Abstracts tagged "Bone"

Abstract Number: 308 • 2018 ACR/ARHP Annual Meeting
Carpal Bones Affectation Frequency in Rheumatoid Arthritis By Magnetic Resonance Imaging
Maria Del Carmen Larios-Forte¹, Cassandra Skinner-Taylor¹, Dionicio A. Galarza-Delgado², Jorge Esquivel-Valerio³, Janett Riega-Torres⁴, David Vega-Morales¹ and Itzel Perez-Onofre⁵, ¹Rheumatology, University Hospital “Dr. José Eleuterio González”, UANL, Monterrey, Mexico, ²Chief of Rheumatology, Hospital Universitario, UANL, Monterrey, Mexico, ³Rheumatology, University Hospital “Dr. José Eleuterio González”, UANL, Mexico, Monterrey, Mexico, ⁴University Hospital “Dr. José Eleuterio González”, UANL, Monterrey, Mexico, ⁵Rheumatology, University Hospital “Dr. José Eleuterio González” U.A.N.L, Monterrey, Mexico
Background/Purpose: Wrist joint between radio-ulna and first carpal row; scaphoid and triquetrum bones stabilize the central carpal column and support the flexion-extension or abduction-adduction movements1.…
Abstract Number: 2335 • 2018 ACR/ARHP Annual Meeting
Osteoporotic Fracture Trends in a Population of US Managed Care Enrollees: 2007-2017
E. Michael Lewiecki¹, Benjamin Chastek², Kevin Sundquist², Setareh A. Williams³, Deane Leader Jr.³, Richard Weiss³, Yamei Wang³, Lorraine A Fitzpatrick³ and Jeffrey R. Curtis⁴, ¹New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, ²Optum, Eden Prairie, MN, ³Radius Health, Inc., Waltham, MA, ⁴University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Osteoporosis-related fractures (fractures) are a leading cause of morbidity and disability in the US. Epidemiological data on the occurrence of fractures are limited and…
Abstract Number: 865 • 2018 ACR/ARHP Annual Meeting
Structural and Microstructural Intraarticular Bone Changes at the Metacarpal Heads in Patients with Psoriatic Arthritis Compared to Controls: A HR-pQCT Study
Dongze Wu¹, James F Griffith², Steven H.M. Lam¹, Jiang Yue¹, Priscilla Wong¹, Lin Shi³, Edmund Li¹, Isaac T. Cheng¹, Tena K. Li¹, Tracy Y. Zhu⁴, Vivian W. Hung⁴, Ling Qin⁵ and Lai-Shan Tam⁶, ¹Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, Hong Kong, China, ²Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, ³Research Centre for Medical Image Computing, Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, ⁴Bone Quality and Health Centre of the Department of Orthopedics & Traumatology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, ⁵Bone Quality and Health Centre of the Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁶Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Metacarpal head directly exposed to intra-articular inflammatory milieu, therefore may lead to abnormal bone remodeling (bone loss and new bone formation). The aims of…
Abstract Number: 2730 • 2018 ACR/ARHP Annual Meeting
Handgrip Strength Predicts the Risk of Bone Fracture and Severe Adverse Events in Patients with Systemic Necrotizing Vasculitis
Soledad Henriquez¹, Bertrand Dunogué², Raphaël Porcher³, Alexis Régent¹, Pascal Cohen⁴, Alice Bérezné¹, Sami Kolta⁵, Claire Le Jeunne¹, Luc Mouthon⁶, Christian Roux⁵, Loïc Guillevin⁷, Karine Briot⁸ and Benjamin Terrier⁹, ¹Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ²Internal Medicine, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ³Université Paris Descartes Sorbonne Paris, Paris, France, ⁴Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, ⁵Department of Rheumatology, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁶Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, ⁷Medecine Interne, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁸Department of Rheumatology, Cochin Hospital and Epidemiology and Biostatistics Unit,Sorbonne Paris Cité Reserach Center,Paris Descartes University,INSERM U1153, Paris, France, ⁹National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France
Background/Purpose: Sarcopenia, characterized by progressive loss of both muscle mass and muscle strength, has been associated with poor outcomes in various diseases. Muscle weakness is…
Abstract Number: 1044 • 2018 ACR/ARHP Annual Meeting
Alendronate-CGS21680 Conjugates Prevent Bone Erosion in a Murine Osteolysis Model
Ane Larrañaga Vera¹, Kiran Toti², Eugene Warnick², Harsha Rao², Zhan-Guo Gao², Alexandra Gadiano², Aranzazu Mediero³, Kenneth A. Jacobson² and Bruce N. Cronstein⁴, ¹Medicine, New York University School of Medicine, New York, NY, ²Molecular Recognition Section, NIDDK-NIH, Bethesda, MD, ³Joint and Bone Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain, ⁴Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: The most common cause of total joint replacement revision surgeries is loosening of the implant due to loss of bone around the prosthesis. Wear…
Abstract Number: 2810 • 2018 ACR/ARHP Annual Meeting
Fracture and Bone Mineral Density Response By Baseline Risk in Patients Treated with Abaloparatide Followed By Alendronate
Benjamin Leder¹, Carol Zapalowski², Ming-Yi Hu³ and Gary Hattersley², ¹Endocrine, Harvard Medical School, Boston, MA, ²Radius Health, Inc., Waltham, MA, ³Biometrics, Radius Health, Inc., Waltham, MA
Background/Purpose: Abaloparatide (ABL) is an anabolic PTHrP analog approved to treat postmenopausal women with osteoporosis at high risk of fracture. In the ACTIVE Phase 3…
Abstract Number: 1067 • 2018 ACR/ARHP Annual Meeting
Simulating the Pathogenesis of Arthritis in Vitro By Developing a Human-Based Multicomponent 3D Joint Model
Alexandra Damerau^1,2, Annemarie Lang^1,2, Moritz Pfeiffenberger^1,2, Timo Gaber^1,3 and Frank Buttgereit^1,2, ¹Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, ³Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Berlin, Germany
Background/Purpose: Although arthritis is a matter of research since more than 140 years, there is currently no valid 3D model available, which is able to…
Abstract Number: 2811 • 2018 ACR/ARHP Annual Meeting
Abaloparatide Effect on Bone Mineral Density and Fracture Incidence in Postmenopausal Women with Osteoporosis Aged 80 Years or Older
Susan L. Greenspan¹, Lorraine A Fitzpatrick², Bruce Mitlak², Yamei Wang², Nicholas C. Harvey³, Chad Deal⁴, Felicia Cosman⁵ and Michael McClung⁶, ¹Medicine, University of Pittsburgh, Pittsburgh, PA, ²Radius Health, Inc., Waltham, MA, ³MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, ⁴Cleveland Clinic, Shaker Heights, OH, ⁵Columbia University College of Physicians and Surgeons, New York, NY, ⁶Oregon Osteoporosis Center, Portland, OR
Background/Purpose: The risk of fracture increases with increasing age. Thus, it is important to understand efficacy and safety of osteoporosis treatments in elderly patients. In…
Abstract Number: 1197 • 2018 ACR/ARHP Annual Meeting
The Characteristics of the Distribution of Normal Feeding Vessels between Young and Elderly Adults in Wrist Joints of Healthy Volunteers Depicted By Ultrasound (MSKUS)
Kenta Misaki¹, Kei Ikeda², Kenshi Inoue³, Moemi Miyazaki³, Naofumi Dobashi³ and Yasuhiko Imaizumi⁴, ¹Rheumatology, Kita-Harima Medical Center, Ono, Japan, ²Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, ³Kita-Harima Medical Center, Ono, Japan, ⁴kita-Harima Medical Center, Ono, Japan
Background/Purpose: Synovial vascularity as measured by power Doppler (PD) of MSKUS is correlated to rheumatoid arthritis disease activity, and PD signal reveals the prevalence of…
Abstract Number: 2812 • 2018 ACR/ARHP Annual Meeting
Evaluation of Cortical Microarchitecture, Bone Stiffness and Bone Remodeling in Patients with Atypical Femoral Fracture
Mariana O Perez¹, Diogo S Domiciano¹, Luciene M Reis², Vanda Jorgetti² and Rosa M R Pereira¹, ¹Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, ²Nephrology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
Background/Purpose: Atypical femoral fractures (AFF) are low energy femoral fractures and subtrochanteric/diaphyseal localization that have been related to long-term bisphosphonate therapy. Patients with AFF exhibit…
Abstract Number: 1481 • 2018 ACR/ARHP Annual Meeting
Are ACPA Associated with More Bone Loss over Time in Patients with RA?
Emma de Moel¹, Josephine Amkreutz¹, Lotte Heimans², Cornelia F. Allaart³, Tom W.J. Huizinga⁴ and Diane van der Woude⁴, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Internal Medicine, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, LUMC, Leiden, Netherlands, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are one of the most important serological markers for rheumatoid arthritis (RA) and have been suggested to play a pathophysiologic…
Abstract Number: 1830 • 2018 ACR/ARHP Annual Meeting
Role of BMP2 in Entheseal Bone Formation in Inflammatory Arthritis
Yukiko Maeda¹, Jozsef Karman² and Ellen M. Gravallese³, ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Abbvie Bioresearch Center, Worcester, MA, ³Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Spondyloarthritis (SpA) is common, with a prevalence of ~1% in the United States. Patients with SpA suffer from pain and disability due to inflammation…
Abstract Number: 1987 • 2018 ACR/ARHP Annual Meeting
Elucidation of the Function of Dendritic Cell-Specific Transmembrane Protein (DCSTAMP) in Osteoclast Differentiation
Ananta Paine¹, Maria de la Luz Garcia-Hernandez², Dongge Li³, Minsoo Kim⁴ and Christopher T. Ritchlin², ¹Department of Medicine, Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ²Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ³Allergy, Immunology and Rheumatology, Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ⁴Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, USA, Rochester, NY
Background/Purpose: Osteoclasts (OC) are bone-resorbing, multinuclear cells that originate from myeloid progenitor cells through repetitive cycles of cell-cell fusion. Dendritic cell-specific transmembrane protein (DCSTAMP) is…
Abstract Number: 1989 • 2018 ACR/ARHP Annual Meeting
A Regulatory Role of ANTXR1 in RANKL-Induced Osteoclast Differentiation and Function
Myeung Su Lee¹, Changhoon Lee², Chong Hyuk Chung³, Wan-Hee Yoo⁴, Jin Jung Choi⁵, Jong Min Baek⁶ and Ju-Young Kim⁷, ¹Department of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, Wonkwnag University Hospital, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, IKSAN, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Research Institute of Clinical Medicine of chonbuk national university-Biomedical Research Institute of chonbuk national university hospital, Jeonju, Korea, Republic of (South), ⁵Rheumatology, CHA University Medical Center at Bundang, Sungnam, Korea, Republic of (South), ⁶Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Korea, Republic of (South), ⁷Imaging Science-based Lung and Bone Diseases Research Center, School of Medicine, Wonkwang University, IKSAN, Korea, Republic of (South)
Background/Purpose: Anthrax toxin receptor 1 (ANTXR1) has been known to have relationship with extracellular transmembrane protein deeply associated with the process of bone formation and…
Abstract Number: 2065 • 2018 ACR/ARHP Annual Meeting
Blockade of the JAK/STAT Pathway Inhibits Inflammation and Bone Formation in Two Murine Models of Spondyloarthritis
Yukiko Maeda¹, Zheni Stavre¹, Tingting Huang², Catherine Manning², Bryant Shaughn³, Michael Macoritto³, Deborah Hyland³, Wendy Waegell³ and Ellen M. Gravallese⁴, ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Medicine, University of Massachusetts Medical School, worcester, MA, ³Abbvie Bioresearch Center, worcester, MA, ⁴Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Spondyloarthritis (SpA) results in significant pain and loss of function due to inflammation and resulting enthesial/periosteal bone formation. Inhibition of the Janus kinase (JAK)/STAT…

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