Abstracts tagged "Biomarkers"

Abstract Number: 1283 • 2013 ACR/ARHP Annual Meeting
Power Doppler Ultrasound Phenotyping of Expanding Versus Collapsed Popliteal Lymph Nodes in Murine Inflammatory Arthritis
Echoe M. Bouta¹, Yawen Ju², Homaira Rahimi³, Ronald Wood⁴, Lianping Xing⁵ and Edward M. Schwarz⁶, ¹University of Rochester, Rochester, NY, ²University of Rochester Medical Center, Rochester, NY, ³Pediatrics, University of Rochester, Rochester, NY, ⁴Department of Urology, University of Rochester Medical Center, Rochester, NY, ⁵Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁶Center for Musculoskeletal Research, University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis is a chronic inflammatory disease manifested by episodic flares in affected joints that are challenging to predict and treat. Longitudinal contrast…
Abstract Number: 307 • 2013 ACR/ARHP Annual Meeting
Abnormal Imaging and Increased Osteoclast Precursors In a Psoriasis Cohort Are Associated with New Onset of Psoriatic Arthritis
Ralf G. Thiele¹, Yahui Grace Chiu¹, Francisco A. Tausk², Bethany A. Marston¹, Gregory Dieudonne³, Vaseem Chengazi³, Michelle Smith¹, Sharon Moorehead¹, Rick Barrett¹ and Christopher T. Ritchlin¹, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Dermatology, University of Rochester, Rochester, NY, ³Radiology, University of Rochester, Rochester, NY
Background/Purpose: Psoriasis (Ps) precedes joint inflammation by about 10 years in patients who develop psoriatic arthritis (PsA). Several studies have documented abnormal musculoskeletal imaging findings…
Abstract Number: 70 • 2013 ACR/ARHP Annual Meeting
Chondrocyte Hypertrophy, Measured By The Secretion Of Collagen Type X, Is Associated With Cartilage Degradation and Systemic Inflammation In Osteoarthritis
Yi He¹, Natasja Stæhr Gudman², Niels Ulrik Hansen¹, Jianxia Wang³, Di Su⁴, Qinlong Zheng⁴, Ole Simonsen⁵, Kristian Kjaer Petersen⁶, Moustapha Kassem⁷, Morten Asser Karsdal² and Anne C. Bay-Jensen⁸, ¹Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Cartilage biology and biomarkers, Nordic Bioscience China, Beijing, China, ⁴Nordic Bioscience China, Beijing, China, ⁵Frederikshavn Hospital, Frederikshavn, Denmark, ⁶Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁷Department of Endocrinology and Metabolism, Odense University Hospital and University of Southern, Odense, Denmark, ⁸Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Osteoarthritis (OA) is the most common degenerative joint disease, of which the pathogenesis is inadequately understood. The hypertrophy-like changes, such as expression of hypertrophy…
Abstract Number: 2288 • 2013 ACR/ARHP Annual Meeting
Novel Biomarkers From Peripheral Blood Mononuclear Cells Indicate Disease Activity In Rheumatoid Arthritis Patients
Jason Ptacek¹, Rachael Hawtin², Brent Louie¹, Erik Evensen¹, James Cordeiro¹, Barbara Mittleman¹, Michelle Atallah¹, Alessandra Cesano², Clifton O. Bingham III³, Stacey Cofield⁴, Jeffrey R. Curtis⁵, Maria I. Danila⁴, Richard A. Furie⁶, MC Genovese⁷, Marc C. Levesque⁸, Larry W. Moreland⁸, Peter A. Nigrovic⁹, James R. O'Dell¹⁰, William H. Robinson¹¹, Nancy A. Shadick⁹, E. William St Clair¹², Christopher C. Striebich¹³, Geoffrey M Thiele¹⁴, Peter K. Gregersen⁶ and S. Louis Bridges Jr.⁴, ¹Nodality, Inc., South San Francisco, CA, ²Nodality Inc., South San Francisco, CA, ³Rheumatology, Johns Hopkins University, Baltimore, MD, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Epidemiology, University of Alabama at Birmingham, School of Public Health, Birmingham, AL, ⁶The Feinstein Institute for Medical Research and North Shore-Long Island Jewish Health System, Lake Success, NY, ⁷Stanford University, Palo Alto, CA, ⁸University of Pittsburgh, Pittsburgh, PA, ⁹Brigham and Women's Hospital/Harvard University, Cambridge, MA, ¹⁰Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ¹¹VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ¹²Medicine, Duke Unversity Medical Center, Durham, NC, ¹³University of Colorado Denver, Aurora, CO, ¹⁴Omaha VA and the University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Biomarkers reflecting immune function and associating with disease activity can help stratify rheumatoid arthritis (RA) patients (pts) in practice and in clinical trials.…
Abstract Number: 1865 • 2013 ACR/ARHP Annual Meeting
Complement Activation and Anaphylatoxin Generation In Response To Staphylococcal Protein A Exposure: Ex Vivo and In Vivo Human Studies
Edward Bernton¹, Antonio Polley², Susan Zondlo², Lynne Mitchell³ and Dennis Hourcade³, ¹Protalex Inc., Summit, NJ, ²QPS Holdings LLC, Newark, DE, ³Division of Rheumatology, Washington University School of Medicine, St. Louis, MO
Background/Purpose: PRTX-100, a highly-purified GMP staphylococcal protein A (SpA), is currently in clinical trials treating patients with active rheumatoid arthritis (RA). It has been reported…
Abstract Number: 1274 • 2013 ACR/ARHP Annual Meeting
Maternal Vitamin D, Fetal C-Reactive Protein and Brain Natriuretic Peptide Associate With The Development and Morbidity Of Cardiac Neonatal Lupus
Amit Saxena¹, Peter M. Izmirly², Joanne H. Reed³, Sara Sahl², Deborah Friedman⁴, Robert M. Clancy³ and Jill P. Buyon², ¹Rheumatology, New York University School of Medicine, New York, NY, ²Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³Medicine, New York University School of Medicine, New York, NY, ⁴Division of Pediatric Cardiology, New York Medical College, Valhalla, NY
Background/Purpose: Women with anti-Ro antibodies face the risk of having a child with cardiac Neonatal Lupus (NL), characterized by congenital heart block and/or cardiomyopathy. Biomarkers…
Abstract Number: 313 • 2013 ACR/ARHP Annual Meeting
The DC-STAMP⁺IL17A⁺ Cell Subset Is Elevated In Psoriatic Arthritis (PsA) Patients and Declines Following Anti-TNFi Therapy
Yahui Grace Chiu¹, Edward M. Schwarz², Hua He³, Francisco A. Tausk⁴, Sharon Moorehead⁵, Michelle Smith⁵ and Christopher T. Ritchlin⁵, ¹Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ²Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ³Biostatistics and Computational Biology, University of Rochester, Rochester, NY, ⁴Dermatology, University of Rochester, Rochester, NY, ⁵Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY
Background/Purpose: Approximately 25% of psoriasis (Ps) patients develop psoriatic arthritis (PsA), a potentially destructive joint disease, within 10 years of Ps onset. Although early diagnosis…
Abstract Number: 2581 • 2012 ACR/ARHP Annual Meeting
Anti- Citrullinated Protein Antibodies but Not Rheumatoid Factor Are Associated with Larger Bone Erosions in rheumatoid arthritis patients- a Cross-Sectional Micro Computed Tomography Study
Carolin Hecht¹, Stephanie Finzel¹, Matthias Englbrecht¹, Sarah Schmidt¹, Juergen Rech², Elizabeth Araujo¹ and Georg Schett¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Anti- citrullinated protein antibodies (ACPA) are known to be associated with joint destruction and a more severe disease course in rheumatoid arthritis (RA) patients.…
Abstract Number: 1938 • 2012 ACR/ARHP Annual Meeting
A New Enzyme-Linked Immunosorbent Assay System for Detecting Autoantibodies to Aminoacyl-tRNA Synthetases: Clinical Usefulness in Myositis and Interstitial Pneumonia
Ran Nakashima¹, Yoshitaka Imura², Minae Seto³, Akihiro Murakami³, Yuji Hosono⁴, Kizuku Watanabe⁵, Tomohiro Handa⁵, Michiaki Mishima⁵, Michito Hirakata⁶, Tsutomu Takeuchi⁷, Keishi Fujio⁸, Kazuhiko Yamamoto⁹, Hitoshi Kohsaka¹⁰, Yoshinari Takasaki¹¹, Noriyuki Enomoto¹², Kingo Chida¹², Toshihiro Nukiwa¹³ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Medical & Biological Laboratories Co., Ltd., Ina, Japan, ⁴Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁵Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Kyoto, Japan, ⁶Internal Medicine, Keio University, Tokyo, Japan, ⁷Keio University School of Medicine, Tokyo, Japan, ⁸Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan, ⁹Department of Allergy & Rheumatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, ¹⁰Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ¹¹Division of Rheumatology, Department of Internal Medicine, Juntendo University, Tokyo, Japan, ¹²Hamamatsu University School of Medicine, Hamamatsu, Japan, ¹³Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Background/Purpose: Autoantibodies to aminoacyl-tRNA synthetases (ARS) are the most frequent myositis-specific antibodies and they are useful in the diagnosis and management of polymyositis (PM)/ dermatomyositis…
Abstract Number: 1122 • 2012 ACR/ARHP Annual Meeting
Identifying Radiographic Phenotypes of Early Knee Osteoarthritis Using Separate Quantitative Features Might Improve Patient Selection for More Targeted Treatment
Margot B. Kinds¹, Anne C. A. Marijnissen¹, Max A. Viergever², P.J. Emans³, J.W.J. Bijlsma¹, F.P.J.G. Lafeber¹ and P.M.J. Welsing⁴, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, ³Orthopaedic Surgery, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Rheumatology & Clinical Immunology, F02.127, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease characterized by pain and functional disability. The expression of OA varies significantly between individuals and over time,…
Abstract Number: 710 • 2012 ACR/ARHP Annual Meeting
Optical Density Measure of the Papillary Dermis Discriminates As Abnormal Clinically Uninvolved Skin in Systemic Sclerosis and Correlates with Severity of Skin Thickness
Giuseppina Abignano¹, Sibel Z. Aydin², Concepcion Castillo-Gallego³, Daniel Woods⁴, Adam Meekings⁵, Dennis McGonagle⁶, Paul Emery⁷ and Francesco Del Galdo⁸, ¹Chapel Allerton Hospital Leeds Insitute of Molecular medicine, Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom, ²Unit of Rheumatology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey, ³Rheumatology, Hospital La Paz - IdiPaz, Madrid, Spain, ⁴Michelson Diagnostics Ltd, Kent, United Kingdom, ⁵Michelson Diagnostics Ltd, Kent, United Kingdom, Kent, United Kingdom, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁷Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom, ⁸Musculoskeletal Diseases, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom
Background/Purpose: Skin involvement in systemic sclerosis (SSc) is often primary outcome in clinical trials and its severity inversely correlates with prognosis. Nevertheless, an objective quantitative…
Abstract Number: 305 • 2012 ACR/ARHP Annual Meeting
Clinicopathologic Correlates for Activity and Damage of Lupus Nephritis in Childhood-Onset Systemic Lupus Erythematosus
Ravi Nunna¹, Rina Mina¹, Michael Bennett², Shannen Nelson³, Jessica Hummel⁴, Prasad Devarajan², David Witte³ and Hermine Brunner⁵, ¹Rheumatology, Cincinnati Children's Hospital Medical Center/University of Cincinnati, Cincinnati, OH, ²Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ⁴Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Cincinnati Children's Hospital, Cincinnati, OH
Background/Purpose: High AI activity (AI), tubulointerstitial (TI), and chronicity index (CI) scores from renal biopsy may predict poor renal outcomes in lupus nephritis (LN)…
Abstract Number: 2532 • 2012 ACR/ARHP Annual Meeting
Whole Transcriptome Analysis in Relapsing Polychondritis: A Single-Center Analysis of 35 Patients
Laurent Arnaud¹, Alexis Mathian², Bruno Faivre³, Karim Dorgham³, Julien Haroche², Nathalie Costedoat-Chalumeau¹, Jean-Charles Piette², Guy Gorochov⁴ and Zahir Amoura¹, ¹Internal Medicine, Hôpital Pitié-Salpêtrière, AP-HP & UPMC Univ Paris 06, Paris, France, ²Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP & UPMC Univ Paris 06, Paris, France, ³Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945, Paris, France, ⁴Inserm UMRS945, Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945, Paris, France
Background/Purpose: Relapsing polychondritis (RP) is a severe and episodic inflammatory condition involving cartilaginous structures, predominantly those of the ears, nose, and laryngotracheobronchial tree. Other affected…
Abstract Number: 1794 • 2012 ACR/ARHP Annual Meeting
Matrix Metalloproteinase 3 and Acute Phase Proteins As Markers of Disease Activity and Radiographic Damage in Early Rheumatoid Arthritis
Mahmood MTM Ally¹, Bridget Hodkinson², Pieter W.A Meyer¹, Eustasius Musenge³, Mohammed Tikly⁴ and Ronald Anderson¹, ¹University of Pretoria, Pretoria, South Africa, ²Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, ³University of Witwatersrand, Johannesburg, South Africa, ⁴Rheumatology, Division of Rheumatology, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Although matrix metalloproteinase-3 (MMP-3) is believed to be intimately involved in the immunopathogenesis of rheumatoid arthritis (RA), relatively little is known about its relationships…
Abstract Number: 1102 • 2012 ACR/ARHP Annual Meeting
Immunoreactive Collagen Type II Cleavage Products and Their Nitrated Forms in Rheumatoid Arthritis and Osteoarthritis: An Outpatient Cross-Sectional Study
Ruediger Mueller¹, Axel Finckh², Guy Heynen³ and Johannes von Kempis⁴, ¹Division of Rheumatology, Cantonal Hospital, St. Gallen, Switzerland, ²Rheumatology, Geneva University Hospitals, Geneva 14, Switzerland, ³Consulting, CH-6300 Zug, Switzerland, ⁴Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland
Background/Purpose: Catabolism of type II collagen (COLII) involves multiple metalloproteinases, aggrecanases and cathepsin, releasing heterogeneous triple helix cleavage products. The complex regulation of these enzymes and of inducible…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].