ACR Meeting Abstracts

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Abstracts tagged "bone disease"

  • Abstract Number: 2206 • 2019 ACR/ARP Annual Meeting

    MRI-based Textural Analysis of Trabecular Bone: A Novel Method for the Opportunistic Screening of Bone Quality

    Jonathan Cheah1, Matthew Koff 1, Ryan Breighner 1, Bin Lin 1, Conor Jones 2, Janice Havasy 2, Mikas Grewal 1 and Emily Stein 1, 1Hospital for Special Surgery, New York, NY, 2Weill Cornell Medicine, New York, NY

    Background/Purpose: A major obstacle to the treatment of osteoporosis and prevention of fractures is that many at-risk patients are never screened. Dual energy x-ray absorptiometry…
  • Abstract Number: 2812 • 2018 ACR/ARHP Annual Meeting

    Evaluation of Cortical Microarchitecture, Bone Stiffness and Bone Remodeling in Patients with Atypical Femoral Fracture

    Mariana O Perez1, Diogo S Domiciano1, Luciene M Reis2, Vanda Jorgetti2 and Rosa M R Pereira1, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, 2Nephrology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

    Background/Purpose: Atypical femoral fractures (AFF) are low energy femoral fractures and subtrochanteric/diaphyseal localization that have been related to long-term bisphosphonate therapy. Patients with AFF exhibit…
  • Abstract Number: 2854 • 2018 ACR/ARHP Annual Meeting

    Majeed Syndrome Causing LPIN2 mutations May Prevent Bone “Healing” By Rendering M2 Macrophage Proinflammatory

    Farzana Bhuyan1, Adriana Almeida de Jesus1, Rachel VanTries1, Ronit Herzog2, Karen Onel3, Bernadette Marrero1, Yan Huang1, Katherine R. Calvo4, Gina A. Montealegre Sanchez1, Polly Ferguson5 and Raphaela Goldbach-Mansky1, 1Translational Autoinflammatory Disease Section (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, 2NYU Langone Medical Center, New York, NY, 3Hospital for Special Surgery, New York, NY, 4Department of Laboratory Medicine, Hematology Section, National Institutes of Health Clinical Center, Bethesda, MD, 5Pediatrics, University of Iowa, Iowa City, IA

    Background/Purpose: To study the mechanism that leads to bone inflammation in a 4-year old patient of mixed Puerto Rican and African-American background who presented with…
  • Abstract Number: 339 • 2018 ACR/ARHP Annual Meeting

    Documenting Bone Health for Veterans with Rheumatoid Arthritis in an Outpatient Academic Clinic

    Brittany Ahmed1, Rabih Nayfe2, Akrithi Udupa3, Una E. Makris4, Rashmi Arora1,5 and Swathi Reddy1,5, 1UT Southwestern Medical Center, Dallas, TX, 2Department of Medicine, UT Southwestern Medical Center, Dallas, TX, 3Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 4UT Southwestern Medical Center and Dallas VA, Dallas, TX, 5Dallas VA Medical Center, Dallas, TX

    Background/Purpose: Rheumatoid arthritis (RA) increases the risk of bone density abnormalities such as osteoporosis, predisposing patients to fragility fractures and subsequent morbidity. Osteoporotic fractures incur…
  • Abstract Number: 400 • 2017 ACR/ARHP Annual Meeting

    Combination of the Collagen-Induced Arthritis and Organic Dust-Induced Airway Inflammation Models As a Model of Interstitial Lung Disease in Rheumatoid Arthritis

    Katherine Janike1, Jill Poole1, Geoffrey M. Thiele2, Michael J. Duryee3, Lynell W. Klassen4, Amy Nelson5, Kristi Warren6, Benjamin Swanson7 and Ted R. Mikuls8, 1Medicine, University of Nebraska Medical Center, Omaha, NE, 2Int Med/Sec of Rheum/Immun, Univ of NE Medical Ctr, Omaha, NE, 3Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 4Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 5Department of Medicine, University of Nebrasa Medical Center, Omaha, NE, 6Department of Medicine, University of Nebraska Medical Center, Omaha, NE, 7Department of Pathology, University of Nebraska Medical Center, Omaha, NE, 8Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose:   Rheumatoid Arthritis (RA) is characterized by extra-articular involvement including interstitial/inflammatory lung disease (ILD).  Whereas the coexistence of RA and ILD is known, mechanisms…
  • Abstract Number: 1891 • 2017 ACR/ARHP Annual Meeting

    Low Alkaline Phosphatase Levels: Could It be Hypophosphatasia?

    C. Tornero1, P. Aguado1, S. García-Carazo1, J.A. Tenorio2, P. Lapunzina2, K. Heath2, A. Buño3, J.M. Iturzaeta3, Irene Monjo4, C. Plasencia1 and Alejandro Balsa1, 1Rheumatology, Rheumatology. La Paz University Hospital, Spain., Madrid, Spain, 2Institute of Medical and Molecular Genetics (INGEMM), Institute of Medical and Molecular Genetics (INGEMM). La Paz University Hospital, Spain., Madrid, Spain, 3Laboratory medicine, Laboratory medicine. La Paz University Hospital, Spain., Madrid, Spain, 4Rheumatology, Rheumatology. La Paz University Hospital, Spain., MADRID, Spain

    Background/Purpose: Hypophosphatasia (HPP) is a rare inherited disorder caused by mutations in ALPL (alkaline phosphatase liver type ALPL gene). Clinical presentation is variable and adult…
  • Abstract Number: 1932 • 2017 ACR/ARHP Annual Meeting

    A2A Adenosine Receptor (A2AR) Stimulation Modulates NR4A2 Orphan Receptor Expression during Osteoclast Differentiation

    Carmen Corciulo1, Tuere Wilder1 and Bruce Cronstein2, 1Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 2Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: Orphan receptors comprise a large number of evolutionarily conserved molecules that have unknown ligands but may have potent biologic effects. Among these receptors are…
  • Abstract Number: 1948 • 2017 ACR/ARHP Annual Meeting

    TNF-α Overrides the Ability of RANK Ligand to Induce Osteoclast Differentiation of Classical Circulating Precursors

    Cecilia Ansalone1, Flavia Sunzini1, Caitlin Duncan1, Sabarinadh Chilaka1, Iain B. McInnes2 and Carl S. Goodyear3, 1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2University of Glasgow, Glasgow, United Kingdom, 3Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: TNF-α is well known to be involved in inflammatory-induced bone destruction. This is widely supported by clinical studies showing reduced bone pathology after anti-TNF-α…
  • Abstract Number: 21 • 2017 Pediatric Rheumatology Symposium

    Enhancing Quality of Care in Childhood-Onset Systemic Lupus Erythematosus by Improving Performance on Quality Indicator Measures in Cardiovascular and Bone Health

    Emily A. Smitherman1, Adam Furnier2, Janalee Taylor3, Mary Beth Burns4, Hermine Brunner5 and Esi Morgan1, 1Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Rheumatology, PRCSG, Cincinnati, OH

    Background/Purpose: Childhood-onset SLE (cSLE) leads to poor health outcomes, including cardiovascular and bone health, due to high rates of potentially devastating disease complications and medication…
  • Abstract Number: 356 • 2016 ACR/ARHP Annual Meeting

    Osteoporotic Fracture As the Main Risk Factor in the Detection of Osteoporosis in Men Under 70 Years

    JUAN MARIA BLANCO MADRIGAL1,2, MARIA LUZ GARCIA VIVAR3, Eva Galindez-Agirregoikoa3, OLAIA BEGOÑA FERNANDEZ BERRIZBEITIA4, Itziar Calvo Zorrilla3, Edurne Guerrero Basterretxea3, Esther Ruíz Lucea5, Ignacio Torre Salaberri6, Lidia Estopiñán-Fortea3, Catalina Gómez Arango7 and Amaia Bilbao-González8, 1Rheumatology Department, Basurto University Hospital, VITORIA, Spain, 2Rheumatology, Rheumatology Department, Basurto University Hospital, VITORIA, Spain, 3Rheumatology Department, Basurto University Hospital, Bilbao, Spain, 4Rheumatology Department, Basurto University Hospital, BILBAO, Spain, 5Rheumatology Department, Basurto University Hospital., Bilbao, Spain, 6Rheumatology, Hospital Universitario de Basurto. Bilbao., Bilbao, Spain, 7Rheumatology, Rheumatology Department, Basurto University Hospital, Bilbao, Spain, 8Research Department, Basurto University Hospital, Bilbao, Spain

    Background/Purpose: Osteoporosis (OP) in males under 70 years is less common than postmenopausal and senile, but generates significant social and health costs associated with morbidity…
  • Abstract Number: 1100 • 2016 ACR/ARHP Annual Meeting

    Tenofovir, a Nucleoside Analog Reverse Transcriptase Inhibitor for Treatment of HIV, Promotes Osteoclast Differentiation and Decreases Osteoblast Formation By a Mechanism Depending on ATP Release and Adenosine

    Aranzazu Mediero1,2, Patricia Llamas3, Sergio Portal-Nuñez4, Raquel Largo5, Gabriel Herrero-Beaumont5 and Bruce Cronstein6, 1Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, 2Bone and Joint Research Unit, Fundación Jiménez Díaz UAM, Madrid, Spain, 3Bone and Joint Research Unit, IIS-Fundacion Jimenez Díaz UAM, Madrid, Spain, 4Bone and Joint Research Unit, IIS-Fundación Jimenez Días UAM, Madrid, Spain, 5Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain, 6Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY

    Background/Purpose:  Human Immunodeficiency Virus (HIV) infection devastates the immune system but also affects tissues and organs such as kidney, liver, central nervous system, heart and…
  • Abstract Number: 1987 • 2016 ACR/ARHP Annual Meeting

    Recessive Coding and Regulatory Mutations in FBLIM1 Underlie the Pathogenesis of Sterile Osteomyelitis

    Allison Cox1, Benjamin W Darbro2, Ronald Laxer3, Xinyu Bing4, Alexis Finer5, Albert Erives6, Vinit Mahajan7, Alexander G Bassuk1 and Polly Ferguson8, 1Pediatrics and Interdisciplinary Graduate Program in Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, 2Department of Pediatrics and Interdisciplinary Graduate Program in Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, 3Div of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 4Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, 5Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, 6Biology and Interdisciplinary Graduate Program in Genetics, University of Iowa Carver College of Medicine, Iowa City, IA, 7Department of Ophthalmology and Visual Sciences,, University of Iowa Carver College of Medicine, Iowa City, IA, 8Department of Pediatrics--Rheumatology, University of Iowa Carver College of Medicine, Iowa City, IA

    Background/Purpose:  Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, pediatric, autoinflammatory disease characterized by bone pain due to sterile osteomyelitis, and is often accompanied by…
  • Abstract Number: 359 • 2015 ACR/ARHP Annual Meeting

    Diminished Health-Related Quality of Life As Measured By the Short Form-10 in Children with Hypophosphatasia

    Thomas J. Weber1, Eileen K. Sawyer2, Scott Moseley2 and Priya S. Kishnani1, 1Duke University Medical Center, Durham, NC, 2Alexion Pharmaceuticals, Cheshire, CT

    Background/Purpose: Hypophosphatasia is a rare metabolic disease caused by loss-of-function mutation(s) in the gene encoding the tissue non-specific alkaline phosphatase (ALP). In children, low tissue…
  • Abstract Number: 377 • 2015 ACR/ARHP Annual Meeting

    Hand Bone Impairment By High-Resolution Peripheral Quantitative Computed Tomography in Patients with Diffuse Systemic Sclerosis: Correlation with Clinical Parameters, Quality of Life and Capillaroscopic Findings

    Marilia Sampaio-Barros1, Liliam Takayama2, Jackeline Couto Alvarenga3, Ana Paula Luppino-Assad2, Percival D Sampaio-Barros4 and Rosa M R Pereira5, 1Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Division of Rheumatology, University of São Paulo, sao paulo, Brazil, 3Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 4Faculdade de Medicina da Universidade de São Paulo, Rheumatology Division, Brazil, Sao Paulo, Brazil, 5Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Skin thickening and hand joint involvement induce bone loss and contribute to functional disability in patients with dcSSc. The high-resolution peripheral quantitative CT (HR-pQCT)…
  • Abstract Number: 2089 • 2015 ACR/ARHP Annual Meeting

    Netrin-1 and Its Receptors Unc5b and DCC May be Useful Targets for Preventing Multiple Myeloma Bone Lesions

    Aranzazu Mediero1, Tuere Wilder2 and Bruce Cronstein3, 1Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, 2Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, 3Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY

    Background/Purpose: Multiple Myeloma is characterized by the uncontrolled proliferation of plasma cells. This type of malignancy is particularly trophic to bone where it induces osteoclastic…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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