², Virginia D. Steen¹³, David Fiorentino¹⁴ and Lorinda Chung¹⁵, ¹Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ²Stanford University School of Medicine, Stanford, CA, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁵Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ⁶Discipline of Medicine, University of Adelaide, Adelaide, Australia, ⁷Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ⁸Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁹University of Michigan, Ann Arbor, MI, ¹⁰Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ¹¹Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ¹²Rheumatology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ¹³Rheumatology, Georgetown University Medical Center, Washington, DC, ¹⁴Department of Dermatology, Stanford University School of Medicine, Palo Alto, CA, ¹⁵Rheumatology, Stanford University Medical Center, Palo Alto, CA
Background/Purpose: Calcinosis cutis is a debilitating complication of systemic sclerosis (SSc) affecting one quarter of patients. Repetitive trauma may be involved in the pathogenesis of…
Abstract Number: 841 • 2016 ACR/ARHP Annual Meeting
Low Nucleoside Triphosphate Pyrophosphohydrolase Activity Contributes to Pathologic Mineralization in Systemic Sclerosis
Yue Ding¹, Supraja Yeturi¹, Claudia Gohr¹, Mary Ellen Csuka¹ and Ann K. Rosenthal^2,3, ¹Medicine, Medical College of Wisconsin, Milwaukee, WI, ²Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, ³Medicine, Clement J. Zablocki VA Medical Center, Milwaukee, WI
Background/Purpose: Calcinosis is a major source of morbidity in patients with systemic sclerosis (SS). In addition, increased coronary calcification has been reported in patients with…
Abstract Number: 830 • 2015 ACR/ARHP Annual Meeting
Calcinosis Is Associated with Digital Ulcers and Osteoporosis in Patients with Systemic Sclerosis
Antonia Valenzuela¹, Murray Baron², Ariane L. Herrick³, Susana Proudman⁴, Wendy Stevens⁵, Tatiana Sofia Rodriguez-Reyna⁶, Alessandra Vacca⁷, Thomas A. Medsger Jr.⁸, Monique Hinchcliff⁹, Vivien Hsu¹⁰, David Fiorentino¹¹, Lorinda Chung¹² and the Canadian Scleroderma Research Group, and the ASIG rubric, ¹Stanford University School of Medicine, Stanford, CA, ²Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ³Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Rheumatology Unit, Royal Adelaide Hospital North Terrace, Adelaide, Australia, ⁵Department of Rheumatology, St. Vincent’s Hospital Melbourne, Melbourne, Australia, ⁶Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁷University Hospital of Cagliari, Rheumatology Unit, Monserrato, Italy, ⁸Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁹Rheumatology, Northwestern University, Chicago, IL, ¹⁰Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ, ¹¹Department of Dermatology, Stanford University School of Medicine, Palo Alto, CA, ¹²Stanford University, Palo Alto, CA
Background/Purpose: Calcinosis is a debilitating complication of systemic sclerosis (SSc). We sought to determine the clinical factors associated with calcinosis in an international multi-center collaborative…
Abstract Number: 1898 • 2015 ACR/ARHP Annual Meeting
Are There Risk Factors for Calcinosis in Scleroderma?
Sneha Pai¹ and Vivien Hsu², ¹Rheumatology, Robert Wood Johnson Medical School Hospital, New Brunswick, NJ, ²Medicine, Rutgers University, New Brunswick, NJ
Background/Purpose: Calcinosis is the deposition of calcium hydroxyapatite in the soft tissues in patients with scleroderma spectrum disorders (SSc). Risk factors are unknown and there…
Abstract Number: 1904 • 2015 ACR/ARHP Annual Meeting
Development of the Mawdsley Calcinosis Questionnaire (MCQ) Version 1 – a Patient-Reported Outcome Measure (PROM) for Systemic Sclerosis Related Calcinosis (SSc-Ca)
Lesley Ann Saketkoo¹, Kim Fligelstone², Evan Busman³, Angela Christensen⁴, Sophia Cenac⁵, Samara Khalique⁶, Andrew Aubin⁷, Veronika K. Jaeger⁸, Anne Mawdsley⁹, Jessica K. Gordon¹⁰, Randi Kaufman¹¹, Murray Baron¹², Virginia D. Steen¹³ and Tracy M. Frech¹⁴, ¹Tulane University Lung Center, New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ²Royal Free Hospital, Scleroderma Unit and Scleroderma Society, London, United Kingdom, ³Atlanta Scleroderma Support Group, Atlanta, GA, ⁴Tulane University School of Medicine, New Orleans, LA, ⁵Louisiana State University Health Science Center, New Orleans, LA, ⁶Louisiana State University Health Sciences Center, New Orleans, LA, ⁷Louisiana State University School of Medicine, New Orleans, LA, ⁸Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ⁹Raynaud's & Scleroderma - Care and Support UK, Cheshire, United Kingdom, ¹⁰Rheumatology, Hospital for Special Surgery, New York, NY, ¹¹Lousiana State University Health Sciences Center - School of Public Health, New Orleans, LA, ¹²Jewish General Hospital, Lady Davis Institute and McGill University, Montreal, QC, Canada, ¹³Rheumatology, Georgetown University Medical Center, Washington, DC, ¹⁴Div of Rheumatology, University of Utah, Salt Lake City, UT
Background/Purpose: SSc-Ca is a poorly understood vascular complication of SSc that usually related to extreme constant pain and infection/amputation risk for persons living with SSc-Ca…
Abstract Number: 2037 • 2015 ACR/ARHP Annual Meeting
Rheumatic Manifestations May be the First Clinical Presentation of Arterial Calcification Due to CD73 Deficiency
Kam Newman¹, megha Sawhney², James D. Katz³, richard siegel⁴, alessandra brofferio⁵ and Manfred Boehm⁶, ¹national institutes of arthritis, musculoskeletal, and skin disease, National Institutes of Health, Bethesda, MD, ²national institutes of health, Bethesda, MD, ³Department of Medicine, Division of Rheumatology, The George Washington University, Washington, DC, ⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, ⁵national institutes of health, Bethesda,, MD, ⁶Laboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: ACDC is a hereditary ectopic mineralization syndrome caused by mutations in the NT5E gene that encodes CD73. CD73 is a membrane bound 5'…
Abstract Number: 2369 • 2015 ACR/ARHP Annual Meeting
Dermatomyositis Associated with Anti-Melanoma Differentiation-Associated Gene 5 Antibodies: A Longitudinal Analysis
Matthew Lewis¹, Shufeng Li¹, Lorinda Chung² and David Fiorentino¹, ¹Dermatology, Stanford University, Stanford, CA, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Dermatomyositis (DM) patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are at increased risk of developing interstitial lung disease (ILD). The natural history of…
Abstract Number: 2960 • 2015 ACR/ARHP Annual Meeting
Sodium Thiosulfate in Calcinosis
Eliza Pelrine¹, Jessica K. Gordon², Murray Baron³ and Robert F. Spiera², ¹Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada
Background/Purpose: Calcinosis occurs in ~25% of patients with Systemic Sclerosis (SSc) and causes pain, morbidity, and decreased quality of life. The treatment of calcinosis is…
Abstract Number: 2707 • 2014 ACR/ARHP Annual Meeting
Systemic Sclerosis Related Calcinosis: Patients Provide What Specialists Want to Learn
Angela Christensen¹, Samara Khalique², Sophia Cenac³, Kim Fligelstone⁴, Anne Mawdsley⁵, Tracy Frech⁶, Jessica K. Gordon⁷, Murray Baron⁸, Evan Busman⁹, Virginia D. Steen¹⁰ and Lesley Ann Saketkoo¹¹, ¹Tulane University School of Medicine, New Orleans, LA, ²Louisiana State University Health Sciences Center, New Orleans, LA, ³Scleroderma and Sarcoidosis Patient Care and Research Center, Louisiana State University Health Science Center, New Orleans, LA, ⁴Royal Free Hospital, Scleroderma Unit and Scleroderma Society, London, United Kingdom, ⁵Raynaud's & Scleroderma - Care and Support UK, Cheshire, United Kingdom, ⁶Div of Rheumatology, University of Utah, Salt Lake City, UT, ⁷Rheumatology, Hospital for Special Surgery, New York, NY, ⁸Pavillion A, Rm 216, Jewish General Hospital, Montreal, QC, Canada, ⁹Atlanta Scleroderma Support Group, Atlanta, GA, ¹⁰Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ¹¹Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA
Background/Purpose: Calcinosis is a disabling, rarely discussed manifestation of SSc for which the natural history and management is poorly understood. Last year, the Scleroderma Clinical…
Abstract Number: 2191 • 2014 ACR/ARHP Annual Meeting
Intravenous Sodium Thiosulfate for Treatment of Refractory Calcinosis in Rheumatic Disease
Ross Thibodaux¹, Bahnsen Miller¹ and Stephen Lindsey^2,3, ¹Internal Medicine, Louisiana State University Health Science Center, Baton Rouge, LA, ²Chief Div of Rheumatology, Ochsner Clinic Baton Rouge, Baton Rouge, LA, ³Internal Medicine - Rheumatology, Louisiana State University Health Science Center, Baton Rouge, LA
Background/Purpose: Calcinosis, or dystrophic calcification, is a poorly understood, debilitating condition commonly manifested in connective tissue diseases such as scleroderma and polymyositis. Despite treatment of…
Abstract Number: 1926 • 2014 ACR/ARHP Annual Meeting
Nailfold Videocapillaroscopy Patterns Associated with Calcinosis and Acro-Osteolysis in Systemic Sclerosis
Jerome Avouac¹, Laetitia Morardet², Maya Sammour³, Andre Kahan², Antoine Feydy³ and Yannick Allanore¹, ¹Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, ²Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ³Paris Descartes University, Radiology B department, Cochin Hospital, Paris, France
Background/Purpose: Calcinosis and acro-osteolysis are frequent in systemic sclerosis (SSc). They may be related to digital vasculopathy, which can be assessed by nailfold videocapillaroscopy (NVC).…
Abstract Number: 1315 • 2014 ACR/ARHP Annual Meeting
Cross-Sectional Evaluation of Hydroxychloroquine (HCQ) Therapy in Children with Juvenile Dermatomyositis (JDM) Enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry
Yonit Sterba¹, Dawn Wahezi² and For the CARRA investigators³, ¹Pediatric Rheumatology, Montefiore Medical Center, Bronx, NY, ²Pediatric Rheumatology, Children's Hospital at Montefiore, Bronx, NY, ³Duke Children's Hospital, Durham, NC
Background/Purpose: Hydroxychloroquine is an antimalarial agent commonly used in the treatment of rheumatologic diseases. Data on the use of HCQ in JDM is limited, primarily…

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