Abstracts tagged "Biomarkers"

Abstract Number: 1938 • 2012 ACR/ARHP Annual Meeting
A New Enzyme-Linked Immunosorbent Assay System for Detecting Autoantibodies to Aminoacyl-tRNA Synthetases: Clinical Usefulness in Myositis and Interstitial Pneumonia
Ran Nakashima¹, Yoshitaka Imura², Minae Seto³, Akihiro Murakami³, Yuji Hosono⁴, Kizuku Watanabe⁵, Tomohiro Handa⁵, Michiaki Mishima⁵, Michito Hirakata⁶, Tsutomu Takeuchi⁷, Keishi Fujio⁸, Kazuhiko Yamamoto⁹, Hitoshi Kohsaka¹⁰, Yoshinari Takasaki¹¹, Noriyuki Enomoto¹², Kingo Chida¹², Toshihiro Nukiwa¹³ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Medical & Biological Laboratories Co., Ltd., Ina, Japan, ⁴Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁵Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Kyoto, Japan, ⁶Internal Medicine, Keio University, Tokyo, Japan, ⁷Keio University School of Medicine, Tokyo, Japan, ⁸Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan, ⁹Department of Allergy & Rheumatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, ¹⁰Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ¹¹Division of Rheumatology, Department of Internal Medicine, Juntendo University, Tokyo, Japan, ¹²Hamamatsu University School of Medicine, Hamamatsu, Japan, ¹³Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Background/Purpose: Autoantibodies to aminoacyl-tRNA synthetases (ARS) are the most frequent myositis-specific antibodies and they are useful in the diagnosis and management of polymyositis (PM)/ dermatomyositis…
Abstract Number: 1122 • 2012 ACR/ARHP Annual Meeting
Identifying Radiographic Phenotypes of Early Knee Osteoarthritis Using Separate Quantitative Features Might Improve Patient Selection for More Targeted Treatment
Margot B. Kinds¹, Anne C. A. Marijnissen¹, Max A. Viergever², P.J. Emans³, J.W.J. Bijlsma¹, F.P.J.G. Lafeber¹ and P.M.J. Welsing⁴, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, ³Orthopaedic Surgery, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Rheumatology & Clinical Immunology, F02.127, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease characterized by pain and functional disability. The expression of OA varies significantly between individuals and over time,…
Abstract Number: 710 • 2012 ACR/ARHP Annual Meeting
Optical Density Measure of the Papillary Dermis Discriminates As Abnormal Clinically Uninvolved Skin in Systemic Sclerosis and Correlates with Severity of Skin Thickness
Giuseppina Abignano¹, Sibel Z. Aydin², Concepcion Castillo-Gallego³, Daniel Woods⁴, Adam Meekings⁵, Dennis McGonagle⁶, Paul Emery⁷ and Francesco Del Galdo⁸, ¹Chapel Allerton Hospital Leeds Insitute of Molecular medicine, Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom, ²Unit of Rheumatology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey, ³Rheumatology, Hospital La Paz - IdiPaz, Madrid, Spain, ⁴Michelson Diagnostics Ltd, Kent, United Kingdom, ⁵Michelson Diagnostics Ltd, Kent, United Kingdom, Kent, United Kingdom, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁷Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom, ⁸Musculoskeletal Diseases, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom
Background/Purpose: Skin involvement in systemic sclerosis (SSc) is often primary outcome in clinical trials and its severity inversely correlates with prognosis. Nevertheless, an objective quantitative…
Abstract Number: 305 • 2012 ACR/ARHP Annual Meeting
Clinicopathologic Correlates for Activity and Damage of Lupus Nephritis in Childhood-Onset Systemic Lupus Erythematosus
Ravi Nunna¹, Rina Mina¹, Michael Bennett², Shannen Nelson³, Jessica Hummel⁴, Prasad Devarajan², David Witte³ and Hermine Brunner⁵, ¹Rheumatology, Cincinnati Children's Hospital Medical Center/University of Cincinnati, Cincinnati, OH, ²Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ⁴Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Cincinnati Children's Hospital, Cincinnati, OH
Background/Purpose: High AI activity (AI), tubulointerstitial (TI), and chronicity index (CI) scores from renal biopsy may predict poor renal outcomes in lupus nephritis (LN)…
Abstract Number: 2532 • 2012 ACR/ARHP Annual Meeting
Whole Transcriptome Analysis in Relapsing Polychondritis: A Single-Center Analysis of 35 Patients
Laurent Arnaud¹, Alexis Mathian², Bruno Faivre³, Karim Dorgham³, Julien Haroche², Nathalie Costedoat-Chalumeau¹, Jean-Charles Piette², Guy Gorochov⁴ and Zahir Amoura¹, ¹Internal Medicine, Hôpital Pitié-Salpêtrière, AP-HP & UPMC Univ Paris 06, Paris, France, ²Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP & UPMC Univ Paris 06, Paris, France, ³Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945, Paris, France, ⁴Inserm UMRS945, Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945, Paris, France
Background/Purpose: Relapsing polychondritis (RP) is a severe and episodic inflammatory condition involving cartilaginous structures, predominantly those of the ears, nose, and laryngotracheobronchial tree. Other affected…
Abstract Number: 1794 • 2012 ACR/ARHP Annual Meeting
Matrix Metalloproteinase 3 and Acute Phase Proteins As Markers of Disease Activity and Radiographic Damage in Early Rheumatoid Arthritis
Mahmood MTM Ally¹, Bridget Hodkinson², Pieter W.A Meyer¹, Eustasius Musenge³, Mohammed Tikly⁴ and Ronald Anderson¹, ¹University of Pretoria, Pretoria, South Africa, ²Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, ³University of Witwatersrand, Johannesburg, South Africa, ⁴Rheumatology, Division of Rheumatology, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Although matrix metalloproteinase-3 (MMP-3) is believed to be intimately involved in the immunopathogenesis of rheumatoid arthritis (RA), relatively little is known about its relationships…
Abstract Number: 1102 • 2012 ACR/ARHP Annual Meeting
Immunoreactive Collagen Type II Cleavage Products and Their Nitrated Forms in Rheumatoid Arthritis and Osteoarthritis: An Outpatient Cross-Sectional Study
Ruediger Mueller¹, Axel Finckh², Guy Heynen³ and Johannes von Kempis⁴, ¹Division of Rheumatology, Cantonal Hospital, St. Gallen, Switzerland, ²Rheumatology, Geneva University Hospitals, Geneva 14, Switzerland, ³Consulting, CH-6300 Zug, Switzerland, ⁴Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland
Background/Purpose: Catabolism of type II collagen (COLII) involves multiple metalloproteinases, aggrecanases and cathepsin, releasing heterogeneous triple helix cleavage products. The complex regulation of these enzymes and of inducible…
Abstract Number: 676 • 2012 ACR/ARHP Annual Meeting
A Novel Biomarker: Nucleotide-Binding Oligomerization Domain 27 in Systemic Lupus Erythematosus
Annika Cutinha¹, Yangsheng Yu², Kaihong Su², James R. O'Dell¹, Lynell W. Klassen³, Amy C. Cannella⁴, Ted R. Mikuls⁵, Alan R. Erickson⁶, Gerald F. Moore⁷ and Michelene Hearth-Holmes⁸, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ³Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴Divison of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁶Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁸Internal Medicine/Rheumatology Division, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease in which a variety of autoantibodies contribute to the diversified disease phenotypes. In our previous…
Abstract Number: 308 • 2012 ACR/ARHP Annual Meeting
Next-Generation Sequencing of Urinary Microrna in Human Lupus Nephritis
Beatrice Goilav¹, Iddo Z. Ben-Dov², Irene Blanco³, Olivier Loudig⁴, Dawn M. Wahezi⁵ and Chaim Putterman⁶, ¹Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ²Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY, ³Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁴Epidemiology, Albert Einstein College of Medicine, Bronx, NY, ⁵Pediatric Rheumatology, Children's Hospital Montefiore, Bronx, NY, ⁶Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Lupus nephritis (LN) is a common manifestation of SLE associated with significant morbidity and mortality. microRNAs (miRs) are small non-coding RNAs that regulate translation…
Abstract Number: 2498 • 2012 ACR/ARHP Annual Meeting
Biomarkers of Mitochondrial Dysfunction Correlate with Disease Activity in SLE
Zhi-Wei Lai¹, Tiffany Telarico², Robert Hanczko¹, Adam Bartos¹, Lisa Francis³, Hajra I. Tily⁴, Ricardo Garcia¹, Maha M. Dawood⁵, Jianghong Yu⁶, Ashwini Shadakshari⁶, Paul E. Phillips⁷ and Andras Perl⁸, ¹Medicine, SUNY, Syracuse, NY, ²Medicine, SUNY Upstate Medical University, Syracuse, NY, ³Medicine/Rheumatology, SUNY upstate medical university, Syracuse, NY, ⁴SUNY, NY, ⁵Medicine/Rheumatology, SUNY Upstate, Syracuse, NY, ⁶Medicine/Rheumatology, SUNY Upstate Medical University, Syracuse, NY, ⁷Dept of Medicine/Div of Rheum, SUNY-Upstate Medical Univ, Syracuse, NY, ⁸Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Systemic lupus erythematosus (SLE) patients’ T cells exhibit mitochondrial dysfunction, characterized by the persistent elevation of the mitochondrial transmembrane potential (Δψm) or mitochondrial hyperpolarization…
Abstract Number: 1707 • 2012 ACR/ARHP Annual Meeting
The Association of Serum Biomarkers and Metabolic Syndrome with Subclinical Atherosclerosis in Systemic Lupus Erythematosus: A Controlled Analysis in Patients with No Clinical Disease Activity
Semra Ertan-Demir¹, Ahmet Yasar Cizgici², Gaye Erten³, Bahar Artim-Esen⁴, Yasemin Sahinkaya⁴, Özlem Pehlivan⁴, Nilüfer Alpay-Kanitez⁴, Kadri Atay¹, Huseyin Oflaz², Gunnur Deniz³ and Murat Inanc⁴, ¹Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Cardiology Department, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ³Department of Immunology, Istanbul University, Institute of Experimental Medicine (DETAE), Istanbul, Turkey, ⁴Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing atherosclerotic cardiovascular disease (CVD). In addition to traditional CVD risk factors or…
Abstract Number: 1078 • 2012 ACR/ARHP Annual Meeting
Prolactin Is Increased in Responders to Anti-TNFá Treatment and the Role of the Prolactin Receptor in Rheumatoid Arthritis
Man Wai Tang¹, Danielle Marie Gerlag², Veronica Codullo³, Elsa Vieira-Sousa⁴, Anne Q. Reuwer⁵, Marcel T. Twickler⁵, Robert B. M. Landewé⁶ and Paul Peter Tak⁷, ¹Division of Clinical Immunology and Rheumatology & Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, Netherlands, ³Rheumatology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, ⁴Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ⁵Vascular Medicine, Academic Medical Center/University of Amsterdam, Amsterddam, Netherlands, ⁶Academic Medical Center/University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ⁷Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is the most common rheumatic disease which mainly affects women. In the last decade, it is known that prolactin (PRL) is…
Abstract Number: 680 • 2012 ACR/ARHP Annual Meeting
Plasma Level of Galectin-3 Binding Protein Reflects Type I Interferon Activity and Is Highly Increased in Patients with Systemic Lupus Erythematosus
Christoffer T. Nielsen¹, Ole Østergaard², Line V. Iversen³, Christian Lood⁴, Anders A. Bengtsson⁴, Anne Voss⁵, Søren Jacobsen⁶ and Niels H. H. Heegaard³, ¹Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen S, Denmark, ²Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institute, Copenhagen S, Denmark, ³Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁴Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, ⁵Dept of Rheumatology, Odense University Hospital, Odense C, Denmark, ⁶Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Background/Purpose: Ongoing production of type I interferons (IFN) is a key element in the pathogenesis of systemic lupus erythematosus (SLE). Type I IFNs trigger the…
Abstract Number: 256 • 2012 ACR/ARHP Annual Meeting
Strontium Ranelate Decreases the Level of Urinary CTX-II in Patients with Knee Osteoarthritis
Julien Collette¹, Olivier Bruyere² and Jean-Yves Reginster³, ¹University of Liege, Labo Ria Chu Sart Tilman, Liege, Belgium, ²Public Health/Epidemiology, University of Liege, Liege, Belgium, ³Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium
Background/Purpose: Knee osteoarthritis is a chronic disease affecting the global joint and characterized by cartilage degradation as well as subchondral bone remodelling. Effects of strontium…
Abstract Number: 2500 • 2012 ACR/ARHP Annual Meeting
Podocyte Injury in Membranous and Proliferative Lupus Nephritis: Distinct Underlying Mechanisms?
Gabriela M. Rezende¹, Vilma S. T. Viana¹, Denise M. Malheiros², Elaine P. Leon³, Eduardo F. Borba¹, Neila AS Silva², Irene L. Noronha⁴, Cleonice Silva⁴ and Eloisa Bonfá⁵, ¹Internal Medicine, Division of Rheumatology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Division of AnatomoPathology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Internal Medicine, Division of Nephrology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Division of Rheumatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Lupus nephritis (LN) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE) with proteinuria being the predominant common…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].