Abstracts tagged "Biomarkers"

Abstract Number: 1257 • 2012 ACR/ARHP Annual Meeting
Subclinical Atherosclerosis in Hispanic Patients with Rheumatoid Arthritis. Correlation with the Presence of Anti-Oxidized LDL Antibodies and Serum Levels of CD40L
Yurilis Fuentes-Silva¹, Soham Al Snih², Natali Serra-Bonett¹, Juan De Sanctis³ and Martin A. Rodriguez⁴, ¹Rheumatology, Centro Nacional de Enfermedades Reumáticas, Caracas, Venezuela, ²Division of Rehabilitation Sciences, Division of Geriatrics. Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX, ³Immunology, Instituto de Inmunología, Caracas, Venezuela, ⁴Centro Nacional de Enfermedades Reumáticas, Hospital Universitario de Caracas, Caracas, Venezuela
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease, associated with an excess of cardiovascular morbidity and mortality due to accelerated atherosclerosis. The appearance of…
Abstract Number: 774 • 2012 ACR/ARHP Annual Meeting
A CD4+ T-Cell Gene Expression Signature Predicts Drug Survival On Methotrexate Monotherapy in Early Rheumatoid Arthritis
Arthur G. Pratt¹, Philip M. Brown², Simon J. Cockell³, Gillian Wilson⁴ and John D. Isaacs¹, ¹Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ²Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom, ³Bioinformatics Unit, Newcastle University, Newcastle-upon-Tyne, United Kingdom, ⁴Directorate of Musculoskeletal Medicine, Freeman Hospital, Newcastle-upon-Tyne, United Kingdom
Background/Purpose: The mechanism of action of methotrexate (MTX) in the management of rheumatoid arthritis (RA) remains incompletely understood. It is nonetheless capable of inducing clinical…
Abstract Number: 407 • 2012 ACR/ARHP Annual Meeting
The I50V IL4R SNP Is Associated with Increased Th17 Cell Frequency and Poor Clinical Outcome in Rheumatoid Arthritis
Jan Leipe¹, Iryna Prots², Markus A. Schramm¹, Matthias Witt¹, Axel P. Nigg¹, Christiane S. Reindl¹, Claudia Dechant¹, Mathias Grunke¹, Hendrik Schulze-Koops¹ and Alla Skapenko³, ¹Division of Rheumatology and Clinical Immunology, Med. Klinik und Poliklinik IV, University of Munich, Munich, Germany, ²Friedrich-Alexander-University Erlangen-Nürnberg, Junior Research Group III, Interdisciplinary Center for Clinical Research Nikolaus-Fiebiger Center for Molecular Medicine, Erlangen, ³Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: A single nucleotide polymorphism (SNP) in the IL4R gene (I50V, rs 1805010) has previously been associated with an aggressive destructive course of rheumatoid arthritis…
Abstract Number: 2616 • 2012 ACR/ARHP Annual Meeting
The Transition From Psoriasis (Ps) to Psoriatic Arthritis (PsA) Is Associated with Elevated Circulating Osteoclast Precursors (OCP) and Increased Expression of DC-STAMP
Ya-Hui Chiu¹, Edward M. Schwarz², Dafna D. Gladman³, Sharon Moorehead⁴, Michelle Smith⁴, Rick Barrett⁴ and Christopher T. Ritchlin⁴, ¹Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ²Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ³Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY
Background/Purpose: Approximately 20% of psoriasis (Ps) patients (pts) develop psoriatic arthritis (PsA). Early diagnosis and therapy of PsA can limit bone and joint damage; however,…
Abstract Number: 2167 • 2012 ACR/ARHP Annual Meeting
Serum Based Biomarkers of Joint Destruction Can Identify Responders and Non-Responder to Tocilizumab
Anne C. Bay-Jensen¹, Inger Byrjalsen², Claus Christiansen³ and Morten Asser Karsdal⁴, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Research & Development, Nordic Bioscience, Herlev, Denmark, ³CCBR, Ballerup, Denmark, ⁴Nordic Bioscience A/S, Herlev, Denmark
Background/Purpose: RA is characterized by synovial inflammation, cartilage loss and erosion of subchondral bone. It is critical to diagnose and effectively treat the disease early…
Abstract Number: 1263 • 2012 ACR/ARHP Annual Meeting
Carotid Arterial Wall Inflammation Is Associated with a Specific Profile of Inflammatory Biomarkers and Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Patients
Caroline Grönwall¹, Gregg J. Silverman¹, Zahi Fayad², Venkatesh Mani², Victoria Furer³, Michael Farkouh², Manish Jain¹, Cheongeun Oh⁴, John Todd⁵, Mukundan Attur⁶, Steven B. Abramson⁷ and Jeffrey D. Greenberg⁸, ¹Rheumatology, NYU School of Medicine, New York, NY, ²Mount Sinai Hospital, New York, NY, ³Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, ⁴Biostatistics, NYU School of Medicine, New York, NY, ⁵Singulex, Alameda, California, Alameda, CA, ⁶Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York, NY, ⁷Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, ⁸New York Hospital for Joint Disease, New York, NY
Background/Purpose: Patients with RA are at increased risk of cardiovascular (CV) comorbidity and premature mortality. While generally attributed to accelerated atherosclerosis, the pathogenesis remains poorly understood.…
Abstract Number: 755 • 2012 ACR/ARHP Annual Meeting
Sifalimumab, an Anti-IFN-Alpha Monoclonal Antibody Shows Target Suppression of a Type I IFN Signature in Blood and Muscle of Dermatomyositis and Polymyositis Patients
Brandon W. Higgs¹, Wei Zhu², Chris Morehouse¹, Wendy White³, Philip Brohawn¹, Charles Le⁴, Anthony A Amato⁵, David Fiorentino⁶, Steven A. Greenberg⁵, Laura Richman¹, Warren Greth⁴, Bahija Jallal¹ and Yihong Yao³, ¹Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ²Translational Science, MedImmune, LLC, Gaithersburg, MD, ³Translational Sciences, MedImmune, Gaithersburg, MD, ⁴Clinical Development, MedImmune, LLC, Gaithersburg, MD, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Dermatology, Stanford University School of Medicine, Redwood City, CA
Background/Purpose: To assess the pharmacodynamic effects of sifalimumab, an investigational anti-IFN-alpha monoclonal antibody, in the blood and muscle of adult dermatomyositis and polymyositis patients by…
Abstract Number: 333 • 2012 ACR/ARHP Annual Meeting
Pressure and Blood Flow Measurements in Efferent Lymphatics As Biomarkers of Arthritic Flare
Echoe M. Bouta¹, Ronald Wood², Christopher T. Ritchlin³, Lianping Xing⁴ and Edward M. Schwarz⁵, ¹University of Rochester, Rochester, NY, ²Department of Urology, University of Rochester School of Medicine and Dentistry, Rochester, NY, ³Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁴Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁵Center for Musculoskeletal Research, University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease with episodic flares in affected joints. These flares are associated with decreased lymphatic drainage. In TNF-Tg mice,…
Abstract Number: 2593 • 2012 ACR/ARHP Annual Meeting
Predictive Markers of Therapeutical Outcome and Their Role in the Ethiopathology of Juvenile Idiopathic Arthritis
Maura Rossetti¹, Roberto Spreafico¹, Hong Zhang¹, Maryam Moshref¹, Nora G. Singer², D. J. Lovell³, Carol A. Wallace⁴ and Salvatore Albani⁵, ¹Translational Immunology, Sanford-Burnham Medical Research Institute, La Jolla, CA, ²Rheumatology, MetroHealth Medical Center, Cleveland, OH, ³Cincinnati Children's Hospital, Cincinnati, OH, ⁴Pediatrics, Seattle Childrens Hospital, Seattle, WA, ⁵Translational Research Program, Infectious and Inflammatory Diseases, Sanford-Burnham Medical Research Institute, La Jolla, CA
Background/Purpose: Currently, juvenile idiopathic arthritis (JIA) is treated with methotrexate (MTX) as a first-line agent. If children fail to respond, a biologic (e.g. anti-TNF) is…
Abstract Number: 2121 • 2012 ACR/ARHP Annual Meeting
A Multi-Biomarker Disease Activity (VECTRA™ DA Algorithm) Score Reflects Clinical Disease Activity and Structural Changes in Rheumatoid Arthritis Patients Treated with Tocilizumab
Yoshiya Tanaka¹, Kentaro Hanami², Hisashi Tasaka¹, Shunsuke Fukuyo¹, Douglas J. Haney³, Nadine Defranoux³, Rebecca Bolce³, Guy Cavet³, David Chernoff³, Kunihiro Yamaoka¹, Kazuyoshi Saito¹ and Shintaro Hirata¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicinei, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³Crescendo Bioscience Inc., South San Francisco, CA
Background/Purpose: The multi-biomarker disease activity (MBDA) score assessed with 0.2 mL serum has been reported as a novel composite disease activity index for patients with…
Abstract Number: 1203 • 2012 ACR/ARHP Annual Meeting
High Expression of Genes in the Toll-Like Receptor and Interferon Pathways Are Associated with Radiographic Damage in African-Americans with ACPA-Positive RA
Maria I. Danila¹, A. D. Steg², Xiangqin Cui³, David Redden⁴, M. R. Johnson², Richard J. Reynolds⁵, D. van der Heijde⁶, Doyt L. Conn⁷, Beth L. Jonas⁸, Leigh F. Callahan⁹, Larry W. Moreland¹⁰, P. K. Gregersen¹¹ and S. Louis Bridges Jr.¹², ¹Med/Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, ³Biostatistics, University of Alabama at Birmingham, ⁴Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁵Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁷Rheumatology, Emory Univ School of Medicine, Atlanta, GA, ⁸Thurston Arthritis Research Ct, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁹Thurston Arthritis Res Ctr, University of North Carolina, Chapel Hill, NC, ¹⁰Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹¹Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY, ¹²Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The clinical phenotype of rheumatoid arthritis (RA) ranges from mild joint inflammation to severe joint destruction, but molecular factors responsible for variability are incompletely…
Abstract Number: 751 • 2012 ACR/ARHP Annual Meeting
Whole Transcriptome Analysis in Erdheim-Chester Disease: A Multicenter Collaborative Study of 58 Patients
Laurent Arnaud¹, Julien Haroche², Lorenzo Dagna³, Augusto Vaglio⁴, Bruno Faivre⁵, Karim Dorgham⁵, Baptiste Hervier⁶, Fleur Cohen-Aubart⁷, Guy Gorochov⁸ and Zahir Amoura¹, ¹Internal Medicine, Hopital Pitié-Salpêtrière, AP-HP & UPMC Univ Paris 06, Paris, France, ²Department of Internal Medicine 2. Referal center for SLE/APS, Hopital Pitié-Salpêtrière, AP-HP & UPMC Univ Paris 06, Paris, France, ³Vita-Salute San Raffaele University, Milan, Italy, ⁴Unit of Nephrology, University Hospital of Parma, Parma, Italy, ⁵Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945, Paris, France, ⁶Internal Medicine I & II, Hopital Pitié-Salpêtrière, AP-HP & UPMC Univ Paris 06, Paris, France, ⁷Internal Medicine Dpt 2, Pitié-Salpêtrière Hospital, APHP, Paris, France, ⁸Inserm UMRS945, Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945, Paris, France
Background/Purpose: To date, gene expression profiling has not been performed in Erdheim-Chester disease (ECD), a rare, non-Langerhans form of histiocytosis. The aim of this study…
Abstract Number: 312 • 2012 ACR/ARHP Annual Meeting
Blood-Based Biomarkers of Neurocognitive Dysfunction in Childhood-Onset Systemic Lupus Erythematosus
Hermine Brunner¹, Jessica Hummel², Shannen Nelson³, Erin C. Thomas⁴, Jennifer L. Huggins¹, Megan L. Curran⁵, Jun Ying⁶ and Marisa S. Klein-Gitelman⁷, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ⁴Division of Rheumatology, Anne & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Medicine-Internal Medicine-General Medicine, University of Cincinnati, Cincinnati, OH, ⁷Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
Background/Purpose: Several brain-reactive autoantibodies in the blood have been inconsistently associated with Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) in adults but very little is known whether…
Abstract Number: 2699 • 2012 ACR/ARHP Annual Meeting
Psychosocial Stress and Complement Activation Product C4d On Reticulocytes in Patients with Systemic Lupus Erythematosus
Xiaotian Chen¹, Yu Cheng², Chau Ching Liu³, Amy H. Kao⁴, Susan Manzi⁵, Joseph M. Ahearn⁶ and Carol M. Greco⁷, ¹Biostatistics, University of Pittsburgh, Pittsburgh, PA, ²Biostatistics and Psychiatry, University of Pittsburgh, Pittsburgh, PA, ³Allegheny Singer Research Institute, Pittsburgh, PA, ⁴Lupus Center of Excellence, Allegheny Singer Research Institute, Pittsburgh, PA, ⁵Division of Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁶Lupus Center of Excellence, West Penn Allegheny Health System, Pittsburgh, PA, ⁷Center for Integrative Med, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Although patients with SLE may report that psychosocial stress is linked with disease flares, research results on stress-disease activity associations are mixed. The lack…
Abstract Number: 2597 • 2012 ACR/ARHP Annual Meeting
Degree of Initial Intracellular Folate Depletion May Predict Methotrexate Response in Juvenile Idiopathic Arthritis
Leon van Haandel¹, Ryan S. Funk¹, Maria F. Ibarra², Mark F. Hoeltzel³, Andrew Lasky⁴, Daisy Dai⁵, Rodger Gaedigk¹, J. Steven Leeder⁶ and Mara L Becker⁵, ¹Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, ²Pediatric Rheumatolgy, Children's Mercy Hospital, Kansas City, MO, ³Rheumatology Section, Children's Mercy Hospital, Kansas City, MO, ⁴Pediatrics Rheumatology, Children's Mercy Hospital, Kansas City, MO, ⁵Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO, ⁶Individualized medicine, Children's Mercy Hospital, Kansas City, MO
Background/Purpose: Despite widespread use, there are no predictors of methotrexate (MTX) response or toxicity. The objective of this study is to test the hypothesis that…

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