ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "B-Lymphocyte"

  • Abstract Number: L16 • ACR Convergence 2024

    Dapirolizumab Pegol Demonstrated Significant Improvement in Systemic Lupus Erythematosus Disease Activity: Efficacy and Safety Results of a Phase 3 Trial

    Megan Clowse1, David Isenberg2, Joan Merrill3, Thomas Dörner4, Michelle Petri5, Edward Vital6, Eric Morand7, Teri Jimenez8, Stephen Brookes9, Janine Gaiha-Rohrbach10, Christophe Martin11, Annette Nelde12 and Christian Stach13, 1Division of Rheumatology and Immunology, Duke University, Durham, NC, 2Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, University College London, London, United Kingdom, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Department of Medicine/Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, 5Johns Hopkins University School of Medicine, Baltimore, MD, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 7Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, 8UCB, Raleigh, NC, 9Biogen, Maidenhead, United Kingdom, 10Biogen, Cambridge, MA, 11UCB, Slough, United Kingdom, 12Biogen, Baar, Switzerland, 13UCB, Monheim am Rhein, Germany

    Background/Purpose: Dapirolizumab pegol (DZP) is a novel, polyethylene glycol (PEG)-conjugated antigen-binding (Fab') fragment, lacking an Fc domain, that inhibits CD40L signaling. By binding to CD40L,…
  • Abstract Number: 0811 • ACR Convergence 2024

    High-Throughput Proteomic Profiling of Longitudinal Serum Samples to Predict Treatment Response in Lupus Nephritis

    Benjamin Jones1, Rufei Lu2, Andrea Fava3, Peter Izmirly4, Jennifer Anolik5, Chaim Putterman6, David Wofsy7, Matthias Kretzler8, Celine Berthier9, E. Steven Woodle10, Michael Weisman11, Mariko Ishimori12, The Accelerating medicines Partnership: RA/SLE Network13, Betty Diamond14, Jill Buyon15, Michelle Petri16, Judith James13 and Joel Guthridge13, 1Oklahoma State University, Oklahoma City, OK, 2University of California San Francisco, San Bruno, CA, 3Johns Hopkins University, Baltimore, MD, 4New York University Grossman School of Medicine, New York, NY, 5University of Rochester Medical Center, Rochester, NY, 6Albert Einstein College of Medicine, Safed, Israel, 7University of California San Francisco, SF, CA, 8University of Michigan, Ann Arbor, MI, USA, Ann Arbor, MI, 9University of Michigan, Ann Arbor, MI, 10University of Cincinnati College of Medicine, Cincinnati, OH, USA, Cinncinnati, OH, 11Stanford University, Los Angeles, CA, 12Cedars-Sinai Health System, Los Angeles, CA, 13Oklahoma Medical Research Foundation, Oklahoma City, OK, 14The Feinstein Institutes for Medical Research, Manhasset, NY, 15NYU Grossman School of Medicine, New York, NY, 16Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Lupus nephritis (LN) can lead to severe morbidity and early mortality in SLE patients. While therapeutic options for LN have improved, they are not…
  • Abstract Number: 1679 • ACR Convergence 2024

    Differential Pharmacodynamic Changes of Circulated Immune Subsets After Treatment with Abatacept or Adalimumab in Patients with ACPA+ Early RA in the AMPLIFIED Study

    Nathanial Eddy1, Jane Buckner2, Paul Emery3, Michael Weinblatt4, Vivian Bykerk5, Andrew Cope6, Gerd Burmester7, Yoshiya Tanaka8, Gustavo Citera9, Peter Nash10, Quentin Dornic11, Peter Schafer12, Sheila Kelly13, Michael Maldonado11 and Jinqi Liu11, 1Bristol Myers Squibb, Princeton, 2Benaroya Research Institute, Seattle, WA, 3University of Leeds, Leeds, United Kingdom, 4Brigham and Women's Hospital/ Harvard Medical School, Waban, MA, 5Hospital For Special Surgery, New York, NY, 6King's College London, London, United Kingdom, 7Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 8Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 9Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 10Griffith University, Brisbane, Australia, 11Bristol Myers Squibb, Princeton, NJ, 12Bristol Myers Squibb, BELLE MEAD, NJ, 13Bristol Myers Squibb, Doylestown, PA

    Background/Purpose: Despite considerable advances in pharmacologic approaches to RA management, a better understanding of the underlying immunopathology is still needed.1,2 A dysregulated immune system is…
  • Abstract Number: 0836 • ACR Convergence 2024

    NF-κB Inducing Kinase Is a Therapeutic Target for Autoimmune Diseases by Orchestrating Both B Cell and T Follicular Helper Cell Responses

    Jee Ho Lee1, Manisha Mohandoss2, Lichchavi Rajasinghe1, Silvia Preite3, Katie Madore2, Mark Birrell4, Jan Piet van Hamburg5, Sander Tas6, Matthew Perry3, Tatiana Ort1 and Gary Sims1, 1Immunology Biosciences, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 2Immunology Biosciences, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaitherburg, 3Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, 4Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, london, United Kingdom, 5Amsterdam UMC, Amsterdam, Netherlands, 6Amsterdam UMC, locatie AMC, Amsterdam, Netherlands

    Background/Purpose: T follicular helper (Tfh) cells are a specialized CD4+ T cell subset which can help B cells in the germinal center (GC) to drive…
  • Abstract Number: 1775 • ACR Convergence 2024

    Childhood-onset Sjögren Disease Has an Altered Peripheral Blood Immune Landscape Compared to Adult-onset Disease Characterized by Activated CD4+ T-cells Which Could Drive B-cell Dysregulation

    Junjie Peng, Lucia Martin-Gutierrez, George Robinson, Elizabeth Jury and Coziana Ciurtin, University College London, London, United Kingdom

    Background/Purpose: Childhood-onset Sjögren Disease (cSjD) is a rare, poorly understood autoimmune rheumatic disease with onset before 18 years. Differences in clinical presentation compared to adults/lack…
  • Abstract Number: 0001 • ACR Convergence 2024

    Type I Interferon and Anifrolumab Effects on Bone Marrow and Blood Plasma Cells in Systemic Lupus Erythematosus

    Diana Alzamareh1, Nida Pellett2, Daria Krenitsky2, Wesley Durrett1, Javier Rangel-Moreno1, Jennifer Anolik2 and Jennifer Barnas1, 1University of Rochester, Rochester, NY, 2University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of pathogenic anti-nuclear antibodies (ANA) by plasma cells (PC).  Importantly, long-lived plasma…
  • Abstract Number: 0839 • ACR Convergence 2024

    Comprehensive Single-cell Analysis Reveals Interferon Pathway Activation and Aberrant B Cell Dynamics in APS Autoimmunity

    Haoyu Pan, Xiaohan Wei, Jinyi Qian, Shuyi Yu, Zhixia Yang, Zetao Ding, Chengde Yang and Hui Shi, Department of Rheumatology and lmmunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai, China (People's Republic)

    Background/Purpose: Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized with the presence of pathogenic antiphospholipid antibodies (aPL) by autoreactive B cells. However, it remains…
  • Abstract Number: 1784 • ACR Convergence 2024

    T-bet Expressing B Cells as a Putative Prognostic and Therapeutic Biomarker for Human SLE

    Athanasios Sachinidis1, Maria Trachana2, Anna Taparkou2, George Gavriilidis3, Vasileios Vasileiou3, Sofoklis Keisaris3, Panayotis Verginis4, Christina Adamichou5, Dimitrios Boumpas6 and Alexandros Garyfallos2, 1School of Medicine, Aristotle University of Thessaloniki, Greece, Thessaloniki, Greece, 2Ippokrateio General Hospital Thessaloniki, Thessaloniki, Greece, 3Centre for Research and Technology Hellas, Thessaloniki, Greece, 4Medical School, University of Crete, Heraklion, Crete, Greece, 5IPPOKRATEION HOSPITAL OF THESSALONIKI, Athens, Greece, 64th Department of Internal Medicine, "Attikon" University Hospital, Athens, Greece, Athens, Greece

    Background/Purpose: T-bet+ B cells, known as age-associated B cells (ABCs) and/or double-negative B cells (DN), expand in various autoimmune diseases. This study aimed to clarify…
  • Abstract Number: 0007 • ACR Convergence 2024

    Bromodomain 2 of BET Proteins Plays a Crucial Role in Follicular/peripheral Helper T Cell and Plasma Cell Differentiation

    Ryota Sato1, Mitsuhiro Akiyama2, Koichi Oshita3, Yuko Kawano3, Yuki Imura3, Piruzyan Mariam4, Manami Kikuchi3, Mikako Murase3, Sachiko Mochiduki3, Naohiro Hashimoto3, Masayuki Watanabe3, Keiko Yoshimoto5, Tsutomu Takeuchi6, Kenji Chiba7 and Yuko Kaneko5, 1Mitsubishi Tanabe Pharma Corporation, Brighton, MA, 2Keio University School of Medicine, Palo Alto, CA, 3Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan, 4Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan, 5Keio University School of Medicine, Tokyo, Japan, 6Department of Internal Medicine, Keio University, Tokyo, Tokyo, Japan, 7Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan

    Background/Purpose: Proteins motifs bromodomain 1 (BD1) and BD2 within the BET family proteins regulate gene expression of inflammatory cytokines and lymphocyte proliferation by binding to…
  • Abstract Number: 0897 • ACR Convergence 2024

    Dynamic eQTLs from Activated Human B Cells Suggest Cell-state Dependent Effects for GWAS Risk Variants in BLK

    Yao Fu, David Murphy, Richard Pelikan, Jeniffer Kelly, Kiely Grundahl, Satish Pasula, Kandice Tessneer and Patrick Gaffney, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex genetic disease in which B cells play a critical role in pathogenesis. Previous genome-wide association studies (GWAS)…
  • Abstract Number: 1786 • ACR Convergence 2024

    Select Immune Cell Dysregulation Identifies Clinically Quiescent Patients at Risk of Flare Who Stop Mycophenolate Mofetil While Continuing Hydroxychloroquine

    Christian Wright1, Rufei Lu2, Catriona Wagner3, Carla Guthridge4, Susan Macwana1, Eliza Chakravarty4, Tammy Utset5, Diane Kamen6, Gabriel Nicolas Contreras Martin7, William McCune8, Cynthia Aranow9, Kenneth Kalunian10, Elena Massarotti11, Megan Clowse12, Brad Rovin13, S. Sam Lim14, Vikas Majithia15, Richard Looney16, Maria Dall'Era17, Doruk Erkan18, Amit Saxena19, Nancy Olsen20, Kichul Ko21, Ellen Goldmuntz22, William Barry23, Ashley Pinckney24, ALE06 Clinical Study Team4, Judith James4 and Joel Guthridge4, 1Oklahoma Medical Research Foundation, Oklahoma City, 2University of California San Francisco, San Bruno, CA, 3Oklahoma Medical Research Foundation, Santa Cruz, CA, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5University of Chicago, Chicago, IL, 6Medical University of South Carolina, Charleston, SC, 7University of Miami, Key Biscayne, FL, 8U Michigan, Ann Arbor, MI, 9Feinstein Institutes for Medical Research, New York, NY, 10University of California San Diego, La Jolla, CA, 11Brigham and Women's Hospital, Boston, MA, 12Duke University, Chapel Hill, NC, 13The Ohio State University, Columbus, OH, 14Emory University, Atlanta, GA, 15Mayo Clinic Florida, Jacksonville, FL, 16University of Rochester, Rochester, NY, 17UCSF, Corte Madera, CA, 18Hospital for Special Surgery, New York, NY, 19NYU School of Medicine, New York, NY, 20Penn State University/Milton S Hershey, Hershey, PA, 21The University of Chicago, Chicago, IL, 22NIAID/ NIH, Washington, DC, 23Rho, Inc, Durham, NC, 24Rho, St Louis Park, NC

    Background/Purpose: Mycophenolate mofetil (MMF) is commonly used to treat major SLE manifestations; however, it is associated with significant toxicities. Thus, MMF withdrawal is desirable in…
  • Abstract Number: 0012 • ACR Convergence 2024

    Dichotomous Expression of CXCR3 and CCR9 and Relationship to Intestinal Permeability in B Cells in Rheumatoid Arthritis

    Ken Yasaka, Ruoqiao Wang, Nida Pellett, Daria Krenitsky, Juilee Thakar and Jennifer Anolik, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: The gut is a key mucosal tissue that can impact the immune system and contribute to systemic inflammation in the setting of increased intestinal…
  • Abstract Number: 0905 • ACR Convergence 2024

    High-Throughput Proteomic Profiling of Sera as a Non-Invasive Method for Identifying Lupus Nephritis Subtypes

    Rufei Lu1, Andrea Fava2, Benjamin Jones3, Peter Izmirly4, Jennifer Anolik5, Chaim Putterman6, David Wofsy7, Matthias Kretzler8, Celine Berthier9, E. Steve Woodle10, Michael Weisman11, Mariko Ishimori12, The Accelerating medicines Partnership: RA/SLE Network13, Betty Diamond14, Jill Buyon15, Michelle Petri16, Richard Furie17, Judith James13 and Joel Guthridge13, 1University of California San Francisco, San Bruno, CA, 2Divison of Rheumatology, Johns Hopkins University, Baltimore, MD, 3Oklahoma State University, Oklahoma City, OK, 4New York University Grossman School of Medicine, New York, NY, 5University of Rochester Medical Center, Rochester, NY, 6Albert Einstein College of Medicine, Safed, Israel, 7University of California San Francisco, SF, CA, 8University of Michigan, Ann Arbor, MI, USA, Ann Arbor, MI, 9University of Michigan, Ann Arbor, MI, 10University of Cincinnati College of Medicine, Cincinnati, OH, USA, Cinncinnati, OH, 11Stanford University, Los Angeles, CA, 12Cedars-Sinai Health System, Los Angeles, CA, 13Oklahoma Medical Research Foundation, Oklahoma City, OK, 14The Feinstein Institutes for Medical Research, Manhasset, NY, 15NYU Grossman School of Medicine, New York, NY, 16Johns Hopkins University School of Medicine, Timonium, MD, 17Northwell Health, Manhasset, NY

    Background/Purpose: Lupus nephritis (LN) treatment decisions are typically informed using histopathological classification based on the International Society of Nephrology/Renal Pathology Society (ISN/RPS) and NIH activity…
  • Abstract Number: 1804 • ACR Convergence 2024

    Investigating Adaptive Immune Receptor Repertoires by Deep Immune Cell Phenotyping in Preclinical Autoimmunity Development

    Aleksandra Bylinska1, Miles Smith1, Rufei Lu1, Benjamin Jones2, Carla Guthridge1, Matthew Caleb Marlin1, Christian Wright3, Susan Macwana3, Wade DeJager3, Marci Beel3, Christopher Lessard1, Cristina Arriens1, Joan Merrill4, Judith James1 and Joel Guthridge1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma State University, Oklahoma City, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, 4Oklahoma Medical Research Foundation, Oklahoma City 73104, OK

    Background/Purpose: A loss of systemic self-tolerance to anti-nuclear autoantibodies (ANAs) is one of the main hallmarks of SLE. However, most healthy females with ANAs will…
  • Abstract Number: 0015 • ACR Convergence 2024

    Profiling of B and T Cells in Kidney Biopsies from ANCA-associated Vasculitis Patients with Glomerulonephritis at Single-Cell Resolution

    Ana Merino Vico1, Yosta Vegting1, Aldo Jongejan1, Jan Piet van Hamburg1, Perry moerland1, Sander Tas2 and Marc Hilhorst1, 1Amsterdam UMC, Amsterdam, Netherlands, 2Amsterdam UMC, locatie AMC, Amsterdam, Netherlands

    Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small-vessel autoimmune vasculitis, associated with severe lung and kidney impairment. B cells are crucial in AAV…
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