Abstracts tagged "Biomarkers"

Abstract Number: 676 • 2012 ACR/ARHP Annual Meeting
A Novel Biomarker: Nucleotide-Binding Oligomerization Domain 27 in Systemic Lupus Erythematosus
Annika Cutinha¹, Yangsheng Yu², Kaihong Su², James R. O'Dell¹, Lynell W. Klassen³, Amy C. Cannella⁴, Ted R. Mikuls⁵, Alan R. Erickson⁶, Gerald F. Moore⁷ and Michelene Hearth-Holmes⁸, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ³Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴Divison of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁶Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁸Internal Medicine/Rheumatology Division, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease in which a variety of autoantibodies contribute to the diversified disease phenotypes. In our previous…
Abstract Number: 308 • 2012 ACR/ARHP Annual Meeting
Next-Generation Sequencing of Urinary Microrna in Human Lupus Nephritis
Beatrice Goilav¹, Iddo Z. Ben-Dov², Irene Blanco³, Olivier Loudig⁴, Dawn M. Wahezi⁵ and Chaim Putterman⁶, ¹Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ²Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY, ³Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁴Epidemiology, Albert Einstein College of Medicine, Bronx, NY, ⁵Pediatric Rheumatology, Children's Hospital Montefiore, Bronx, NY, ⁶Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Lupus nephritis (LN) is a common manifestation of SLE associated with significant morbidity and mortality. microRNAs (miRs) are small non-coding RNAs that regulate translation…
Abstract Number: 2498 • 2012 ACR/ARHP Annual Meeting
Biomarkers of Mitochondrial Dysfunction Correlate with Disease Activity in SLE
Zhi-Wei Lai¹, Tiffany Telarico², Robert Hanczko¹, Adam Bartos¹, Lisa Francis³, Hajra I. Tily⁴, Ricardo Garcia¹, Maha M. Dawood⁵, Jianghong Yu⁶, Ashwini Shadakshari⁶, Paul E. Phillips⁷ and Andras Perl⁸, ¹Medicine, SUNY, Syracuse, NY, ²Medicine, SUNY Upstate Medical University, Syracuse, NY, ³Medicine/Rheumatology, SUNY upstate medical university, Syracuse, NY, ⁴SUNY, NY, ⁵Medicine/Rheumatology, SUNY Upstate, Syracuse, NY, ⁶Medicine/Rheumatology, SUNY Upstate Medical University, Syracuse, NY, ⁷Dept of Medicine/Div of Rheum, SUNY-Upstate Medical Univ, Syracuse, NY, ⁸Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Systemic lupus erythematosus (SLE) patients’ T cells exhibit mitochondrial dysfunction, characterized by the persistent elevation of the mitochondrial transmembrane potential (Δψm) or mitochondrial hyperpolarization…
Abstract Number: 1707 • 2012 ACR/ARHP Annual Meeting
The Association of Serum Biomarkers and Metabolic Syndrome with Subclinical Atherosclerosis in Systemic Lupus Erythematosus: A Controlled Analysis in Patients with No Clinical Disease Activity
Semra Ertan-Demir¹, Ahmet Yasar Cizgici², Gaye Erten³, Bahar Artim-Esen⁴, Yasemin Sahinkaya⁴, Özlem Pehlivan⁴, Nilüfer Alpay-Kanitez⁴, Kadri Atay¹, Huseyin Oflaz², Gunnur Deniz³ and Murat Inanc⁴, ¹Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Cardiology Department, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ³Department of Immunology, Istanbul University, Institute of Experimental Medicine (DETAE), Istanbul, Turkey, ⁴Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing atherosclerotic cardiovascular disease (CVD). In addition to traditional CVD risk factors or…
Abstract Number: 1078 • 2012 ACR/ARHP Annual Meeting
Prolactin Is Increased in Responders to Anti-TNFá Treatment and the Role of the Prolactin Receptor in Rheumatoid Arthritis
Man Wai Tang¹, Danielle Marie Gerlag², Veronica Codullo³, Elsa Vieira-Sousa⁴, Anne Q. Reuwer⁵, Marcel T. Twickler⁵, Robert B. M. Landewé⁶ and Paul Peter Tak⁷, ¹Division of Clinical Immunology and Rheumatology & Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, Netherlands, ³Rheumatology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, ⁴Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ⁵Vascular Medicine, Academic Medical Center/University of Amsterdam, Amsterddam, Netherlands, ⁶Academic Medical Center/University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ⁷Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is the most common rheumatic disease which mainly affects women. In the last decade, it is known that prolactin (PRL) is…
Abstract Number: 680 • 2012 ACR/ARHP Annual Meeting
Plasma Level of Galectin-3 Binding Protein Reflects Type I Interferon Activity and Is Highly Increased in Patients with Systemic Lupus Erythematosus
Christoffer T. Nielsen¹, Ole Østergaard², Line V. Iversen³, Christian Lood⁴, Anders A. Bengtsson⁴, Anne Voss⁵, Søren Jacobsen⁶ and Niels H. H. Heegaard³, ¹Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen S, Denmark, ²Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institute, Copenhagen S, Denmark, ³Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁴Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, ⁵Dept of Rheumatology, Odense University Hospital, Odense C, Denmark, ⁶Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Background/Purpose: Ongoing production of type I interferons (IFN) is a key element in the pathogenesis of systemic lupus erythematosus (SLE). Type I IFNs trigger the…
Abstract Number: 256 • 2012 ACR/ARHP Annual Meeting
Strontium Ranelate Decreases the Level of Urinary CTX-II in Patients with Knee Osteoarthritis
Julien Collette¹, Olivier Bruyere² and Jean-Yves Reginster³, ¹University of Liege, Labo Ria Chu Sart Tilman, Liege, Belgium, ²Public Health/Epidemiology, University of Liege, Liege, Belgium, ³Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium
Background/Purpose: Knee osteoarthritis is a chronic disease affecting the global joint and characterized by cartilage degradation as well as subchondral bone remodelling. Effects of strontium…
Abstract Number: 2500 • 2012 ACR/ARHP Annual Meeting
Podocyte Injury in Membranous and Proliferative Lupus Nephritis: Distinct Underlying Mechanisms?
Gabriela M. Rezende¹, Vilma S. T. Viana¹, Denise M. Malheiros², Elaine P. Leon³, Eduardo F. Borba¹, Neila AS Silva², Irene L. Noronha⁴, Cleonice Silva⁴ and Eloisa Bonfá⁵, ¹Internal Medicine, Division of Rheumatology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Division of AnatomoPathology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Internal Medicine, Division of Nephrology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Division of Rheumatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Lupus nephritis (LN) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE) with proteinuria being the predominant common…
Abstract Number: 1623 • 2012 ACR/ARHP Annual Meeting
Serum Biomarkers Signature Identifies Patients with Overt B-Cell Non-Hodgkin Lymphoma Associated with Mixed Cryoglobulinemia in Chronic HCV Infection
Benjamin Terrier¹, Wahiba Chaara², Guillaume Geri³, David Saadoun⁴, Michelle Rosenzwajg Sr.⁵, Damien Sene Sr.⁶, Adrien Six², David Klatzmann Sr.⁵ and Patrice Cacoub Sr.⁷, ¹Internal Medicine, Cochin University Hospital, Paris, France, ²Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Paris, France, ³Intensive Care Unit, Cochin Hospital, Paris, France, ⁴Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ⁵Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Paris, France, ⁶Department of Internal Medicine; 5 P3S post-genomic plateform, Groupe Hospitalier Pitié-Salpétrière, Université Pierre et Marie Curie, Paris, France, ⁷Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France
Background/Purpose: Hepatitis C virus (HCV) is associated with B-cell disorders, including mixed cryoglobulinemia (MC) and B-cell non-Hodgkin lymphoma (B-NHL). Early diagnosis of B-NHL in HCV-infected…
Abstract Number: 1050 • 2012 ACR/ARHP Annual Meeting
Assessment of Validity of Magnetic Resonance Imaging Measures of Joint Inflammation and Damage in Rheumatoid Arthritis Wrist/Hand – a Systematic Literature Review
TG Woodworth¹, O. Morgacheva², OM Troum³, OL Pimienta⁴, P. Maranian⁵, V.K. Ranganath⁵ and Daniel Furst⁵, ¹Medicine, Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA, ²Medicine/Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles, CA, ³Medicine, USC Keck School of Medicine, Santa Monica, CA, ⁴Keck School of Medicine, University of Southern California, Los Angeles, CA, ⁵Medicine, Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles, CA
Background/Purpose: Limitation of x-ray joint damage is a key indicator of therapeutic efficacy in rheumatoid arthritis (RA). Although magnetic resonance imaging (MRI) is increasingly used…
Abstract Number: 686 • 2012 ACR/ARHP Annual Meeting
Cell-Type Specific Type I Interferon Signatures in Autologous Stem Cell Transplanted Lupus Patients: Different Molecular Behavior Between CD4+ T Cells and Monocytes
Chieko Kyogoku¹, Joachim R. Grün¹, Tobias Alexander², Robert Biesen³, Falk Hiepe⁴, Thomas Häupl³, Andreas Radbruch¹ and Andreas Grützkau¹, ¹German Rheumatism Research Centre Berlin (DRFZ), an institute of the Leibniz Association, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ³department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, ⁴Med. Klinik m. Sp. Rheumatologie und klin. Immunologie, Charité University Hospital Berlin, Berlin, Germany
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that affects multiple organs, whose pathology is mainly caused by the augmented interferon (IFN)…
Abstract Number: 207 • 2012 ACR/ARHP Annual Meeting
Interferon-Driven Chemokines Are Associated with Changes in Disease Activity Among Rituximab-Treated Refractory Myositis Patients with Pulmonary Involvement – the RIM Study
Cynthia S. Crowson¹, Ann M. Reed², Molly Hein³, Abigail B. Green¹, Consuelo Lopez de Padilla⁴, Rohit Aggarwal⁵, Dana P. Ascherman⁶, Marc C. Levesque⁷ and Chester V. Oddis⁸, ¹Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Mayo Clinic, Rochester, MN, ⁴Rheumatology/Immunology Research, Mayo Clinic, Rochester, MN, ⁵Medicine, University of Pittsburgh, Pittsburgh, PA, ⁶Medicine/Rheumatology, University of Miami, Miami, FL, ⁷Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: The Rituximab in Myositis (RIM) Study provides a unique resource for biomarker investigation of homogeneously treated refractory adult and juvenile myositis patients. Building on…
Abstract Number: 2474 • 2012 ACR/ARHP Annual Meeting
Urine Biomarkers Distinguish Between Proliferative and Membranous Lupus Nephritis in Childhood Onset Systemic Lupus Erythematosus
Rina Mina¹, Michael Bennett², Lining Qi³, Shannen Nelson⁴, Jessica Hummel⁵, Pavel Shiyanov³, John Schlager³, Prasad Devarajan² and Hermine Brunner⁶, ¹Rheumatology, Cincinnati Children's Hospital Medical Center/University of Cincinnati, Cincinnati, OH, ²Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³US Air Force Research Lab, Wright-Patterson Air Force Base, OH, ⁴Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ⁵Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Cincinnati Children's Hospital, Cincinnati, OH
Background/Purpose: The ISN/RPS Morphologic Classification of Lupus Nephritis (LN) reports on histological features that differentiate among various forms of LN, most notably between proliferative and…
Abstract Number: 1531 • 2012 ACR/ARHP Annual Meeting
Comparative Proteomic Analysis of Neutrophils Between Microscopic Polyangiitis and Granulomatosis with Polyangiitis
Teisuke Uchida¹, Kouhei Nagai², Toshiyuki Sato², Mitsumi Arito², Nobuko Iizuka², Manae Kurokawa², Naoya Suematsu², Kazuki Okamoto², Shoichi Ozaki³ and Tomohiro Kato⁴, ¹Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine,, Kawasaki, Japan, ²Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan, ³Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁴Clinical Proteomics and Molecular Medicine, St. Mariannna University Graduate School of Medicine., Kawasaki, Japan
Background/Purpose: Both microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) belong to ANCA-associated vasculitis (AAV), in which dysfunction of polymorphonuclear cells (PMN) is thought to…
Abstract Number: 1004 • 2012 ACR/ARHP Annual Meeting
A Unique Single Nucleotide Polymorphism in the 3’ UTR of the MED29 Gene On Chromosome 19 Is Associated with the Clinical Outcome of Different Biologic Response Modifiers
Susanne Drynda¹, David Leesch², Marietta Gloetzner² and Joern Kekow², ¹Clinic of Rheumatology, Univ of Magdeburg, Clinic of Rheumatology, Vogelsang-Gommern, Germany, ²Clinic of Rheumatology, Univ of Magdeburg, Vogelsang-Gommern, Germany
Background/Purpose: Due to the wide range of highly specific and effective biologic response modifiers that are available today for the treatment of RA it has…

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