Abstracts tagged "Biologics"

Abstract Number: 1343 • 2016 ACR/ARHP Annual Meeting
Efficacy of Biological-Targeted Treatments in MDS-Related Systemic Autoimmune Diseases: Multicenter Retrospective Study of 28 Patients
Guillaume Dervin¹, Arsène Mékinian², Jean-Emmanuel Kahn³, louis Terriou⁴, Eric Liozon⁵, Eric Grignano⁶, odile beyne Rauzy⁷, Pascal Godmer⁸, Julien Rossignol⁹, Geraldine Falgarone¹⁰, Laurence Bouillet¹¹, Achille Aouba¹², Philippe Guilpain¹³, David Launay¹⁴, jonathan Broner¹⁵, jerome gillard¹⁶, lionel ades¹⁷, clemence salvado¹⁸, thierry cardon¹⁹, Jean-Charles Piette²⁰, Pierre Fenaux²¹ and Olivier Fain², ¹Medecine Interne Hopital Saint antoine, Paris, France, ²Service de médecine interne. Hôpital Saint-Antoine., Paris, France, ³Internal Medicine, Foch Hospital, Suresnes, France, ⁴médecine interne CHRU lille, Lille, France, ⁵Departement of Internal Medicine, Limoges University Hospital, Limoges, France, ⁶Internal Medicine, DHUi2B Saint Antoine Hospital, paris, France, ⁷Medecine interne CHU Purpan, toulouse, France, ⁸CH Vannes, Vannes, France, ⁹haematology, paris, France, ¹⁰Medecine Interne Hopital Avicenne, Bobigny, France, ¹¹CHU, Grenoble, France, ¹²Medecine Interne Hopital Necker, Paris, France, ¹³Medecine interne CHU Montpellier, Montpellier, France, ¹⁴Service de Médecine Interne, Centre National de Référence des Maladies Systémiques Rares, Hôpital Claude Huriez, CHRU Lille, Lille, France, ¹⁵Medecine Interne CHRU Montpellier, Montpellier, France, ¹⁶Medecine Interne CHRU Lons le Saunier, Lons, France, ¹⁷Service Hématologie Hopital d'Avicennes, Bobigny, France, ¹⁸Service d'hématologie CHU Mondor, Creteil, France, ¹⁹Medecine interne CHU Lille, lille, France, ²⁰Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France, ²¹Hematologie Hopital Avicenne, Bobigny, France
Background/Purpose: This study analyze the safety and efficiency of biologics (TNF-α antagonists, tocilizumab, rituximab and IL-1 inhibitors) in patients with autoimmune systemic diseases (SAIDs) associated…
Abstract Number: 1718 • 2016 ACR/ARHP Annual Meeting
Ustekinumab, Apremilast, TNFi and the Risk for Hospitalized Infection in Patients with Psoriasis and Psoriatic Arthritis
Fenglong Xie¹, Lang Chen¹, Huifeng Yun², Timothy Beukelman³ and Jeffrey Curtis⁴, ¹Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, ³Pediatric Rheumatology, University of Alabama-Birmingham, Birmingham, AL, ⁴Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Ustekinumab (UST), an anti IL12/IL23 monoclonal antibody and apremilast, an inhibitor of phosphodiesterase 4 are two relatively new agents used for the treatment of…
Abstract Number: 2929 • 2016 ACR/ARHP Annual Meeting
The Baseline Th17 Lymphocytes Level Is a Predictive Marker of Good Response to Biologics in Rheumatoid Arthritis
Sarah Salomon¹, Caroline Guignant², Pierre Morel³, Brigitte Gubler⁴, Patrice Fardellone⁵, Jean-Pierre Marolleau⁶ and Vincent Goeb⁷, ¹Rheumatology, University Hospital of Amiens, Amiens, France, ²Immunology Laboratory, University Hospital of Amiens, Amiens, France, ³Hematology, University Hospital of Amiens, Amiens, France, ⁴Immunology, University Hospital of Amiens, Amiens, France, ⁵Department of Rheumatology, Amiens University hospital, Amiens, France, ⁶hematology, University Hospital of Amiens, Amiens, France, ⁷Rheumatology, Amiens University Hospital, Amiens, France
Background/Purpose: In clinical daily practice, the response to biologic drugs is unpredictable in patients with rheumatoid arthritis (RA). Thus, there is a crucial need for…
Abstract Number: 17 • 2016 ACR/ARHP Annual Meeting
The Importance of Achieving Clinical Response to Treatment and Changes in Physical Ability and Quality of Life on Worker Productivity Outcomes in Rheumatoid Arthritis: Results from the British Society for Rheumatology Biologics Register
Sarah Leggett¹, Kimme L. Hyrich^1,2, Mark Lunt¹, Karen Walker-Bone³ and Suzanne M.M. Verstappen¹, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK, Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ³University of Southampton, Arthritis Research UK / MRC Centre for Musculoskeletal Health and Work, Southampton, United Kingdom
Background/Purpose: It is well known that patients with RA experience health-related job loss, more days absent from work (i.e., absenteeism), and to a greater extent,…
Abstract Number: 1495 • 2016 ACR/ARHP Annual Meeting
Lipoprotein(a) Concentrations in Rheumatoid Arthritis on Biologic Therapy: Results from the Cardiovascular in Rheumatology [CARMA] Study Project
Maria Carmen Garcia-Gomez¹, Maria Auxiliadora Martin², Santos Castañeda³, Fernando Sánchez-Alonso⁴, Miren Uriarte Ecenarro⁵, Carlos González-Juanatey⁶, Romera-Baures Monserrat⁷, Santos-Rey Jose⁸, Jose A Pinto-Tasende⁹, Estefania QuesadaMasachs¹⁰, Jesús Tornero¹¹, Olga Martínez González¹², Tatiana Cobo-Ibáñez¹³, Eugenio Chamizo Carmona¹⁴, Sara Manrique-Arija¹⁵, Dolores Fábregas-Canales¹⁶, Federico Díaz-González¹⁷, Javier Llorca¹⁸, Miguel Angel González-Gay¹⁹ and CARMA Collaborative Group, ¹Rheumatology, Consorci Sanitari de Terrassa, Terrassa (Barcelona), Spain, ²Research Unit of Spanish Society of Rheumatology,, Madrid, Spain, ³Rheumatology, Hospital de la Princesa, IIS-IP, Madrid, Spain, ⁴Research Unit of Spanish Society of Rheumatology, Madrid, Spain, ⁵Donostia University Hospital, San Sebastian, Spain, ⁶Division or Cardiology, Hospital Lusus Augusti, Lugo, Spain, ⁷Rheumatology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat (Barcelona), Spain, ⁸Rheumatology, Hospital Virgen de la Salud, Toledo, Spain, ⁹Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruna, Spain, ¹⁰Rheumatology, Hospital Universitari Vall d’Hebron, Barcelona, Spain, ¹¹Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, ¹²Rheumatology, HOSPITAL CLÍNICO UNIVERSITARIO DE SALAMANCA, Salamanca, Spain, ¹³Hospital Universitario Reina Sofía, Universidad Europea de Madrid, Madrid, Spain, ¹⁴Rheumatology, Hospital de Mérida, Mérida, Spain, ¹⁵Rheumatology, Hospital Carlos Haya, Malaga, Spain, ¹⁶Rheumatology, Hospital de Barbastro, Barbastro (Huesca), Spain, ¹⁷Rheumatology, Hospital Universitario de Canarias, S/C Tenerife, Spain, ¹⁸Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ¹⁹Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain
Background/Purpose: Plasma concentrations of lipoprotein (a) [Lp(a)], a lipoprotein with proatherogenic and thrombogenic properties, have a strong genetic basis, although high concentrations of Lp(a) have…
Abstract Number: 1730 • 2016 ACR/ARHP Annual Meeting
Disease Progression Among Non-Achievers of Minimal Disease Activity in Psa Patients Treated with Infliximab or Golimumab
Dalton Sholter¹, Proton Rahman², Maqbool Sheriff³, Michel Zummer⁴, Suneil Kapur⁵, Philip Baer⁶, Michael Starr⁷, John Kelsall⁸, Emmanouil Rampakakis⁹, Eliofotisti Psaradellis¹⁰, Brendan Osborne¹¹, Karina Maslova¹², Cathy Tkaczyk¹¹, Francois Nantel¹³ and Allen J Lehman¹², ¹University of Alberta, Edmonton, AB, Canada, ²Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ³Nanaimo Regional General Hospital, Nanaimo, BC, Canada, ⁴Rheumatology, Ch Maisonneuve-Rosemont, Montreal, QC, Canada, ⁵University of Ottawa, 139 Greenbank Rd, Suite 203, ON, Canada, ⁶Independent Rheumatology Practice, Scarborough, ON, Canada, ⁷Rheumatology, Mcgill University, Pointe-Claire,, QC, Canada, ⁸Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁹JSS Medical Research, St-Laurent, QC, Canada, ¹⁰JSS Medical Research, Montreal, QC, Canada, ¹¹Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹²Janssen Inc., Toronto, ON, Canada, ¹³19 Green belt Dr, Janssen Inc., Toronto, ON, Canada
Background/Purpose : Early achievement of minimal disease activity (MDA) is recommended as a valid treat-to-target approach in psoriatic arthritis (PsA). The purpose of the current…
Abstract Number: 3092 • 2016 ACR/ARHP Annual Meeting
Predictive Factors for Better Outcome of Switching of Biologics for Patients with Rheumatoid Arthritis in Daily Clinical Practice
Kazuyoshi Saito¹, Kazuhisa Nakano², Shingo Nakayamada³, Satoshi Kubo⁴, Ippei Miyagawa¹, Shigeru Iwata⁵ and Yoshiya Tanaka⁶, ¹University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The First department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁴The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁵First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁶University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: Eight biologics have been approved for rheumatoid arthritis (RA) in Japan. However, little is known regarding what to do when patients have an inadequate…
Abstract Number: 137 • 2016 ACR/ARHP Annual Meeting
Imaging Remission By Musculoskeletal Ultrasound Leads to a Better Functional Outcome – Results of the US Impera Study – US 7-Score Implementation Study in Early Rheumatoid Arthritis
Anne-Marie Glimm¹, Sarah Ohrndorf², Imma Fischer³, Johannes Strunk⁴, Wolfgang A. Schmidt⁵, Wolfgang Hartung⁶, Herbert Kellner⁷, Horst Sattler⁸, Gabriela Schmittat¹, GR Burmester⁹ and Marina Backhaus¹⁰, ¹Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, ²Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, ³Biostatistik Tuebingen, Tuebingen, Germany, ⁴Department of Rheumatology, Hospital 'Porz am Rhein', Academic Hospital of the University of Cologne, Cologne, Germany, ⁵Medical Center for Rheumatology and Clinical Immunology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany, ⁶Department of Rheumatology and Clinical Immunology, Asklepios Klinik Bad Abbach, Bad Abbach, Germany, ⁷Department of Internal Medicine – Rheumatologic Day Clinic, Krankenhaus Neuwittelsbach, Academic Hospital of Ludwig-Maximilians-University Munich, Munich, Germany, ⁸Internal Medicine and Rheumatology Practice, Bad Duerkheim, Bad Duerkheim, Germany, ⁹Charité – University Medicine Berlin, Berlin, Germany, ¹⁰Department of Rheumatology & Immunology, University Medicine Charit, Berlin, Germany
Background/Purpose: Novel treat-to-target strategies present new challenges to treatment monitoring in rheumatoid arthritis (RA). To compare functional outcomes in early RA patients monitored by standard…
Abstract Number: 1507 • 2016 ACR/ARHP Annual Meeting
Our Strategy of Preventing Tuberculosis (TB) in Patients with Rheumatic Diseases Under the Treatment with Biologic Dmards
Shinji Motojima¹, Tamao Nakashita², Akira Jibatake¹, Akira Yoshida¹ and Yoshiki Yamamoto¹, ¹Department of Rheumatology and Allergy, Kameda Medical Center, Kamogawa city, Japan, ²Department of Rheumatology and Allergy, Kameda Medical Center, Kamogawa-city, Japan
Background/Purpose: According to the report by WHO, Japan is still in moderately-prevailing countries of TB. The annual incidence of TB in Japan is approximately 15/100,000,…
Abstract Number: 1732 • 2016 ACR/ARHP Annual Meeting
Articular and Axial Involvement Differences in Psoriatic Arthritis Patients Treated with Golimumab in Canadian Real-World Practice
Majed M. Khraishi¹, Proton Rahman², Alexander Tsoukas³, Suneil Kapur⁴, Milton F. Baker⁵, Niall Jones⁶, Michael Starr⁷, Emmanouil Rampakakis⁸, Eliofotisti Psaradellis⁹, Karina Maslova¹⁰, Francois Nantel¹¹, Allen J Lehman¹⁰, Cathy Tkaczyk¹² and Brendan Osborne¹², ¹Nexus Clinical Research, St Johns, NF, Canada, ²Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, ³McGill University, Montreal, QC, Canada, ⁴University of Ottawa, 139 Greenbank Rd, Suite 203, ON, Canada, ⁵VIHA, Victoria, BC, Canada, ⁶University of Alberta, Edmonton, AB, Canada, ⁷McGill University, Pointe-Claire, QC, Canada, ⁸JSS Medical Research, St-Laurent, QC, Canada, ⁹JSS Medical Research, Montreal, QC, Canada, ¹⁰Janssen Inc., Toronto, ON, Canada, ¹¹19 Green belt Dr, Janssen Inc., Toronto, ON, Canada, ¹²Medical Affairs, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a complex rheumatic disease with severity that ranges from mild to severe. The mild form of PsA can be referred…
Abstract Number: 3116 • 2016 ACR/ARHP Annual Meeting
Risk of Infections in Juvenile Idiopathic Arthritis Patients Treated with Biologic Agentsand/or Methotrexate: Results from Pharmachild Registry
Gabriella Giancane¹, Joost Swart², Francesca Bovis², Elio Castagnola², Andreas Groll², Gerd Horneff², Hans-Iko Huppertz², Daniel J. Lovell², Tom Wolfs², Michaël Hofer², Ekaterina Alexeeva², Violeta Vladislava Panaviene², Susan Nielsen², Jordi Anton², Florence Uettwiller², Valda Stanevicha², Maria Trachana², Denise Pires Marafon³, Constantin Ailioaie², Elena Tsitsami², Sylvia S.M. Kamphuis², Troels Herlin², Pavla Dolezalová³, Gordana Susic², Berit Flato², Flavio Sztajnbok², Angela Pistorio¹, Alberto Martini², Nico Wulffraat² and Nicolino Ruperto², ¹Pediatria II, Reumatologia, PRINTO, Istituto Giannina Gaslini, Genoa, Italy, ²Istituto Giannina Gaslini, Genoa, Italy, ³Istituto Giannina Gaslini, genoa, Italy
Background/Purpose: Pharmachild is an international registry involving over 100 the Paediatric Rheumatology INternational Trials Organisation (PRINTO)/ the Paediatric Rheumatology European Society (PRES) centres in 38 countries. The registry was set up to evaluate long term safety and efficacy…
Abstract Number: 331 • 2016 ACR/ARHP Annual Meeting
Biologic Disease-Modifying Anti-Rheumatic Drug Use and the Risk of Non-Vertebral Osteoporotic Fractures in Japanese Patients with Rheumatoid Arthritis: Results from the IORRA Cohort Study
Takefumi Furuya¹, Eisuke Inoue^1,2, Masanori Nakayama¹, Eiichi Tanaka¹, Katsunori Ikari¹, Ayako Nakajima³, Atsuo Taniguchi¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Center for Clinical Research and Development, National Center for Child Health and Development, Tokyo, Japan, ³Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: Previous U.S. and Canadian studies [1-3] have suggested that no significant associations exist between use of biologic disease-modifying anti-rheumatic drugs (DMARDs) and risk of…
Abstract Number: 1546 • 2016 ACR/ARHP Annual Meeting
Clinical Features at the Onset of Lymphoproliferative Disorder in Patients with Rheumatoid Arthritis
Daisuke Kobayashi^1,2, Satoshi Ito¹, Chinatsu Takai^1,3, Akira Murasawa¹, Ichiei Narita² and Kiyoshi Nakazono¹, ¹Department of Rheumatology, Niigata Rheumatic Center, Shibata, Japan, ²Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ³Department of clinical rheumatology and nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Background/Purpose: Rheumatoid arthritis (RA) is intrinsically associated with an increased incidence of lymphoproliferative disorders (LPDs). Although treatment with immunosuppressive agents, such as methotrexate, tacrolimus, or…
Abstract Number: 1733 • 2016 ACR/ARHP Annual Meeting
Sustained Efficacy of Ixekizumab in Patients with Moderate-to-Severe Plaque Psoriasis and Concomitant Psoriatic Arthritis
Kim Papp¹, Alice B. Gottlieb², Catherine L. Shuler³, Russel T. Burge³, Gregory Cameron³, Lisa Kerr³ and Philip J Mease⁴, ¹K Papp Clinical Research, Inc. and Probity Medical Research, Waterloo, ON, Canada, ²Tufts University School of Medicine, Boston, MA, ³Eli Lilly and Company, Indianapolis, IN, ⁴Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA
Background/Purpose: PsA, a chronic immune-mediated inflammatory disease, can be progressive and destructive, resulting in physical deformities, impaired function, decreased quality of life, and increased mortality.…
Abstract Number: 3149 • 2016 ACR/ARHP Annual Meeting
“Early Use of Subcutaneous MTX Monotherapy Vs. MTX Oral or Combination Therapy Significantly Delays Time to Initiating Biologics in Early RA
Stephanie Gottheil¹, J Carter Thorne², Orit Schieir³, Gilles Boire⁴, Boulos Haraoui⁵, Carol Hitchon⁶, Diane Tin⁷, Cheryl Barnabe⁸, Glen Hazlewood⁸, Edward Keystone⁹, Vivian P. Bykerk¹⁰, Janet E. Pope¹¹, Susan J. Bartlett¹² and Canadian Early Arthritis Cohort, ¹University of Western Ontario, LONDON, ON, Canada, ²Southlake Regional Health Centre, Newmarket, ON, Canada, ³McGill University, Montreal, ON, Canada, ⁴Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, ⁵Institute de Rheumatologie, Montreal, QC, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ⁸Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ⁹Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada, ¹⁰Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ¹¹University of Western Ontario, St Joseph's Health Care, London, ON, Canada, ¹²Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada
Background/Purpose: Optimal treatment for moderate-severe early rheumatoid arthritis involves using a methotrexate-based, treat-to-target strategy aiming for remission. Achieving remission without using biologics may be preferable…

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