ACR Meeting Abstracts

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Abstracts tagged "Biomarkers"

  • Abstract Number: 0727 • ACR Convergence 2024

    Prospective Cellular Biomarkers in ANCA Associated Vasculitis: A Pilot Study

    Jakub Videman1, Adela Skoumalova1, Marketa Dudkova1, Martina Skacelova1, Anna Petrackova2, Zuzana Mikulkova2, Eva Kriegova3 and Pavel Horak1, 13rd Department of Internal Medicine - Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc & Palacky University Olomouc, Faculty of Medicine and Dentistry, Olomouc, Olomoucky kraj, Czech Republic, 2Department of Immunology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czechia, Olomouc, Olomoucky kraj, Czech Republic, 3Department of Immunology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czechia, Olomouc, Czech Republic

    Background/Purpose: Significant progress has been achieved over the course of recent time in elucidating the complex underlying pathophysiological mechanisms of ANCA associated vasculitis (AAV). Despite…
  • Abstract Number: 0867 • ACR Convergence 2024

    Development of a Remote Patient Monitoring System Based on a Novel Digital Biomarker for Swelling in Rheumatoid Arthritis

    Marc Blanchard1, Cinja Koller2, Jules Maglione3, Patrick Hermann1 and Thomas Hügle3, 1Lausanne University Hospital, Lausanne, Vaud, Switzerland, 2Doctoral School, Faculty of Biology and Medicine, University of Lausanne, Genève, Vaud, Switzerland, 3Lausanne University Hospital, Lausanne, Switzerland

    Background/Purpose: Rheumatoid arthritis (RA) care faces challenges due to a shortage of healthcare providers, an increasing patient population and the remote locations of many patients.…
  • Abstract Number: 1113 • ACR Convergence 2024

    2nd Analysis of IgG4-Related Disease in a Diverse Long Island Population: Utilizing Serological and Histological Markers for Assessing Treatment Response

    Young Min Cho1, Alejandro Quintero Villegas2, Matt Means3, Zanos Theodoros2, Lara El Khoury4 and Galina Marder3, 1Northwell, Glen Cove, NY, 2Feinstein Institutes for Medical Research, Manhasset, NY, 3Northwell, Manhasset, NY, 4Division of Rheumatology/Northwell Health, Great Neck, NY

    Background/Purpose: IgG4-RD presents various clinical manifestations, making it challenging to assess treatment responses.  B-cell depletion agents such as Rituximab (RTX) are used in refractory cases.…
  • Abstract Number: 1357 • ACR Convergence 2024

    Kidney Function in Rheumatoid Arthritis: Estimating Glomerular Filtration Rate Using Creatinine versus Cystatin C in a Secondary Analysis of the TARGET Trial

    Sho Fukui1, Lesley Inker2, Leah Santacroce3, Jon Giles4, Katherine Liao3, Joan Bathon5 and Daniel Solomon6, 1Brigham and Women's Hospital, Brookline, MA, 2Tufts Medical Center, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Cedars Sinai Medical Center, Los Angeles, CA, 5Columbia University, NEW YORK, NY, 6Brigham and Women's Hospital, Newton, MA

    Background/Purpose: Glomerular filtration rate (GFR) is difficult to measure in patients with RA since creatinine-based estimated glomerular filtration rate (eGFRcr) may overestimate GFR due to…
  • Abstract Number: 1638 • ACR Convergence 2024

    Calprotectin, a Mechanistically Informed Biomarker for Clinically Isolated Aortitis

    Katarina Kmetova1, Emily Chong2, NaveenKumar Somanathapura K3, Kavya Sugur2, Lyndsay Kluge2, Srilakshmi Yalavarthi3, Julia Ford3, Ora Singer4 and Yu Zuo3, 1Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, MI, 2Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann arbor, Ann arbor, MI, 3University of Michigan, Ann arbor, MI, 4University of Michigan, Huntington Woods, MI

    Background/Purpose: Clinically isolated aortitis (CIA) is aortitis in patients without evidence of systemic disease, infection, or involvement of other vascular territories. CIA is discovered incidentally…
  • Abstract Number: 1839 • ACR Convergence 2024

    PPP2R3C Overexpression Suppresses TCR -mediated CD4+ T Cell Abnormal Activation in Systemic Lupus Erythematosus via JNK and AKT-mTOR Pathways

    Xuan Fang, Xiangpei Li and Xiaomei Li, The First Affiliated Hospital of University of Science and Technology of China., He Fei, China (People's Republic)

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is distinguished by immune system dysfunction, leading to heightened activation of T and B cells. This increased activity leads to…
  • Abstract Number: 2232 • ACR Convergence 2024

    Anti-RA33 Autoantibodies Are Unique, Sensitive Biomarkers for the Identification of Seronegative Rheumatoid Arthritis in a U.S. Cohort

    Andrew Concoff1, Touba Warsi2, Sepehr Taghavi2, Sudha Kumar2, Abigail Patalinghug2, Christine Schleif2, Brittany Partain3, Joseph Ahearn4, Nicole Wilson5, Susan Manzi5, Veena Joy6 and Tyler O'Malley7, 1Exagen, Inc., Los Angeles, CA, 2Exagen, Carlsbad, CA, 3Exagen, Boston, MA, 4Allegheny Health Network, Wexford, PA, 5Allegheny Health Network, Pittsburgh, PA, 6ThermoFisher, Philadelphia, PA, 7Exagen, Vista, CA

    Background/Purpose: Novel autoantibodies (Ab) capable of identifying unique subgroups of seronegative rheumatoid arthritis (SN-RA) while providing specificity for RA comparable to ACPA reflects an opportunity…
  • Abstract Number: 2400 • ACR Convergence 2024

    Predicting Adverse Pregnancy Outcomes in Women with Systemic Lupus Erythematosus: External Validation of the PROMISSE Model Using Multiple Independent Cohorts

    Melissa Fazzari1, Jane Salmon2, Marta Guerra2, Nathalie Costedoat-Chalumeau3, Veronique LE GUERN4, Gaëlle Guettrot-Imbert4, Marta Mosca5, Dina Zucchi6, Chiara Tani7, Rebecca Fischer-Betz8, Isabell Haase9, Anna Broder10, Navneet Kaur11, Jill Buyon12, Brooke Cohen12, Diane Kamen13, Jessica English14, Anna Arar13 and Mimi Kim15, 1Albert Einstein College of Medicine, Bronx, NY, 2Hospital for Special Surgery, New York, NY, 3Inserm DR Paris 5, Paris, France, 4Cochin hospital, Paris, France, 5University of Pisa, Department of Clinical and Experimental Medicine - Rheumatology Unit, Pisa, Italy, 6Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 7University of Pisa, Pisa, Italy, 8Uniklinik Düsseldorf, Düsseldorf, Germany, 9Heinrich-Heine University Duesseldorf, Düsseldorf, Germany, 10Hackensack Network, Hackensack, NJ, 11Touro University Medical Group, Sacramento, CA, 12NYU Grossman School of Medicine, New York, NY, 13Medical University of South Carolina, Charleston, SC, 14Medical University of South Carolina, Johns Island, SC, 15Albert Einstein College of Medicine, Larchmont, NY

    Background/Purpose: Nearly 20% of pregnancies in systemic lupus erythematosus (SLE) patients result in an adverse pregnancy outcome (APO); early identification of those at high APO…
  • Abstract Number: 2594 • ACR Convergence 2024

    A Novel Therapeutically Active CSF-1R Agonist Promotes Tissue Macrophages Inflammation Resolution and Induces Tissue Repair Pathways

    Saul Kivimae1, Sandip Mukherjee2, Phi Quach3, Rhoneil Pena4, Olga Zemska3, Michal Olszewski5, Jicai Huang3, Michael Labson6, Donald Walker1, Mekhala Maiti7, Chakrapani Tripathi8, Thomas Chang3, Suresh Adapala9, Damon Hamel3, Katherine Brendza3, Takahiro Miyazaki3 and Jonathan Zalevsky1, 1Nektar Therapeutics, San Francisco, CA, 2Nurix Therapeutics, San Francisco, 3Nektar Therapeutics, San Francisco, 4Sutro Biopharma, South San Francisco, 5Vaxcyte, San Francisco, 6Guardant Health, Palo Alto, 7Alumis, Inc, South San Francisco, 8Theragent Inc, Arcadia, CA, 9Inotiv, Rockville, MD

    Background/Purpose: Current standard of care chronic inflammatory disease therapies are designed to suppress inflammation and are not optimized for inflammation resolution and restoration of tissue…
  • Abstract Number: 0319 • ACR Convergence 2024

    Sporadic Inclusion Body Myositis Novel Autoantibody and Biomarker Research Utilizing Proteome Microarray and Mass Spectrometry Proteomics Analysis

    Farbod Moghaddam1, Mark Tarnopolsky2, Valérie Leclair3, marie Hudson3, Ross Mitchell4, Katherine Buhler1, Erin Hatcher5, Meifeng Zhang1, Antoine Dufour1, Luiz de Almeida1, Marvin Fritzler6 and May Choi1, 1University of Calgary, Calgary, AB, Canada, 2McMaster University, Hamilton, ON, Canada, 3McGill University, Montreal, QC, Canada, 4University of Alberta, Edmonton, Canada, 5McMaster University, Hamilton, Canada, 6Mitogen Diagnostics Corp, Calgary, AB, Canada

    Background/Purpose: Sporadic inclusion body myositis (sIBM) is often challenging to diagnose because many patients have no known biomarkers (seronegative). Machine learning was applied to identify…
  • Abstract Number: 0491 • ACR Convergence 2024

    Small Molecule Metabolites, Potential Disease-specific Biomarkers for Predicting Treatment Response in Rheumatoid Arthritis

    Jiayi Xu1, Yi Zhao2, Chenxi Zhu3, Yi Liu4, Tao Chen1, Rui Sun3, Huifang Hu5, Zhen Zhou1 and Yan Liu1, 1Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, Cheng du, China (People's Republic), 2Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, Sichuan, China (People's Republic), 3Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, chengdu, China (People's Republic), 4Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, chengdu, 5Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, Chengdu, Sichuan, China (People's Republic)

    Background/Purpose: Rheumatoid arthritis (RA) is a complex chronic inflammatory condition primarily affecting joints, presenting a challenge in understanding its causes, varied subtypes, diagnostic indicators, and…
  • Abstract Number: 0636 • ACR Convergence 2024

    Evaluation of Clinical, Histological and Biomarker Response After Induction Treatment of Lupus Nephritis (LN)

    Danielle Egypto1, Edgard Reis Neto2, Guilherme Carlesso3, Luis Andrade4, Luiz Moura3, Debora Calderaro5 and Emília Sato6, and Emília Inoue Sato; Edgar Torres dos Reis Neto., 1Federal University of Paraiba, JOÃO PESSOA, Paraiba, Brazil, 2Division of Rheumatology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal, São Paulo, SP, Brazil, 3Federal University of São Paulo, São Paulo, SP, Brazil, 4Division of Rheumatology, Department of Medicine, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP, Brazil, 5Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, 6Universidade Federal de Sao Paulo, São Paulo, SP, Brazil

    Background/Purpose: LN occurrs in 50 to 75 percent of SLE patients and is associated with a significant morbimortality. LN presents distinct severity, with frequent flares…
  • Abstract Number: 0738 • ACR Convergence 2024

    Quantitative Vascular US Has Additional Diagnostic and Prognostic Value in GCA

    Colm Kirby1, Rachael Flood1, Sharon Cowley2, Emma Finlay3, Ronan Mullan1, Grainne Murphy4 and David Kane5, 1Tallaght University Hospital, DUBLIN, Dublin, Ireland, 2Tallaght University Hospital, Dublin, Dublin, Dublin, Ireland, 3School of Biotechnology, Dublin City University, Dublin, Ireland, 4Cork University Hospital, Cork, Ireland, 5Tallaght University Hospital & Trinity College Dublin, D24, Ireland

    Background/Purpose: Vascular Ultrasound (VUS) performs well in diagnosing Giant Cell Arteritis (GCA) but its role in monitoring disease activity and in predicting outcomes is unknown…
  • Abstract Number: 0871 • ACR Convergence 2024

    Disease-associated Central Nervous System Activation Predicts Good Clinical Response to Tumor Necrosis Factor Inhibition in Rheumatoid Arthritis Patients – “The PreCePRA Study”

    Juergen Rech1, Prof. Dr. Andreas Hess2, Koray Tascilar1, Dr. Hannah Schenker3, verena schönau1, Marina Sergeeva2, Jutta Prade2, Silke Kreitz2, Mageshva Sulvakumar2, Laura Konerth2, Sandra Strobelt2, Matthias Englbrecht4, Prof. Dr. Dr. Axel Hueber5, Eugen Feist6, Prof. Dr. Mario Zaiss1, Gerd Burmester7, Frank Behrens8, Dr. Michaela Koehm9, Prof. Dr. Christoph Baerwald10, Dr. Stephanie Finzel11, Dr. Arnd Kleyer12, Prof. Dr. Reinhard Voll11, Dr. Julie Roesch13, Prof. Dr. Arnd Doerfler13, Prof. Dr. Nemanja Damjanov14, Prof. José António P. Da Silva15 and Georg Schett16, 1Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 2Institute for Experimental Pharmacology FAU Erlangen-Nürnberg, Erlangen, Germany, 3Department of Internal Medicine 3 - Rheumatology and Immunology, Department of Internal Medicine 1 - Gastroenterology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 4Freelance Healthcare Data Scientist, Eckental, 5Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, + Rheumatologie, Klinik für Innere Medizin 5, Klinikum Nürnberg Nord, Prof.-Ernst-Nathan-Str. 1, 90419, Nürnberg, Deutschland, Erlangen, Germany, 6Department of Rheumatology, Helios Clinic Vogelsang-Gommern, cooperation partner of the Otto von Guericke University Magdeburg, Gommern, Germany, 7Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 8University Hospital Goethe University Frankfurt and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, Germany, 9Goethe-University & Fraunhofer ITMP, Frankfurt, Germany, 10Medizinische Klinik III - Bereich Rheumatologie, Liebigstraße 20, 04103 Leipzig, Leipzig, Germany, 11Universitätsklinikum Freiburg, Klinik für Rheumatologie und Klinische Immunologie, Hugstetterstraße 55, 79106 Freiburg, Freiburg, Germany, 12Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany; Charité - Universitätsmedizin Berlin Med. Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie Berlin, Erlangen, Germany, 13Department of Neuroradiology, Friedrich - Alexander - Universitaet Erlangen - Nuernberg and Universitaetsklinikum Erlangen , Erlangen , Germany, Erlangen, Germany, 14Belgrade University School of Medicine, Institute Institute of Rheumatology, Belgrade, Belgrade, Serbia, 15Head of Department Reumatologia. Hospitais da Universidade (SRHUC), Coimbra, Portugal, 16Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is an chronic inflammatory disease that is frequently treated with tumor necrosis factor inhibitors (TNFi). Little is known about predictors of…
  • Abstract Number: 1121 • ACR Convergence 2024

    A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of Single and Multiple Ascending Doses of AMG 329, a Monoclonal Antibody, in Conventional and Plasmacytoid Dendritic Cell-Mediated Rheumatic Diseases

    Alan Kivitz1, Stanley Cohen2, Annie Lau-Kilby3, Yajing Sun3, Jiayin Huang3, Atasi Jana3, Susie Kim3, Yanping Wu3, Quinnie Yang3 and Lin Zhao3, 1Altoona Center for Clinical Research, Duncansville, PA, 2Metroplex Clinical Research Center, dallas, TX, 3Amgen Inc., Thousand Oaks, CA

    Background/Purpose: AMG 329 (formerly HZN-1116), a human monoclonal antibody (mAb), binds to soluble and membrane-bound human feline McDonough sarcoma (FMS)-like tyrosine kinase 3 receptor ligand…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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