Abstract Number: 0285 • ACR Convergence 2026
Transcriptional changes associated with cenerimod therapy, a selective S1PR1 modulator, in systemic lupus erythematosus: analysis from the placebo-controlled Phase 2b CARE trial
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving dysregulated innate and adaptive immunity, with autoreactive B and T cells being central to…Abstract Number: 1104 • ACR Convergence 2026
HB2198: A Tetravalent Bispecific anti-CD19/CD20 Antibody with Dual Fc Domains for Enhanced Immune Effector Functions and Deep B Cell Depletion in SLE
Background/Purpose: Systemic lupus erythematosus (SLE) remains a disease of high unmet need, where conventional monoclonal antibodies often fail to achieve consistent B cell depletion and…Abstract Number: 1908 • ACR Convergence 2026
Cloning and Functional Characterization of Pathogenic Autoantibodies from Systemic Lupus Erythematosus Patients
Background/Purpose: The presence and pathogenic effect of autoantibodies in systemic lupus erythematosus (SLE) have been well recognized, but lacks validation at monoclonal level. This study…Abstract Number: 2890 • ACR Convergence 2026
Double-negative B-cell expansion predicts relapse in newly diagnosed giant cell arteritis
Background/Purpose: Giant cell arteritis, traditionally considered T cell-driven, exhibits vascular B/plasma-cell infiltrates and altered circulating B-cell homeostasis, suggesting a pathogenic role for B cells. Relapse…Abstract Number: 0429 • ACR Convergence 2026
In Anti-SSA-Positive Sjögren’s Disease, Labial Biopsy Focus Score Is Associated with B-cell-Axis Serologies, but Not with Clinical Disease Manifestations
Background/Purpose: The minor salivary gland biopsy (MSGB) focus score (FS) is a continuous measure of focal lymphocytic infiltration that is used as a binary variable…Abstract Number: 1105 • ACR Convergence 2026
High-Fat Diet-Induced Obesity Reprograms B Cell Tolerance and Promotes Autoimmune Humoral Dysregulation
Background/Purpose: Obesity is highly prevalent among patients with rheumatic disease and is associated with altered inflammation, impaired vaccine responses, and worse autoimmune outcomes. However, how…Abstract Number: 1945 • ACR Convergence 2026
Single-cell profiling of peripheral B cells reveals disease-associated naïve B-cell states and altered inflammatory programs in IgA vasculitis
Background/Purpose: IgA vasculitis (IgAV) is a small-vessel vasculitis characterized by immune-complex deposition containing galactose-deficient IgA1[1]. Although B cells are central to IgA biology, their heterogeneity…Abstract Number: 2975 • ACR Convergence 2026
Stromal Cells Express IL-6 within Critical Tissue Niches in IgG4-Related Disease
Background/Purpose: IgG4-Related Disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory disorder characterized by immune cell infiltration and fibrosis across multiple organs. Despite growing insights into its…Abstract Number: 0453 • ACR Convergence 2026
FT839: An Off-the-Shelf, Dual CAR T-Cell Therapy for the Comprehensive Elimination of Multicellular Drivers of Rheumatoid Arthritis
Background/Purpose: Rheumatoid Arthritis (RA) is a complex, multicellular autoimmune disease driven by autoantibody producing CD19+ B cells and CD38+ plasma cells, as well as CD38+…Abstract Number: 1108 • ACR Convergence 2026
Interferon-α-Driven Stratification Reveals Metabolic Reprogramming of Double Negative, Naive and Transitional B cell subsets and Refines Molecular Classification in Sjögren’s Disease
Background/Purpose: Sjögren's disease (SjD) is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands and production of autoantibodies such as anti-SSA/Ro, anti-SSB/La, and…Abstract Number: 1994 • ACR Convergence 2026
Probing Remission in SLE (PRiSE): Persistent Interferon Transcriptional and Epigenetic Signatures Distinguish Serologically Active from Serologically Quiescent Drug-Free Remission
Background/Purpose: Sustained drug-free remission is the therapeutic goal in SLE; however, patients in remission remain at risk of relapse, particularly those with serological activity. B…Abstract Number: 0646 • ACR Convergence 2026
Anti-HMGCR Immune-mediated Necrotizing Myopathy Shows Robust Treatment Response With Early Rituximab Initiation
Background/Purpose: Rituximab (RTX) is used in refractory anti-3-hydroxy-3-methylglutaryl-CoA-reductase (anti-HMGCR) immune-mediated necrotizing myopathy (IMNM). Data on treatment outcomes with RTX is limited. We analyzed patients with…Abstract Number: 1109 • ACR Convergence 2026
JMB-2502, a Novel and Potent Anti-BAFF (B-Cell Activating Factor)/APRIL (A Proliferation-Inducing Ligand) Bispecific Antibody with an Extended Half-Life for the Treatment of SLE and Other B-Cell-Related Autoimmune Diseases
Background/Purpose: BAFF and APRIL are TNF superfamily cytokines that sustain B‑cell development, plasma cell survival, and autoantibody production via transmembrane activator and CAML interactor (TACI),…Abstract Number: 2081 • ACR Convergence 2026
Atypical B Cells Are Expanded in Children and Adults with Still’s Disease-Associated Lung Disease and Exhibit a Transcriptional Program of Environmental Surveillance and Inflammatory Activation
Background/Purpose: Still's disease (SD) is a complex inflammatory disorder marked by chronic innate immune activation. SD-associated lung disease (SD-LD) is a severe complication linked to…Abstract Number: 0069 • ACR Convergence 2026
Altered circulating B-cell subsets in axial spondyloarthritis and their association with anti-TNF treatment response
Maria-Eugenia Miranda-Carus1, Beatriz Nieto Carvalhal1, Claudia Campos-Fabre2, Mariela Uyaguari3, Diana peiteado López1, Alejandro Villalba4, Irene Monjo Henry4, Sara García-Carazo1 and Eugenio De Miguel4 Affiliations: 1Hospital Universitario La Paz - IdiPAZ, Madrid, Madrid, Spain, 2Hospital Universitario La Paz - idiPAZ, Madrid, Spain, 3Hospital Universitario de Tortosa Verge de la Cinta, Tortosa, Catalonia, Spain, 4Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain
Background/Purpose: Axial spondyloarthritis (axSpA) pathogenesis integrates autoinflammatory and autoimmune pathways. Innate immune cells drive early IL-23/IL-17 axis activation at entheses, amplified by adaptive Th17/Tc17 cells. Emerging…
ACR Meeting Abstracts