ACR Meeting Abstracts

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Abstracts tagged "bone biology"

  • Abstract Number: L11 • ACR Convergence 2022

    Romosozumab versus Denosumab in High-risk Patients with Glucocorticoid-induced Osteoporosis: A Pilot Randomized Controlled Trial

    Wai Han Ma1, Chi Chiu Mok2, Ling Yin Ho2, Kar Li Chan3, Sau Mei Tse4 and Sammy Chen5, 1Department of Nuclear Medicine, Hong Kong, Hong Kong, 2Tuen Mun Hospital, Hong Kong, Hong Kong, 3Tuen Mun Hospital, Tsing Yi, Hong Kong, 4Department of Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, 5Department of Pathology, Hong Kong, Hong Kong

    Background/Purpose: To compare the efficacy and safety of romozosumab (ROMO) and denosumab (DEN) in high-risk patients with glucocorticoid -induced osteoporosis (GIOP)Methods: Adult patients (≥18 years)…
  • Abstract Number: 0031 • ACR Convergence 2022

    Discovery of GSTT1 Gene That Promotes Osteogenic Differentiation of Adipose Stem Cells

    Eugene Lee, GUNIL IM and ji-Yun Koh, Dongguk University, Goyang, Republic of Korea

    Background/Purpose: In this study, we describe the discovery of a new GSTT1 gene that promotes the osteogenic differentiation of adipose stem cells (ASCs). While adipose-derived…
  • Abstract Number: 0429 • ACR Convergence 2022

    No Change in Serum Levels of Bone Turnover Markers Corrected for Age and Gender During the First Year of Secukinumab Treatment in Patients with Ankylosing Spondylitis

    Mark Siderius1, Suzanne Arends2, Freke Wink3 and Anneke Spoorenberg2, 1University Medical Centre Groningen, Groningen, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands, 3Medical Center Leeuwarden, Leeuwarden, Netherlands

    Background/Purpose: In patients with ankylosing spondylitis (AS), TNF-α inhibitors influence the course of serum bone turnover markers (BTM), favoring an increase in mineralization during the…
  • Abstract Number: 1995 • ACR Convergence 2022

    Baricitinib Improves Bone Biomechanical Properties in Rheumatoid Arthritis (RA) – Results of a Prospective Interventional Study

    Stephan Kemenes1, Koray Tascilar2, David Simon1, Sara Bayat3, Gerhard Kroenke2, Larissa Valor Mendez2, Fabian Hartmann4, Louis Schuster4, Anna-Maria Liphardt1, Georg Schett5 and Arnd Kleyer2, 1Department of Internal Medicine 3, Rheumatoloy and Immunology, University Hospital Erlangen, Erlangen, Germany, 2Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-UniversityErlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 3University Hospital Erlangen; Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, 4University Hospital Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, 5Universitätsklinikum Erlangen, Erlangen, Germany

    Background/Purpose: Deterioration of peripheral bone mass and bone biomechanics are well-known consequences of Rheumatoid Arthritis (RA)[1]. CCP-AB pos. RA, in particular, leads to a significant…
  • Abstract Number: 0171 • ACR Convergence 2021

    Bone Erosions and Osteophytes in Premenopausal Women with Long-standing Rheumatoid Arthritis: Association with Systemic Bone Involvement Using HR-pQCT

    Mariana Perez1, Camille Figueiredo1, Lucas Sales1, ANA MEDEIROS-RIBEIRO1, Liliam Takayama1, Diogo Domiciano1, Karina Bonfiglioli1, Valeria Caparbo1 and Rosa Pereira2, 1Rheumatology Division, University of São Paulo, São Paulo, SP, Brazil, 2Rheumatology Division, University of São Paulo, São Paulo, Brazil

    Background/Purpose: Two patterns of bone involvement are described in rheumatoid arthritis (RA), systemic and localized. Systemic bone involvement is characterized by loss of generalized bone…
  • Abstract Number: 0447 • ACR Convergence 2021

    Bone Anabolic Effects of a Novel Orally-Available Small Molecule SIK2/SIK3 Inhibitor

    Cheng-Chia Tang1, Shiv Verma1, Steve De Vos2, David Amantini3, Philippe Clement-Lacroix3, Nicolas Desroy3, Antonio Speziale4, Daniel Brooks5, Mary Bouxsein5, Janaina da Silva Martins1, Yingshe Zhao6, Henry Kronenberg1 and Marc Wein1, 1MGH Endocrine Unit, Boston, MA, 2Galapagos NV, Mechelen, Belgium, 3Galapagos SASU, Romainville, France, 4Galapagos GmbH, Basel, Switzerland, 5Beth Israel Deaconess Medical Center, Boston, MA, 6MGH Endocrine Unnit, Boston, MA

    Background/Purpose: Orally-available bone anabolic agents represent a major unmet medical need for patients with osteoporosis. Widespread use of parathyroid hormone (PTH)-based osteo-anabolic therapies is limited…
  • Abstract Number: 0670 • ACR Convergence 2021

    Hemochromatosis Is Associated with CPPD Through Iron’s Effect on Bone

    Jennifer Velasco, Claudia Gohr, Elizabeth MItton-Fitzgerald and Ann Rosenthal, Medical College of Wisconsin, Milwaukee, WI

    Background/Purpose: Hemochromatosis (HH) is one of the strongest known risk factors for calcium pyrophosphate (CPP) crystal deposition. The pathogenic mechanisms causing CPP crystal formation in…
  • Abstract Number: 0996 • ACR Convergence 2021

    The Stimulator of Interferon Genes (STING) Protects from Bone Loss Through Regulation of Tonic and Induced Type I Interferon Pathways

    Susan MacLauchlan1, Priyanka Kushwaha1, Albert Tai2, Jia (Sijia) Chen3, Catherine Manning1, Katherine Fitzgerald4, Shruti Sharma2 and Ellen Gravallese5, 1Brigham and Women's Hospital, Boston, MA, 2Tufts University School of Medicine, Boston, MA, 3Brigham and Women's Hospital, Cambridge, MA, 4University of Massachusetts Medical School, Worcester, MA, 5Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: The intracellular DNA sensing Stimulator of Interferon Genes (STING) pathway is critical for detection of viral and bacterial pathogen DNA. Hyperactivating mutations in this…
  • Abstract Number: 1472 • ACR Convergence 2021

    Characterization and Function of Tumor Necrosis Factor α and Interleukin-6–Induced Osteoclasts in Rheumatoid Arthritis

    Kazuhiro Yokota1, Kojiro Sato2, Yoshimi Aizaki3, Shinya Tanaka4, Miyoko Sekikawa4, Noritsune Kozu5, Yuho Kadono4, Hiromi Oda6 and Toshihide Mimura7, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 2Jichi Medical University, Tochigi, Japan, 3Saitama Medical University, Saitama, Japan, 4Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan, 5Kozu Orthopaedic Clinic, Chiba, Japan, 6Department of Orthopaedic Surgery, National Hospital Organization Ibusuki Medical Center, Kagoshima, Japan, 7Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama, Japan

    Background/Purpose: We have previously reported that stimulation of mouse bone marrow–derived macrophages with a combination of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) induces…
  • Abstract Number: 1555 • ACR Convergence 2020

    18F-NaF PET/CT Identifies Active Calcium Uptake in Calcinosis Due to Dermatomyositis and Scleroderma

    Carrie Richardson1, Mehrbod Javadi2, Ami Shah3, Lilja Solnes2, Fredrick Wigley4, Laura Hummers5 and Lisa Christopher-Stine6, 1Rush University Medical Center, Chicago, IL, 2Johns Hopkins University, Baltimore, 3Johns Hopkins University School of Medicine, Ellicott City, MD, 4Johns Hopkins University School of Medicine, Baltimore, MD, 5Johns Hopkins Univerisity, Ellicott City, MD, 6Johns Hopkins University, Baltimore, MD

    Background/Purpose: Ectopic soft tissue deposition of hydroxyapatite (calcinosis) is a frequent and morbid complication of dermatomyositis and scleroderma with no known effective pharmacologic treatment. 18F-NaF…
  • Abstract Number: 1970 • ACR Convergence 2020

    Mimicking Cytokine-driven Key Features of Arthritis Using a Human in Vitro 3D Joint Model

    Alexandra Damerau1, Moritz Pfeiffenberger1, Annemarie Lang1, Timo Gaber1 and Frank Buttgereit2, 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, 2Charité University Medicine, Berlin, Germany

    Background/Purpose: Our ultimate goal is to study potential drug candidates in an experimental setting of arthritis. Therefore, we aim to develop a human in vitro…
  • Abstract Number: 0074 • ACR Convergence 2020

    The Intracellular DNA Sensor STING Protects Against Bone Loss Through Regulation of Type I Interferons

    Susan MacLauchlan1, Catherine Manning2, Sijia Chen3, Katherine Fitzgerald4, Shruti Sharma5 and Ellen Gravallese1, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women’s Hospital, Boston, 3Brigham and Women's Hospital, Boston, 4University of Massachusetts medical school, Worcester, MA, 5Tufts University, Boston, MA

    Background/Purpose: The intracellular DNA sensor Stimulator of Interferon Genes (STING) is essential for detection of viral and bacterial pathogen DNA. As with other pathways in…
  • Abstract Number: 0107 • ACR Convergence 2020

    Effects of Abaloparatide on Modeling and Remodeling Based Bone Formation

    David W Dempster1, Hua Zhou1, Sudhaker D Rao2, Chris Recknor3, Paul D Miller4, Benjamin Z Leder5, Miriam Annett6, Michael S Ominsky6 and Bruce H Mitlak6, 1Regional Bone Center, Helen Hayes Hospital, West Haverstraw, NY, West Haverstraw, NY, 2Bone & Mineral Research Laboratory, Henry Ford Health System, Detroit, MI, Detroit, MI, 3United Osteoporosis Centers, Gainesville, GA, Gainesville, GA, 4Colorado Center for Bone Research, Lakewood, CO, Lakewood, CO, 5Mass General Hospital, Harvard Medical School, Boston, MA, Boston, MA, 6Radius Health, Inc., Waltham, MA, Waltham, MA

    Background/Purpose: To evaluate abaloparatide-induced changes in the bone formation indices of mineralizing surface (MS), bone formation rate (BFR) and mineral apposition rate (MAR); and to…
  • Abstract Number: 0110 • ACR Convergence 2020

    Does Urate Directly Influence Bone Turnover? Randomized Controlled Trial of Inosine Supplementation

    Nicola Dalbeth1, Anne Horne2, Borislav Mihov1, Tony Merriman3, Gregory Gamble1, Lisa Stamp4 and Ian Reid1, 1University of Auckland, Auckland, New Zealand, 2The University of Auckland, Auckland, New Zealand, 3University of Otago, Dunedin, New Zealand, 4University of Otago Christchurch, Christchurch, New Zealand

    Background/Purpose: Observational studies have reported that serum urate positively correlates with bone mineral density (BMD) and that hyperuricaemia is protective for the development of osteoporosis…
  • Abstract Number: 0116 • ACR Convergence 2020

    The in Vitro 3D Fracture Gap Model: A Tool for Preclinical Testing

    Moritz Pfeiffenberger1, Alexandra Damerau1, Paula Hoff2, Annemarie Lang1, Frank Buttgereit3 and Timo Gaber1, 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, 2Endokrinologikum Berlin, Rheumatologie, Berlin, Germany, 3Charité University Medicine, Berlin, Germany

    Background/Purpose: Approximately 10% of fractures lead to significant fracture healing disorders. Of note, especially immunosuppressed patients with ongoing inflammation show difficulties in the correct course…
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ACR Pediatric Rheumatology Symposium 2020

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