- Abstract Number: 0912 • ACR Convergence 2025 - CD11c⁺CD21⁻ Autoimmune-Associated B Cells Derived from Double-Negative IgD⁻CD27⁻ Subsets Exhibit Enhanced IFNLR1 Expression in Systemic Lupus ErythematosusBackground/Purpose: Autoimmune-associated B cells (ABCs) are increasingly recognized for their role in the pathogenesis of systemic lupus erythematosus (SLE), yet their developmental origins and specific…
- Abstract Number: 1723 • ACR Convergence 2025 - Impaired Maintenance of X-Chromosome Inactivation in B Cells, But Not T Cells, Exacerbates Interferon-Driven Systemic AutoimmunityBackground/Purpose: Many systemic autoimmune diseases associated with chronic type 1 interferon (IFN) signaling, including SLE, SjD, and SSc, preferentially afflict females. The biological basis of…
- Abstract Number: 0909 • ACR Convergence 2025 - Loss of MicroRNA29 expression in B cells and skin microbiota synergize to promote atopic dermatitis in mice.Background/Purpose: The microRNA(miR)29 family is encoded by two separate loci, the miR29ab1 and miR29b2c alleles. We have previously shown that the microRNA(miR)29 family regulates the…
- Abstract Number: 1697 • ACR Convergence 2025 - Dynamic Effects of T cell Engager Therapy on B and T cells in Autoimmune Disease.Background/Purpose: Treatment of autoimmune disease with T cell engagers (TCEs) leads to profound peripheral B cell depletion, followed by their reconstitution. However, the dynamics of…
- Abstract Number: 0897 • ACR Convergence 2025 - APECED Disease Reorganizes The B Cell Compartment Toward Alternatively Activated SubsetsBackground/Purpose: Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy (APECED) is a rare syndrome of multi-organ autoimmunity driven by the presence of self-reactive T cells and autoantibodies caused…
- Abstract Number: 1696 • ACR Convergence 2025 - A multi-omics resource of B cell activation reveals genetic mechanisms for autoimmune diseasesBackground/Purpose: Most genetic variants that confer risk of complex autoimmune diseases affect gene regulation in specific cell types. Their target genes and focus cell types…
- Abstract Number: 0894 • ACR Convergence 2025 - Altered B cell subpopulations in Giant Cell ArteritisBackground/Purpose: Giant cell arteritis (GCA), a large-vessel granulomatous vasculitis, has been considered as a T cell-dependent condition. Interestingly, tertiary lymphoid structures, B cell and plasma…
- Abstract Number: 1695 • ACR Convergence 2025 - The B Cell Compartment Exhibits a Pro-Inflammatory Skewing During Progression to Rheumatoid ArthritisBackground/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation and bone destruction. RA is preceded by a subclinical phase defined by elevated…
- Abstract Number: 0782 • ACR Convergence 2025 - Expansion of T-bet⁺ Age-Associated B Cells Is Associated with Clinical Complications in Still’s DiseaseBackground/Purpose: Still’s disease is a rare and severe autoinflammatory disorder characterized by daily spiking fevers, arthritis, an evanescent rash, and prominent systemic features, including lymphadenopathy,…
- Abstract Number: 1694 • ACR Convergence 2025 - Obesity Exacerbates Autoimmunity by Dysregulating B Cell BehaviorBackground/Purpose: Obesity is a major public health concern in the United States, affecting over 100 million individuals. While its detrimental effects on multiple organ systems…
- Abstract Number: 0521 • ACR Convergence 2025 - Umbilical cord-derived mesenchymal stem cells suppress the pathogenesis of primary Sjögren’s disease by inducing Bach2 expressionBackground/Purpose: Primary Sjögren's disease (pSD) is characterized by lymphocytic infiltration of the salivary and lacrimal glands, leading to functional loss and gradually causing dry mouth…
- Abstract Number: 1693 • ACR Convergence 2025 - Characterizing ANCA-specific B Cells in ANCA-associated VasculitisBackground/Purpose: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a severe autoimmune disease, characterized by ANCAs targeting myeloperoxidase (MPO) or proteinase-3 (PR3). ANCA-specific B cells have…
- Abstract Number: 0143 • ACR Convergence 2025 - High-dimensional Spectral Flow Cytometry Reveals a Unique Distribution of Circulating B Cells in Patients with Antiphospholipid SyndromeBackground/Purpose: Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by the presence of pathogenic antiphospholipid antibodies (aPL) in the setting of venous or…
- Abstract Number: 1692 • ACR Convergence 2025 - Rheumatoid factor is associated with increased gut permeability and migration of B cells to the joint via CXCR3 in rheumatoid arthritisBackground/Purpose: It has been proposed that the mucosal environment is associated with the pathogenesis of rheumatoid arthritis (RA). In addition to gut dysbiosis, intestinal barrier…
- Abstract Number: 0029 • ACR Convergence 2025 - A Novel B Cell Subpopulation Characteristic of IgA Vasculitis Identified by Single-Cell RNA SequencingBackground/Purpose: IgA vasculitis (IgAV) is a systemic small-vessel vasculitis characterized by immune complex deposition containing aberrantly glycosylated IgA1. While its clinical manifestations are well defined…
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