ACR Meeting Abstracts

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Abstracts tagged "B-Lymphocyte"

  • Abstract Number: 0912 • ACR Convergence 2025

    CD11c⁺CD21⁻ Autoimmune-Associated B Cells Derived from Double-Negative IgD⁻CD27⁻ Subsets Exhibit Enhanced IFNLR1 Expression in Systemic Lupus Erythematosus

    Roukaya Yaakoub, Diana Alzamareh, Alexander Bae William and Jennifer Barnas, university of rochester, rochester, NY

    Background/Purpose: Autoimmune-associated B cells (ABCs) are increasingly recognized for their role in the pathogenesis of systemic lupus erythematosus (SLE), yet their developmental origins and specific…
  • Abstract Number: 1723 • ACR Convergence 2025

    Impaired Maintenance of X-Chromosome Inactivation in B Cells, But Not T Cells, Exacerbates Interferon-Driven Systemic Autoimmunity

    Nikhil Jiwrajka1, Claudia Lovell1, Zowie Searcy1, Katherine Forsyth1, Emma Welter1, Natalie Toothacre2, Nuriban Valero-Pacheco1, Katherine Premo1 and Montserrat Anguera1, 1University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia

    Background/Purpose: Many systemic autoimmune diseases associated with chronic type 1 interferon (IFN) signaling, including SLE, SjD, and SSc, preferentially afflict females. The biological basis of…
  • Abstract Number: 0909 • ACR Convergence 2025

    Loss of MicroRNA29 expression in B cells and skin microbiota synergize to promote atopic dermatitis in mice.

    Marcus Hines1, Timothy Borbet2 and Sergei Koralov2, 1New York University Grossman School of Medicine, New York, NY, 2NYU Langone Medical Center, New York

    Background/Purpose: The microRNA(miR)29 family is encoded by two separate loci, the miR29ab1 and miR29b2c alleles. We have previously shown that the microRNA(miR)29 family regulates the…
  • Abstract Number: 1697 • ACR Convergence 2025

    Dynamic Effects of T cell Engager Therapy on B and T cells in Autoimmune Disease.

    Laura Bucci1, Tobias Rothe2, Ann-Kathrin Goetz3, Kirill Anoshkin1, Danae-Mona Nöthling1, Melanie Hagen1, Sebastian Böltz1, Andreas Wirsching1, Georg Schett4 and Ricardo Grieshaber-Bouyer5, 1Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, 2Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlagen, Germany, 3Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, 4Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany, 5University Hospital Erlangen, Erlangen, Germany

    Background/Purpose: Treatment of autoimmune disease with T cell engagers (TCEs) leads to profound peripheral B cell depletion, followed by their reconstitution. However, the dynamics of…
  • Abstract Number: 0897 • ACR Convergence 2025

    APECED Disease Reorganizes The B Cell Compartment Toward Alternatively Activated Subsets

    william Galbavy, Hyunjin Kim, Brian Klotz, Marine Malbec, Carley Tasker, Eva Conde, Andrea Vecchione, Seblewongel Asrat, Benjamin Daniel, Weikeat Lim, Andre Limnander and Jamie Orengo, Regeneron, Tarrytown, NY

    Background/Purpose: Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy (APECED) is a rare syndrome of multi-organ autoimmunity driven by the presence of self-reactive T cells and autoantibodies caused…
  • Abstract Number: 1696 • ACR Convergence 2025

    A multi-omics resource of B cell activation reveals genetic mechanisms for autoimmune diseases

    Vitor Aguiar1, Marcella Franco1, Nada Abdel Aziz1, Daniela Fernandez-Salinas2, Marcos Chinas1, Mariasilvia Colantuoni2, Qian Xiao1, Nicolaj Hackert1, Yifei Liao3, Rodrigo Cervantes-Diaz1, Marc Todd1, Brian Wauford1, Alex Wactor1, Vaishali Prahalad1, Raquel Laza-Briviesca1, Roxane Darbousset1, Qiang Wang1, Scott Jenks4, Kevin Cashman4, Esther Zumaquero4, Zhu Zhu1, Junning Case3, Paloma Cejas5, Miguel Munoz-Gomez5, Hannah Ainsworth6, Miranda Marion7, Mehdi Benamar1, Pui Lee8, Lauren Henderson9, Margaret Chang2, Kevin Wei10, Henry Long5, Carl Langefeld11, Benjamin Gewurz3, Ignacio Sanz4, Jeffrey Sparks12, Esra Meidan13, Peter Nigrovic2 and Maria Gutierrez-Arcelus2, 1Boston Children's Hospital, Boston, 2Boston Children's Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, 4Emory University, Atlanta, 5Dana Farber Cancer Institute, Boston, 6Wake Forest University, Winston-Salem, NC, 7Wake Forest, Winston-Salem, 8Boston Children's Hospital, Newton, MA, 9Boston Children's Hospital, Watertown, MA, 10Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 11Wake Forest University School of Medicine, Winston Salem, NC, 12Brigham and Women's Hospital, Boston, MA, 13Boston Children's Hospital, Somerville, MA

    Background/Purpose: Most genetic variants that confer risk of complex autoimmune diseases affect gene regulation in specific cell types. Their target genes and focus cell types…
  • Abstract Number: 0894 • ACR Convergence 2025

    Altered B cell subpopulations in Giant Cell Arteritis

    Maria-Eugenia Miranda-Carus1, Beatriz Nieto-Carvalhal2, Irene Monjo Henry1, Sara García-Carazo3 and Eugenio de Miguel1, 1Hospital Universitario La Paz, Madrid, Spain, 2Hospital Universitario La Paz, Mdrid, 3Hospital La Paz, Madrid

    Background/Purpose: Giant cell arteritis (GCA), a large-vessel granulomatous vasculitis, has been considered as a T cell-dependent condition. Interestingly, tertiary lymphoid structures, B cell and plasma…
  • Abstract Number: 1695 • ACR Convergence 2025

    The B Cell Compartment Exhibits a Pro-Inflammatory Skewing During Progression to Rheumatoid Arthritis

    Ziyuan He1, Marla Glass1, Mark Gillespie1, Elisabeth Dornisch1, Pravina Venkatesan2, Troy Torgerson3, Kevin Deane4, Gary Firestein5, Adam Savage1, Xiaojun Li1, V. Michael Holers6, Fan Zhang7, David Boyle8, Christy Bennett1, Kristine Kuhn9, Kristen Demoruelle10, Peter Skene11 and Ananda Goldrath11, 1Allen Institute for Immunology, Seattle, WA, 2Allen Insitute, Seattle, WA, 3Allen Institute for Immunology, Enumclaw, WA, 4University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 5University of California, San Diego, San Diego, CA, 6University of Colorado, Denver, CO, 7The University of Colorado, Aurora, CO, 8UCSD, La Jolla, CA, 92022 - 2023 / Adult/ University of Colorado, Aurora, CO, 10University of Colorado Anschutz Medical Campus, Golden, CO, 11Allen Institute for Immunology, Seattle

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation and bone destruction. RA is preceded by a subclinical phase defined by elevated…
  • Abstract Number: 0782 • ACR Convergence 2025

    Expansion of T-bet⁺ Age-Associated B Cells Is Associated with Clinical Complications in Still’s Disease

    Krisztian Csomos1, Boglarka Ujhazi1, Mariana Correia Marques2, Emily Rosenbaum1 and Michael Ombrello3, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, 2Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), North Bethesda, MD

    Background/Purpose: Still’s disease is a rare and severe autoinflammatory disorder characterized by daily spiking fevers, arthritis, an evanescent rash, and prominent systemic features, including lymphadenopathy,…
  • Abstract Number: 1694 • ACR Convergence 2025

    Obesity Exacerbates Autoimmunity by Dysregulating B Cell Behavior

    Munir Akkaya, Sohret Gokcek, Billur Akkaya and Wael Jarjour, The Ohio State University, Columbus, OH

    Background/Purpose: Obesity is a major public health concern in the United States, affecting over 100 million individuals. While its detrimental effects on multiple organ systems…
  • Abstract Number: 0521 • ACR Convergence 2025

    Umbilical cord-derived mesenchymal stem cells suppress the pathogenesis of primary Sjögren’s disease by inducing Bach2 expression

    Yukitomo Hagiwara1, Goh Murayama2, Taiga Kuga3, Yujin Nishioka4, Masaki Nojima1, Takumi Saito5, Yu Yamaji6, Tomoko Miyashita6, Makio Kusaoi7, Ken Yamaji5 and Naoto Tamura8, 1Juntendo University, Department of Internal Medicine and Rheumatology, Bunkyo-ku, Tokyo, Japan, 2Department of Internal Medicine and Rheumatology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Juntendo University, Tokyo, Japan, 4Juntendo University, Department of Internal Medicine and Rheumatology, Shizuoka, Japan, 5Juntendo University, Department of Internal Medicine and Rheumatology, Tokyo, Japan, 6Juntendo University, Department of Internal Medicine and Rheumatology, Bunkyo-ku, Tokyo, 7Juntendo University, Department of Internal Medicine and Rheumatology, Bunkyo, Tokyo, Japan, 8Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Primary Sjögren's disease (pSD) is characterized by lymphocytic infiltration of the salivary and lacrimal glands, leading to functional loss and gradually causing dry mouth…
  • Abstract Number: 1693 • ACR Convergence 2025

    Characterizing ANCA-specific B Cells in ANCA-associated Vasculitis

    Laura van Dam1, Mengrui Zhang1, Shima Parsafar2, Audra Horomanski3, Sajede Rasouli2, Orr Sharpe2, Jolijn van Leeuwen4, Tobias Lanz2, Cees van Kooten4, Onno Teng5 and William H. Robinson3, 1Stanford University, Stanford, CA, 2Stanford University, Stanford, 3Stanford University, Palo Alto, CA, 4Leiden University Medical Center, Leiden, Netherlands, 5Leiden University Medical Center, Leiderdorp, Netherlands

    Background/Purpose: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a severe autoimmune disease, characterized by ANCAs targeting myeloperoxidase (MPO) or proteinase-3 (PR3). ANCA-specific B cells have…
  • Abstract Number: 0143 • ACR Convergence 2025

    High-dimensional Spectral Flow Cytometry Reveals a Unique Distribution of Circulating B Cells in Patients with Antiphospholipid Syndrome

    Yuzhou Gan1, Srilakshmi Yalavarthi2, Yiran Shen1, Cyrus Sarosh3, Xiangjun Liu4, Ajay Tambralli1, Jacqueline Madison1, Yu (Ray) Zuo1 and Jason S. Knight1, 1University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, 3University of Michigan, Temperance, MI, 4Peking University, Beijing, Beijing, China

    Background/Purpose: Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by the presence of pathogenic antiphospholipid antibodies (aPL) in the setting of venous or…
  • Abstract Number: 1692 • ACR Convergence 2025

    Rheumatoid factor is associated with increased gut permeability and migration of B cells to the joint via CXCR3 in rheumatoid arthritis

    Ken Yasaka1, Nida Pellett2, Daria Krenitsky1 and Jennifer Anolik2, 1University of Rochester, Rochester, NY, 2University of Rochester Medical center, Rochester, NY

    Background/Purpose: It has been proposed that the mucosal environment is associated with the pathogenesis of rheumatoid arthritis (RA). In addition to gut dysbiosis, intestinal barrier…
  • Abstract Number: 0029 • ACR Convergence 2025

    A Novel B Cell Subpopulation Characteristic of IgA Vasculitis Identified by Single-Cell RNA Sequencing

    Joao Carlos Batista-Liz1, María Sebastián Mora-Gil2, Evan Troendle3, Oisin Cappa3, Maite Leonardo4, Ana Peñalba4, Luis mARTIN pENAGOS5, Ligia Gabrie-Rodriguez6, Rafael Gálvez Sánchez6, Jose Luis Callejas7, Belen Sevilla8, Diego de Argila9, Esther Vicente-Rabaneda9, Santos Castañeda10, David Simpson3, Ricardo Blanco11, Verónica Pulito Cueto1 and Raquel Lopez Mejias1, 1IDIVAL, Santander, Spain, 2Immunopathology Group, IDIVAL, Santander, Spain, 3Queens University, Wellcome-Wolfson Institute for Experimental Medicine, Belfast, United Kingdom, 4Division of Pediatrics, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 5Immunopathology Group, IDIVAL and Division of Nephrology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 6Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander , Spain, Santander, Spain, 7Department of Internal Medicine, Hospital San Cecilio, Granada, Spain, 8Division of Pediatrics, Hospital Universitario San Cecilio, Granada, Spain, 9Hospital Universitario de la Princesa, Madrid, Spain, 10Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Madrid, Spain, 11Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain, Santander, Cantabria, Spain

    Background/Purpose: IgA vasculitis (IgAV) is a systemic small-vessel vasculitis characterized by immune complex deposition containing aberrantly glycosylated IgA1. While its clinical manifestations are well defined…
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Embargo Policy

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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