ACR Meeting Abstracts

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Abstracts tagged "Biomarkers"

  • Abstract Number: 2579 • 2012 ACR/ARHP Annual Meeting

    Novel Autoantibodies to 14-3-3 Eta Are Highly Specific for Rheumatoid Arthritis

    Walter P. Maksymowych1, Désirée van der Heijde2, R. Landewe3, Vivian P. Bykerk4 and Anthony Marotta5, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 4Rheumatology, Hospital for Special Surgery, New York, NY, 5Augurex Life Sciences Corp, North Vancouver, BC, Canada

    Background/Purpose: Serum 14-3-3 eta, a protein biomarker that is differentially expressed in rheumatoid arthritis (RA), has been reported to add incrementally to rheumatoid factor (RF)…
  • Abstract Number: 2128 • 2012 ACR/ARHP Annual Meeting

    Matrix Metalloproteinase 3: A Biomarker of Disease Activity in Rheumatoid Arthritis

    Sandra Reuter1, Torsten Matthias2 and Bruno Larida3, 1AIRA e.V., AESKU.KIPP Institute, Wendelsheim, Germany, 2AESKU.Diagnostics GmbH & Co. KG, Wendelsheim, Germany, 3AESKU.DIAGNOSTICS INC, Oakland, CA

    Background/Purpose: New biomarkers for monitoring Rheumatoid Arthritis (RA) disease activity and prognosis of progression are urgently needed to individually optimize drug therapy and prevent joint…
  • Abstract Number: 1151 • 2012 ACR/ARHP Annual Meeting

    Low-Dose Methotrexate and the Selective Accumulation of Intracellular Aminoimidazolecarboxamide Ribotide

    Ryan S. Funk1, Leon van Haandel1, Mara L Becker2 and J.S. Leeder1, 1Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, 2Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO

    Background/Purpose:   Current evidence suggests that the anti-folate methotrexate (MTX) mediates its anti-inflammatory effects through inhibition of the purine synthesis pathway causing the accumulation of…
  • Abstract Number: 732 • 2012 ACR/ARHP Annual Meeting

    Changes in Subchondral Bone Provide a Sensitive Marker for Osteoarthritis and Its Progression: Results From a Large Osteoarthritis Initiative Cohort

    Michael A. Bowes1, Christopher B. Wolstenholme1, Devan Hopkinson1, Graham R. Vincent1 and Philip G. Conaghan2, 1Imorphics Ltd, Manchester, United Kingdom, 2University of Leeds, Leeds, United Kingdom

    Background/Purpose: Change in subchondral bone has been clinically associated with progression of osteoarthritis (OA). Modern image analysis techniques allow accurate, automated identification of bone in…
  • Abstract Number: 317 • 2012 ACR/ARHP Annual Meeting

    Fatty Acid Profiling: Potential New Biomarkers in Juvenile Idiopathic Arthritis (pilot study)

    Weng Tarng Cham1, Enzo Ranieri2, Janice Fletcher2 and Christina A. Boros3, 1Paediatric Rheumatology, Women's and Children's Hospital, North Adelaide, SA 5006, Australia, 2Chemical Pathology and Molecular Genetics, SA Pathology, North Adelaide, SA 5006, Australia, 3Paediatrics, University of Adelaide/Women's and Children's Hospital, Adelaide, Australia

    Background/Purpose: The prostanoids are a family of biologically active lipids derived from the 20-carbon essential fatty acids (LCPUFA) all of which are involved in the…
  • Abstract Number: 2581 • 2012 ACR/ARHP Annual Meeting

    Anti- Citrullinated Protein Antibodies but Not Rheumatoid Factor Are Associated with Larger Bone Erosions in rheumatoid arthritis patients- a Cross-Sectional Micro Computed Tomography Study

    Carolin Hecht1, Stephanie Finzel1, Matthias Englbrecht1, Sarah Schmidt1, Juergen Rech2, Elizabeth Araujo1 and Georg Schett1, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Anti- citrullinated protein antibodies (ACPA) are known to be associated with joint destruction and a more severe disease course in rheumatoid arthritis (RA) patients.…
  • Abstract Number: 1938 • 2012 ACR/ARHP Annual Meeting

    A New Enzyme-Linked Immunosorbent Assay System for Detecting Autoantibodies to Aminoacyl-tRNA Synthetases: Clinical Usefulness in Myositis and Interstitial Pneumonia

    Ran Nakashima1, Yoshitaka Imura2, Minae Seto3, Akihiro Murakami3, Yuji Hosono4, Kizuku Watanabe5, Tomohiro Handa5, Michiaki Mishima5, Michito Hirakata6, Tsutomu Takeuchi7, Keishi Fujio8, Kazuhiko Yamamoto9, Hitoshi Kohsaka10, Yoshinari Takasaki11, Noriyuki Enomoto12, Kingo Chida12, Toshihiro Nukiwa13 and Tsuneyo Mimori1, 1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3Medical & Biological Laboratories Co., Ltd., Ina, Japan, 4Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 5Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Kyoto, Japan, 6Internal Medicine, Keio University, Tokyo, Japan, 7Keio University School of Medicine, Tokyo, Japan, 8Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan, 9Department of Allergy & Rheumatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, 10Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, 11Division of Rheumatology, Department of Internal Medicine, Juntendo University, Tokyo, Japan, 12Hamamatsu University School of Medicine, Hamamatsu, Japan, 13Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

    Background/Purpose: Autoantibodies to aminoacyl-tRNA synthetases (ARS) are the most frequent myositis-specific antibodies and they are useful in the diagnosis and management of polymyositis (PM)/ dermatomyositis…
  • Abstract Number: 1122 • 2012 ACR/ARHP Annual Meeting

    Identifying Radiographic Phenotypes of Early Knee Osteoarthritis Using Separate Quantitative Features Might Improve Patient Selection for More Targeted Treatment

    Margot B. Kinds1, Anne C. A. Marijnissen1, Max A. Viergever2, P.J. Emans3, J.W.J. Bijlsma1, F.P.J.G. Lafeber1 and P.M.J. Welsing4, 1Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 3Orthopaedic Surgery, Maastricht University Medical Center, Maastricht, Netherlands, 4Rheumatology & Clinical Immunology, F02.127, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease characterized by pain and functional disability. The expression of OA varies significantly between individuals and over time,…
  • Abstract Number: 710 • 2012 ACR/ARHP Annual Meeting

    Optical Density Measure of the Papillary Dermis Discriminates As Abnormal Clinically Uninvolved Skin in Systemic Sclerosis and Correlates with Severity of Skin Thickness

    Giuseppina Abignano1, Sibel Z. Aydin2, Concepcion Castillo-Gallego3, Daniel Woods4, Adam Meekings5, Dennis McGonagle6, Paul Emery7 and Francesco Del Galdo8, 1Chapel Allerton Hospital Leeds Insitute of Molecular medicine, Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom, 2Unit of Rheumatology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey, 3Rheumatology, Hospital La Paz - IdiPaz, Madrid, Spain, 4Michelson Diagnostics Ltd, Kent, United Kingdom, 5Michelson Diagnostics Ltd, Kent, United Kingdom, Kent, United Kingdom, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 7Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom, 8Musculoskeletal Diseases, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom

    Background/Purpose: Skin involvement in systemic sclerosis (SSc) is often primary outcome in clinical trials and its severity inversely correlates with prognosis. Nevertheless, an objective quantitative…
  • Abstract Number: 305 • 2012 ACR/ARHP Annual Meeting

    Clinicopathologic Correlates for Activity and Damage of Lupus Nephritis in Childhood-Onset Systemic Lupus Erythematosus

    Ravi Nunna1, Rina Mina1, Michael Bennett2, Shannen Nelson3, Jessica Hummel4, Prasad Devarajan2, David Witte3 and Hermine Brunner5, 1Rheumatology, Cincinnati Children's Hospital Medical Center/University of Cincinnati, Cincinnati, OH, 2Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 3Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, 4Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Cincinnati Children's Hospital, Cincinnati, OH

    Background/Purpose:   High AI activity (AI), tubulointerstitial (TI), and chronicity index (CI) scores from renal biopsy may predict poor renal outcomes in lupus nephritis (LN)…
  • Abstract Number: 2532 • 2012 ACR/ARHP Annual Meeting

    Whole Transcriptome Analysis in Relapsing Polychondritis: A Single-Center Analysis of 35 Patients

    Laurent Arnaud1, Alexis Mathian2, Bruno Faivre3, Karim Dorgham3, Julien Haroche2, Nathalie Costedoat-Chalumeau1, Jean-Charles Piette2, Guy Gorochov4 and Zahir Amoura1, 1Internal Medicine, Hôpital Pitié-Salpêtrière, AP-HP & UPMC Univ Paris 06, Paris, France, 2Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP & UPMC Univ Paris 06, Paris, France, 3Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945, Paris, France, 4Inserm UMRS945, Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945, Paris, France

    Background/Purpose: Relapsing polychondritis (RP) is a severe and episodic inflammatory condition involving cartilaginous structures, predominantly those of the ears, nose, and laryngotracheobronchial tree. Other affected…
  • Abstract Number: 1794 • 2012 ACR/ARHP Annual Meeting

    Matrix Metalloproteinase 3 and Acute Phase Proteins As Markers of Disease Activity and Radiographic Damage in Early Rheumatoid Arthritis

    Mahmood MTM Ally1, Bridget Hodkinson2, Pieter W.A Meyer1, Eustasius Musenge3, Mohammed Tikly4 and Ronald Anderson1, 1University of Pretoria, Pretoria, South Africa, 2Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, 3University of Witwatersrand, Johannesburg, South Africa, 4Rheumatology, Division of Rheumatology, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: Although matrix metalloproteinase-3 (MMP-3) is believed to be intimately involved in the immunopathogenesis of rheumatoid arthritis (RA), relatively little is known about its relationships…
  • Abstract Number: 1102 • 2012 ACR/ARHP Annual Meeting

    Immunoreactive Collagen Type II Cleavage Products and Their Nitrated Forms in Rheumatoid Arthritis and Osteoarthritis: An Outpatient Cross-Sectional Study

    Ruediger Mueller1, Axel Finckh2, Guy Heynen3 and Johannes von Kempis4, 1Division of Rheumatology, Cantonal Hospital, St. Gallen, Switzerland, 2Rheumatology, Geneva University Hospitals, Geneva 14, Switzerland, 3Consulting, CH-6300 Zug, Switzerland, 4Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland

    Background/Purpose: Catabolism of type II collagen (COLII) involves multiple metalloproteinases, aggrecanases and cathepsin, releasing heterogeneous triple helix cleavage products. The complex regulation of these enzymes and of inducible…
  • Abstract Number: 676 • 2012 ACR/ARHP Annual Meeting

    A Novel Biomarker: Nucleotide-Binding Oligomerization Domain 27 in Systemic Lupus Erythematosus

    Annika Cutinha1, Yangsheng Yu2, Kaihong Su2, James R. O'Dell1, Lynell W. Klassen3, Amy C. Cannella4, Ted R. Mikuls5, Alan R. Erickson6, Gerald F. Moore7 and Michelene Hearth-Holmes8, 1Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 3Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 4Divison of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 6Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 7Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 8Internal Medicine/Rheumatology Division, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease in which a variety of autoantibodies contribute to the diversified disease phenotypes. In our previous…
  • Abstract Number: 308 • 2012 ACR/ARHP Annual Meeting

    Next-Generation Sequencing of Urinary Microrna in Human Lupus Nephritis

    Beatrice Goilav1, Iddo Z. Ben-Dov2, Irene Blanco3, Olivier Loudig4, Dawn M. Wahezi5 and Chaim Putterman6, 1Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, 2Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY, 3Rheumatology, Albert Einstein College of Medicine, Bronx, NY, 4Epidemiology, Albert Einstein College of Medicine, Bronx, NY, 5Pediatric Rheumatology, Children's Hospital Montefiore, Bronx, NY, 6Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Lupus nephritis (LN) is a common manifestation of SLE associated with significant morbidity and mortality. microRNAs (miRs) are small non-coding RNAs that regulate translation…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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