ACR Meeting Abstracts

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Abstracts tagged "Bone marrow"

  • Abstract Number: 817 • 2019 ACR/ARP Annual Meeting

    Enhanced Expression of mRNA for TAK1 in CD34+ Cells of the Bone Marrow in Rheumatoid Arthritis

    Shunsei Hirohata1, Tatsuo Nagai 2, Tetsuya Tomita 3 and Hideki Yoshikawa 3, 1Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Tatsuno, Japan, 2Kitasato University School of Medicine, Sagamihara, Japan, 3Osaka University Graduate School of Medicine, Osaka, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia, consisting of type A macrophage-like synoviocytes and type B fibroblast-like synoviocytes (FLS).…
  • Abstract Number: 1983 • 2019 ACR/ARP Annual Meeting

    Preclinical Evaluation of Targeting TGF-beta Signaling and Senescence in ex Vivo Models of Human Knee and Spine Osteoarthritis

    Jeroen Geurts1, Cordula Netzer 2, Stefan Schären 2 and Thomas Hugle 3, 1University Hospital Lausanne (CHUV), Lausanne, Switzerland, 2University Hospital Basel, Basel, Switzerland, 3University Hospital Lausanne, Lausanne, Switzerland

    Background/Purpose: The absence of effective disease-modifying drugs remains an important unmet need in the treatment of osteoarthritis. In recent years, novel pharmacological treatments including targeting…
  • Abstract Number: 49 • 2017 ACR/ARHP Annual Meeting

    G Protein-Coupled Receptor Kinase 3 Modulates Mesenchymal Stem Cell Proliferation and Differentiation through Sphingosine-1-Phosphate Receptor Regulation

    Jaime M. Brozowski1, Roman G. Timoshchenko2, D. Stephen Serafin2, Jessica Koontz2, Brittney Allyn2, Amanda M. Eudy3, Taylor Harris4, David Abraham4, Clinton T. Rubin5, Janet Rubin6, Nancy Allbritton4, Matthew J. Billard2 and Teresa K. Tarrant7, 1Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC, 4Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 5Biomedical Engineering, Stony Brook University, Stony Brook, NY, 6General endocrinology, metabolic bone diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 7Rheumatology and Immunology, Duke University, Durham, NC

    Background/Purpose: Mesenchymal stem cells are multipotent stromal cells that can differentiate into tissue-specific lineages, such as osteocytes and chondrocytes. Their multipotency has made them an…
  • Abstract Number: 2300 • 2017 ACR/ARHP Annual Meeting

    Predictive Value of Magnetic Resonance Imaging in Patients with Juvenile Idiopathic Arthritis in Clinical Remission

    Clara Malattia1, Marta Mazzoni Sr.2, Stefania Viola Sr.2, Angela Pistorio3, Francesca Magnaguagno4, Alessia Urro Jr.2, Angelo Ravelli5 and Alberto Martini6, 1Pediatria2 Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, 2Pediatria 2 Reumatologia, Istituto Giannina Gaslini, Genova, Italy, 3Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genoa, Italy, 4UO Radiologia, Istituto Giannina Gaslini, Genoa, Italy, 5University of Genova, IRCCS Istituto Giannina Gaslini, Genova, Italy, 6Istituto Giannina Gaslini, Genoa, Italy

    Background/Purpose: MRI studies on RA revealed that subclinical synovitis is common in patients in clinical remission and it is responsible for structural damage progression. MRI-detected…
  • Abstract Number: 1119 • 2016 ACR/ARHP Annual Meeting

    The Enhanced Expression of mRNA for Calgranulins, S100A8, S100A9 and S100A12, in CD34+ Cells of the Bone Marrow in Rheumatoid Arthritis

    Tatsuo Nagai1, Yu Matsueda2, Tetsuya Tomita3, Hideki Yoshikawa3 and Shunsei Hirohata2, 1Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, 2Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 3Department of Orthopedics, Osaka University Graduate School of Medicine, Suita Osaka, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory arthritis of unknown etiology. A subset of S100 proteins known as calgranulins (S100A8, S100A9 and S100A12) are…
  • Abstract Number: 1563 • 2016 ACR/ARHP Annual Meeting

    Enhanced Expression of mRNA for Response Gene to Complement 32 in CD34+ Cells of the Bone Marrow in Rheumatoid Arthritis

    Yu Matsueda1, Tatsuo Nagai2, Tetsuya Tomita3, Hideki Yoshikawa3, Sumiaki Tanaka1 and Shunsei Hirohata1, 1Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 2Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, 3Department of Orthopedics, Osaka University Graduate School of Medicine, Suita Osaka, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by hyperplasia of synovial lining cells, consisting of macrophage-like type A synoviocytes and fibroblast-like type…
  • Abstract Number: 1656 • 2016 ACR/ARHP Annual Meeting

    Compare the Potential of Osteoclast Precursors (OCPs) Residing in Bone Marrow and Peripheral Blood As the Surrogates of Psoriasis Pathogenesis

    Yahui Grace Chiu1, Edward Schwarz2, Dongge Li3, Nelson Huertas3, Cristy Bell4, Debbie Campbell4 and Christopher T. Ritchlin5, 1Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, 2Orthopedeatrics, University of Rochester, Rochester, NY, 3Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 4Allergy, Immunology & Rheumatology, University of Rochester, Rochester, NY, 5Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Bone marrow (BM) is not only the place where osteoclast precursors (OCPs) are derived from, but also the major reservoirs of OCPs. Current data…
  • Abstract Number: 1832 • 2016 ACR/ARHP Annual Meeting

    Increased Interferon b Expression in Bone Marrow Mediates a Senescent Phenotype and Impaired Production of Immunomodulatory Factors By SLE Mesenchymal Stromal Cells

    Lin Gao1, Jennifer H. Anolik2 and R. John Looney2, 1medicine- allergy, immunology and rheumatology, University of Rochester Medical Center, Rochester, NY, 2Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Bone marrow mesenchymal stromal cells (MSCs) are multipotent stem cells that create a special microenvironment for hematopoiesis and immunity. MSCs display robust immunomodulatory properties…
  • Abstract Number: 522 • 2015 ACR/ARHP Annual Meeting

    The Expression of mRNA for Peptidylarginine Deiminase Type 2 and Type 4 in CD34+ Cells of the Bone Marrow in Rheumatoid Arthritis

    Tatsuo Nagai1, Tetsuya Tomita2, Hideki Yoshikawa2 and Shunsei Hirohata1, 1Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 2Department of Orthopedics, Osaka University Graduate School of Medicine, Suita Osaka, Japan

    Background/Purpose: We previously showed that bone marrow (BM) CD34+ cells from rheumatoid arthritis (RA) patients have abnormal capacities to respond to tumor necrosis factor alpha…
  • Abstract Number: 2755 • 2013 ACR/ARHP Annual Meeting

    The Clinical Significance and Natural History Of Knee Bone Marrow Lesions Over 8 Years

    Yi Chao Foong1, Hussain Ijaz Khan1, Dawn Aitken1, Changhai Ding2, Flavia Cicuttini3 and Graeme Jones2, 1Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, 2Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, 3Department of Epidemiology and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, Australia

    Background/Purpose: There is increasing evidence to suggest that bone marrow lesions (BMLs) play a key role in the pathogenesis of OA. Whilst many studies have…
  • Abstract Number: 2427 • 2013 ACR/ARHP Annual Meeting

    Enhanced Expression Of mRNA For Triggering Receptor Expressed On Myeloid Cells 1 In CD34+ Cells Of The Bone Marrow In Rheumatoid Arthritis

    Tatsuo Nagai1, Tetsuya Tomita2, Hideki Yoshikawa2 and Shunsei Hirohata3, 1Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, 2Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan, 3Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan

    Background/Purpose: We previously showed that bone marrow (BM) CD34+ cells from rheumatoid arthritis (RA) patients have abnormal capacities to respond to tumor necrosis factor alpha…
  • Abstract Number: 1694 • 2013 ACR/ARHP Annual Meeting

    A Randomised Trial Of A Brace For Patellofemoral Osteoarthritis Targeting Knee Pain and Bone Marrow Lesions

    David T. Felson1,2, Matthew J. Parkes1, Andrew D. Gait3, Elizabeth J. Marjanovic3, Mark Lunt4, Charles E. Hutchinson5, Laura Forsythe6, Timothy F. Cootes3 and Michael Callaghan1, 1Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, 2Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, 3Imaging Sciences, School of Cancer & Enabling Sciences, University of Manchester, Manchester, United Kingdom, 4Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, 5Warwick Medical School, University of Warwick, Coventry, United Kingdom, 6Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom

    Background/Purpose: Patellofemoral (PF) braces have been shown to increase contract area in this joint, decreasing focal stress  and may also correct patellar malalignment. Bone marrow…
  • Abstract Number: 636 • 2013 ACR/ARHP Annual Meeting

    Neutrophil-Mediated Interferon Activation In Systemic Lupus Erythematosus Bone Marrow

    Anna Bird1, Nida Meednu2, Javier Rangel-Moreno3, Srilakshmi Yalavarthi4, Jennifer Barnard1, Teresa Owen5, Jason S. Knight6, Alfred Rabinovich1, Arumugam Palanichamy2, Jane Liesveld7, Jason W Bauer8, Emily Baechler9, Mariana J. Kaplan10 and Jennifer H. Anolik11, 1Medicine-Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 2Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 3Medicine- Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, 4University of Michigan Rheumatology, Ann Arbor, MI, 5Medicine- Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, 6Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 7Hematology/Oncology, University of Rochester Medical Center, Rochester, NY, 8University of Minnesota, Minneapolis, MN, 9Medicine, University of Minnesota, Minneapolis, MN, 10Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD, 11Medicine- Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY

    Background/Purpose: Although SLE is known to be associated with a type I interferon signature in the peripheral blood, the precise site and mechanism of IFN…
  • Abstract Number: 524 • 2013 ACR/ARHP Annual Meeting

    Expansion Of DC-STAMP+ IL-17+ Cells In Bone Marrow From Psoriasis and Psoriatic Arthritis Patients

    Yahui Grace Chiu1, Edward M. Schwarz2, Jamie Biear1, Debbie Campbell3, Jennifer Hossler1, Jennifer H. Anolik4, R. John Looney1 and Christopher T. Ritchlin1, 1Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 2Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 3Allergy, Immunology and Rheumatology, Univerity of Rochester, Rochester, NY, 4Medicine- Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY

    Background/Purpose: Focal erosions in inflammatory arthritis are mediated by bone marrow (BM) derived osteoclasts (OC) that enter the joint as OC precursors (OCP) from peripheral…
  • Abstract Number: 271 • 2012 ACR/ARHP Annual Meeting

    Bone Marrow Lesions in Knees with Osteoarthritis: Can Parameters From Dynamic Contrast Enhancement Predict Change in Bone Marrow Lesion Volume or Knee Pain Change?

    Andrew D. Gait1, Timothy F. Cootes1, Elizabeth J. Marjanovic1, Matthew J. Parkes2, Charles E. Hutchinson3 and David T. Felson4, 1Imaging Sciences, School of Cancer & Enabling Sciences, University of Manchester, Manchester, United Kingdom, 2Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, 3Warwick Medical School, University of Warwick, Coventry, United Kingdom, 4ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom

    Background/Purpose: Dynamic contrast enhancement is a powerful tool for highlighting features of a medical image which may not otherwise be seen on "static" scans. While…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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