Date: Sunday, November 8, 2015
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: Skin thickening and hand joint involvement induce bone loss and contribute to functional disability in patients with dcSSc. The high-resolution peripheral quantitative CT (HR-pQCT) can analyze the microarchitecture and bone mass at distal radius and allow the better understanding of bone impairment in dcSSc. The objetive is to analyze the volumetric BMD (vBMD) and bone microarchiteture by HR-pQCT in dcSSc patients, and correlates with the disease clinical variables.Methods: 38 dcSSc patients and 76 healthy controls (HC) were selected. HR-pQCT were performed in distal radius using X-Treme CT (Scanco). The SSc clinical and HR-pQCT parameters were correlated. Results: The density, structure and mechanical characteristics were significantly impaired in dcSSc compared to HC, with decrease of trabecular BMD [Tb.BMD], cortical BMD [Ct.BMD], trabecular number [TbN], trabecular thickness [TbTh], cortical thickness [CtTh], stiffness [S] (p<0.05). Clinical and HR-pQCT parameters were correlated: BMI with Tb.BMD (r=+0.67, p<0.001), Tb.N (r=+0.55, p<0.0001), Tb.Th (r=+0.47, 0.003); Tb.Sp (r=-0.45, p=0.004); Ct.Th (r=+0.45, p=0.04). Right/left Range of motion with Tb.BMD (r=+0.41, p=0.01; r=+0.39, p=0.02), Ct.BMD (r=+0.46, p=0.03; r=+0.49, p=0.001), Tb.N (r=+0.05, p=0.005; r=+0.44, p=0.006), Tb.Sp (r=-0.43, p=0.008; r=-0.4, p=0.01), Ct.Th (r=+0.39, p=0.01; r=+0.420, p=008). Grip Strength (HAQ) with Tb.N (r=–0.33; p=0.04), Tb.Sp (r=+0.37, p=0.02). The following clinical manifestations were associated with worse HR-pQCT parameters: Esophageal dismotility with Tb.BMD (109.23±45.53 vs 147.17±35.71, p=0.01), Tb.N (1.5±0.44 vs 1.88±0.27, p=0.006), Tb.Sp (0.69±0.34 vs 0.47±0.1, p=0.02); Intersticial lung Disease with Tb.BMD (113.81±40.89 vs 158.46±47.66, p=0.01), Tb.N (1.49±0.44 vs 1.87±0.31, p=0.006), Tb.Sp (0.7 ±0.35 vs 0.48±0.12, p=0.02), Tb.Th (0.06±0.01 vs 0.07±0.01, p=0.02), Ct.Th (0.52±0.15 vs 0.7±025, p=0.007); Acroosteolysis with Tb.BMD (103.61±36.6 vs 153.27±42.37, p<0.001), Tb.N (1.5±0.44 vs 1.88±0.27, p=0.006), Tb.Sp (0.69±0.34 vs 0.47±0.1, p=0.02), Scl-70 with Tb.Th (0.06±0.008 vs 0.07±0.01, p=0,03), Ct.Th (0.52±0.18 vs 0.66±0.22, p=0.03); Late capillaroscopy pattern with Ct.BMD (803.79±112.91 vs 873.07±69.75, p=0.03) Tb.Th (0.07±0.01 vs 0.06±0.008, p=0,03), Ct.Th (0.66±0.22 vs 0.52±0.18, p=0.03). No correlation was observed with age, menopausal age, digital ulcers, Modified Rodnan skin score, Medsger Disease Severity Index. Conclusion: dcSSc patients had lower bone quality and bone mass at distal radius compared to HC. Quality of life and clinical parameters showed a significant correlation suggesting that the SSc clinical profile should indicate patients at increased risk of bone disease.
To cite this abstract in AMA style:Sampaio-Barros M, Takayama L, Alvarenga JC, Luppino-Assad AP, Sampaio-Barros PD, Pereira RMR. Hand Bone Impairment By High-Resolution Peripheral Quantitative Computed Tomography in Patients with Diffuse Systemic Sclerosis: Correlation with Clinical Parameters, Quality of Life and Capillaroscopic Findings [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/hand-bone-impairment-by-high-resolution-peripheral-quantitative-computed-tomography-in-patients-with-diffuse-systemic-sclerosis-correlation-with-clinical-parameters-quality-of-life-and-capillar/. Accessed September 28, 2021.
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