Abstracts tagged "Biomarkers"

Abstract Number: 2397 • 2012 ACR/ARHP Annual Meeting
Urinary Biomarkers in Vasculitis Associated with Anti-Neutrophil Cytoplasmic Antibodies
Jason G. Lieberthal¹, David Cuthbertson², Simon Carette³, Gary S. Hoffman⁴, Nader A. Khalidi⁵, Curry L. Koening⁶, Carol A. Langford⁷, Kathleen Maksimowicz-McKinnon⁸, Philip Seo⁹, Ulrich Specks¹⁰, Steven R. Ytterberg¹¹, Peter A. Merkel¹² and Paul A. Monach¹³, ¹Medicine, Boston University School of Medicine, Boston, MA, ²Department of Biostatistics, University of South Florida, Tampa, FL, ³Div of Rheum/E1-422, UHN/MSH, Toronto, ON, Canada, ⁴Rheumatic & Immunologic Dis, Cleveland Clinic, Cleveland, OH, ⁵Internal Medicine/Rheumatology, McMaster University, Hamilton, ON, Canada, ⁶Internal Medicine, Salt Lake City Veterans Administration, Salt Lake City, UT, ⁷Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁸Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁹Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ¹⁰Mayo Clinic, Rochester, MN, ¹¹Rheumatology Division, Mayo Clinic, Rochester, MN, ¹²University of Pennsylvania, Philadelphia, PA, ¹³Rheumatology, Boston University, Boston, MA
Background/Purpose: Glomerulonephritis is common in ANCA-associated vasculitis (AAV), but non-invasive tools for early detection of renal involvement suffer from low sensitivity (red blood cell…
Abstract Number: 1483 • 2012 ACR/ARHP Annual Meeting
Predictors of Digital Ulcers in Systemic Sclerosis: Correlation Between Clinical and Hemodynamic Features, Capillaroscopy, Endothelium Dysfunction and Angiogenesis Biomarkers
Ivone Silva¹, Isabel Almeida¹, António Marinho² and Carlos Vasconcelos³, ¹Raynaud Clinics, Porto, Portugal, ²Unidade de Imunologia Clínica, Porto, Portugal, ³Imunologia Clinica - M Interna, Hospital Geral Santo Antonio, Porto, Portugal
Background/Purpose: Digital Ulcers (DU) are a major disabling complication of Systemic Sclerosis (SSc) interfering with personal and professional life of our patients. The aim of…
Abstract Number: 866 • 2012 ACR/ARHP Annual Meeting
Pain Is Associated with Telomere Shortening in Women with Fibromyalgia
Afton L. Hassett¹, Daniel J. Clauw², Richard E. Harris¹, Steven E. Harte¹, Anson E. Kairys³, Steven Buyske⁴ and David A. Williams⁵, ¹Anesthesiology, University of Michigan, Ann Arbor, MI, ²Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, ³Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, ⁴Statistics, Rutgers University, Piscataway, NJ, ⁵Chronic Pain & Fatigue Rsch Ctr, Univ of MI Hlth System-Lobby M, Ann Arbor, MI
Background/Purpose: Telomere length is considered a marker of cellular aging and has been linked to an increased risk for morbidity and mortality. Psychosocial factors associated…
Abstract Number: 668 • 2012 ACR/ARHP Annual Meeting
Markers of Nitric Oxide and Hydroxyl Radical Formation Are Increased in Proliferative Lupus Nephritis and May Emanate From Increased Nitric Oxide Synthase and NADPH Oxidase Production and Reduced Endothelial Nitric Oxide Synthase-Derived NO Scavenging
Jim Oates¹, Ahmad Mashmoushi¹, Thomas Fleury¹, Ann Hofbauer¹ and Gary S. Gilkeson², ¹Medicine, Medical University of South Carolina, Charleston, SC, ²Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: The role of redox regulation of cell function in the different International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of lupus nephritis (LN) is…
Abstract Number: L14 • 2012 ACR/ARHP Annual Meeting
Treatment of Diffuse Systemic Sclerosis Patients with Anti-Transforming Growth Factor-Beta, Fresolimumab, Inhibits Transforming Growth Factor-Beta-Regulated Gene Expression in Skin and Is Associated with a Rapid Decline in Skin Score
Robert Lafyatis¹, Sashidhar Nakerakanti², Allison Mathes², Cristina Padilla², Sarah McLaughlin³, Michael R. York², Giuseppina Farina⁴, Romy Christmann¹, Richard P. Polisson⁵ and Robert W. Simms¹, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University Medical Center, Boston, MA, ³Division of Rheumatology, Boston University Medical Center, Boston, MA, ⁴Arthritis center, Boston University, Boston, MA, ⁵Sanofi-Aventis US, Cambridge, MA
Background/Purpose: Transforming growth factor-beta (TGFb) has long been suspected to mediate fibrotic signals in systemic sclerosis (SSc) as it potently stimulates collagen deposition in vitro,…
Abstract Number: 2270 • 2012 ACR/ARHP Annual Meeting
The DNA Methylome of Systemic Lupus Erythematosus (SLE) From Whole Peripheral Blood Mononuclear Cells (PBMCs)
Robert Shoemaker¹, Lou H. Bookbinder², David L. Boyle³, Gary S. Firestein⁴, Jonathan E. Lim⁵ and David W. Anderson⁶, ¹Bioinformatics, NexDx, Inc., San Diego, CA, ²Molecular Biology, NexDx, Inc., San Diego, ³Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁴Div of Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁵Research and Development, NexDx, Inc., San Diego, ⁶Research and Development, NexDx, Inc., San Diego, CA
Background/Purpose: SLE is a disease where epigenetic mechanisms play a role. Methylation of DNA at CpG loci is known to influence the suppression or activation…
Abstract Number: 1495 • 2012 ACR/ARHP Annual Meeting
Platelet Aggregability, Eicosanoid Biosynthesis and Oxidative Stress in Primary Raynaud’s Phenomenon and Systemic Sclerosis
John D. Pauling¹ and Neil McHugh², ¹Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom
Background/Purpose: Increased platelet activation, endothelial dysfunction and oxidative stress are all thought to contribute to the pathogenesis of Raynaud’s phenomenon (RP), particularly in the context…
Abstract Number: 838 • 2012 ACR/ARHP Annual Meeting
Association of Urinary and Serum Soluble Fn14 Levels and TWEAK Levels with Lupus Nephritis Disease Activity
Irene Blanco¹, Ping Wu², Timothy S. Zheng³, Shawn Weng⁴, Jennifer S. Michaelson², Linda C. Burkly² and Chaim Putterman⁵, ¹Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ²Biogen Idec, Cambridge, MA, ³R&D - Rheumatology/Immunology, Biogen Idec Inc, Cambridge, MA, ⁴Biogen Idec, Inc., Cambridge, MA, ⁵Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: We have showed that the cytokine TWEAK is a biomarker for lupus nephritis (LN). However, soluble receptors for key immune pathways are also potential…
Abstract Number: 645 • 2012 ACR/ARHP Annual Meeting
Altered Soluble Inflammatory Mediators Mark Impending Systemic Lupus Erythematosus Disease Flare in European-American Lupus Patients Who Receive Influenza Vaccination
Melissa E. Munroe¹, Jourdan R. Anderson², Joan T. Merrill³, Joel M. Guthridge⁴, Virginia C. Roberts⁴, Gillian M. Air⁵, Linda F. Thompson⁶ and Judith A. James⁷, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Biochemistry, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Immunobiology and Cancer, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: SLE is a multifaceted autoimmune disease denoted by immune dysregulation that contributes to increased morbidity and mortality in part due to infectious complications. Vaccination…
Abstract Number: L1 • 2012 ACR/ARHP Annual Meeting
A Randomized, Placebo-Controlled Phase 2 Study of ARRY-797 in Patients with Osteoarthritis Pain Refractory to NSAID Treatment Showed Statistically Significant Improvements in WOMAC Pain and in Biomarkers of Bone and Cartilage Degradation
Alan J. Kivitz¹, Shane G. Christensen², John Agaiby³, Egilius Spierings⁴, Julie Daves⁵, Roger Aitchison⁶, Stephen G. Miller⁷, Karsten Witt⁸ and Joseph Gimbel⁹, ¹Altoona Center for Clinical Research, Duncansville, PA, ²J. Lewis Research, Inc., Salt Lake City, UT, ³Clinical Investigation Specialists, Gurnee, IL, ⁴MedVadis Research Corporation, Watertown, MA, ⁵Clinical Operations, Array Biopharma, Inc., Boulder, CO, ⁶Biostatistics & Data Management, Array Biopharma, Inc., Boulder, CO, ⁷Translational Medicine, Array Biopharma, Inc., Boulder, CO, ⁸Clinical Sciences, Array Biopharma, Inc., Boulder, CO, ⁹Arizona Research Center, Phoenix, AZ
Background/Purpose: Osteoarthritis (OA) is the most common chronic joint disease and OA pain is a leading cause of work disability. p38 inhibition suppresses the production…

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