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Abstracts tagged "B-Lymphocyte"

  • Abstract Number: 0002 • ACR Convergence 2021

    Salivary Sodium Levels in the Parotid Salivary Gland of SS Patients Suggest B-cell Mediated Epithelial Sodium Channel Disruption

    Sarah Pringle1, Bas Berkhof1, Martha S. van Ginkel2, Silvia Liefers1, Bert van der vegt2, Fred Spijkervet2, Hendrika Bootsma1, Arjan Vissink1 and Frans Kroese1, 1University Medical Center Groningen, Groningen, Netherlands, 2University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Patients with Sjögren’s syndrome (SS) suffer from significantly reduced saliva production. Saliva is important for oral health. A careful of sodium, chloride, potassium and…
  • Abstract Number: 1484 • ACR Convergence 2021

    B Cell Intracellular IFNβ as a Unique Cellular Marker for the Development of Lupus Nephritis

    Fatima Alduraibi1, Huma Fatima1, Winn Chatham2, Hui-Chen Hsu1 and John Mountz1, 1University of Alabama Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Our laboratory previously demonstrated a strong association of B cell intracellular interferon beta (IFNβ) with the development of anti-Smith/ribonuclear protein (Sm/RNP), anti-DNA, and lupus…
  • Abstract Number: 0004 • ACR Convergence 2021

    Unappreciated Systemic Metabolic Functions of the Canonical B Cell Cytokines, BAFF and APRIL: Regulation of Lipolysis and Non-shivering Thermogenesis and Protection from Obesogenic Diet Induced Weight Gain

    Isaac Harley1, Calvin Chan2, Paul Pfluger3, Trompette Aurelien4, Traci Stankiewicz5, Jessica Allen5, Maria Moreno-Fernandez5, Michelle Damen5, Jarren Oates5, Pablo Alarcon5, Jessica Doll6, Matthew Flick7, Leah Flick8, Juan Sanchez-Gurmaches9, Rajib Mukherjee9, Rebekah Karns10, Michael Helmrath11, Thomas Inge12, Stuart Weisberg13, Sunje Pamp14, David Relman15, Randy Seeley16, Matthias Tschoep17, Chris Karp18 and Senad Divanovic8, 1University of Colorado Anschutz Medical Campus, Aurora, CO, 2University of Cincinnati, Cincinnati, OH, 3Technical University of Munich, Munich, Germany, 4Le Centre hospitalier universitaire vaudois, Lausanne, Switzerland, 5Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinnati, OH, 6Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinn, OH, 7Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 8Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9Division of Endocrinology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 10Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 11Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 12Department of Surgery, Children’s Hospital Colorado, Aurora, CO, 13Columbia University Medical Center, New York, NY, USA, New York, NY, 14Danmarks Tekniske Universitet, Lyngby, Denmark, 15Department: Medicine - Med/Infectious Diseases - Stanford University, Stanford, 16Department of Surgery, Internal Medicine and Nutritional Sciences, University of Michigan, Ann Arbor, MI, 17Division of Metabolic Diseases, Technische Universität München, Munich, Germany, 18Division of Molecular Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati

    Background/Purpose: The impact of immune mediators on weight homeostasis and systemic metabolism remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative…
  • Abstract Number: 1490 • ACR Convergence 2021

    Myeloid and B Cell Transcriptional Phenotypes Reveal Race Dependent Differences in Early Autoimmunity

    Aleksandra Bylinska, Samantha Slight-Webb, Kevin Thomas, Miles Smith, Susan Macwana, Nicolas Dominguez, Eliza Chakravarty, Joan Merrill, Judith James and Joel Guthridge, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Early immune events leading to clinical autoimmune disease are complex and the pathways involved remain incompletely defined. Anti-nuclear antibody (ANA) positivity is a feature…
  • Abstract Number: 0006 • ACR Convergence 2021

    Metabolic Characteristics of Age-related B Cells in Lupus-prone Mice and Effects on Follicular Helper T Cells

    Ivan Ramirez1, Betty Diamond2 and Sun Jung Kim3, 1Northwell, Little Neck, NY, 2Northwell Health, Manhasset, NY, 3Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Since the description of age-associated B cells (ABC), there has been a growing interest in the role of these cells in autoimmunity. Evidence suggests…
  • Abstract Number: 1502 • ACR Convergence 2021

    Longitudinal Changes in B Cell Subsets in Patients in the Mesenchymal Stromal Cell Trial in Lupus: Analysis of the First Cohort

    Diane Kamen1, S Sam Lim2, Scott Jenks3, Regina Bugrovosky3, Aisha Hill3, Chungwen Wei3, Cristina Drenkard3, Kenneth Kalunian4, Ummara Shah5, Mariko Ishimori6, Rosalind Ramsey-Goldman7, Saira Sheikh8, Mary Alison Mahieu7, Daniel Wallace9, Ellen Goldmuntz10 and Gary Gilkeson1, 1Medical University of South Carolina, Charleston, SC, 2Department of Medicine, Division of Rheumatology, Emory University School of Medicine, Atlanta, GA, 3Emory University, Atlanta, GA, 4UC San Diego, La Jolla, CA, 5University of Rochester, Rochester, NY, 6Cedars-Sinai Health System, Los Angeles, CA, 7Northwestern University, Chicago, IL, 8University of North Carolina, Chapel Hill, NC, 9Attune Health, Beverly Hills, CA, 10National Institutes of Health, Bethesda, MD

    Background/Purpose: Recent advances allow expanded identification of B cell subtypes of pathogenic potential in lupus. Of particular interest are IgD- CD27- double negative (DN2) B…
  • Abstract Number: 0008 • ACR Convergence 2021

    Jo-1-Binding and Clonally-Expanded Memory B Cells Express Germline and Somatically-Mutated B Cell Receptors in Anti-tRNA Synthetase Syndrome Patients

    Erin Wilfong, Alberto Cisneros, Jennifer Young-Glazer, Scott Smith, Leslie Crofford and Rachel Bonami, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Anti-tRNA synthetase syndrome (ARS) is a severe systemic autoimmune disease associated with myositis, interstitial lung disease, rash, and arthritis. ARS is associated with autoantibodies…
  • Abstract Number: 1905 • ACR Convergence 2021

    CD11c+ Expression Associates with IFN-λ Responsiveness in Human B Cells with Clinical Implications for SLE

    Jennifer Barnas1, Jennifer Barnard2, Cameron Baker2, Nida Meednu2, Andrew McDavid1, R. John Looney1 and Jennifer Anolik2, 1University of Rochester, Rochester, NY, 2University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Type I interferon (IFN), namely IFN- α, and B cell aberrations are long recognized in systemic lupus erythematosus (SLE) pathogenesis. Type I IFN receptor…
  • Abstract Number: 0010 • ACR Convergence 2021

    Relaxed Peripheral Tolerance Drives Broad de Novo Autoreactivity in Severe COVID-19

    Matthew Woodruff1, Richard Ramonell2, Ankur Singh Saini2, Mark Rudolph3, F. Eun-Hyung Lee2 and Iñaki Sanz4, 1Emory University, Decatur, GA, 2Emory University, Atlanta, GA, 3Exagen Inc., Vista, CA, 4Emory University School of Medicine, Atlanta, GA

    Background/Purpose: An emerging feature of COVID-19 is the identification of autoreactivity in patients with severe disease that may contribute to disease pathology, however the origins…
  • Abstract Number: 1907 • ACR Convergence 2021

    Increased Otoferlin Expression in B Cells Is Associated with Muscle Weakness in Untreated Juvenile Dermatomyositis: A Pilot Study

    Ameera Bukhari1, Amer Khojah2, Wilfredo Marin3, Gabrielle Morgan4 and Lauren Pachman5, 1Department of Microbiology and Immunology, Loyola University Chicago, Chicago, IL, 2Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 3Ann & Robert H. Lurie Children's Hospital, Chicago, IL, 4Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 5Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL

    Background/Purpose: Juvenile Dermatomyositis (JDM) is a rare pediatric inflammatory myopathy with a complex pathophysiology. Previously our group showed a significant increase in Otoferlin mRNA expression…
  • Abstract Number: 0321 • ACR Convergence 2021

    Sequential Administration of Belimumab and Rituximab in Primary Sjögren’s Syndrome Reduces Minor Salivary Gland–Resident B Cells and Delays B-Cell Repopulation in Circulation

    André van Maurik1, David Gardner2, Saba Nayar2, Charlotte Smith2, Kenneth Clark1, Prafull Mistry1, Rajesh Punwaney3, David Roth3, Robert Henderson1, Xavier Mariette4 and Francesca Barone2, 1GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom, 2University of Birmingham, College of Medical and Dental Sciences, Birmingham, United Kingdom, 3GlaxoSmithKline, Collegeville, PA, 4Université Paris- Saclay, Rheumatology, Paris, France

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is characterized by B-cell hyperactivity and elevated serum and saliva B-lymphocyte stimulator (BLyS) levels.1 Sequential administration of belimumab (BEL; anti-BLyS)…
  • Abstract Number: 0322 • ACR Convergence 2021

    Histopathological Changes in Parotid and Labial Salivary Gland Tissue in Primary Sjögren’s Syndrome Patients After Abatacept Treatment

    Uzma Nakshbandi1, Liseth de Wolff2, Frans Kroese1, Silvia Liefers3, Neelanjana Ray4, Gwenny Verstappen1, Fred Spijkervet3, Marleen Nys5, Arjan Vissink6, Robert Wong7, Bert van der vegt3 and Hendrika Bootsma1, 1University Medical Center Groningen, Groningen, Netherlands, 2University Medical Centre Groningen, Groningen, Netherlands, 3University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 4Bristol-Myers Squibb Company, Lawrenceville, GA, 5Bristol Myers Squibb, Braine-l'Alleud, Belgium, 6University of Groningen, University Medical Center Groningen, Leek, Netherlands, 7Bristol Myers Squibb, Basking Ridge, NJ

    Background/Purpose: In a previous open-label phase II study, we showed that abatacept treatment might inhibit local formation of autoreactive memory B cells in parotid glands…
  • Abstract Number: 0416 • ACR Convergence 2021

    Pharmacological Response of Rituximab Based on Dose Intensity in Maintenance Therapy of ANCA-Associated Vasculitis

    Jason Springer1 and Ryan Funk2, 1Vanderbilt University Medical Center, Franklin, TN, 2University of Kansas Medical Center, Kansas City, KS

    Background/Purpose: Rituximab (RTX) has demonstrated efficacy in maintenance therapy in ANCA-associated vasculitis. However, different dosing protocols have been used in clinical trials and there is…
  • Abstract Number: 0460 • ACR Convergence 2021

    Single-cell Profiling of B and T Cell Repertoire and Gene Expression in the RA Synovium Reveals Tissue Specific Clonal Expansion

    Nida Meednu1, Aaron Wagner2, Garett Dunlap3, Fan Zhang4, Anna Helena Jonsson5, Kevin Wei5, Paul Utz6, William Robinson7, Holden Maecker7, Judith James8, Joel Guthridge8, S. Louis Bridges, Jr.9, Vivian Bykerk9, Laura Donlin9, Susan Goodman9, Edward DiCarlo9, Christopher Ritchlin10, Darren Tabechian2, James Lederer11, Ellen Gravallese12, Mandy McGeachy13, Gary Firestein14, David Boyle15, Peter Gregersen16, Diane Horowitz17, Harris Perlman18, Arthur Mandelin18, Joan Bathon19, Laura Geraldino-Pardilla19, Laura Hughes20, V. Michael Holers21, Kevin Deane22, Larry Moreland21, Andrew Filer23, Costantino Pitzalis24, Lindsy Forbess25, Ami Ben-artzi26, Karen Salomon-Escoto27, Soumya Raychaudhuri5, Michael Brenner28, Deepak Rao5, Andrew McDavid2, Jennifer Anolik1 and Accelerating Medicines Partership (AMP) RA/SLE Network29, 1University of Rochester Medical center, Rochester, NY, 2University of Rochester, Rochester, NY, 3Harvard University, Somerville, MA, 4Harvard Medical School, Boston, MA, 5Brigham and Women's Hospital, Boston, MA, 6Stanford University, Stanford, CA, 7Stanford University, Palo Alto, CA, 8Oklahoma Medical Research Foundation, Oklahoma City, OK, 9Hospital for Special Surgery, New York, NY, 10Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, 11Brigham and Women's Hospital and Harvard Medical School, Millis, MA, 12Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA, 13University of Pittsburgh, Pittsburgh, PA, 14University of California San Diego, San Diego, CA, 15University of California San Diego, La Jolla, CA, 16The Feinstein Institute for Medical Research, Larchmont, NY, 17Northwell Health, Jericho, NY, 18Northwestern University, Chicago, IL, 19Columbia University, New York, NY, 20University of Alabama at Birmingham, Birmingham, AL, 21University of Colorado, Denver, CO, 22University of Colorado Denver, Denver, CO, 23University of Birmingham, Birmingham, United Kingdom, 24Queen Mary University of London, London, United Kingdom, 25Cedars-Sinai Medical Center, Los Angeles, CA, 26Cedars-Sinai Medical Center, Beverly Hills, CA, 27University of Massachusetts Medical School, Shrewsbury, MA, 28Brigham and Women's Hospital, Harvard Medical School, Newton, MA, 29Brigham and Women's Hospital, Everett, MA

    Background/Purpose: B cell and T cell activation pathways in the synovium are an incompletely understood feature of rheumatoid arthritis. In this study, utilizing single cell…
  • Abstract Number: 0982 • ACR Convergence 2021

    B Cells Repertoire Repartition Predicts Response to Methotrexate at 6 and 12 Months in Naïve RA: A Machine Learning Driven Approach

    Aurelie Najm1, Shrutii Sarda2, Michelle Toro3, Loni Pickle3, Stephanie Ostresh3, Fraser Morton4, Geoffrey Lowman3, Andrew Felton5 and Carl Goodyear4, 1Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 2Clinical Sequencing Division, Specialty Diagnostics Group, Thermo Fisher Scientific, South San Francisco-CA, United States, San Francisco, 3Clinical Sequencing Division, Specialty Diagnostics Group, Thermo Fisher Scientific, Carlsbad, CA, 4University of Glasgow, Glasgow, United Kingdom, 5VP, Platforms, Research & Applied, Specialty Diagnostics Group, South San Francisco, CA

    Background/Purpose: The adaptive immune system plays a central role in Rheumatoid Arthritis (RA) pathogenesis. Moreover, the composition of the B cell repertoire and its perturbation…
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