Abstracts tagged "Biomarkers"

Abstract Number: 754 • 2014 ACR/ARHP Annual Meeting
The Global miRNA Whole Blood Profile in Systemic Sclerosis and Its Correlation with Serum Cytokine Levels
Gloria Salazar¹, Maureen Mayes², John Hagan³, Minghua Wu¹, John D. Reveille^4,5 and Shervin Assassi¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Internal Medicine/Rheumatology, University of TX Health Science Center -Houston, Houston, TX, ³Neurosurgery, University of Texas at Houston, Houston, TX, ⁴Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁵Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX
The Global miRNA Whole Blood Profile in Systemic Sclerosis and its Correlation with Serum Cytokine LevelsBackground/Purpose: Several studies have implicated miRNAs in the pathogenesis of…
Abstract Number: 376 • 2014 ACR/ARHP Annual Meeting
Using the Multi-Biomarker Disease Activity Score As a Complementary Inclusion Criterion for Clinical Trials in Rheumatoid Arthritis May Enhance Recruitment
Ronald F. van Vollenhoven¹, Rebecca J. Bolce², Karen Hambardzumyan³, Saedis Saevarsdottir⁴, Kristina Forslind⁴, Ingemar Petersson⁵, Eric H. Sasso², CC Hwang⁶, Oscar Segurado² and Pierre Geborek⁷, ¹Unit for clinical therapy research (ClinTrid), Karolinska Institute, Stockholm, Sweden, ²Crescendo Bioscience Inc., South San Francisco, CA, ³ClinTRID, the Karolinska Institute, Stockholm, Sweden, ⁴Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁵Lund University, Department of Orthopedics, Clinical Sciences Lund, Lund, Sweden, ⁶Biostatistics, Crescendo Bioscience Inc., South San Francisco, CA, ⁷Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
Background/Purpose Clinical trials in rheumatoid arthritis (RA) often require elevated C-reactive protein (CRP) as an inclusion criterion, which may limit recruitment by excluding some patients…
Abstract Number: 2795 • 2014 ACR/ARHP Annual Meeting
Blockade of IL-6R Signaling by Sarilumab Suppressed Circulating Markers of Bone Resorption and Synovial Damage in Rheumatoid Arthritis Patients from a Phase 3, Randomized, Double-Blind, Placebo-Controlled, International Study
Anita Boyapati¹, Jérôme Msihid², Emmanuelle Cousin³, Ling Cai⁴, Janet van Adelsberg¹, Jennifer D Hamilton¹, Neil Graham⁵, Tanya Momtahen⁶ and Stefano Fiore⁷, ¹Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ²Sanofi R&D, France, Chilly-Mazarin, NJ, France, ³Sanofi R&D, France, Chilly-Mazarin, France, ⁴Sanofi R&D, China, Beijing, China, ⁵Program Direction, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ⁶Sanofi, Bridgewater, NJ, ⁷Distinct Project Unit, Sanofi, Bridgewater, NJ
Background/Purpose Rheumatoid arthritis (RA) patients develop bone and joint damage due to chronic inflammation mediated by critical cytokines, eg, IL-6. Pre-clinical studies have implicated IL-6…
Abstract Number: 1730 • 2014 ACR/ARHP Annual Meeting
Identification of Novel Scleroderma –associated Antigens and Development of an Autoantibody Assay Panel Enabling Their Subsequent Validation
Hans-Dieter Zucht¹, Petra Budde¹, Peter Schulz-Knappe¹, Nicolas Hunzelmann², Karsten Conrad³ and Prof. Dr. Matthias Schneider⁴, ¹Protagen AG, Dortmund, Germany, ²Department of Dermatology, University of Cologne, Cologne, Germany, ³Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, ⁴Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany
Background/Purpose: Scleroderma (systemic sclerosis or SSc) has a highly variable clinical presentation and course resulting in difficulties for disease management. When SSc is suspected, autoantibodies…
Abstract Number: 1293 • 2014 ACR/ARHP Annual Meeting
Identification of an Inflammation-Driven Phenotype of Osteoarthritis By Quantification of Synovial Inflammation Ex Vivo and in Serum from Patients
Cecilie F. Kjelgaard-Petersen¹, Anne Sofie Siebuhr², Kristian Kjaer Petersen³, Lars Arendt-Nielsen⁴, Thomas Eskehave⁵, Hans Christian Hoeck⁵, Ole Simonsen⁶, Thorbjørn Christiansen⁷, Line Lindhardt Egsgaard⁸, Morten A. Karsdal⁹ and Anne C. Bay-Jensen¹, ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁴Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁵Center for Clinical and Basic Research (CCBR), Aalborg, Denmark, ⁶Frederikshavn Hospital, Frederikshavn, Denmark, ⁷Orthopaedic Surgery Unit, Gentofte University Hospital, Gentofte, Denmark, ⁸Center for Sensory-Motor Interaction (SMI), Aalborg University, Aalborg, Denmark, ⁹Research & Development, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose Osteoarthritis (OA) is a multifaceted degenerative joint disease, where inflammation of the synovial membrane leads to accelerated joint destruction, resulting in elevated release of…
Abstract Number: 750 • 2014 ACR/ARHP Annual Meeting
Molecular Characterization of Systemic Sclerosis Esophageal Pathology Identifies Inflammatory and Proliferative Signatures with Few Fibrotic Markers
Jaclyn Taroni¹, Viktor Martyanov², Chiang-Ching Huang³, J. Matthew Mahoney⁴, Ikuo Hirano⁵, Tammara A. Wood², Brandon Shetuni⁶, Guang-Yu Yang⁶, Darren Brenner⁵, Barbara Jung⁷, Swati Bhattacharyya⁸, Orit Almagor⁹, Jungwha Lee¹⁰, Arlene Sirajuddin¹¹, Rowland W. Chang¹², John Varga¹³, Michael Whitfield¹⁴ and Monique Hinchcliff¹⁵, ¹Genetics, Giesel School of Medicine at Dartmouth, Hanover, NH, ²Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Zilber School of Public Health, University of Wisconsin, Milwaukee, Milwaukee, WI, ⁴Department of Neurological Sciences, College of Medicine, University of Vermont, Burlington, VT, ⁵Department of Medicine, Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Department of Medicine, Division of Gastroenterology, University of Illinois at Chicago, Chicago, IL, ⁸Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁹Northwestern University, Chicago, IL, ¹⁰Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹¹Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹²Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁴Geisel School of Medicine at Dartmouth, Hanover, NH, ¹⁵Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Esophageal involvement in patients with systemic sclerosis (SSc) is common, but tissue-specific pathological mechanisms are poorly understood. Esophageal muscle atrophy without concomitant fibrosis is…
Abstract Number: 350 • 2014 ACR/ARHP Annual Meeting
Rho-Associated Protein Kinase (ROCK) Activity Is Elevated in Rheumatoid Arthritis (RA) Patients and May be Responsive to RA Therapies
Reena Khianey¹, Cristina Rozo², Sanjay Gupta³, Vivian P. Bykerk¹, Susan M. Goodman¹ and Alessandra B. Pernis⁴, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²535 East 70th Street, Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Research, Hospital for Special Surgery, New York, NY
Background/Purpose: Rho-associated protein kinases (ROCKs) regulate cytoskeletal reorganization and gene expression through protein phosphorylation, and are implicated in the pathogenesis of a wide range of…
Abstract Number: 2787 • 2014 ACR/ARHP Annual Meeting
Identification of Urinary Biomarkers for Lupus Nephritis
Carolina Landolt-Marticorena¹, Stephenie Prokopec², Heather Reich³, James Scholey⁴, Carmen Avila-Casado⁵, Paul R. Fortin⁶, Paul Boutros² and Joan Wither⁷, ¹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ²Ontario Institute for Cancer Research, Toronto, ON, Canada, ³Nephrology, University Health Network, Toronto, ON, Canada, ⁴Department of Medicine, The Toronto Western Hospital, Toronto, ON, Canada, ⁵Pathology, University Health Network, Toronto, ON, Canada, ⁶Rheumatology, Laval University, Division of Rheumatology, Centre de Recherche du CHU de Québec and Department of Medicine, Quebec City, QC, Canada, ⁷Immunology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Lupus nephritis (LN) is a major determinant of morbidity and mortality in Systemic Lupus Erythematosus (SLE). Variability in clinical course, underlying renal injury, and…
Abstract Number: 1699 • 2014 ACR/ARHP Annual Meeting
Endothelial and Platelet Microparticles As Potential Novel Biomarkers of Peripheral Microvascular Dysfunction in Systemic Sclerosis and Primary Raynaud’s Phenomenon
John D. Pauling^1,2, Daniel Moreno-Martinez³, Fiona Wilkinson⁴, Ben Parker^5,6, Jacqueline A. Shipley¹, Darren Hart¹, Neil J McHugh^1,2 and Yvonne Alexander³, ¹Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ³Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁴School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Institute of Inflammation and Repair School of Translation Medicine The University of Manchester, Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁶Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). MPs form during cell activation…
Abstract Number: 1289 • 2014 ACR/ARHP Annual Meeting
Classification of Osteoarthritis Phenotypes By Metabolomics Analysis
Weidong Zhang¹, Sergei Likhodii², Yuhua Zhang¹, Erfan Aref-Eshghi¹, Patricia E. Harper¹, Edward Randell², Roger Green¹, Glynn Martin³, Andrew Furey³, Guang Sun⁴, Proton Rahman^5,6 and Guangju Zhai¹, ¹Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ²Department of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ³Department of Surgery, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁴Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁵Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁶Rheumatology, St. Claires Mercy Hospital, St. Johns, NF, Canada
Background/Purpose: Osteoarthritis (OA) is a group of heterogeneous conditions consisting of different subgroups or phenotypes that continuously evolve, eventually leading to common clinical manifestations. Identifying…
Abstract Number: 738 • 2014 ACR/ARHP Annual Meeting
Troponin T as a Diagnostic and Prognostic Biomarker of Primary Cardiac Involvement in Systemic Sclerosis
Silvia Laura Bosello, Giacomo De Luca, Federico Parisi, Giorgia Berardi, Manuela Rucco, Giovanni Canestrari and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose .Heart involvement is common in Systemic Sclerosis (SSc), even if often clinically silent, and represents one of the leading cause of death in these…
Abstract Number: 342 • 2014 ACR/ARHP Annual Meeting
Vascular Permeability As an Imaging Biomarker for Chronic Inflammatory Arthritis: A Dynamic Contrast Enhanced Magnetic Resonance Imaging Study
Eon Jeong Nam¹, Yongmin Chang², Jang-Woo Park³, Shijin Sung⁴, Jungwan Hong⁴, Md. Hasan Al Faruque⁴, Jongmin Lee⁵ and Young Mo Kang⁶, ¹Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea, ²Molecular Medicine, Kyungpook National University School of Medicine, Daegu, South Korea, ³Medical and Biological Engineering, Kyungpook National University School of Medicine, Daegu, South Korea, ⁴Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea, ⁵Radiology, Kyungpook National University School of Medicine, Daegu, South Korea, ⁶Dept of Internal Medicine, Kyungpook National Univ Hosp, Daegu, South Korea
Vascular permeability as an imaging biomarker for chronic inflammatory arthritis: A dynamic contrast enhanced magnetic resonance imaging study Background/Purpose Rheumatoid arthritis (RA) is a chronic…
Abstract Number: 2765 • 2014 ACR/ARHP Annual Meeting
Putative Blood Biomarkers of Reversible Cerebral Vasoconstriction Syndrome
Seby John¹, Belinda Willard², Leonard H. Calabrese², Ken Uchino³, Tariq Hammad², Stewart Tepper², Mark Stillman² and Rula A Hajj-Ali⁴, ¹9500 Euclid Avenue S10-C, Cleveland Clinic Foundation, Cleveland, OH, ²Cleveland Clinic Foundation, Cleveland, OH, ³Neurology, Cleveland Clinic Foundation, Cleveland, OH, ⁴Rheumatology, Cleveland Clinic Foundation, Cleveland, OH
Putative blood biomarkers of Reversible Cerebral Vasoconstriction Syndrome Background/Purpose The pathophysiology and molecular mechanisms of Reversible Cerebral Vasoconstriction Syndrome (RCVS) are unknown. Objective of the…
Abstract Number: 1666 • 2014 ACR/ARHP Annual Meeting
The Relevance of Urinary Podocyte Number and Urinary Podocalyxin Level with Response to Treatment and 1 Year Renal Prognosis in Systemic Lupus Erythematosus
Hiroshi Kajiyama¹, Keiju Hiromura², Daisuke Ikuma¹, Hidekazu Ikeuchi², Hiroyuki Kurosawa³, Yoshiaki Hirayama³, Fumio Gondaira³, Masanori Hara⁴, Yoshihisa Nojima² and Toshihide Mimura⁵, ¹Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan, ²Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan, ³Department of reagent research and development, Denka Seiken Co. Ltd., Niigata, Japan, ⁴Department of Pediatrics, Yoshida Hospital, Niigata, Japan, ⁵Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose Podocytes are glomerular visceral epithelial cells, whose number decrease due to death and/or detachment from capillary wall leads to severe proteinuria and end stage…
Abstract Number: 1266 • 2014 ACR/ARHP Annual Meeting
Anti-MDA5 Is Associated with Rapidly-Progressive Interstitial Lung Disease and Poor Survival in U.S. Patients with Amyopathic and Myopathic Dermatomyositis
Siamak Moghadam-Kia¹, Chester V. Oddis², Shinji Sato³, Masataka Kuwana⁴ and Rohit Aggarwal¹, ¹Medicine, University of Pittsburgh, Pittsburgh, PA, ²Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan, ⁴Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose : Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) presenting with the characteristic rash(es) of DM without objective muscle weakness. Asian studies…

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