Abstracts tagged "bone metabolism"

Abstract Number: 1967 • 2012 ACR/ARHP Annual Meeting
Hypophosphatemic Osteomalacia Induced by Tenofovir in Patients with Human Immunodeficiency Virus Infection
Beatriz Tejera¹, Lourdes Mateo-Soria², Susana Holgado³, Luisa Mariñoso⁴, Ricard Pérez⁵, Anna Bonjoch⁶, Melania Martínez-Morillo⁷, Dolors Grados³ and Alejandro Olivé³, ¹Rheumatology, University Hospital of Canary Islands, Santa Cruz de Tenerife, Spain, ²Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ³Rheumatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ⁴Pathology, Hospital del Mar, Barcelona, Spain, ⁵Radiology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ⁶HIV Unit, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ⁷Rheumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Background/Purpose: treatment of human immunodeficiency virus (HIV) infection has dramatically changed survival prognosis of these patients.New drugs included in antiretroviral therapy are much more effective. …
Abstract Number: 1973 • 2012 ACR/ARHP Annual Meeting
Effect of Adalimumab On the Serum Level of Undercarboxylated Osteocalcin (ucOC), Bone Biochemical Markers and Bone Mineral Density
Yoshitada Sakai¹, Akira Hashiramoto², Takaichi Okano², Yoshiko Kawasaki³, Nao Shibanuma⁴ and Masahiro Kurosaka⁵, ¹The Center of Rheumatic Diseases/ Division of Rehabilitation Medicine, Kobe University Hospital, Kobe, Japan, ²The Center for Rheumatic Diseases,, Kobe University Hospital, Kobe, Japan, ³The Center of Rheumatic Diseases, Kobe University Hospital, Kobe, Japan, ⁴The Center for Rheumatic Diseases, Kobe University Hospital / Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁵Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: The osteoporotic fracture in patients with rheumatiod arthritis (RA) is caused by systemic osteoporosis as well as periarticular osteoporosis, On the other hand, the…
Abstract Number: 1789 • 2012 ACR/ARHP Annual Meeting
Evidence for an Additive Effect of Tumor Necrosis Factor Alpha and Hypoxia to Promote Bone Destruction in Arthritis
Shankar Revu¹, Akilan Krishnamurthy², Vivekananda Sunkari³, Ileana R. Botusan³, Xiaowei Zheng³, Sergiu-Bogdan Catrina⁴ and Anca Catrina¹, ¹Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ²Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Molecular Medicine and Surgery, Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Hypoxia is a major feature of the inflamed rheumatoid arthritis synovial membrane and promotes osteoclasts formation in vitro. We aimed to investigate the molecular…
Abstract Number: 1281 • 2012 ACR/ARHP Annual Meeting
IL-6 Signaling Inhibition Improves Abnormal Bone Homeostasis in Active Rheumatoid Arthritis
Masayasu Kitano¹, Sachie Kitano¹, Chieri Sato¹, Kazuyuki Fujita¹, Takahiro Yoshikawa¹, Yuki Katashima¹, Masahiro Sekiguchi¹, Naoto Azuma¹, Naoaki Hashimoto, Shinichiro Tsunoda¹, Kiyoshi Matsui¹ and Hajime Sano¹, ¹Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya-city, Japan
Background/Purpose: Tocilizumab (TCZ) is a humanized monoclonal anti-IL-6 receptor antibody. TCZ has demonstrated efficacy in moderate to severe active rheumatoid arthritis (RA) with inadequate clinical…
Abstract Number: 1209 • 2012 ACR/ARHP Annual Meeting
Functional Role of Chondrogenic Progenitor Cells in Rheumatoid Arthritis
Sabine Blaschke¹, Sandra Trautmann¹, Alexander W. Beham², Burkhard Mai³, Sebastian Koelling¹, Caroline Breysach⁴, Gabriele Wolf¹, Gerhard A. Mueller¹ and Nicolai Miosge⁵, ¹Nephrology & Rheumatology, University Medical Center Goettingen, Goettingen, Germany, ²Department of Surgery, Germany, ³Vitos Orthopaedic Clinic Kassel, Kassel, Germany, ⁴Department of Surgery, Goettingen, Germany, ⁵Dept. of Prosthodontics, Goettingen, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease of still unknown etiology leading to progressive cartilage and bone destruction. Proinflammatory cytokines, immunoregulatory cells…
Abstract Number: 1007 • 2012 ACR/ARHP Annual Meeting
High Resolution Peripheral Quantitative CT Detects Marked Differences in Metacarpal Head and Shaft and Ultra-Ultra-Distal Radius Bone Volumetric Density and Microstructure in Early Rheumatoid Arthritis
Lynne M. Feehan¹, Helen R. Buie², Linda C. Li¹, Kamran Shojania³, Cheryl Barnabe⁴ and Heather A. McKay⁵, ¹Physical Therapy, Arthritis Research Centre of Canada and University of British Columbia, Vancouver, BC, Canada, ²Mechanical Engineering, University of Calgary, Calgary, AB, Canada, ³Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁴Medicine, Community Health Sciences, University of Calgary, Calgary, AB, Canada, ⁵Family Practice and Orthoepedics, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Despite improvements in clinical management of rheumatoid arthritis (RA), many with early disease are still at high risk for developing periarticular erosions and osteopenia,…
Abstract Number: 823 • 2012 ACR/ARHP Annual Meeting
Positive Effects of Tocilizumab On Bone Remodeling in Patients with Rheumatoid Arthritis
Karine Briot¹, Thierry Schaeverbeke², Fabien Etchepare³, Philippe Gaudin⁴, Aleth Perdriger⁵, Muriel Vray⁶, Stephanie Rouanet⁷, Ghislaine Steinberg⁸ and Christian Roux¹, ¹Cochin hospital, Paris Descartes University, Paris, France, ²Service de Rhumatologie, Groupe Hospitalier Pellegrin, Bordeaux, France, ³G.H. Pitié-Salpêtrière, Paris, France, ⁴Rheumatology Department, CHU Hôpital Sud, Grenoble Teaching Hospital, Echirolles, France, ⁵Rheumatology, Hôpital Sud, Rennes, France, ⁶Institut Pasteur, Paris, France, ⁷Medical Department, Roche, Boulogne-Billancourt, France, ⁸Medical Department, Roche, Neuilly sur Seine, France
Background/Purpose: The anti-IL6-R antibody tocilizumab (TCZ) is an effective treatment of rheumatoid arthritis (RA). Previous studies showed that TCZ has a positive effect on bone…
Abstract Number: 594 • 2012 ACR/ARHP Annual Meeting
Evidence of Human Leucozyte Antigen-B27 in Healthy Individuals and Patients with Uveitis Is a Risk Factor for Alterations in Bone Metabolism
Sarah Schmidt¹, Stephanie Finzel¹, Jürgen Rech², Matthias Englbrecht¹, Silke Winkler¹, Isabel Schmidt¹, Roula Said-Nahal³, Maxime A. Breban³ and Georg A. Schett¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medizinische Klinik 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Background/Purpose: To test whether positivity for HLA-B27 per se is associated with changes of biomarkers of the Wnt pathway. HLA-B27 is strongly associated with the…
Abstract Number: 35 • 2012 ACR/ARHP Annual Meeting
Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis
Brett A. Tonkin¹, Evange Romas², Natalie A. Sims¹ and Nicole C. Walsh¹, ¹St Vincent's Institute of Medical Research, Melbourne, Australia, ²Dept. of Rheumatology, St Vincent's Hospital, Melbourne, Australia
Background/Purpose: The destabilisation of the medial meniscus (DMM) mouse osteoarthritis (OA) model is commonly used to study OA joint degeneration. In DMM-OA, the knee is…
Abstract Number: 38 • 2012 ACR/ARHP Annual Meeting
Bone Marrow Lesions On Magnetic Resonance Imaging Are Not Associated with Regions of Hypermetabolism in an Animal Model of Osteoarthritis
Arash Panahifar¹, Jacob Jaremko², Robert GW Lambert², Walter P. Maksymowych³ and Michael R. Doschak¹, ¹Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada, ²Radiology, University of Alberta, Edmonton, AB, Canada, ³Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: The underlying histopathological basis for bone marrow lesions (BML) on magnetic resonance imaging (MRI) in osteoarthritis (OA) is unclear, but may be associated with…
Abstract Number: 44 • 2012 ACR/ARHP Annual Meeting
Inhibition of WNT Signaling Pathway by Sclerostin Maintains Cartilage Homeostasis
Wafa Bouaziz¹, Thomas Funck-Brentano¹, Hilene Lin¹, Eric Hay¹ and Martine Cohen-Solal², ¹INSERM U606 Paris 7 university, Paris, France, ²Rhumatologie A, INSERM U606 Hôpital Lariboisière, Centre Viggo Petersen, Paris, France
Background/Purpose: Cartilage homeostasis is regulated by several mechanisms that influence the anabolic and catabolic tissue balance. Among them, the local activation of Wnt signaling pathway…
Abstract Number: 16 • 2012 ACR/ARHP Annual Meeting
Adenosine A_2A Receptor Diminishes Bone Destruction At Inflamed Sites, in Part, Via Downregulating Semaphorin4D-PlexinB1 Communication Between Osteoclasts and Osteoblasts
Aranzazu Mediero¹ and Bruce N. Cronstein², ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Communication between osteoclasts and osteoblasts is essential for bone homeostasis. Semaphorin4D (Sema4D), expressed on the surface of and secreted by osteoclasts, macrophages and T…
Abstract Number: 24 • 2012 ACR/ARHP Annual Meeting
The Negative Effects of Glucocorticoids On Bone Are Primarily Mediated by Genes Involved in Osteoblast Differentiation and Bone Remodelling
Katharina Blankenstein¹, Tara C. Brennan-Speranza¹, Karin Lyon¹, Colin R. Dunstan¹, Frank Buttgereit², Hong Zhou³ and Markus J. Seibel³, ¹ANZAC Research Institute, Concord, NSW, Bone Research Program, Sydney, Australia, ²Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Bone Research Program, ANZAC Research Institute, The University of Sydney, Concord, Australia
Background/Purpose: Glucocorticoids are widely used as anti-inflammatory and immunosuppressive drug for the treatment of many inflammatory and auto-immune diseases. However, long-term and high-dose glucocorticoid treatment…
Abstract Number: 25 • 2012 ACR/ARHP Annual Meeting
Activation of the Canonical Wnt Signaling Pathway Is Tissue Dependent in Osteoarthritic Joints: Distinct Mechanisms of Regulation by Wnt Antagonists
Thomas Funck-Brentano¹, Wafa Bouaziz¹, Hilene Lin¹, Valerie Geoffroy¹, Eric Hay¹ and Martine Cohen-Solal², ¹INSERM U606 Paris 7 university, Paris, France, ²Rhumatologie A, INSERM U606 Hôpital Lariboisière, Centre Viggo Petersen, Paris, France
Background/Purpose: Wnt signaling pathway is a major regulator of bone and cartilage remodeling. Modulation of this pathway has lead to controversial results on joint cartilage…

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