ACR Meeting Abstracts

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Abstracts tagged "Biomechanics"

  • Abstract Number: 0028 • ACR Convergence 2022

    Microenvironmental Stiffness Modulates Macrophage Responsiveness and Communication with Mesenchymal Stem Cells

    Sung Yeon Kim, Carla Scanzello, Robert Mauck and Edward Bonnevie, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The synovium envelopes the diarthodial joint and is composed of fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS). In healthy joints, the synovial cavity maintains…
  • Abstract Number: 0196 • ACR Convergence 2022

    The Impact of Barometric Pressure Waves on Connective Tissue Disorders

    Fehmida Zahabi1 and Kevin Kerr2, 1Texas Rheumatology Care, Plano, TX, 2Chimera Innovations LLC, Allen, TX

    Background/Purpose: Pain is a disabling, depressing state which reduces an individual's productivity. Weather changes have been vaguely attributed to cause pain. Previous studies have had…
  • Abstract Number: 0839 • ACR Convergence 2022

    Association of Tibial Acceleration During Walking to Knee Pain and Loading in Adults with Knee Osteoarthritis

    Khara James1, Patrick Corrigan2, Corey Lanois3, Chun-Hao Huang4, Irene Davis5 and Joshua Stefanik4, 1Northeastern Unviersity, Boston, MA, 2Saint Louis University, St. Louis, MO, 3Northeastern University, Providence, RI, 4Northeastern University, Boston, MA, 5University of South Florida, Tampa, FL

    Background/Purpose: Pain and abnormal loading are known to be associated with the progression of knee osteoarthritis (OA). Individuals with knee OA have increased vertical loading…
  • Abstract Number: 0970 • ACR Convergence 2022

    Influence of Sociodemographic and Clinical Features on Ground Reaction Force Variability Among Individuals with Symptomatic Knee Osteoarthritis: A Novel Computational Approach

    Yvonne Golightly1, Siqi Xiang2, Elyse Borgert2, Liubov Arbeeva3, Richard Loeser2, Stephen Messier4, Amanda Nelson5 and J.S. Marron2, 1University of Nebraska Medical Center, Omaha, NE, 2University of North Carolina, Chapel Hill, NC, 3University of North Carolina Chapel Hill, Chapel Hill, NC, 4Wake Forest University, Winston-Salem, NC, 5University of North Carolina at Chapel Hill, Chapel Hill, NC

    Background/Purpose: Abnormally applied forces across the knee during walking play a central role in knee osteoarthritis (OA) disease pathways. Biomechanical data collected continuously during gait…
  • Abstract Number: 1094 • ACR Convergence 2022

    Mechanical Loading-induced BHLHE40 Promotes Inflammatory Arthritis

    Eric Gracey1, Carolien Vlieghe2, Isabelle Cambre1, Elisabeth Gilis1, Flore Stappers3, Guillaume Planckaert1, Rik Lories4, Aline Bozec5 and Dirk Elewaut6, 1Ghent University, Gent, Belgium, 2VIB-UGent Center for Inflammation Research, Ghent University, Belgium, Gent, Belgium, 3VIB-UGent Center for Inflammation Research, Ghent University, Ghent, Belgium, 4KU Leuven, Leuven, Belgium, 5Universitätsklinikum Erlangen, Erlangen, Germany, 6Department of Rheumatology, Ghent University Hospital, Belgium, VIB-UGent Center for Inflammation Research, Ghent University, Heusden, Belgium

    Background/Purpose: Force induced microdamage to joint tissue is hypothesized to trigger inflammatory events in the joint leading to arthritis. Patients with inflammatory arthritis, such as…
  • Abstract Number: 1688 • ACR Convergence 2022

    Biomechanical Phenotype of Circulating Neutrophils Is Altered in ANCA Associated Vasculitis

    Noelle Pisacano1, Stephen P. McAdoo1, Jochen Guck2, Charles D. Pusey1, Edwin R. Chilvers1, Andrew S. Cowburn1, Katharine M. Lodge1 and Maria F. Prendecki1, 1Imperial College London, London, United Kingdom, 2Max Planck Institute, Erlangen, Germany

    Background/Purpose: Real Time-Deformability Cytometry (RT-DC) is a novel technique able to identify morpho-rheological characteristics of individual cells such as size, deformability, and elasticity using only…
  • Abstract Number: 1920 • ACR Convergence 2022

    Gait and Physical Activity Predictors of Knee Replacement: A Machine Learning Analysis in the Multicenter Osteoarthritis Study

    Kerry Costello1, David Felson1, S. Reza Jafarzadeh2, Neil Segal3, Cora E. Lewis4, Michael Nevitt5, Vijaya Kolachalama2 and Deepak Kumar1, 1Boston University, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3University of Kansas, Kansas City, KS, 4University of Alabama at Birmingham, Birmingham, AL, 5University of California at San Francisco, Orinda, CA

    Background/Purpose: Rates of knee replacement (KR) due to knee osteoarthritis (OA) are rising exponentially and currently no interventions prevent KR. Gait and physical activity are…
  • Abstract Number: 1995 • ACR Convergence 2022

    Baricitinib Improves Bone Biomechanical Properties in Rheumatoid Arthritis (RA) – Results of a Prospective Interventional Study

    Stephan Kemenes1, Koray Tascilar2, David Simon1, Sara Bayat3, Gerhard Kroenke2, Larissa Valor Mendez2, Fabian Hartmann4, Louis Schuster4, Anna-Maria Liphardt1, Georg Schett5 and Arnd Kleyer2, 1Department of Internal Medicine 3, Rheumatoloy and Immunology, University Hospital Erlangen, Erlangen, Germany, 2Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-UniversityErlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 3University Hospital Erlangen; Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, 4University Hospital Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, 5Universitätsklinikum Erlangen, Erlangen, Germany

    Background/Purpose: Deterioration of peripheral bone mass and bone biomechanics are well-known consequences of Rheumatoid Arthritis (RA)[1]. CCP-AB pos. RA, in particular, leads to a significant…
  • Abstract Number: 1125 • ACR Convergence 2021

    Synovial Perivascular Edema Is Associated with Altered Knee Loading Patterns During Gait in Patients with Medial Compartment-Dominant Knee Osteoarthritis

    McKenzie Carter1, Holly Philpott1, Trevor Birmingham2, Ryan Pinto3, Codie Primeau1, J. Robert Giffin1, Brent Lanting2 and Tom Appleton2, 1Western University, London, ON, Canada, 2University of Western Ontario, London, ON, Canada, 3Western University, Kitchener, ON, Canada

    Background/Purpose: Synovial inflammation and aberrant joint loads are independent risk factors for knee osteoarthritis (OA) incidence and progression. Perivascular edema, the accumulation of fluid around…
  • Abstract Number: 0565 • ACR Convergence 2020

    In Those with Unilateral Frequent Knee Pain, Between-Limb Differences in Stance Time During Walking Increase the Risk of Frequent Pain in the Other Knee: The MOST Study

    Patrick Corrigan1, David Felson2, Cara Lewis3, K. Douglas Gross4, Michael Nevitt5, Beth Lewis6, James Torner7 and Joshua Stefanik1, 1Northeastern University, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3Boston University, Brookline, MA, 4MGH Institute of Health Professionals, Boston, MA, 5Department of Epidemiology and Biostatistics, University of California San Francisco, Orinda, CA, 6University of Alabama at Birmingham, Birmingham, 7University of Iowa, Iowa City, IA

    Background/Purpose: Knee osteoarthritis (OA) commonly begins as a unilateral disease, with pain in only one knee. Yet 88% of persons with unilateral knee OA develop…
  • Abstract Number: 724 • 2019 ACR/ARP Annual Meeting

    Biomechanical Properties of Skin for Assessment of Scleroderma: A Systemic Review

    Peiyun Ni1, Lilit Garibyan 2 and Rox Anderson 2, 1Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA, 2Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA

    Background/Purpose: Skin involvement is one of the early features of scleroderma and an important predictor of internal organ involvement and mortality. Skin fibrosis alters the…
  • Abstract Number: 2600 • 2019 ACR/ARP Annual Meeting

    ‘If You Don’t Use It, You Lose It’: Rehabilitation of Finger Dexterity and Ability to Perform Activities of Daily Living in Systemic Sclerosis

    Elena Eusterwiemann1, Marina Anderson 2, Mark Robinson 1 and Gabor Barton 1, 1Liverpool John Moores University, Liverpool, United Kingdom, 2Aintree University Hospital, Liverpool

    Background/Purpose: Hand involvement due to increased skin thickness and skin collagen content is one of the first manifestations of systemic sclerosis (SSc) leading to a…
  • Abstract Number: 957 • 2018 ACR/ARHP Annual Meeting

    Biomechanical Therapy for Osteoarthritis of the Knee: A Randomized Controlled Trial

    Stephan Reichenbach1,2, Sarah Heldner1, Armando Lenz3, David T. Felson4 and Peter Jüni5, 1Institute for Social and Preventive Medicine, Bern, Bern, Switzerland, 2Department of Rheumatology, Immunology and Allergology, Bern, Bern, Switzerland, 3CTU Bern, University of Bern, Bern, Switzerland, 4Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 5Applied Health Research Centre (AHRC), Toronto, Toronto, ON, Canada

    Background/Purpose: Biomechanics plays an important role in knee osteoarthritis (OA). A new biomechanical footwear system aims at altering knee loading patterns and retraining neuromuscular control…
  • Abstract Number: 1369 • 2018 ACR/ARHP Annual Meeting

    The Influence of Hand Osteoarthritis on Bone Microstructure and Biomechanical Properties of Radial Bone

    David Simon, Sara Unbehend, Sara Bayat, Juergen Rech, Axel J. Hueber, Georg Schett and Arnd Kleyer, Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen–Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Primary hand osteoarthritis (HOA) is a heterogeneous disease, with erosive and osteoproliferative changes of the finger joints. [1] Due to the lack of treatment…
  • Abstract Number: 2002 • 2018 ACR/ARHP Annual Meeting

    Dynamic Compression of Articular Cartilage Explants Increases Formation and Decreases Degradation of Type II Collagen

    Amalie Engstrøm1,2, Anne C. Bay-Jensen2, Morten A. Karsdal2 and Christian S. Thudium2, 1Department of Biomedical Science, University of Copenhagen, København, Denmark, 2Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Mechanical loading is recognized as a major factor in initiation and progression of osteoarthritis (OA). Conversely loading is believed to play an essential role…
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