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Abstracts tagged "B cells"

  • Abstract Number: 1762 • 2012 ACR/ARHP Annual Meeting

    IL-6 Receptor Inhibition by Tocilizumab Modulates Double Negative (CD19+IgD-CD27-) B Cells in RA

    Zafar Mahmood1, Khalid Muhammad1, Petra Roll2, Stefan Kleinert3, Thomas Dörner4 and Hans Peter Tony5, 1Department of Medicine II, Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany, 2Department of Medicine II, Rheumatology/Clinical immunology, University of Würzburg, Würzburg, Germany, 3Rheumatology/Clinical Immunology,, University Hospital Würzburg, Würzburg, Germany, 4CC12, Dept. Medicine/Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, 5Rheumatology/Immunology, University of Würzburg, Würzburg, Germany

    Background/Purpose: Double negative (CD19+IgD-CD27-) B cells have been reported to be part of human memory B cell compartment. Detailed studies of DN B cells in…
  • Abstract Number: 2575 • 2012 ACR/ARHP Annual Meeting

    Inhibition of Pathogenic Autoantibodies by Accelerating the Exit of Germinal Center B Cells Via Manipulation of Regulator of G-Protein Signaling

    John D. Mountz1, John H. Wang2, James S. New3, PingAr Yang4, Qi Wu4, Bao Luo5, Jun Li6, Kirk M. Druey7 and Hui-Chen Hsu4, 1Dept of Med/Rheumatology Div, Univ of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL, 2Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, 3Grad Sch - Biomed Sciences, University of Alabama at Birmingham, Birmingham, AL, 4Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 5Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 6Medicine, University of Alabama at Birmingham, Birmingham, AL, 7Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD

    Background/Purpose:  Regulator of G-protein Signaling (RGS) plays a key role in inhibiting chemokine signaling by desensitizing G-protein coupled receptor signals. RGS13 and RGS16 are two…
  • Abstract Number: 514 • 2012 ACR/ARHP Annual Meeting

    Frequencies and Numbers of Circulating IL-10 Producing Regulatory B Cells Are Not Disturbed in Pss-Patients but Correlate Negatively with the EULAR Sjögren Syndrome Disease Activity Score (ESSDAI)

    Wayel H. Abdulahad1, Gwenny Verstappen1, Arjan Vissink2, Minke G. Huitema1, Petra M. Meiners2, Hendrika Bootsma3 and Frans Kroese4, 1Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 2Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, Netherlands, 3Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 4University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Recently, a specific and functionally important subset of regulatory B cells (Breg) that negatively regulate autoimmunity and inflammation has been described. Breg cells exert…
  • Abstract Number: 1756 • 2012 ACR/ARHP Annual Meeting

    Peripheral Blood B Cell Subsets and BAFF/APRIL Receptor Expression, Together with Circulating BAFF and APRIL Levels, Are Disturbed in Rheumatoid Arthritis but Not in Ankylosing Spondylitis

    Béatrice Gaugler1, Caroline Laheurte2, Ewa Bertolini3, Daniel Wendling4, Philippe Saas5, Eric Toussirot6 and CIC BT5067, 1EFS Bourgogne Franche Comté, INSERM UMR1098 / Etablissement Français du Sang / Université de Franche Comté, Besançon, France, 2Etablissement Français du Sang/ Université de Franche Comté / CBT506 / CHRU, INSERM UMR1098 / Plateforme Biomonitoring, Besançon, France, 3University Hospital, Rheumatology, Besançon, France, 4Service de Rhumatologie, Minjoz University Hospital, Besancon, France, 5Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France, 6Université de Franche Comté , CHRU, CIC Biotherapy 506 and Rheumatology and EA 4266 Pathogens and Inflammation, Besançon, France, 7Chru, Clinical Investigation Center Biotherapy, Besançon, France

    Background/Purpose: B cells play a critical role in systemic autoimmune disease and especially rheumatoid arthritis (RA). BAFF and APRIL are involved in B cell activation…
  • Abstract Number: 1760 • 2012 ACR/ARHP Annual Meeting

    A Gene Expression Signature to Monitor Depletion of Plasma Cells Following MEDI-551 (anti-CD19) Administration

    Katie Streicher1, Chris Morehouse1, Christopher Groves2, Bhargavi Rajan2, Fernanda Pilataxi1, Kim Lehmann1, Philip Brohawn1, Kathleen McKeever3, Volker Knappertz4, Ronald Herbst2, Yihong Yao1 and Koustubh Ranade1, 1Translational Sciences, MedImmune, LLC, Gaithersburg, MD, 2Respiration, Inflammation and Autoimmunity, MedImmune, LLC, Gaithersburg, MD, 3Translational Sciences, MedImmune, Gaithersburg, MD, 4Clinical, MedImmune, LLC, Gaithersburg, MD

    Background/Purpose: Production of pathogenic autoantibodies by inappropriately self-reactive plasma cells (PC) is a hallmark of autoimmune diseases. MEDI-551 is an anti-CD19 antibody which is expected…
  • Abstract Number: 2668 • 2012 ACR/ARHP Annual Meeting

    Interferon and B-Cell Gene Signatures Contribute to Diagnosis of  pre-Clinical Rheumatoid Arthritis

    Joyce Lubbers1, Lotte A. van de Stadt2, Saskia Vosslamber1, John G. Wesseling1, Dirkjan van Schaardenburg2 and Cornelis L. Verweij3, 1Pathology, VU University Medical Center, Amsterdam, Netherlands, 2Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 3Pathology and Rheumatology, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Diagnosis of the preclinical phase of rheumatoid arthritis (pre-RA) allows timely start of treatment with the potential to prevent disease progression. It is known…
  • Abstract Number: 510 • 2012 ACR/ARHP Annual Meeting

    IL-7 and IL-7 Receptor Blockade to Selectively Inhibit TLR7-Induced B Cell Activation in Primary Sjögren’s Syndrome

    A. Bikker1, C.R. Willis2, A.a. Kruize1, J.W.J. Bijlsma3, F.P.J.G. Lafeber3 and J.A.G. van Roon4, 1Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Amgen Inc., Seattle, WA, 3Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 4Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose:  Toll-like receptors (TLRs) are involved in the recognition of nucleic acids (viral, bacterial, and possibly self) and have been implicated in several auto-immune diseases.…
  • Abstract Number: 1755 • 2012 ACR/ARHP Annual Meeting

    The Alternative ΔCD20 Transcript Variant Is Not Expressed in B Cells and Synovial Tissue From Patients with Rheumatoid Arthritis

    Clémentine Gamonet1, Marina Deschamps2, Béatrice Gaugler3, Philippe Saas4, Isabelle Auger5, Christophe Ferrand4, Eric Toussirot6 and CIC BT5067, 1INSERM UMR1098/ Etablissement Français du Sang / Université de Franche Comté, France, 2INSERM UMR1098 / Etablissement Français du Sang/ Université de Franche Comté, Besançon, France, 3EFS Bourgogne Franche Comté, INSERM UMR1098 / Etablissement Français du Sang / Université de Franche Comté, Besançon, France, 4Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France, 5Université Aix Marseille II, INSERM UMR1097, Marseille, France, 6University Hospital, CIC Biotherapy 506 and Rheumatology and EA 4266 Pathogens and Inflammation, Besançon, France, 7Chru, Clinical Investigation Center Biotherapy 506, Besançon, France

    Background/Purpose: determining predictive factors for response to biologics may help to select appropriate treatment in patients with RA. Rituximab (RTX) is a chimeric monoclonal antibody…
  • Abstract Number: 1761 • 2012 ACR/ARHP Annual Meeting

    Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti-CD19 Monoclonal Antibody That Co-Engages the B Cell Antigen Receptor and the FcγRIIb Inhibitory Receptor

    Seung Y. Chu1, Karen Yeter2, Roshan Kotha3, Erik Pong1, Yvonne Miranda1, Hsing Chen1, Sung-Hyung Lee1, Irene Leung1, John R. Desjarlais1, William Stohl2 and David E. Szymkowski4, 1Xencor, Inc., Monrovia, CA, 2Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, 3Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, 4Biotherapeutics, Xencor, Inc., Monrovia, CA

    Background/Purpose: XmAb®5871 is a humanized and Fc-engineered antibody that coengages CD19, part of the B cell receptor (BCR) complex, with the inhibitory receptor FcγRIIb (CD32b).…
  • Abstract Number: 2666 • 2012 ACR/ARHP Annual Meeting

    A Link Between B Cells and Bone Erosion in RA: RANKL Production by Memory B Cells

    Nida Meednu1, Teresa Owen2, Hengwei Zhang3, Christopher A. Cistrone1, Lianping Xing4 and Jennifer H. Anolik5, 1Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 2Allergy, Immununolgy and Rheumatology,, University of Rochester, Rochester, NY, 3Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, 4Pathology & Lab Medicine, University of Rochester, Rochester, NY, 5Medicine- Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disorder that often leads to joint damage. Several lines of evidence suggests the role of B cells…
  • Abstract Number: 610 • 2012 ACR/ARHP Annual Meeting

    B Lymphocyte Stimulator Levels Are Higher in Caucasian SLE Patients Earlier in Disease Course and Predict Damage Accumulation

    Eoghan M. McCarthy1, Ruth Lee1, Joan Ni Gabhann2, Siobhan Smith2, Michele Doran3, Gaye Cunnane3, Donough G. Howard1, Paul G. O'Connell4, Grainne M. Kearns5 and Caroline Jefferies2, 1Rheumatology, Beaumont Hospital, Dublin 9, Ireland, 2Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, 3Dept of Rheumatology, St. James Hospital, Dublin, Ireland, 4Department of Rheumatology, Beaumont Hospital, Dublin 9, Ireland, 5Rheumatology Department, Beaumont Hospital, Dublin, Ireland

    Background/Purpose: B Lymphocyte Stimulator(BLyS) plays an important role in the pathogenesis of Systemic Lupus Erythematosus(SLE). Whilst trials of anti BLyS-targeted therapy have shown promise, the optimal…
  • Abstract Number: 1754 • 2012 ACR/ARHP Annual Meeting

    Disruption of Dominant B-Cell and Plasma Cell Clones in Rheumatoid Arthritis Synovium by Rituximab Correlates with Treatment Response

    Marieke E. Doorenspleet1, Paul L. Klarenbeek1, Maartje J. Boumans1, Rogier M. Thurlings2, Rebecca E. Esveldt1, Barbera D. van Schaik3, Antoine H. van Kampen3, Danielle M. Gerlag4, Frank Baas5, Paul-Peter Tak1, Robert M. Plenge6 and Niek de Vries1, 1Division of Clinical Immunology and Rheumatology, Academic Medical Center of the University of Amsterdam, Amsterdam, Netherlands, 2Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Department of Bioinformatics, Academic Medical Center of the University of Amsterdam, Amsterdam, Netherlands, 4Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Department of Genome Analysis, Academic Medical Center of the University of Amsterdam, Amsterdam, Netherlands, 6Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Autoreactive B lymphocytes are thought to play an important role in rheumatoid arthritis (RA). B-cell depletion therapy by rituximab (RTX) has shown that targeting…
  • Abstract Number: 1759 • 2012 ACR/ARHP Annual Meeting

    Expression of Surface APRIL and Its Receptor, TACI, Is Upregulated On B Cells From Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients

    Abby Jones Weldon1, Sheri Hsu2, Seyed K. Nazeri3, Saru Sachdeva2, Jennifer Gonzalez4, Andrea D. Parra5, Abigail Benitez1, Keith K. Colburn6, Ioana Moldovan7 and Kimberly J. Payne8, 1Microbiology and Molecular Genetics, Loma Linda University, Loma Linda, CA, 2Rheumatology, Loma Linda University Medical Center, Loma Linda, CA, 3Rheumatology, Loma Lida University Medical Center, Loma Lida, CA, 4Center of Health Disparities and Molecular Medicine, Loma Linda University, Loma Linda, CA, 5Center for Health Disparities and Molecular Medicine, Loma Linda University, Loma Linda, CA, 6Dept Med - Rheum Sect, Loma Linda Univ Medical Center, Loma Linda, CA, 7Loma Linda Univ Medical Center, Loma Linda, CA, 8Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA

    Background/Purpose: Autoimmune disease affects more than 23 million Americans. Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) are chronic, systemic B-cell mediated autoimmune diseases. During…
  • Abstract Number: 621 • 2012 ACR/ARHP Annual Meeting

    Prolonged Improvement of Systemic Lupus Erythematosus Following Systematic Administration of Rituximab and Cyclophosphamide

    Thomas J. A. Lehman1, Emily Baird2, Anusha Ramanathan3, Risa Alperin3, Emma J. MacDermott3, Alexa B. Adams3, Laura V. Barinstein3 and Lakshmi N. Moorthy4, 1Chief Div Ped Rheum PTD, Hosp for Special Surgery, New York, NY, 2Hospital for Special Surgery, NY, 3Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 4Pediatric Rheumatology, Robert Wood Johnson Medical School-Rutgers University, New Brunswick, NJ

    Prolonged improvement of systemic lupus erythematosus following systematic administration of rituximab and cyclophosphamide. Background/Purpose: We report sustained improvement in 15 patients with corticosteroid dependent SLE…
  • Abstract Number: 1752 • 2012 ACR/ARHP Annual Meeting

    Depletion of CD4-Effector Memory T Cells and Clonally Expanded IgG4 Memory B Cells May Explain the Therapeutic Efficacy of Rituximab in IgG4-Related Disease: Studies Using Flow Cytometry and Single-Cell Sequencing

    Hamid Mattoo1, Arezou Khosroshahi2, Vinay Mahajan3, Mollie Carruthers2, John Stone3 and Shiv Pillai4, 1Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Rheumatology, Massachusetts General Hospital, Boston, MA, 3Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 4Oncology, Massachusetts General Hospital, Boston, MA

    Depletion of CD4-effector memory T cells and clonally expanded IgG4 memory B cells may explain the therapeutic efficacy of rituximab in IgG4-related disease: Studies using…
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