Abstracts tagged "Biomarkers"

Abstract Number: 0031 • ACR Convergence 2020
Metabolomics Profiling Predicts Outcome of Tocilizumab in Rheumatoid Arthritis
Jessica Murillo-Saich¹, Cesar Diaz-Torne², M. Angeles Ortiz², Roxana Coras¹, Arthur Kavanaugh³, Hector Corominas², Silvia Vidal² and Monica Guma⁴, ¹University of California San Diego, La Jolla, CA, ²Institut Rec. Hospital de la Santa Creu I Sant Pau., Barcelona, Spain, ³Division of Rheumatology, Allergy, & Immunology, University of California San Diego Medical School, San Diego, CA, ⁴Division of Rheumatology, University of California San Diego, Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Metabolomics may provide information about the activity and severity of specific diseases and potentially help discriminate between diseases. Choosing the right biological therapy earlier…
Abstract Number: 0490 • ACR Convergence 2020
Fine Specificity Anti-Citrullinated Protein Antibodies as Biomarkers for Prediction of Incident Rheumatoid Arthritis-Associated Interstitial Lung Disease
Vanessa Kronzer¹, Weixing Huang², Paul Dellaripa³, Sicong Huang⁴, Vivi Feathers², Bing Lu⁵, Christine Iannaccone⁴, Ritu Gill⁶, Hiroto Hatabu⁷, Mizuki Nishino⁷, Cynthia Crowson⁸, John Davis¹, William Robinson⁹, Tripta Rughwani⁹, Jeremy Sokolove¹⁰, Michael Weinblatt⁴, Nancy Shadick¹¹, Tracy J. Doyle¹² and Jeffrey Sparks¹¹, ¹Mayo Clinic, Rochester, MN, ²Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, ³Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA, Boston, MA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Brigham and Women's Hospital and Harvard Medical School, Newton, MA, ⁶Beth Israel Deaconess Medical Center, Boston, MA, ⁷Department of Radiology; Brigham and Women’s Hospital, Boston, ⁸Mayo Clinic, Rochester, Minnesota, USA, Rochester, MN, ⁹Stanford University, Palo Alto, CA, ¹⁰Stanford University, Mountain View, CA, ¹¹Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ¹²Brigham and Women's Hospital, West Roxbury, MA
Background/Purpose: Seropositivity for anti-citrullinated protein antibodies (ACPA) has been shown to increase risk for RA-associated interstitial lung disease (RA-ILD). However, RA-related autoantibodies used in clinical…
Abstract Number: 0762 • ACR Convergence 2020
Anti-Protein-Arginine Deiminase (PAD) 1 IgG Is a Promising Novel Autoantigen in Rheumatoid Arthritis (RA) and Increases Diagnostic Performance in Combination with Anti-PAD4 IgG Using a Composite Biomarker Score
Marcos Lopez-Hoyos¹, Chelsea Bentow², Andy Ishii², Laura Martinez-Prat³ and Michael Mahler², ¹Marques de Valdecilla University Hospital-IDIVAL, Santander, Spain, ²Research and Development, Inova Diagnostics, San Diego, CA, ³Research and Development, Inova Diagnostics, Barcelona, Spain
Background/Purpose: Over the past years, novel biomarkers have been identified in the sera of rheumatoid arthritis (RA) patients, including autoantibodies to the protein-arginine deiminase (PAD)…
Abstract Number: 1108 • ACR Convergence 2020
Cartilage Biomarkers s-Coll2-1 and s-Coll2-1NO2 Are Associated with Knee Osteoarthritis MRI Features and Predict Disease Worsening
Yves Henrotin¹, Anne-Christine Hick², Berenice Costes³, Alain Labasse³, Thierry Conrozier⁴, Michel Malaise⁵, Yves Maugars⁶, Franz Pelousse⁷, Jean-Marc Lemaire⁸, Cedric Tits⁹, Thibault Helleputte⁹ and Damien Loeuille¹⁰, ¹University of Liège, Liège, Belgium, ²Artialis SA, Liège, Belgium, ³Artialis SA, Liege, Belgium, ⁴5. Department of Rheumatology, Hôpital Nord Franche-Comté, Belfort, France, ⁵University of Liège, Liege, Belgium, ⁶Service de rhumatologie, Hôtel-Dieu, CHU de Nantes, Nantes, France, ⁷SODIRAY, Solution Diagnostique Radiologique, Liège, Belgium, ⁸SODIRAY, Solution Diagnostique Radiologique, Liege, Belgium, ⁹Data-Driven Precision Medicine, DNAlytics, Louvain-la-Neuve, Belgium, ¹⁰CHU NANCY Rheumatology, NANCY
Background/Purpose: To identify if biochemical markers s-Coll2-1, a peptide of type collagen and its nitrated from, s-Coll2-1NO2 are associated to knee osteoarthritis (OA), focusing on…
Abstract Number: 1221 • ACR Convergence 2020
Evaluation of Methotrexate Efficacy and Exploration of Metabolites Associated with Disease Activity in Collagen-induced Arthritis Mouse Model
Yu Kyoung Cho¹ and Ryan Funk¹, ¹UNIVERSITY OF KANSAS, Kansas City, KS
Background/Purpose: Methotrexate (MTX) is cornerstone of therapy for rheumatoid arthritis. However, response to MTX is variable and unpredictable among patients. Therefore, there is a critical…
Abstract Number: 1522 • ACR Convergence 2020
Biomarkers of Hemodynamic Severity of Systemic-Sclerosis Associated Pulmonary Arterial Hypertension by Serum Proteome Analysis
Sebastien Sanges¹, Lisa Rice², Ly Tu³, Jean-Luc Cracowski⁴, David Montani⁵, Julio Mantero⁶, Camille Ternynck⁷, Guillemette Marot⁷, Eric Hachulla⁸, David Launay⁹, Marc Humbert⁵, Christophe Guignabert⁵ and Robert Lafyatis¹⁰, ¹Medecine Interne CHRU Lille, Lille, France, ²E5 Arthritis Center, Boston, MA, ³INSERM U1286, Le Kremlin Bicetre, France, ⁴Univ. Grenoble Alpes, INSERM, HP2, Grenoble, France, ⁵INSERM U999 "Pulmonary hypertension: Pathophysiology and Novel Therapies", Le Kremlin-Bicêtre, France, ⁶Boston University School of Medicine, E5 Arthritis Center, Boston, ⁷Univ. Lille, CHU Lille, ULR2694 – METRICS, Lille, France, ⁸Department of Internal Medicine, CHRU, Lille Cedex, France, ⁹Medecine Interne CHRU Lille, Lille Cedex, France, ¹⁰University of Pittsburgh, Pittsburgh, PA
Background/Purpose: To investigate alterations in the serum proteome of patients with systemic sclerosis (SSc)-associated pulmonary hypertension (PAH), to identify proteins that correlated with hemodynamic severity…
Abstract Number: 1804 • ACR Convergence 2020
Impact of the Kynurenine/Tryptophan Pathway on Cognitive Dysfunction and Depression in Systemic Lupus Erythematosus
Erik Anderson¹, Joanna Fishbein², Joseph Hong², Julien Roeser³, Richard Furie⁴, Cynthia Aranow², Bruce Volpe², Betty Diamond⁵ and Meggan Mackay⁶, ¹Feinstein Institutes for Medical Research, New York, NY, ²Feinstein Institutes for Medical Research, Manhasset, NY, ³Charles River Laboratories, South San Francisco, CA, ⁴Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, ⁵Northwell Health, Manhasset, NY, ⁶Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Tryptophan (TRP) is metabolized to kynurenine (KYN), quinolonic acid [QA, a N-methyl D-aspartate receptor (NMDAR) agonist] and kynurenic acid (KA, an NMDAR antagonist). KYN/TRP…
Abstract Number: 2005 • ACR Convergence 2020
Histo-pathological Cellular Markers of Treatment Response to Rituximab and Tocilizumab in Matched Pre- and Post-treatment Synovial Biopsies from the R4RA Randomised Clinical Trial in Rheumatoid Arthritis
Felice Rivellese¹, Frances Humby², Giovanni Giorli², Alessandra Nerviani¹, Rebecca Hands², Liliane Fossati-Jimack², Georgina Thorborn², Myles Lewis¹ and Costantino Pitzalis², ¹Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ²Queen Mary University of London, London, United Kingdom
Background/Purpose: The results of the R4RA trial, the first biopsy-based RCT in TNF-i inadequate responders patients with Rheumatoid Arthritis (RA), showed that molecular stratification of…
Abstract Number: 0034 • ACR Convergence 2020
Gene Expression Signatures in C-Reactive Protein High and Low Rheumatoid Arthritis
Adam Cornish¹, Kristin Wipfler¹ and Kaleb Michaud², ¹FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ²University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Transcriptome profiling has expanded our ability to identify biomarkers and therapeutic targets and better understand disease progression in a wide variety of conditions. Serum…
Abstract Number: 0502 • ACR Convergence 2020
Integration of Clinical and Protein Markers Through Machine Learning to Distinguish Patients with Psoriasis Arthritis from Those with Psoriasis Without Psoriatic Arthritis
Sara Rahmati¹, Fatima Abji¹, Proton Rahman² and Vinod Chandran³, ¹University Health Network, Toronto, ON, Canada, ²Memorial University of Newfoundland, Department of Medicine, St John's, Canada, ³Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic Arthritis (PsA) is a progressive inflammatory arthritis that occurs in about 24% of psoriasis patients. Early diagnosis of PsA is associated with better…
Abstract Number: 0763 • ACR Convergence 2020
Plasmatic Proteome in Individuals with Arthralgia at Risk of Developing Rheumatoid Arthritis
Klára Prajzlerová¹, Nora Petrovská¹, Monika Gregová¹, Jiří Baloun², Petra Hánová², Karel Pavelka¹, Jiří Vencovský¹, Ladislav Šenolt¹ and Mária Filková¹, ¹Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic
Background/Purpose: The presence of antibodies against citrullinated proteins (ACPA) significantly increases the risk of developing rheumatoid arthritis (RA). EULAR characterised individuals with arthralgia suspicious for…
Abstract Number: 1109 • ACR Convergence 2020
Pain in Women with Knee and/or Hip Osteoarthritis Is Related to Systemic Inflammation and to Adipose Tissue Dysfunction and Distribution: A Cross-sectional Metabolic Biomarkers Cohort Study
Jeremie Sellam¹, Anne-Christine Rat², Soraya Fellahi³, Jean-Philippe Bastard⁴, Willy NGUEYON SIME⁵, Hang Korng EA⁶, Pascal Richette⁷, Jacqueline Capeau⁸, Francis Guillemin⁹ and Francis Berenbaum¹, ¹AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, ²Universite de Caen Normandie and Université de Lorraine, EA 4360, Caen, France, ³AP-HP INSERM, Paris, France, ⁴INSERM AP-HP UPEC, Paris, France, ⁵Universite de Lorraine, INSERM, CIC, Nancy, France, ⁶Universite de Paris, AP-HP, INSERM, paris, France, ⁷Department of Rheumatology, Lariboisière Hospital, Paris, France, ⁸INSERM Sorbonne Universite, Paris, France, ⁹Universite de Lorraine CIC INSERM, Nancy, France
Background/Purpose: Beyond the link between metabolic diseases and osteoarthritis (OA) risk, some studies have suggested an association between metabolic syndrome or visceral obesity and OA-related…
Abstract Number: 1229 • ACR Convergence 2020
Blood Lymphocyte Subsets for Early Identification of Non-Remission to TNF Inhibitors in Rheumatoid Arthritis
Eulalia Rodriguez-Martín¹, Israel Nieto-Gañán¹, Borja Hernández-Breijo², Cristina Sobrino³, Carlota García-Hoz¹, Javier Bachiller-Corral⁴, Ana Martínez-Feito⁵, Victoria Navarro-Compán⁶, Paloma Lapuente-Suanzes¹, Gema Bonilla⁷, Dora Pascual-Salcedo⁸, Garbiñe Roy¹, Teresa Jurado², Pilar Nozal², Mónica Vázquez⁴, Alejandro Balsa⁷, Luisa M Villar¹ and Chamaida Plasencia⁷, ¹Hospital Universitario Ramón y Cajal-IRYCIS, Madrid, Spain, ²Hospital Universitario La Paz-Idipaz, Madrid, Spain, ³Hospital Ramón y Cajal-IRYCIS, Madrid, Spain, ⁴Rheumatology, Hospital Universitario Ramón y Cajal, Madrid, Spain, ⁵Hospital Unversitario La Paz- idipaz, Madrid, Spain, ⁶Hospital Universitario La Paz IdiPaz, Madrid, Pais Vasco, Spain, ⁷Rheumatology, La Paz University Hospital-IdiPAZ, Madrid, Spain, ⁸Hospital Universitario La Paz- Idipaz, Madrid, Spain
Background/Purpose: TNF inhibitors (TNFis) are widely used for the treatment of rheumatoid arthritis (RA), although the response rates to this therapy in patients with RA…
Abstract Number: 1529 • ACR Convergence 2020
Differentially Expressed Chemokines and Cytokines in Peripheral Blood Mononuclear Cells (PBMCs) of Rheumatoid Arthritis (RA) Patients
Noha Elemam¹, Mahmood Hachim², Suad Hannawi³ and Azzam Maghazachi⁴, ¹University of Sharjah, Sharjah, United Arab Emirates, ²Mohammed Bin Rashid University Of Medicine and Health Sciences, Dubai, ³Ministry of Health and Prevention, Dubai, United Arab Emirates, ⁴University of Sharjah, Sharjah
Background/Purpose: Rheumatoid arthritis (RA) is the most prevalent autoimmune disease, where various immune cells are associated such as monocytes, natural killer (NK) cells, B cells,…
Abstract Number: 1806 • ACR Convergence 2020
The Association of Interferon-α with Kynurenine/Tryptophan Pathway Activation in Systemic Lupus Erythematosus
Erik Anderson¹, Ying Jin², Sara Goodwin², Julien Roeser³, Richard Furie⁴, Cynthia Aranow⁵, Bruce Volpe⁵, Betty Diamond⁶ and Meggan Mackay⁷, ¹Feinstein Institutes for Medical Research, New York, NY, ²Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, ³Charles River Laboratories, South San Francisco, CA, ⁴Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, ⁵Feinstein Institutes for Medical Research, Manhasset, NY, ⁶Northwell Health, Manhasset, NY, ⁷Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Type I IFN contributes to SLE pathogenesis and stimulates the kynurenine/tryptophan (KYN/TRP) pathway, producing elevated quinolinic acid (QA) levels relative to kynurenic acid (KA)…

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