Abstracts tagged "calcinosis"

Abstract Number: 1641 • 2019 ACR/ARP Annual Meeting
Change in Calcinosis over 1 Year Using the SCTC Radiologic Scoring System for Calcinosis of the Hands in Patients with Systemic Sclerosis
Antonia Valenzuela¹, Melody Chung ², Tatiana S. Rodríguez-Reyna ³, Susanna Proudman ⁴, Murray Baron ⁵, Flavia Castelino ⁶, Vivien Hsu ⁷, Shufeng Li ⁸, David Fiorentino ⁹, Kathryn Stevens ¹⁰ and Lorinda Chung ², ¹Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile, ²Stanford University, Palo Alto, CA, ³Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁴Royal Adelaide Hospital North Terrace, Adelaide, Australia, ⁵Jewish General Hospital, McGill University, Montreal, Canada, ⁶Harvard University, Boston, MA, ⁷Rutgers- RWJ Medical School, SOUTH PLAINFIELD, NJ, ⁸Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA, ⁹Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, ¹⁰Stanford University, Stanford
Background/Purpose: Calcinosis cutis is a debilitating complication of systemic sclerosis (SSc) affecting one quarter of patients, most frequently involving the hands. We previously developed and…
Abstract Number: 2590 • 2019 ACR/ARP Annual Meeting
Computer Vision Applied to Dual Energy Computed Tomography Images for Precise Calcinosis Cutis Quantification in Patients with Systemic Sclerosis
Anita Chandrasekaran¹, Imran Omar ², Zhicheng Fu ³, Shangping Ren ³ and Monique Hinchcliff ¹, ¹Yale University, Section of Rheumatology, Allergy and Immunology, New Haven, CT, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³San Diego State University, Department of Computer Science, San Diego, CA
Background/Purpose: Calcinosis cutis, found in both systemic sclerosis (SSc) and juvenile dermatomyositis patients, can be extensive and debilitating. Potential treatments have been identified, but a…
Abstract Number: 2607 • 2019 ACR/ARP Annual Meeting
Ultrasound Detection of Calcinosis and Correlation with Ulnar Artery Occlusion in Patients with Systemic Sclerosis
Robert Fairchild¹, Melody Chung ¹, Laurel Sharpless ¹, Shufeng Li ² and Lorinda Chung ¹, ¹Stanford University, Palo Alto, CA, ²Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA
Background/Purpose: Systemic Sclerosis (SSc) is a progressive fibrotic and vascular disease affecting multiple organs. Calcinosis cutis in SSc is characterized by calcium deposition in the…
Abstract Number: 2612 • 2019 ACR/ARP Annual Meeting
Minocycline for Refractory Calcinosis in Systemic Sclerosis: A Single-Centre Observational Cohort Study
Carmen Fonseca¹, Voon Ong ² and Christopher Denton ³, ¹UCL Medical School, Royal Free Campus, London, United Kingdom, ²UCL Medical School, Royal Free Campus, London, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: Calcinosis represents a major challenge for patients with systemic sclerosis (SSc) for which there is no standard therapy. Minocycline has been proposed for treatment…
Abstract Number: 479 • 2018 ACR/ARHP Annual Meeting
Intravenous Immunoglobulin in Combination with Intravenous Methylprednisolone in the Treatment of Calcinosis Associated with Juvenile Dermatomyositis (JDM)
Marc Phillpotts¹, Eman Alshaikh¹, Yaseen Aleatany¹, Olcay Y. Jones², Gulnara Mamyrova¹, Lisa G. Rider³ and Rodolfo Curiel¹, ¹Department of Medicine, Division of Rheumatology, The George Washington University, Washington, DC, ²Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, ³Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD
Background/Purpose: Calcinosis is a major complication of JDM and is associated with disability and poor quality of life. There are no known effective treatments for…
Abstract Number: 482 • 2018 ACR/ARHP Annual Meeting
The Association of Short-Term Ultraviolet Radiation Exposure and Calcinosis in Juvenile Dermatomyositis in the Childhood Arthritis & Rheumatology Research Alliance Registry
Jessica Neely¹, Craig S. Long², Hugh Sturrock³ and Susan Kim⁴, ¹Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA, ²National Oceanic and Atmospheric Administration (NOAA)/Climate Prediction Center, College Park, MD, ³Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴Pediatric Rheumatology, University of California, San francisco School of Medicine, San Francisco, CA
Background/Purpose: JDM is an autoimmune systemic vasculopathy characterized by myositis and skin rash. Some myositis specific antibodies (MSAs) are associated with clinical manifestations in JDM,…
Abstract Number: 1724 • 2018 ACR/ARHP Annual Meeting
Effectiveness and Safety of Rituximab for the Treatment of Refractory Systemic Sclerosis Associated Calcinosis: A Case Series
Francisco Javier Narváez¹, Juan Pablo Pirola², Judit Lluch³, Pablo Juárez³, Isabel Morales³ and Joan Miquel Nolla³, ¹Rheumatology Department, Hospital de Bellvitge. Barcelona. Spain, L’Hospitalet de Llobregat, Spain, ²Rheumatology, Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, ³Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain
Background/Purpose: To analyze the effectiveness and safety of rituximab (RTX) for the treatment of refractory systemic sclerosis (SSc)–associated calcinosis. Methods: We undertook an observational study…
Abstract Number: 2026 • 2018 ACR/ARHP Annual Meeting
Calcium Crystal-Mediated Netosis in Juvenile Dermatomyositis and Anti-RNP+ Overlap Syndrome with Skin Involvement
Christian Lood¹, Gabrielle A. Morgan², Marisa Klein-Gitelman³, Megan L. Curran⁴ and Lauren M. Pachman⁵, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Cure JM Program of Excellence in Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ³Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁴Section of Rheumatology, Children's Hospital of Colorado, Denver, CO, ⁵Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
Background/Purpose: Neutrophils are key immune cells participating in host defense through several mechanisms, including the formation of neutrophil extracellular traps (NETs). Although beneficial from a…
Abstract Number: 2981 • 2018 ACR/ARHP Annual Meeting
Mitochondrial Extrusion and Autoimmunity in Juvenile Dermatomyositis
Christian Lood¹, Bhargavi Duvvuri², Richard Moore², Gabrielle A. Morgan³, Marisa Klein-Gitelman⁴, Megan L. Curran⁵ and Lauren M. Pachman⁶, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA, ³Cure JM Program of Excellence in Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁴Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Section of Rheumatology, Children's Hospital of Colorado, Denver, CO, ⁶Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
Background/Purpose: We recently made the fundamental observation that mitochondrial extrusion is instrumental in mediating inflammation, autoimmunity and organ damage in lupus. Mitochondrial stress and mitochondrial…
Abstract Number: 2053 • 2017 ACR/ARHP Annual Meeting
Computed Tomography Dependent Diagnosis of Crowned Dens Syndrome; A Cervical Manifestation of Patients with Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
Ammar Haikal¹, Brian Everist², Pim Jetanalin³ and Mehrdad Maz³, ¹Department Internal Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, ²Department of Radiology (MSK), Department of Radiology (MSK), University of Kansas Medical Center, Kansas City, KS, ³Allergy, Clinical Immunology, and Rheumatology, Division of Allergy, Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Crowned Dens Syndrome (CDS), a variation of Calcium Pyrophosphate Deposition Disease (CPPD), is a radiologic-clinical entity defined by the association of radiological calcifications around…
Abstract Number: 2137 • 2017 ACR/ARHP Annual Meeting
Clinical Factors Associated with Long-Term Damage and Calcinosis in an Adult-Age Referral Population of Juvenile Myositis Patients
Vladislav Tsaltskan¹, Annette Aldous², Sam Serafi¹, Heidi Sami¹, Gulnara Mamyrova¹, Frederick W Miller³, Sam Simmens², Rodolfo Curiel¹, Olcay Y. Jones⁴ and Lisa G Rider³, ¹Department of Rheumatology, George Washington University, Washington, DC, ²Department of Epidemiology and Biostatistics, George Washington University Milken Institute School of Public Health, Washington, DC, ³Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ⁴Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD
Background/Purpose: Juvenile idiopathic inflammatory myopathies (JIIM) are rare, autoimmune chronic muscle diseases of childhood with significant potential long-term morbidity. In this study we investigate associations…
Abstract Number: 1898 • 2016 ACR/ARHP Annual Meeting
The Lack of Association of Osteoporosis with Proton Pump Inhibitor in Scleroderma: A UK Single Centre Cohort Experience
Ana Afonso¹, Svetlana Nihtyanova², Christopher Denton³ and Voon H. Ong⁴, ¹Internal Medicine, Hospital Pedro Hispano, EPE, Porto, Portugal, ²Centre for Rheumatology and Connective Tissue Diseases, University College London Medical School, Royal Free Hospital, London, United Kingdom, ³Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁴Rheumatology, UCL Division of Medicine, London, United Kingdom
Background/Purpose: Recent studies suggest that proton pump inhibitor (PPI) use is variably associated with risk of osteoporosis. The aim of this study was to investigate…
Abstract Number: 836 • 2016 ACR/ARHP Annual Meeting
Comprehensive Characterization of Calcinosis in a Multicenter International Cohort of Patients with Systemic Sclerosis
Antonia Valenzuela^1,2, Jessica K. Gordon³, Tatiana Sofia Rodriguez-Reyna⁴, Susanna Proudman^5,6, Murray Baron⁷, Monique Hinchcliff⁸, Dinesh Khanna⁹, Amber Young¹⁰, Flavia V. Castelino¹¹, Sara R. Schoenfeld¹², Virginia D. Steen¹³, David Fiorentino¹⁴ and Lorinda Chung¹⁵, ¹Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ²Stanford University School of Medicine, Stanford, CA, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁵Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ⁶Discipline of Medicine, University of Adelaide, Adelaide, Australia, ⁷Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ⁸Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁹University of Michigan, Ann Arbor, MI, ¹⁰Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ¹¹Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ¹²Rheumatology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ¹³Rheumatology, Georgetown University Medical Center, Washington, DC, ¹⁴Department of Dermatology, Stanford University School of Medicine, Palo Alto, CA, ¹⁵Rheumatology, Stanford University Medical Center, Palo Alto, CA
Background/Purpose: Calcinosis cutis is a debilitating complication of systemic sclerosis (SSc) affecting one quarter of patients. Repetitive trauma may be involved in the pathogenesis of…
Abstract Number: 841 • 2016 ACR/ARHP Annual Meeting
Low Nucleoside Triphosphate Pyrophosphohydrolase Activity Contributes to Pathologic Mineralization in Systemic Sclerosis
Yue Ding¹, Supraja Yeturi¹, Claudia Gohr¹, Mary Ellen Csuka¹ and Ann K. Rosenthal^2,3, ¹Medicine, Medical College of Wisconsin, Milwaukee, WI, ²Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, ³Medicine, Clement J. Zablocki VA Medical Center, Milwaukee, WI
Background/Purpose: Calcinosis is a major source of morbidity in patients with systemic sclerosis (SS). In addition, increased coronary calcification has been reported in patients with…
Abstract Number: 2960 • 2015 ACR/ARHP Annual Meeting
Sodium Thiosulfate in Calcinosis
Eliza Pelrine¹, Jessica K. Gordon², Murray Baron³ and Robert F. Spiera², ¹Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada
Background/Purpose: Calcinosis occurs in ~25% of patients with Systemic Sclerosis (SSc) and causes pain, morbidity, and decreased quality of life. The treatment of calcinosis is…