Abstracts tagged "Behcet’s syndrome"

Abstract Number: 2959 • 2016 ACR/ARHP Annual Meeting
Baseline Endothelial Dysfunction Might Predict Immunosuppressive Need in Young, Male Behcet’s Patients with Early Disease: A Prospective Follow-up
Fatma Alibaz-Oner¹, Emrah Karatay², Belgin Aldag¹, I.Nuri Akpınar², Tulin Ergun³ and Haner Direskeneli⁴, ¹Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, ²Radiology, Marmara University, School of Medicine, Istanbul, Turkey, ³Marmara University, School of Medicine, Dermatology, Istanbul, Turkey, ⁴Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Background/Purpose: Major organ involvement, especially in young males, is one of the main causes of mortality and morbidity in Behcet’s Disease (BD). However, the prognosis…
Abstract Number: 2963 • 2016 ACR/ARHP Annual Meeting
BehçEt’s Disease in Children: Eastern Mediterranean Experience
Hafize Emine Sonmez¹, Ezgi Deniz Batu¹, Betul Sozeri², Yonatan Butbul Aviel³, Yelda Bilginer⁴ and Seza Ozen⁵, ¹Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ²Pediatric Rheumatology, Erciyes University Faculty of Medicine, Kayseri, Turkey, ³Pediatric Rheumatology, Rambam Medical Center, Haifa, Israel, ⁴Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, ANKARA, Turkey, ⁵Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Background/Purpose: Behçet’s disease (BD) is a variable vessel vasculitis which is more common in adults. The most widely used diagnostic criteria for adult onset disease…
Abstract Number: 2966 • 2016 ACR/ARHP Annual Meeting
Assessment of Damage in Behcet’s Disease: Do We Need a Specific Damage Index?
Ali Ugur Unal¹, Hale Gulcin Yildirim², Ceylan Cikikci², Gulsen Ozen³, Nevsun Inanc³, Pamir Atagunduz³, Tulin Ergun⁴ and Haner Direskeneli⁵, ¹Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, ²Marmara University Faculty of Medicine, Istanbul, Turkey, ³Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁴Marmara University, School of Medicine, Dermatology, Istanbul, Turkey, ⁵Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Background/Purpose: Behcet’s Disease (BD) is a systemic vasculitis characterized by involvement of vessels of any size and type. In the course systemic vasculitis, it is…
Abstract Number: 182 • 2016 ACR/ARHP Annual Meeting
Histone Methylation in γδ T Cells As a Biomarker of Behcet’s Disease Activity
Yoshimi Aizaki^1,2, Yasuto Araki^1,2, Kojiro Sato¹, Kazuhiro Yokota¹ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Behcet’s disease (BD) is a chronic recurrent, multisystem inflammatory disorder. The phenotypic characteristics include oral aphtha, genital ulcers, uveitis and skin lesions. No specific…
Abstract Number: 2967 • 2016 ACR/ARHP Annual Meeting
Identifying Core Domains for BehçEt’s Syndrome Trials: An International Physician and Patient Delphi Exercise
Alexa Meara¹, Yesim Ozguler², Alfred Mahr³, Haner Direskeneli⁴, Ahmet Gul⁵, Yusuf Yazici⁶, Hasan Yazici², Peter A. Merkel⁷ and Gulen Hatemi², ¹Internal Medicine/Rheumatology, The Ohio State University, Columbus, OH, ²Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ³Hospital Saint-Louis, Paris, France, ⁴Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ⁵Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁶Rheumatology, New York University Medical Center, La Jolla, CA, ⁷Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: An unmet need for reliable, validated, and widely accepted outcome measures for trials in BehetÕs syndrome (BS) was identified through: i) a systematic review;…
Abstract Number: 879 • 2016 ACR/ARHP Annual Meeting
Associated Inflammatory Diseases in Takayasu’s Arteritis: The Many Faces of a Disease
Sinem Nihal Esatoglu¹, Ayse Merve Celik², Didar Ucar³, Aykut Ferhat Celik⁴, Serdal Ugurlu⁵, Gulen Hatemi⁵, Melike Melikoglu⁵, Izzet Fresko⁵, Vedat Hamuryudan⁵, Huri Ozdogan⁶, Sebahattin Yurdakul⁵, Hasan Yazici⁵ and Emire Seyahi⁵, ¹Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ²Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey, ³Istanbul University, Cerrahpasa Medical Faculty, Department of Ophthalmology, Istanbul, Turkey, ⁴Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Gastroenterology, Istanbul, Turkey, ⁵Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ⁶Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: Case reports and series suggest that Takayasu’s arteritis (TA) can co-exist with various inflammatory disorders. Inflammatory bowel disease [(IBD; Crohn's disease (CD) or ulcerative…
Abstract Number: 2978 • 2016 ACR/ARHP Annual Meeting
Psychiatric Involvement and Behcet’S Syndrome: Does Bipolar Disorder Represent a Clinical Feature of the Disease?
Rosaria Talarico¹, Elena Elefante², Laura Palagini³, Anna d'Ascanio⁴, Chiara Stagnaro⁴, Chiara Tani⁴, Chiara Baldini⁴, Rossella Neri¹ and Marta Mosca⁴, ¹Rheumatology Unit, University of Pisa, PISA, Italy, ²RHEUMATOLOGY UNIT, University of Pisa, Pisa, Italy, ³Psychiatric Unit, University, PISA, Italy, ⁴Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Frequency of psychiatric disorders in Behçet’s syndrome (BS) is a debated issue: while some experts attribute their presence to the chronicity of the illness,…
Abstract Number: 1202 • 2016 ACR/ARHP Annual Meeting
Characteristic Compositional and Functional Alteration of Gut Microbiota in Patients with Behcet’s Disease
Noboru Suzuki¹, Jun Shimizu² and Takao Kubota³, ¹Department of Immunology and medicine, St. Marianna University School of Medicine, Kawasaki-shi, 216-8511, Japan, ²Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ³The Japan Self Defense Forces Central Hospital, Tokyo, Japan
Background/Purpose: We have presented evidence that the frequency of helper T (Th)17 cells increased and the cells had already been activated in vivo in patients…
Abstract Number: 2979 • 2016 ACR/ARHP Annual Meeting
a Systematic Literature Review on the Treatment of Skin, Mucosa and Joint Involvement of BehçEt’s Syndrome Informing the Eular Recommendations for the Management of BehçEt’s Syndrome
Pietro Leccese¹, Yesim Ozguler², Robin Christensen³, Sinem Nihal Esatoglu⁴, Dongsik Bang⁵, Bahram Bodaghi⁶, Aykut Ferhat Celik⁷, Farida Fortune⁸, Julien Gaudric⁹, Ahmet Gul¹⁰, Ina Kotter¹¹, Alfred Mahr¹², Robert J Moots¹³, Ignazio Olivieri¹⁴, Jutta Richter¹⁵, David Saadoun¹⁶, Carlo Salvarani¹⁷, Frances Scuderi¹⁸, PETROS P SFIKAKIS¹⁹, Aksel Siva²⁰, Miles Stanford²¹, Ilknur Tugal-tutkun²², Richard West²³, Sebahattin Yurdakul², Hasan Yazici² and Gulen Hatemi², ¹Rheumatology, Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Matera, Italy, Matera, Italy, ²Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ³The Parker instutute, RC, Copenhagen, Denmark, ⁴Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ⁵Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea, Seoul, Korea, The Democratic People's Republic of, ⁶Ophthalmology, Pierre and Marie Curie University - Paris 6 Paris, France, Paris, France, ⁷Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Gastroenterology, Istanbul, Turkey, ⁸Dental Institute, Barts and The London NHS Trust, London, United Kingdom, ⁹Department of Vascular surgery GHPS, Paris, France, ¹⁰Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ¹¹Internal Medicine, Robert-Bosch-Hospital, Stuttgart, Germany, ¹²Hospital Saint-Louis, Paris, France, ¹³Academic Rheumatology Unit, University of Liverpool, Liverpool, United Kingdom, ¹⁴U.O. Reumatologia, A.O. Ospedale San Carlo, Potenza, Italy, ¹⁵Tubingen University, Tubingen, Germany, ¹⁶Department of Internal Medicine and Clinical Immunology, AP-HP Pitié-Salpêtrière Hospital, Paris, France, ¹⁷Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ¹⁸Patient partner, Catania, Italy, ¹⁹First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ²⁰Department of Neurology, Istanbul University, Cerrahpasa Medical Faculty, Department of Neurology, Istanbul, Turkey, ²¹Ophthalmology, Guy's and St. Thomas' Hospital, London, United Kingdom, ²²Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ²³Patient partner, London, United Kingdom
A Systematic Literature Review on the Treatment of Skin, Mucosa and Joint Involvement of Behçet’s Syndrome Informing the Eular Recommendations for the Management of Behçet’s…
Abstract Number: 1285 • 2016 ACR/ARHP Annual Meeting
PET/CT Imaging in Patients with Vascular Behcet Disease
Bahtiyar Toz¹, Burak Erer¹, Sevil Kamali¹, Murat Inanc², Lale Ocal³ and Ahmet Gul¹, ¹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, İstanbul, Turkey, ³Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: BehetÕs disease (BD) is a multisystemic disease characterized by recurrent inflammatory manifestations. BD is classified as variable vessel vasculitis. While inflammatory thrombotic venous findings…
Abstract Number: 3043 • 2016 ACR/ARHP Annual Meeting
Dense Genotyping of Immune Related Loci in a Multi-Ethnic Behçet’s Disease Cohort Identifies Genetic Associations in a Long Noncoding RNA Near QSOX2, RASIP1/FUT2, and IL12A-AS1
Paul Renauer¹, Patrick Coit¹, Travis Hughes², Mikhail Ognenovski¹, Adam Adler³, Lourdes Ortiz-Fernández⁴, Vuslat Yilmaz⁵, Kenan Aksu⁶, Nursen Duzgun⁷, Gokhan Keser⁸, Ayse Cefle⁹, Ayten Yazici¹⁰, Andac Ergen¹¹, Erkan Alpsoy¹², Carlo Salvarani¹³, Bruno Casali¹⁴, Ina Koetter¹⁵, Alexandra Zhernakova¹⁶, Cisca Wijmenga¹⁷, Fujio Takeuchi¹⁸, Shinji Harihara¹⁹, Toshikatsu Kaburaki²⁰, Yeong Wook Song²¹, Francisco David Carmona²², Marta E. Alarcon Riquelme²³, Javier Martín²², Güher Saruhan-Direskeneli²⁴, María Francisca Gonzalez Escribano²⁵, Haner Direskeneli²⁶ and Amr H Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, ³Oklahoma Medical Research Foundation, OK, OK, ⁴Immunology department, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ⁵Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Istanbul, Turkey, ⁶İnternal Medicine Division of Rheumatology, Ege University Medical Faculty, Izmir, Turkey, ⁷Internal Medicines, Rheumatology Department, Ankara University School of Medicine, Ankara, Turkey, ⁸Rheumatology, Ege University Medical Faculty, Izmir, Turkey, ⁹Rheumatology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey, ¹⁰Rheumatology, Kocaeli University School of Medicine, Kocaeli, Turkey, ¹¹Okmeydaný Research and Education Hospital, Istanbul, Turkey, ¹²Department of Dermatology, Akdeniz University School of Medicine, Antalya, Turkey, ¹³Rheumatology, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy, ¹⁴Molecular Biology Laboratory, Azienda Ospedaliera Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy, ¹⁵Internal Medicine IV Rheumatology, Asklepios Klinik Altona, Hamburg, Germany, ¹⁶Rheumatology and Clinical Immunology, University of Groningen, University Medical Center, Groningen, Netherlands, ¹⁷Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, ¹⁸#504 Lab/ Dep of Internal Medicine (Allergy & Rheumatology), Faculty of Medicine, University of Toyko, Tokyo, Japan, ¹⁹Division of Anthropology, Department of Biological Science, The University of Tokyo Graduate School of Science, Tokyo, Japan, ²⁰Ophthalmology, The University of Tokyo School of Medicine, Bunkyo-ku, Japan, ²¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea, ²²Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ²³Centro de Genomica e Investigación Oncológica, Pfizer-University of Granada-Junta de Andalucía, Granada, Spain, ²⁴Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ²⁵Hospital Universitario Virgen del Rocío (IBiS,CSIC,US), Sevilla, Spain, ²⁶Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Background/Purpose: Behçet’s disease is a chronic relapsing inflammatory disease characterized by recurrent mucocutaneous involvement. We performed dense genotyping in immune related loci in a large…
Abstract Number: 2034 • 2016 ACR/ARHP Annual Meeting
Novel Susceptible Genes for Behçet’s Disease Identified By Dense Genotyping of Immune-Related Loci Implicate Host Responses to Microbial Exposure
Masaki Takeuchi^1,2, Nobuhisa Mizuki³, Akira Meguro⁴, Michael J. Ombrello⁵, Yohei Kirino⁶, Colleen Satorius⁷, Julie Le¹, Mary Blake⁸, Burak Erer⁹, Tatsukata Kawagoe², Duran Ustek¹⁰, Ilknur Tugal-tutkun¹¹, Emire Seyahi¹², Yilmaz Ozyazgan¹³, Inês Sousa¹⁴, Fereydoun Davatchi¹⁵, Vânia Francisco¹⁴, Farhad Shahram¹⁶, Bahar Abdollahi¹⁷, Abdolhadi Nadji¹⁷, Niloofar Shafiee¹⁷, Fahmida Ghaderibarmi¹⁸, Shigeaki Ohno¹⁹, Atsuhisa Ueda⁶, Yoshiaki Ishigatsubo²⁰, Massimo G. Gadina²¹, Sofia Oliveira¹⁴, Ahmet Gul⁹, Daniel L. Kastner¹ and Elaine F. Remmers²², ¹National Human Genome Research Institute, Bethesda, MD, ²Yokohama City University Graduate School of Medicine, Yokohama, Japan, ³Yokohama City University, Yokohama, Japan, ⁴Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ⁵Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD, ⁶Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ⁷NIAMS, N.I.H, Bethesda, MD, ⁸National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ¹⁰Istanbul University, Istanbul, Turkey, ¹¹Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ¹²Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ¹³Ophthalmology, Istanbul University, Cerrahpasa Medical Faculty, Department of Ophthalmology, Istanbul, Turkey, ¹⁴Universidade de Lisboa, Lisboa, Portugal, ¹⁵Internal Medicine, Rheumatology Research Ctr-Tehran Univ, Tehran, Iran, ¹⁶Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ¹⁷Tehran University of Medical Sciences, Teheran, Iran (Islamic Republic of), ¹⁸Tehran University of Medical Sciences, Teheran, Portugal, ¹⁹Hokkaido University Graduate School of Medicine, Hokkaido, Japan, ²⁰Int. Med. & Clin. Immunology, Yokohama City Grad Sch of Med, Yokohama, Japan, ²¹Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²²National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: Recent genetic studies have identified multiple susceptibility loci for Behçet’s disease. However, these genetic factors do not fully explain the apparent disease heritability.The purpose…
Abstract Number: 2144 • 2016 ACR/ARHP Annual Meeting
Functional Analysis of Macrophages in BehçEt’s Disease: C-C Chemokine Receptor Type 1 (CCR1) and IL-10 Are Implicated in Pathogenesis of the Disease
Hiroto Nakano¹, Yohei Kirino¹, Momoko Ohno¹, Kana Higashitani¹, Mitsuhiro Takeno², Ryusuke Yoshimi¹ and Hideaki Nakajima³, ¹Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ³Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
Background/Purpose: The recent GWAS and subsequent studies have identified susceptible genes such as CCR1 and IL10 genes, suggesting pathological roles of macrophages in Behçet's disease…
Abstract Number: 2150 • 2016 ACR/ARHP Annual Meeting
Autoimmune Uveitis : Potential Role of Interleukin-22 (IL-22) in Pathogenesis
El-Desouki Fouda¹, El-Sayed Mostafa Elewah², Mona Elrayes³, Ghada Fouda⁴ and Mohamed Ahmed Bakry⁵, ¹Al-Azhar University, Dokki Cairo, Egypt, ²Opthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt, ³Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt, ⁴Faculty of Medicine, Al-Azhar University, Cairo, Egypt, ⁵Al-Azhar University, Allergy & Immunology Center, Cairo, Egypt
Background/Purpose: : IL-22 is a member of IL-10 family, with both anti- inflammatory and pro- inflammatory functions, orchestrating the immune and inflammatory response.IL-22 is secreted…
Abstract Number: 2940 • 2016 ACR/ARHP Annual Meeting
Bechet’s Disease and Sleep Quality in Korean Patients
Chang-Nam Son¹, Ji Min Lee¹, Hye-Jin Jeong², Ji-Min Kim¹, Sang-Hyon Kim¹, Sung Soo Kim³ and Seung-Hyeon Bae⁴, ¹Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Ulsan University School of Medicine, GangNeung Asan Hospital, Gangneung, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
Background/Purpose: The purpose of this study was to find out the effects of sleep quality on Behcet’s disease in Korean population. We also investigated the…

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