Abstracts tagged "bone biology"

Abstract Number: 0107 • ACR Convergence 2020
Effects of Abaloparatide on Modeling and Remodeling Based Bone Formation
David W Dempster¹, Hua Zhou¹, Sudhaker D Rao², Chris Recknor³, Paul D Miller⁴, Benjamin Z Leder⁵, Miriam Annett⁶, Michael S Ominsky⁶ and Bruce H Mitlak⁶, ¹Regional Bone Center, Helen Hayes Hospital, West Haverstraw, NY, West Haverstraw, NY, ²Bone & Mineral Research Laboratory, Henry Ford Health System, Detroit, MI, Detroit, MI, ³United Osteoporosis Centers, Gainesville, GA, Gainesville, GA, ⁴Colorado Center for Bone Research, Lakewood, CO, Lakewood, CO, ⁵Mass General Hospital, Harvard Medical School, Boston, MA, Boston, MA, ⁶Radius Health, Inc., Waltham, MA, Waltham, MA
Background/Purpose: To evaluate abaloparatide-induced changes in the bone formation indices of mineralizing surface (MS), bone formation rate (BFR) and mineral apposition rate (MAR); and to…
Abstract Number: 0110 • ACR Convergence 2020
Does Urate Directly Influence Bone Turnover? Randomized Controlled Trial of Inosine Supplementation
Nicola Dalbeth¹, Anne Horne², Borislav Mihov¹, Tony Merriman³, Gregory Gamble¹, Lisa Stamp⁴ and Ian Reid¹, ¹University of Auckland, Auckland, New Zealand, ²The University of Auckland, Auckland, New Zealand, ³University of Otago, Dunedin, New Zealand, ⁴University of Otago Christchurch, Christchurch, New Zealand
Background/Purpose: Observational studies have reported that serum urate positively correlates with bone mineral density (BMD) and that hyperuricaemia is protective for the development of osteoporosis…
Abstract Number: 0116 • ACR Convergence 2020
The in Vitro 3D Fracture Gap Model: A Tool for Preclinical Testing
Moritz Pfeiffenberger¹, Alexandra Damerau¹, Paula Hoff², Annemarie Lang¹, Frank Buttgereit³ and Timo Gaber¹, ¹Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, ²Endokrinologikum Berlin, Rheumatologie, Berlin, Germany, ³Charité University Medicine, Berlin, Germany
Background/Purpose: Approximately 10% of fractures lead to significant fracture healing disorders. Of note, especially immunosuppressed patients with ongoing inflammation show difficulties in the correct course…
Abstract Number: 0343 • ACR Convergence 2020
Co-expression of DC-STAMP and CX3CR1: Biomarkers for Tissue Resident Osteoclasts in Psoriatic Arthritis
Maria de la Luz Garcia-Hernandez¹, Javier Rangel-Moreno², Ananta Paine³, Benjamin Korman³, Marc Nuzzo⁴, Lihi Eder⁵ and Christopher Ritchlin³, ¹University of Rochester, Rochester, NY, ²University of Rochester Medical Center, Rochester, NY, ³Department of Medicine, University of Rochester Medical Center, Rochester, NY, ⁴Department of Medicine, University of Rochester Medical Center, Rochester, ⁵Women’s College Research Institute, University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) patients often experience joint damage mediated by osteoclasts (OC). Although PsA pathogenesis is poorly understood, the production of the cytokines IL-17,…
Abstract Number: 0964 • ACR Convergence 2020
Is Meniscal Status in the Anterior Cruciate Ligament Injured Knee Associated with Change in Bone Surface Area? An Exploratory Analysis of Data from the KANON Trial
Barbara Snoeker¹, Aleksandra Turkiewicz¹, Mike Bowes², Frank Roemer³, Stefan Lohmander¹, Richard Frobell¹ and Martin Englund¹, ¹Lund University, Lund, Sweden, ²Imorphics Ltd, Manchester, United Kingdom, ³Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Bone shape changes, which may be an important feature of osteoarthritis (OA) development, have been observed to occur early in the knee after anterior…
Abstract Number: 0966 • ACR Convergence 2020
Decoupling Inflammation and Bone Loss in Rheumatoid Arthritis via Schnurri-3
Zheni Stavre¹, JungMin Kim², Jae-Hyuck Shim² and Ellen Gravallese³, ¹University of Massachusetts Medical School-Rheumatology Division, Worcester, MA, ²University of Massachusetts Medical School, Worcester, MA, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to local and systemic bone loss. TNF is a key mediator of bone loss,…
Abstract Number: 1518 • ACR Convergence 2020
The Role for Neutrophils in the Early Phases of Enthesitis in Spondyloarthritis
Zheni Stavre¹, Charles Bridgewood², Qiao Zhou², Yukiko Maeda³, Jozsef Karman⁴, Dennis McGonagle⁵ and Ellen Gravallese⁶, ¹University of Massachusetts Medical School-Rheumatology Division, Worcester, MA, ²University of Leeds, Leeds, United Kingdom, ³University of Massachusetts Medical School, worcester, MA, ⁴Abbvie Inc., Worcester, MA, ⁵The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, ⁶Brigham and Women's Hospital, Boston, MA
Background/Purpose: Neutrophils are present in the early phases of spondyloarthritis (SpA)-associated uveitis, skin and intestinal disease, but their role in enthesitis remains unknown. We investigated…
Abstract Number: 1555 • ACR Convergence 2020
18F-NaF PET/CT Identifies Active Calcium Uptake in Calcinosis Due to Dermatomyositis and Scleroderma
Carrie Richardson¹, Mehrbod Javadi², Ami Shah³, Lilja Solnes², Fredrick Wigley⁴, Laura Hummers⁵ and Lisa Christopher-Stine⁶, ¹Rush University Medical Center, Chicago, IL, ²Johns Hopkins University, Baltimore, ³Johns Hopkins University School of Medicine, Ellicott City, MD, ⁴Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Johns Hopkins Univerisity, Ellicott City, MD, ⁶Johns Hopkins University, Baltimore, MD
Background/Purpose: Ectopic soft tissue deposition of hydroxyapatite (calcinosis) is a frequent and morbid complication of dermatomyositis and scleroderma with no known effective pharmacologic treatment. 18F-NaF…
Abstract Number: 1970 • ACR Convergence 2020
Mimicking Cytokine-driven Key Features of Arthritis Using a Human in Vitro 3D Joint Model
Alexandra Damerau¹, Moritz Pfeiffenberger¹, Annemarie Lang¹, Timo Gaber¹ and Frank Buttgereit², ¹Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, ²Charité University Medicine, Berlin, Germany
Background/Purpose: Our ultimate goal is to study potential drug candidates in an experimental setting of arthritis. Therefore, we aim to develop a human in vitro…
Abstract Number: 1874 • 2019 ACR/ARP Annual Meeting
Extensive Modeling-Based Bone Formation After 2 Months of Romosozumab Treatment: Results from the FRAME Clinical Trial
Erik Eriksen¹, Roland Chapurlat ², Rogely Boyce ³, Jacques Brown ⁴, Stéphane Horlait ⁵, Cesar Libanati ⁶, Yifei Shi ³, Rachel Wagman ³ and Pascale Chavassieux ², ¹Department of Clinical Endocrinology, Oslo University Hospital and Institute of Clinical Medicine Oslo University, Oslo, Norway, ²INSERM UMR 1033, Université de Lyon, Lyon, France, ³Amgen Inc., Thousand Oaks, CA, ⁴CHU de Quebec Research Centre and Laval University, Quebec, QC, Canada, ⁵Amgen Inc., Boulogne Billancourt, France, ⁶UCB Pharma, Brussels, Belgium
Background/Purpose: The bone-forming agent romosozumab (Romo) is a monoclonal antibody that binds to/inhibits sclerostin, leading to increased bone formation and decreased bone resorption. The highest…
Abstract Number: 846 • 2018 ACR/ARHP Annual Meeting
CD14 Deficiency Dampens Osteoclastogenesis and Alters Bone Remodeling in a Murine Model of Osteoarthritis
Cheng Zhou^1,2, Vu Nguyen^2,3, Ryan Smalley², Nisha Sambamurthy^1,2, George R. Dodge^2,4 and Carla Scanzello^1,2, ¹Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, ³University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁴Department of Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Background/Purpose: Pathogenesis of osteoarthritis (OA) is accompanied by chronic inflammation evidenced by macrophage infiltration into the joint. CD14, is expressed by monocyte/macrophage lineage cells, and…
Abstract Number: 2399 • 2018 ACR/ARHP Annual Meeting
Bone Density, Structure and Strength in Canadian Children and Youth with Juvenile Idiopathic Arthritis: The LEAP Study (Linking Exercise, Activity, and Pathophysiology in Canadian Children with Arthritis)
Ciarán M. Duffy¹, Adam Baxter-Jones², Leanne Ward³, Heather Macdonald⁴, Heather McKay⁴, Marta Erlandson², Adam Huber⁵, Susanne Benseler⁶, Michele Gibbon⁷, Jaime Guzman⁸ and Lori Tucker⁸, ¹Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ²University of Saskatchewan, Saskatoon, SK, Canada, ³Department of Paediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵IWK Health Centre, Halifax, NS, Canada, ⁶Alberta Children's Hospital, Calgary, AB, Canada, ⁷Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, ⁸BC Children's Hospital, Vancouver, BC, Canada
Bone Density, Structure and Strength in Canadian Children and Youth with Juvenile Idiopathic Arthritis: The LEAP Study (Linking Exercise, Activity, and Pathophysiology in Canadian Children…
Abstract Number: 68 • 2017 ACR/ARHP Annual Meeting
Tankyrase/Wnt Inhibitor Upregulates Osteoclastogenesis and Osteoblastogenesis Via SH3BP2
Shunichi Fujita¹, Tomoyuki Mukai¹, Takafumi Mito¹, Shoko Kodama¹, Akiko Nagasu¹, Mizuho Kittaka², Yasuyoshi Ueki³ and Yoshitaka Morita¹, ¹Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, ²Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO, MO, ³Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO
Background/Purpose: Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors increase Axin protein, a negative regulator…
Abstract Number: 69 • 2017 ACR/ARHP Annual Meeting
The Effect of Myostatin Inhibition on Bone Loss in Murine Osteoporosis Models
Tomoyuki Mukai¹, Takafumi Mito¹, Shunichi Fujita¹, Shoko Kodama¹, Akiko Nagasu¹, Teruki Sone², Shinichiro Nishimatsu³, Yutaka Ohsawa⁴, Yoshihide Sunada⁴ and Yoshitaka Morita¹, ¹Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, ²Department of Nuclear Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan, ³Department of Natural Sciences, Kawasaki Medical School, Kurashiki, Okayama, Japan, ⁴Department of Neurology, Kawasaki Medical School, Kurashiki, Okayama, Japan
Background/Purpose: Myostatin, also called as growth differentiation factor-8 (GDF-8), is a secreted member of TGF-β superfamily. Myostatin is a negative regulator of skeletal muscle mass…
Abstract Number: 652 • 2017 ACR/ARHP Annual Meeting
Investigating the Role of Mechanical Stress in Spondyloarthritis Pathogenesis
Breanna Nguyen¹, Robert Colbert² and Gerlinde Layh-Schmitt¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD
Background/Purpose: Mechanotransduction is a cell’s ability to translate mechanical stimuli into biochemical signals and has been implicated in signaling pathways involving differentiation and proliferation. Mechanical…

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