Abstracts tagged "bone disease"

Abstract Number: 2206 • 2019 ACR/ARP Annual Meeting
MRI-based Textural Analysis of Trabecular Bone: A Novel Method for the Opportunistic Screening of Bone Quality
Jonathan Cheah¹, Matthew Koff ¹, Ryan Breighner ¹, Bin Lin ¹, Conor Jones ², Janice Havasy ², Mikas Grewal ¹ and Emily Stein ¹, ¹Hospital for Special Surgery, New York, NY, ²Weill Cornell Medicine, New York, NY
Background/Purpose: A major obstacle to the treatment of osteoporosis and prevention of fractures is that many at-risk patients are never screened. Dual energy x-ray absorptiometry…
Abstract Number: 339 • 2018 ACR/ARHP Annual Meeting
Documenting Bone Health for Veterans with Rheumatoid Arthritis in an Outpatient Academic Clinic
Brittany Ahmed¹, Rabih Nayfe², Akrithi Udupa³, Una E. Makris⁴, Rashmi Arora^1,5 and Swathi Reddy^1,5, ¹UT Southwestern Medical Center, Dallas, TX, ²Department of Medicine, UT Southwestern Medical Center, Dallas, TX, ³Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, ⁴UT Southwestern Medical Center and Dallas VA, Dallas, TX, ⁵Dallas VA Medical Center, Dallas, TX
Background/Purpose: Rheumatoid arthritis (RA) increases the risk of bone density abnormalities such as osteoporosis, predisposing patients to fragility fractures and subsequent morbidity. Osteoporotic fractures incur…
Abstract Number: 2812 • 2018 ACR/ARHP Annual Meeting
Evaluation of Cortical Microarchitecture, Bone Stiffness and Bone Remodeling in Patients with Atypical Femoral Fracture
Mariana O Perez¹, Diogo S Domiciano¹, Luciene M Reis², Vanda Jorgetti² and Rosa M R Pereira¹, ¹Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, ²Nephrology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
Background/Purpose: Atypical femoral fractures (AFF) are low energy femoral fractures and subtrochanteric/diaphyseal localization that have been related to long-term bisphosphonate therapy. Patients with AFF exhibit…
Abstract Number: 2854 • 2018 ACR/ARHP Annual Meeting
Majeed Syndrome Causing LPIN2 mutations May Prevent Bone “Healing” By Rendering M2 Macrophage Proinflammatory
Farzana Bhuyan¹, Adriana Almeida de Jesus¹, Rachel VanTries¹, Ronit Herzog², Karen Onel³, Bernadette Marrero¹, Yan Huang¹, Katherine R. Calvo⁴, Gina A. Montealegre Sanchez¹, Polly Ferguson⁵ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Disease Section (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, ²NYU Langone Medical Center, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Department of Laboratory Medicine, Hematology Section, National Institutes of Health Clinical Center, Bethesda, MD, ⁵Pediatrics, University of Iowa, Iowa City, IA
Background/Purpose: To study the mechanism that leads to bone inflammation in a 4-year old patient of mixed Puerto Rican and African-American background who presented with…
Abstract Number: 1891 • 2017 ACR/ARHP Annual Meeting
Low Alkaline Phosphatase Levels: Could It be Hypophosphatasia?
C. Tornero¹, P. Aguado¹, S. García-Carazo¹, J.A. Tenorio², P. Lapunzina², K. Heath², A. Buño³, J.M. Iturzaeta³, Irene Monjo⁴, C. Plasencia¹ and Alejandro Balsa¹, ¹Rheumatology, Rheumatology. La Paz University Hospital, Spain., Madrid, Spain, ²Institute of Medical and Molecular Genetics (INGEMM), Institute of Medical and Molecular Genetics (INGEMM). La Paz University Hospital, Spain., Madrid, Spain, ³Laboratory medicine, Laboratory medicine. La Paz University Hospital, Spain., Madrid, Spain, ⁴Rheumatology, Rheumatology. La Paz University Hospital, Spain., MADRID, Spain
Background/Purpose: Hypophosphatasia (HPP) is a rare inherited disorder caused by mutations in ALPL (alkaline phosphatase liver type ALPL gene). Clinical presentation is variable and adult…
Abstract Number: 1932 • 2017 ACR/ARHP Annual Meeting
A2A Adenosine Receptor (A2AR) Stimulation Modulates NR4A2 Orphan Receptor Expression during Osteoclast Differentiation
Carmen Corciulo¹, Tuere Wilder¹ and Bruce Cronstein², ¹Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Orphan receptors comprise a large number of evolutionarily conserved molecules that have unknown ligands but may have potent biologic effects. Among these receptors are…
Abstract Number: 1948 • 2017 ACR/ARHP Annual Meeting
TNF-α Overrides the Ability of RANK Ligand to Induce Osteoclast Differentiation of Classical Circulating Precursors
Cecilia Ansalone¹, Flavia Sunzini¹, Caitlin Duncan¹, Sabarinadh Chilaka¹, Iain B. McInnes² and Carl S. Goodyear³, ¹Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ²University of Glasgow, Glasgow, United Kingdom, ³Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: TNF-α is well known to be involved in inflammatory-induced bone destruction. This is widely supported by clinical studies showing reduced bone pathology after anti-TNF-α…
Abstract Number: 400 • 2017 ACR/ARHP Annual Meeting
Combination of the Collagen-Induced Arthritis and Organic Dust-Induced Airway Inflammation Models As a Model of Interstitial Lung Disease in Rheumatoid Arthritis
Katherine Janike¹, Jill Poole¹, Geoffrey M. Thiele², Michael J. Duryee³, Lynell W. Klassen⁴, Amy Nelson⁵, Kristi Warren⁶, Benjamin Swanson⁷ and Ted R. Mikuls⁸, ¹Medicine, University of Nebraska Medical Center, Omaha, NE, ²Int Med/Sec of Rheum/Immun, Univ of NE Medical Ctr, Omaha, NE, ³Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Department of Medicine, University of Nebrasa Medical Center, Omaha, NE, ⁶Department of Medicine, University of Nebraska Medical Center, Omaha, NE, ⁷Department of Pathology, University of Nebraska Medical Center, Omaha, NE, ⁸Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Rheumatoid Arthritis (RA) is characterized by extra-articular involvement including interstitial/inflammatory lung disease (ILD). Whereas the coexistence of RA and ILD is known, mechanisms…
Abstract Number: 21 • 2017 Pediatric Rheumatology Symposium
Enhancing Quality of Care in Childhood-Onset Systemic Lupus Erythematosus by Improving Performance on Quality Indicator Measures in Cardiovascular and Bone Health
Emily A. Smitherman¹, Adam Furnier², Janalee Taylor³, Mary Beth Burns⁴, Hermine Brunner⁵ and Esi Morgan¹, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Rheumatology, PRCSG, Cincinnati, OH
Background/Purpose: Childhood-onset SLE (cSLE) leads to poor health outcomes, including cardiovascular and bone health, due to high rates of potentially devastating disease complications and medication…
Abstract Number: 356 • 2016 ACR/ARHP Annual Meeting
Osteoporotic Fracture As the Main Risk Factor in the Detection of Osteoporosis in Men Under 70 Years
JUAN MARIA BLANCO MADRIGAL^1,2, MARIA LUZ GARCIA VIVAR³, Eva Galindez-Agirregoikoa³, OLAIA BEGOÑA FERNANDEZ BERRIZBEITIA⁴, Itziar Calvo Zorrilla³, Edurne Guerrero Basterretxea³, Esther Ruíz Lucea⁵, Ignacio Torre Salaberri⁶, Lidia Estopiñán-Fortea³, Catalina Gómez Arango⁷ and Amaia Bilbao-González⁸, ¹Rheumatology Department, Basurto University Hospital, VITORIA, Spain, ²Rheumatology, Rheumatology Department, Basurto University Hospital, VITORIA, Spain, ³Rheumatology Department, Basurto University Hospital, Bilbao, Spain, ⁴Rheumatology Department, Basurto University Hospital, BILBAO, Spain, ⁵Rheumatology Department, Basurto University Hospital., Bilbao, Spain, ⁶Rheumatology, Hospital Universitario de Basurto. Bilbao., Bilbao, Spain, ⁷Rheumatology, Rheumatology Department, Basurto University Hospital, Bilbao, Spain, ⁸Research Department, Basurto University Hospital, Bilbao, Spain
Background/Purpose: Osteoporosis (OP) in males under 70 years is less common than postmenopausal and senile, but generates significant social and health costs associated with morbidity…
Abstract Number: 1100 • 2016 ACR/ARHP Annual Meeting
Tenofovir, a Nucleoside Analog Reverse Transcriptase Inhibitor for Treatment of HIV, Promotes Osteoclast Differentiation and Decreases Osteoblast Formation By a Mechanism Depending on ATP Release and Adenosine
Aranzazu Mediero^1,2, Patricia Llamas³, Sergio Portal-Nuñez⁴, Raquel Largo⁵, Gabriel Herrero-Beaumont⁵ and Bruce Cronstein⁶, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Bone and Joint Research Unit, Fundación Jiménez Díaz UAM, Madrid, Spain, ³Bone and Joint Research Unit, IIS-Fundacion Jimenez Díaz UAM, Madrid, Spain, ⁴Bone and Joint Research Unit, IIS-Fundación Jimenez Días UAM, Madrid, Spain, ⁵Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain, ⁶Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Human Immunodeficiency Virus (HIV) infection devastates the immune system but also affects tissues and organs such as kidney, liver, central nervous system, heart and…
Abstract Number: 1987 • 2016 ACR/ARHP Annual Meeting
Recessive Coding and Regulatory Mutations in FBLIM1 Underlie the Pathogenesis of Sterile Osteomyelitis
Allison Cox¹, Benjamin W Darbro², Ronald Laxer³, Xinyu Bing⁴, Alexis Finer⁵, Albert Erives⁶, Vinit Mahajan⁷, Alexander G Bassuk¹ and Polly Ferguson⁸, ¹Pediatrics and Interdisciplinary Graduate Program in Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, ²Department of Pediatrics and Interdisciplinary Graduate Program in Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, ³Div of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ⁵Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ⁶Biology and Interdisciplinary Graduate Program in Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, ⁷Department of Ophthalmology and Visual Sciences,, University of Iowa Carver College of Medicine, Iowa City, IA, ⁸Department of Pediatrics--Rheumatology, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, pediatric, autoinflammatory disease characterized by bone pain due to sterile osteomyelitis, and is often accompanied by…
Abstract Number: 359 • 2015 ACR/ARHP Annual Meeting
Diminished Health-Related Quality of Life As Measured By the Short Form-10 in Children with Hypophosphatasia
Thomas J. Weber¹, Eileen K. Sawyer², Scott Moseley² and Priya S. Kishnani¹, ¹Duke University Medical Center, Durham, NC, ²Alexion Pharmaceuticals, Cheshire, CT
Background/Purpose: Hypophosphatasia is a rare metabolic disease caused by loss-of-function mutation(s) in the gene encoding the tissue non-specific alkaline phosphatase (ALP). In children, low tissue…
Abstract Number: 377 • 2015 ACR/ARHP Annual Meeting
Hand Bone Impairment By High-Resolution Peripheral Quantitative Computed Tomography in Patients with Diffuse Systemic Sclerosis: Correlation with Clinical Parameters, Quality of Life and Capillaroscopic Findings
Marilia Sampaio-Barros¹, Liliam Takayama², Jackeline Couto Alvarenga³, Ana Paula Luppino-Assad², Percival D Sampaio-Barros⁴ and Rosa M R Pereira⁵, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Division of Rheumatology, University of São Paulo, sao paulo, Brazil, ³Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Faculdade de Medicina da Universidade de São Paulo, Rheumatology Division, Brazil, Sao Paulo, Brazil, ⁵Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Skin thickening and hand joint involvement induce bone loss and contribute to functional disability in patients with dcSSc. The high-resolution peripheral quantitative CT (HR-pQCT)…
Abstract Number: 2089 • 2015 ACR/ARHP Annual Meeting
Netrin-1 and Its Receptors Unc5b and DCC May be Useful Targets for Preventing Multiple Myeloma Bone Lesions
Aranzazu Mediero¹, Tuere Wilder² and Bruce Cronstein³, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: Multiple Myeloma is characterized by the uncontrolled proliferation of plasma cells. This type of malignancy is particularly trophic to bone where it induces osteoclastic…

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