Abstracts tagged "Biomechanics"

Abstract Number: 0701 • ACR Convergence 2024
Diagnostic Performances of Vascular Biomarkers Soluble Fms-like Tyrosine Kinase (sFlt-1) and Placental Growth Factor (PlGF) in Scleroderma Renal Crisis: A Case Control Study
Aïcha Kante¹, Paul Legendre², Bérangère Joly³, bertrand Dunogue⁴, Alexandre Hertig⁵, Benjamin Terrier⁶, Elodie Massolin⁷, Felix Ackermann⁸, Luc Mouthon⁴, Jean Guibourdenche⁹ and Benjamin Chaigne¹⁰, ¹Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Université Paris Cité, Paris, Ile-de-France, France, ²Service immunologie clinique, Centre hospitalier du Mans, Le Mans, France, Le Mans, ³Service d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris (APHP.Nord), Université Paris Cité, Paris, Ile-de-France, France, ⁴Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l’Est et de l’Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, ⁵Department of Nephrology, Hôpital Foch, Suresnes, France, Suresnes, Ile-de-France, France, ⁶Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France, ⁷UF d'Hormonologie, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (APHP), Paris, Paris, Ile-de-France, France, ⁸Department of Internal Medicine, Foch Hospital, Suresnes, France., Suresnes, France, ⁹APHP-CUP, Hôpital Cochin, F-75014 Paris, Université Paris Cité, Paris, Ile-de-France, France, ¹⁰Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l’Est et de l’Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, Ile-de-France, France
Background/Purpose: Scleroderma renal crisis (SRC) is a major vascular complication of systemic sclerosis (SSc), associated with high morbidity and mortality. Few biomarkers are available to predict…
Abstract Number: 1175 • ACR Convergence 2024
Physical Activity and Symmetry Following Total Knee Arthroplasty:Results of an Exploratory Trial
Kelli Allen¹, Liubov Arbeeva², Daniel Bracey³, Derek Hales³, Carla Hill⁴, Katie Huffman⁵, Todd Schwartz⁶ and Robin Queen⁷, ¹University of North Carolina, Durham, NC, ²University of North Carolina, Chapel Hill, Carrboro, NC, ³University of North Carolina at Chapel HIll, Chapel Hill, NC, ⁴UNC Health, Raleigh, NC, ⁵UNC Thurston Arthritis Research Center, Chapel Hill, NC, ⁶University of North Carolina-Chapel Hill, Chapel Hill, NC, ⁷Virginia Tech, Blacksburg, VA
Background/Purpose: Studies have identified two key deficits in individuals’ activity-related trajectories following total knee arthroplasty (TKA). First, overall physical activity (PA) levels remain very low.…
Abstract Number: 1293 • ACR Convergence 2023
Single Camera Hand Motion Capturing as a Digital Biomarker for Disease Activity in Rheumatoid Arthritis Using Computer Vision: The Proof-of-Concept MeFisto Study
Vincenzo Venerito¹, Tobias Maningold², Deborah Markham³, Marc Blanchard⁴, Florenzo Iannone¹ and Thomas Hügle⁵, ¹Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Bari, Italy, ²Department of Rheumatology, University Hospital Bern (Inselspital), University Bern, Bern, Switzerland, ³on behalf of Department Rheumatology, University Hospital Lausanne, Lausanne, Switzerland, ⁴Dept. of Rheumatology, University Hospital Lausanne (CHUV) and University Lausanne, Lausanne, Switzerland, ⁵Dept. of Rheumatology, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland
Background/Purpose: Computer vision technology offerspromising possibilities for remotely assessing disease activity in rheumatoid arthritis (RA) patients, enabling telemedicine and improving access to care. The objective…
Abstract Number: 2106 • ACR Convergence 2023
Evaluation of the Construct of Constitutional Stiffness (CS) in Anti-CCP-Antibody-Positive Rheumatoid Arthritis (ACPA+RA) and Controls
Stephen Oakley¹, Samantha Stott¹, Kerri Gill¹, Chan Virgil¹, Lyanne Weston² and Theo de Malmanche¹, ¹John Hunter Hospital, New Lambton, Australia, ²Australian Red Cross Blood Service, Alexandria, Australia
Background/Purpose: The risk of developing ACPA+RA, predictors of severity and causes of excess cardiovascular disease (CVD) are incompletely understood. We have observed that RA patients…
Abstract Number: 2524 • ACR Convergence 2023
Relation of Pain Sensitivity to Forces While Walking in Adults with and Without Knee Pain: The Multicenter Osteoarthritis (MOST) Study
Patrick Corrigan¹, Cara Lewis², Kerry Costello³, Deepak Kumar², David Felson², Tuhina Neogi⁴, Laura Frey Law⁵, Michael LaValley⁶, Michael Nevitt⁷, Beth Lewis⁸ and Joshua Stefanik⁹, ¹Saint Louis University, St. Louis, MO, ²Boston University, Boston, MA, ³University of Florida, Gainesville, FL, ⁴Boston University School of Medicine, Boston, MA, ⁵University of Iowa, Iowa City, IA, ⁶Boston University School of Public Health, Arlington, MA, ⁷University of California San Francisco, San Francisco, CA, ⁸University of Alabama at Birimingham, Birmingham, AL, ⁹Northeastern University, Boston, MA
Background/Purpose: Knee osteoarthritis (KOA) is a leading cause of pain and disability worldwide with no definitive treatment. There is a need to identify mechanisms that…
Abstract Number: 0312 • ACR Convergence 2023
Frontal Lobe Activation and Gait Alterations During Single- and Dual-task Walking in People with Knee Osteoarthritis: A Functional Near-infrared Spectroscopy Study
Soyoung Lee, Meryem Yücel, Claudio Ferre, Baekdong Cha, Ehyun Kim and Deepak Kumar, Boston University, Boston, MA
Background/Purpose: Altered gait patterns, including high variability or muscular co-contraction, can increase fall risk and worsen disease progression in people with knee osteoarthritis (OA). However,…
Abstract Number: 0846 • ACR Convergence 2023
Preosteoclast Plays a Pathogenic Role in Syndesmophyte Formation of Ankylosing Spondylitis Through the Secreted PDGFB – GRB2/ERK/RUNX2 Pathway
Yulong Tang¹, Qingmei Liu¹, Kunhai Tang¹, Chengchun Geng¹, Jiangnan Xie¹, Jiucun Wang², Qi Zhu³ and Jing Liu¹, ¹Fudan University, Shanghai, China, ²Shanghai, Shanghai, China, ³Guanghua Integrative Medicine Hospital, Shanghai, China
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joint and spine. However, the real mechanisms of immune cells acting…
Abstract Number: 1184 • ACR Convergence 2023
A Wearable-Sensor for Assessment of Gait and Chair Stand Patterns in People with Knee Osteoarthritis: Validation and Responsiveness to Treatment of a Potential Digital Biomarker
Deepak Kumar¹, Lukas Adamowicz², Benjamin Senderling¹, Mary Gheller¹, Michael LaValley³, Kathryn Bacon¹, Pirinka Georgiev², Charmaine Demanuele², Paul Wacnik² and Tuhina Neogi⁴, ¹Boston University, Boston, MA, ²Pfizer Inc., Cambridge, MA, ³Boston University School of Public Health, Arlington, MA, ⁴Boston University School of Medicine, Boston, MA
Background/Purpose: The objectives of this study in people with knee osteoarthritis (OA) were to (a) examine the agreement between measures of gait and chair stand…
Abstract Number: 1193 • ACR Convergence 2023
The Association of Peak Forces and Loading Rates During Walking with MRI-Based Structural Worsening of the Knee: The Multicenter Osteoarthritis Study
Lauren Sara¹, David Felson¹, Michael LaValley², Gabriela Rabasa¹, Beth Lewis³, John Lynch⁴, Neil Segal⁵, Ali Guermazi¹, Frank Roemer⁶, Joshua Stefanik⁷ and Cara Lewis¹, ¹Boston University, Boston, MA, ²Boston University School of Public Health, Arlington, MA, ³University of Alabama at Birimingham, Birmingham, AL, ⁴University of California San Francisco, San Francisco, CA, ⁵University of Kansas, Kansas City, KS, ⁶Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, ⁷Northeastern University, Boston, MA
Background/Purpose: Mechanical loading is an important, modifiable risk factor for knee osteoarthritis (OA). Walking loads have been previously proposed as a risk factor for developing…
Abstract Number: 0028 • ACR Convergence 2022
Microenvironmental Stiffness Modulates Macrophage Responsiveness and Communication with Mesenchymal Stem Cells
Sung Yeon Kim, Carla Scanzello, Robert Mauck and Edward Bonnevie, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The synovium envelopes the diarthodial joint and is composed of fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS). In healthy joints, the synovial cavity maintains…
Abstract Number: 0196 • ACR Convergence 2022
The Impact of Barometric Pressure Waves on Connective Tissue Disorders
Fehmida Zahabi¹ and Kevin Kerr², ¹Texas Rheumatology Care, Plano, TX, ²Chimera Innovations LLC, Allen, TX
Background/Purpose: Pain is a disabling, depressing state which reduces an individual's productivity. Weather changes have been vaguely attributed to cause pain. Previous studies have had…
Abstract Number: 0839 • ACR Convergence 2022
Association of Tibial Acceleration During Walking to Knee Pain and Loading in Adults with Knee Osteoarthritis
Khara James¹, Patrick Corrigan², Corey Lanois³, Chun-Hao Huang⁴, Irene Davis⁵ and Joshua Stefanik⁴, ¹Northeastern Unviersity, Boston, MA, ²Saint Louis University, St. Louis, MO, ³Northeastern University, Providence, RI, ⁴Northeastern University, Boston, MA, ⁵University of South Florida, Tampa, FL
Background/Purpose: Pain and abnormal loading are known to be associated with the progression of knee osteoarthritis (OA). Individuals with knee OA have increased vertical loading…
Abstract Number: 0970 • ACR Convergence 2022
Influence of Sociodemographic and Clinical Features on Ground Reaction Force Variability Among Individuals with Symptomatic Knee Osteoarthritis: A Novel Computational Approach
Yvonne Golightly¹, Siqi Xiang², Elyse Borgert², Liubov Arbeeva³, Richard Loeser², Stephen Messier⁴, Amanda Nelson⁵ and J.S. Marron², ¹University of Nebraska Medical Center, Omaha, NE, ²University of North Carolina, Chapel Hill, NC, ³University of North Carolina Chapel Hill, Chapel Hill, NC, ⁴Wake Forest University, Winston-Salem, NC, ⁵University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Abnormally applied forces across the knee during walking play a central role in knee osteoarthritis (OA) disease pathways. Biomechanical data collected continuously during gait…
Abstract Number: 1094 • ACR Convergence 2022
Mechanical Loading-induced BHLHE40 Promotes Inflammatory Arthritis
Eric Gracey¹, Carolien Vlieghe², Isabelle Cambre¹, Elisabeth Gilis¹, Flore Stappers³, Guillaume Planckaert¹, Rik Lories⁴, Aline Bozec⁵ and Dirk Elewaut⁶, ¹Ghent University, Gent, Belgium, ²VIB-UGent Center for Inflammation Research, Ghent University, Belgium, Gent, Belgium, ³VIB-UGent Center for Inflammation Research, Ghent University, Ghent, Belgium, ⁴KU Leuven, Leuven, Belgium, ⁵Universitätsklinikum Erlangen, Erlangen, Germany, ⁶Department of Rheumatology, Ghent University Hospital, Belgium, VIB-UGent Center for Inflammation Research, Ghent University, Heusden, Belgium
Background/Purpose: Force induced microdamage to joint tissue is hypothesized to trigger inflammatory events in the joint leading to arthritis. Patients with inflammatory arthritis, such as…
Abstract Number: 1688 • ACR Convergence 2022
Biomechanical Phenotype of Circulating Neutrophils Is Altered in ANCA Associated Vasculitis
Noelle Pisacano¹, Stephen P. McAdoo¹, Jochen Guck², Charles D. Pusey¹, Edwin R. Chilvers¹, Andrew S. Cowburn¹, Katharine M. Lodge¹ and Maria F. Prendecki¹, ¹Imperial College London, London, United Kingdom, ²Max Planck Institute, Erlangen, Germany
Background/Purpose: Real Time-Deformability Cytometry (RT-DC) is a novel technique able to identify morpho-rheological characteristics of individual cells such as size, deformability, and elasticity using only…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].