Abstract Number: 0964 • ACR Convergence 2020
Is Meniscal Status in the Anterior Cruciate Ligament Injured Knee Associated with Change in Bone Surface Area? An Exploratory Analysis of Data from the KANON Trial
Background/Purpose: Bone shape changes, which may be an important feature of osteoarthritis (OA) development, have been observed to occur early in the knee after anterior…Abstract Number: 0966 • ACR Convergence 2020
Decoupling Inflammation and Bone Loss in Rheumatoid Arthritis via Schnurri-3
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to local and systemic bone loss. TNF is a key mediator of bone loss,…Abstract Number: 1518 • ACR Convergence 2020
The Role for Neutrophils in the Early Phases of Enthesitis in Spondyloarthritis
Background/Purpose: Neutrophils are present in the early phases of spondyloarthritis (SpA)-associated uveitis, skin and intestinal disease, but their role in enthesitis remains unknown. We investigated…Abstract Number: 1555 • ACR Convergence 2020
18F-NaF PET/CT Identifies Active Calcium Uptake in Calcinosis Due to Dermatomyositis and Scleroderma
Background/Purpose: Ectopic soft tissue deposition of hydroxyapatite (calcinosis) is a frequent and morbid complication of dermatomyositis and scleroderma with no known effective pharmacologic treatment. 18F-NaF…Abstract Number: 1970 • ACR Convergence 2020
Mimicking Cytokine-driven Key Features of Arthritis Using a Human in Vitro 3D Joint Model
Background/Purpose: Our ultimate goal is to study potential drug candidates in an experimental setting of arthritis. Therefore, we aim to develop a human in vitro…Abstract Number: 0074 • ACR Convergence 2020
The Intracellular DNA Sensor STING Protects Against Bone Loss Through Regulation of Type I Interferons
Background/Purpose: The intracellular DNA sensor Stimulator of Interferon Genes (STING) is essential for detection of viral and bacterial pathogen DNA. As with other pathways in…Abstract Number: 0107 • ACR Convergence 2020
Effects of Abaloparatide on Modeling and Remodeling Based Bone Formation
Background/Purpose: To evaluate abaloparatide-induced changes in the bone formation indices of mineralizing surface (MS), bone formation rate (BFR) and mineral apposition rate (MAR); and to…Abstract Number: 0110 • ACR Convergence 2020
Does Urate Directly Influence Bone Turnover? Randomized Controlled Trial of Inosine Supplementation
Background/Purpose: Observational studies have reported that serum urate positively correlates with bone mineral density (BMD) and that hyperuricaemia is protective for the development of osteoporosis…Abstract Number: 0116 • ACR Convergence 2020
The in Vitro 3D Fracture Gap Model: A Tool for Preclinical Testing
Background/Purpose: Approximately 10% of fractures lead to significant fracture healing disorders. Of note, especially immunosuppressed patients with ongoing inflammation show difficulties in the correct course…Abstract Number: 1874 • 2019 ACR/ARP Annual Meeting
Extensive Modeling-Based Bone Formation After 2 Months of Romosozumab Treatment: Results from the FRAME Clinical Trial
Background/Purpose: The bone-forming agent romosozumab (Romo) is a monoclonal antibody that binds to/inhibits sclerostin, leading to increased bone formation and decreased bone resorption. The highest…Abstract Number: 846 • 2018 ACR/ARHP Annual Meeting
CD14 Deficiency Dampens Osteoclastogenesis and Alters Bone Remodeling in a Murine Model of Osteoarthritis
Background/Purpose: Pathogenesis of osteoarthritis (OA) is accompanied by chronic inflammation evidenced by macrophage infiltration into the joint. CD14, is expressed by monocyte/macrophage lineage cells, and…Abstract Number: 2399 • 2018 ACR/ARHP Annual Meeting
Bone Density, Structure and Strength in Canadian Children and Youth with Juvenile Idiopathic Arthritis: The LEAP Study (Linking Exercise, Activity, and Pathophysiology in Canadian Children with Arthritis)
Bone Density, Structure and Strength in Canadian Children and Youth with Juvenile Idiopathic Arthritis: The LEAP Study (Linking Exercise, Activity, and Pathophysiology in Canadian Children…Abstract Number: 68 • 2017 ACR/ARHP Annual Meeting
Tankyrase/Wnt Inhibitor Upregulates Osteoclastogenesis and Osteoblastogenesis Via SH3BP2
Background/Purpose: Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors increase Axin protein, a negative regulator…Abstract Number: 69 • 2017 ACR/ARHP Annual Meeting
The Effect of Myostatin Inhibition on Bone Loss in Murine Osteoporosis Models
Background/Purpose: Myostatin, also called as growth differentiation factor-8 (GDF-8), is a secreted member of TGF-β superfamily. Myostatin is a negative regulator of skeletal muscle mass…Abstract Number: 652 • 2017 ACR/ARHP Annual Meeting
Investigating the Role of Mechanical Stress in Spondyloarthritis Pathogenesis
Background/Purpose: Mechanotransduction is a cell’s ability to translate mechanical stimuli into biochemical signals and has been implicated in signaling pathways involving differentiation and proliferation. Mechanical…