Abstracts tagged "calcinosis"

Abstract Number: 027 • 2023 Pediatric Rheumatology Symposium
Identifying and Understanding JDM in Africa: A Survey of Rheumatology Care Providers from Africa
Jessica Perfetto¹, Laura Lewandowski², Dawn Wahezi¹, Christiaan Scott³ and Angela Migowa⁴, ¹Children's Hospital at Montefiore, New York, NY, ²NIAMS, NIH, Bethesda, MD, ³Red Cross War Memorial Children's Hospital, ⁴Aga Khan University, Nairobi, Kenya
Background/Purpose: There is a paucity of data on pediatric rheumatic disease (PRD) in low and middle-income countries (LMIC), creating a false perception of low prevalence…
Abstract Number: 008 • 2023 Pediatric Rheumatology Symposium
Treatment Response and Outcomes of 63 Cases of Juvenile Dermatomyositis-Associated Calcinosis
Belina Yi¹, Dawn Wahezi², Lauren Covert³, Kaveh Ardalan⁴, Joyce Hui-Yuen⁵, Natalia Vasquez Canizares², Doaa Mosad Mosa⁶, Madison Jones⁷, Colleen Correll⁸, Alexis Begezda⁹, Susan Shenoi¹⁰, Eveline Wu¹¹, Leonard Kovalick¹², William Lapin¹³, Stacey Tarvin¹⁴, Melissa Oliver¹⁵, Martha Rodriguez¹⁴, Itay Marmor¹⁶, Kevin Baszis¹⁷, Alysha Taxter¹⁸, Andrew Hanson¹⁹, Cynthia Crowson¹⁹ and Amir Orandi¹⁹, ¹Children's Hospital Los Angeles, Los Angeles, CA, ²Children's Hospital at Montefiore, New York, NY, ³Duke University, Durham, NC, ⁴Duke University School of Medicine, Durham, NC, ⁵Cohen Children's Medical Center, Northwell Health, Lake Success, New York; Center for Autoimmune, Musculoskeletal, and Hematopoietic Diseases Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, ⁶Mansoura University Hospitals, Mansoura University Faculty of Medicine, El Mansoura, Egypt, ⁷Keck School of Medicine at University of Southern California, Los Angeles, CCA, ⁸University of Minnesota, Minneapolis, MN, ⁹Penn State, State College, PA, ¹⁰Seattle Children's Hospital, Seattle, WA, ¹¹UNC Chapel Hill, Chapel Hill, NC, ¹²UNC Health Care, Durham, NC, ¹³Connecticut Children's, Hartford, CT, ¹⁴Riley Hospital for Children at Indiana University Health, Indianapolis, IN, ¹⁵Indiana University, Indianapolis, IN, ¹⁶Dana-Dwek Children's Hospital, Hod Hasharon, Israel, ¹⁷Washington University School of Medicine, St Louis, MO, ¹⁸Nationwide Children's Hospital, Columbus, OH, ¹⁹Mayo Clinic, Rochester, MN
Background/Purpose: Calcinosis is a poorly understood and morbid complication of juvenile dermatomyositis (JDM). As there is no consensus treatment approach for calcinosis, and limited knowledge…
Abstract Number: 1064 • ACR Convergence 2022
Test-retest Reliability for the Mawdsley Calcinosis Questionnaire for the Measurement of Calcinosis Burden in Patients with Systemic Sclerosis
Antonia Valenzuela¹, Anne-Marie Russell², Lorinda Chung³, Kelly Jensen⁴ and Lesley Ann Saketkoo⁵, ¹Pontificia Universidad Catolica de Chile, Santiago, Chile, ²University of Exeter, Exeter, United Kingdom, ³Stanford University, Stanford, CA, ⁴University of Colorado, Bellevue, WA, ⁵University Medical Center - Comprehensive Pulmonary Hypertension Center and ILD Clinic Programs // New Orleans Scleroderma and Sarcoidosis Patient Care & Research Centeris, New Orleans, LA
Background/Purpose: Calcinosis cutis is a debilitating manifestation in systemic sclerosis (SSc) responsible for a high burden of disability and hand dysfunction, contributing as much as…
Abstract Number: 1661 • ACR Convergence 2022
Osteoclastogenesis and Vascular Endothelial Growth Factor Blood Levels in Patients with Systemic Sclerosis with and Without Calcinosis Cutis
Antonia Valenzuela¹, Guillermo Perez², Carolina Iturriaga² and Rebeca Montalva², ¹Pontificia Universidad Catolica de Chile, Santiago, Chile, ²Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile
Background/Purpose: Calcinosis cutis is a debilitating complication of systemic sclerosis (SSc) with no effective treatments. Although the pathogenesis of SSc-related calcinosis remains unknown, there is…
Abstract Number: 1787 • ACR Convergence 2022
The Impact of Topically Applied pH Modulator on Acute Inflammatory Pain, Serum Calcium, and C-Reactive Protein (CRP) During an Acute Gout Flare – a Phase 2a Randomized, Double-Blind, Placebo-Controlled Study
Puja Khanna¹ and Ryan Beal², ¹University of Michigan, Ann Arbor, MI, ²Dyve Biosciences, Inc, Camarillo, CA
Background/Purpose: Inflammatory cytokine-mediated bone resorption increases serum calcium (Ca2+) and can lead to calcification at chronically inflamed sites. Ca2+ influences cytokine activity to intensify the…
Abstract Number: 0150 • ACR Convergence 2022
Growth and Differentiation Factor 15, an Emerging Biomarker of Mitochondrial Dysfunction- Associated Myopathies: Implications for Juvenile Dermatomyositis
Bhargavi Duvvuri¹, Lauren Pachman², Gabrielle Morgan³, Payton Hermanson⁴, TING WANG⁴ and Christian Lood⁴, ¹University of Washington, Seattle, WA, ²Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL, ³Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Our prior work has demonstrated mitochondrial involvement in JDM including the accumulation of calcified mitochondria in affected muscle tissue, and elevated levels of circulating…
Abstract Number: 0174 • ACR Convergence 2022
Intra-rater Validation of Calcinosis Durometer Measurements in Juvenile and Adult Dermatomyositis
Meghan Nelson¹, Adam Schiffenbauer², Hanna Kim³, Scott Gillespie⁴, Vy Do⁵, Julie Fuller⁶, Lisa G Rider⁷ and Kelly Rouster-Stevens⁸, ¹Division of Pediatric Rheumatology, Department of Pediatrics, Emory University School of Medicine; Children's Healthcare of Atlanta, Atlanta, GA, ²National Institutes of Health, Bethesda, MD, ³Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences; Juvenile Myositis Therapeutic and Translation Studies Unit, PTRB, NIAMS, NIH, Bethesda, MD, ⁴Emory University, Atlanta, GA, ⁵UT Austin Dell Medical School, Austin, TX, ⁶UT Southwestern, Frisco, TX, ⁷Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, ⁸Division of Pediatric Rheumatology, Department of Pediatrics, Emory University School of Medicine; Children’s Healthcare of Atlanta, Atlanta, GA
Background/Purpose: Dermatomyositis (DM) and juvenile dermatomyositis (JDM) are idiopathic inflammatory myopathies primarily affecting proximal skeletal muscle and skin. Calcinosis, a known complication of DM, is…
Abstract Number: 1063 • ACR Convergence 2022
Assessment of Calcinosis in Portuguese Patients with Systemic Sclerosis – a Multicenter Study
Beatriz Samões¹, Diogo Fonseca¹, Tiago Beirão¹, Flavio Costa¹, Romana Vieira¹, Georgina Terroso², Raquel Ferreira², Rafaela teixeira³, André Saraiva⁴, Maria João Henriques⁵, Ana Catarina Duarte⁶, Ana Cristina Cordeiro⁶, Paulo Vilas-Boas⁷, Inês Genrinho³, Ana Bento da Silva⁸, Laura Gago⁸, Catarina Resende⁹, Patricia Martins⁹, Nathalie Madeira¹⁰, Sara Paiva Dinis¹⁰, Maura Couto³, Inês Santos³, Filipe Araújo¹¹, Ana Filipa Mourão¹¹, Miguel Guerra¹², Margarida Oliveira¹², Alexandra Daniel¹³, Marília Rodrigues¹³, Catarina Soares¹⁴, Hugo Parente¹⁵, Carolina Furtado¹⁶, Tomás Fontes¹⁶ and Joana Abelha-Aleixo¹, ¹Rheumatology Department, Centro Hospitalar de Vila Nova de Gaia / Espinho, Vila Nova de Gaia, Portugal, ²Rheumatology department, Centro Hospitalar Universitário de São João, Porto, Portugal, ³Rheumatology department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal, ⁴Rheumatology department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ⁵Rheumatology department, Centro Hospitalar e Universitário de Coimbra, Lisboa, Portugal, ⁶Rheumatology department, Hospital Garcia de Orta, Almada, Portugal, ⁷Rheumatology Department, Centro Hospitalar Baixo Vouga, Aveiro, Portugal, ⁸Rheumatology department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal, ⁹Rheumatology department, Centro Hospitalar e Universitário de Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisboa, Portugal, ¹⁰Rheumatology department, Unidade Local de Saúde da Guarda - Hospital Sousa Martins, Guarda, Portugal, ¹¹Rheumatology and Osteoporosis Unit, Hospital de Sant´Ana, SCML, Lisboa, Portugal, ¹²Rheumatology Department, Centro Hospitalar Universitário da Cova da Beira, Covilhã, Portugal, ¹³Rheumatology department, Hospital Distrital de Leiria, Leiria, Portugal, ¹⁴Rheumatology department, Unidade Local de Saúde do Alto Minho, Ponte de Lima, Viana do Castelo, Portugal, ¹⁵Rheumatology department, Unidade Local de Saúde do Alto Minho, Ponte de Lima, Portugal, ¹⁶Rheumatology department, Hospital do Divino Espírito Santo, Ponta Delgada, Portugal
Background/Purpose: Calcinosis is a challenging problem among Systemic Sclerosis (SSc) patients with a reported prevalence of 18-49%. We aim to define the prevalence of clinical…
Abstract Number: 1380 • ACR Convergence 2021
Quality of Life in Patients with Scleroderma Associated Calcinosis Cutis: A Cross-Sectional Study
Aditi Patel¹, Mehnaj Grewal², Robert Butler² and Soumya Chatterjee³, ¹Cleveland Clinic, Cleveland Heights, OH, ²Cleveland Clinic, Cleveland, OH, ³Cleveland Clinic, Richmond Heights, OH
Background/Purpose: Calcinosis cutis (CC) can commonly affect patients with systemic sclerosis (SSc), which is often painful, resulting in functional impairment and morbidity. A radiographic scoring…
Abstract Number: 1641 • 2019 ACR/ARP Annual Meeting
Change in Calcinosis over 1 Year Using the SCTC Radiologic Scoring System for Calcinosis of the Hands in Patients with Systemic Sclerosis
Antonia Valenzuela¹, Melody Chung ², Tatiana S. Rodríguez-Reyna ³, Susanna Proudman ⁴, Murray Baron ⁵, Flavia Castelino ⁶, Vivien Hsu ⁷, Shufeng Li ⁸, David Fiorentino ⁹, Kathryn Stevens ¹⁰ and Lorinda Chung ², ¹Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile, ²Stanford University, Palo Alto, CA, ³Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁴Royal Adelaide Hospital North Terrace, Adelaide, Australia, ⁵Jewish General Hospital, McGill University, Montreal, Canada, ⁶Harvard University, Boston, MA, ⁷Rutgers- RWJ Medical School, SOUTH PLAINFIELD, NJ, ⁸Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA, ⁹Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, ¹⁰Stanford University, Stanford
Background/Purpose: Calcinosis cutis is a debilitating complication of systemic sclerosis (SSc) affecting one quarter of patients, most frequently involving the hands. We previously developed and…
Abstract Number: 2590 • 2019 ACR/ARP Annual Meeting
Computer Vision Applied to Dual Energy Computed Tomography Images for Precise Calcinosis Cutis Quantification in Patients with Systemic Sclerosis
Anita Chandrasekaran¹, Imran Omar ², Zhicheng Fu ³, Shangping Ren ³ and Monique Hinchcliff ¹, ¹Yale University, Section of Rheumatology, Allergy and Immunology, New Haven, CT, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³San Diego State University, Department of Computer Science, San Diego, CA
Background/Purpose: Calcinosis cutis, found in both systemic sclerosis (SSc) and juvenile dermatomyositis patients, can be extensive and debilitating. Potential treatments have been identified, but a…
Abstract Number: 2607 • 2019 ACR/ARP Annual Meeting
Ultrasound Detection of Calcinosis and Correlation with Ulnar Artery Occlusion in Patients with Systemic Sclerosis
Robert Fairchild¹, Melody Chung ¹, Laurel Sharpless ¹, Shufeng Li ² and Lorinda Chung ¹, ¹Stanford University, Palo Alto, CA, ²Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA
Background/Purpose: Systemic Sclerosis (SSc) is a progressive fibrotic and vascular disease affecting multiple organs. Calcinosis cutis in SSc is characterized by calcium deposition in the…
Abstract Number: 2612 • 2019 ACR/ARP Annual Meeting
Minocycline for Refractory Calcinosis in Systemic Sclerosis: A Single-Centre Observational Cohort Study
Carmen Fonseca¹, Voon Ong ² and Christopher Denton ³, ¹UCL Medical School, Royal Free Campus, London, United Kingdom, ²UCL Medical School, Royal Free Campus, London, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: Calcinosis represents a major challenge for patients with systemic sclerosis (SSc) for which there is no standard therapy. Minocycline has been proposed for treatment…
Abstract Number: 479 • 2018 ACR/ARHP Annual Meeting
Intravenous Immunoglobulin in Combination with Intravenous Methylprednisolone in the Treatment of Calcinosis Associated with Juvenile Dermatomyositis (JDM)
Marc Phillpotts¹, Eman Alshaikh¹, Yaseen Aleatany¹, Olcay Y. Jones², Gulnara Mamyrova¹, Lisa G. Rider³ and Rodolfo Curiel¹, ¹Department of Medicine, Division of Rheumatology, The George Washington University, Washington, DC, ²Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, ³Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD
Background/Purpose: Calcinosis is a major complication of JDM and is associated with disability and poor quality of life. There are no known effective treatments for…
Abstract Number: 482 • 2018 ACR/ARHP Annual Meeting
The Association of Short-Term Ultraviolet Radiation Exposure and Calcinosis in Juvenile Dermatomyositis in the Childhood Arthritis & Rheumatology Research Alliance Registry
Jessica Neely¹, Craig S. Long², Hugh Sturrock³ and Susan Kim⁴, ¹Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA, ²National Oceanic and Atmospheric Administration (NOAA)/Climate Prediction Center, College Park, MD, ³Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴Pediatric Rheumatology, University of California, San francisco School of Medicine, San Francisco, CA
Background/Purpose: JDM is an autoimmune systemic vasculopathy characterized by myositis and skin rash. Some myositis specific antibodies (MSAs) are associated with clinical manifestations in JDM,…