ACR Meeting Abstracts

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Abstracts tagged "B cells"

  • Abstract Number: 1763 • 2012 ACR/ARHP Annual Meeting

    The Role of SYK in Human B CELL Activation and Its Relevance to Autoimmune Diseases

    Shigeru Iwata1, Kunihiro Yamaoka1, Hiroaki Niiro2, Kazuhisa Nakano1, Sheau-Pey Wang1, Koichi Akashi2 and Yoshiya Tanaka1, 1The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, Japan, 2Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Fukuoka, Japan

    Background/Purpose: B cells play a pivotal role in pathological processes of autoimmune diseases. Spleen tyrosine kinase (Syk) functions as a key molecule in B-cell receptor…
  • Abstract Number: 1530 • 2012 ACR/ARHP Annual Meeting

    Plasma Cell Analysis As a Biomarker for Disease Activity in Patients with Granulomatosis with Polyangiitis

    Bimba F. Hoyer1, Adriano Taddeo2, Maika Rothkegel2, Gerd Burmester3, Andreas H. Radbruch2 and Falk Hiepe4, 1Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, 2Deutsches Rheumaforschungszentrum, Berlin, Germany, 3Department of Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, 4Med. Klinik m. Sp. Rheumatologie und klin. Immunologie, Charité University Hospital Berlin, Berlin, Germany

    Background/Purpose: B cells are thought to play an important role in granulomatosis with polyangiitis (GPA) due to the presence of autoantibodies reacting with specific neutrophil…
  • Abstract Number: 521 • 2012 ACR/ARHP Annual Meeting

    Differences in Genome-Wide DNA Methylation Profiles Across Multiple Cell and Tissue Types in Sjögren’s Syndrome (SS)

    Lindsey A. Criswell1, Diana Quach2, Hong L. Quach2, Emon Elboudwarej2 and Lisa F. Barcellos2, 1Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Division of Rheumatology, University of California San Francisco, San Francisco, CA, 2Epidemiology, University of California, Berkeley, Berkeley, CA

    Background/Purpose: Increasing evidence supports a role for epigenetic factors, including DNA methylation status, in autoimmune disease risk and severity. Our goal is to characterize DNA…
  • Abstract Number: 2577 • 2012 ACR/ARHP Annual Meeting

    Characterization of Circulating Human B Cells That Bind Cyclic Citrullinated Peptide Antigens in Clinically Active Rheumatoid Arthritis

    Gregg J. Silverman1, John Jung2, Jeffrey D. Greenberg3, Adam J. Pelzek4, Caroline Gronwall5 and Jaya Vas5, 1Medical and Pathology, NYU School of Medicine, New York, NY, 2School of Medicine, NYU, New York, NY, 3New York Hospital for Joint Disease, New York, NY, 4School of Medicine, NYU School of Medicine, New York, NY, 5Rheumatology, NYU School of Medicine, New York, NY

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) were first identified based on their high specificity for RA and now are commonly used as a diagnostic tool. Yet,…
  • Abstract Number: 1764 • 2012 ACR/ARHP Annual Meeting

    B Cells in Early Rheumatoid Arthritis: ZAP-70 More Than SYK Characterize Seropositive Disease

    Anna Laura Fedele, Barbara Tolusso, Elisa Gremese, Silvia Laura Bosello, Angela Carbonella, Silvia Canestri and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy

    Background/Purpose: B cells are involved as central players in the pathogenesis of rheumatoid arthritis (RA). Our aim was to define whether a specific B cell…
  • Abstract Number: 1457 • 2012 ACR/ARHP Annual Meeting

    A Novel Small Molecular Anti-Rheumatic Drug, T-614, Ameliorates Lupus-Like Disease in MRL/Lpr Mice by Suppressing B Cell Functions

    Qingran Yan1, Fang Du2 and Chunde Bao2, 1Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, 2Rheumatology, Renji Hospital, Shanghai, China

    Background/Purpose: T-614 is a small molecular drug that has multiple immunomodulatory effects and has been used for treating rheumatoid arthritis. Previous work has revealed this…
  • Abstract Number: 509 • 2012 ACR/ARHP Annual Meeting

    IL-7 and Toll-Like Receptor 7 Synergistically Increase Th1/Th17/Th22 Cytokine Secretion and Activity of B Cells

    A. Bikker1, A.a. Kruize1, F. Redegeld2, W. de Jager3, F.P.J.G. Lafeber4 and J.A.G. van Roon5, 1Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Dept Pharmacology UU, Utrecht, Netherlands, 3Dept Immunology, UMC Utrecht, Utrecht, Netherlands, 4Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose:  IL-7 is a potent T cell activating cytokine that has been shown to cause proliferation, survival and differentiation of T cells as well as…
  • Abstract Number: 2578 • 2012 ACR/ARHP Annual Meeting

    Monoclonal IgG Antibodies (ACPAs) From Synovial Fluid B Cells of Rheumatoid Arthritis Patients – Antigen-Driven Affinity Maturation and Cross Reactivity

    Khaled Amara1, Johanna Steen2, Fiona Murray2, Henner Morbach3, Blanca Fernandez-Rodriguez4, Vijay Balasingh2, Marianne Engström2, Omri Snir2, Lena Israelsson5, Anca Catrina2, Hedda Wardemann6, Davide Corti4, Eric Meffre Sr.3, Lars Klareskog7 and Vivianne Malmström8, 1Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, SE-17176 Solna, Stockholm, Sweden., Stockholm, Sweden, 2Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 3Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 4Institute for Research in Biomedicine, Bellinzona, Switzerland, 5Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 6Max Planck Research Group Molecular Immunology, Max Planck Institute for Infection Biology, Berlin, Germany, 7Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 8Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Antibodies targeting citrullinated proteins (ACPA) are commonly found in patients with Rheumatoid Arthritis (RA), strongly associate with distinct HLA-DR alleles and predict a more…
  • Abstract Number: 1765 • 2012 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Is Associated with Signaling Alterations in Naturally Occurring Autoreactive B-Lymphocytes

    Taras Lyubchenko1, Ganna Liubchenko2, Holly C. Appleberry2, Christopher C. Striebich2, Karen E. Franklin2, Lezlie A. Derber3 and V. Michael Holers4, 1Medicine, University of Colorado Denver, Aurora, CO, 2University of Colorado Denver, Aurora, CO, 3Division of Rheumatology, University of Colorado Denver, Aurora, CO, 4Rheumatology Division, University of Colorado Denver, Aurora, CO

    Background/Purpose: Alterations in B cell immune tolerance are important in the development of autoimmune rheumatoid arthritis (RA). Recent studies in healthy human subjects have identified…
  • Abstract Number: 1450 • 2012 ACR/ARHP Annual Meeting

    MEDI-551 Depletes a Majority of Murine B Cells and Reduces Serum Titers of Autoantibodies in the SLE1-huCD19 TG Mice

    Sandra Gallagher1, Yue Wang1, Isharat Yusuf1, Thomas McCaughtry1, Ronald Herbst2 and Laura Carter1, 1Respiratory, Inflammation and Autoimmune, MedImmune, Gaithersburg, MD, 2Respiration, Inflammation and Autoimmunity, MedImmune, Gaithersburg, MD

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by chronic inflammation that can affect various organs.  Hyperactive B cells appear to be key drivers in SLE…
  • Abstract Number: 482 • 2012 ACR/ARHP Annual Meeting

    B-Lymphocyte Count Is Not Associated with an Increased Risk of Infection in Patients Treated with Rituximab for Auto-Immune Diseases

    Ilias Lazarou1, Axel Finckh2, Lara Fischer3, Camillo Ribi3, Joerg Seebach3 and Pierre A. Guerne2, 1University Hospitals of Geneva, Geneva, Switzerland, 2Rheumatology, University Hospitals of Geneva, Geneva, Switzerland, 3Immunology, University Hospitals of Geneva, Geneva, Switzerland

    Background/Purpose: B-Lymphocyte (B-Ly) depletion therapy with the monoclonal anti-CD20 antibody rituximab (RTX) is widely used in a variety of autoimmune (AI) diseases. The risk of…
  • Abstract Number: 2529 • 2012 ACR/ARHP Annual Meeting

    Molecular Mechanism of IgG4 Class Switch Recombination in IgG4-Related Disease

    Hiroto Tsuboi1, Mana Iizuka1, Hiromitsu Asashima1, Sayaka Tsuzuki1, Yuya Kondo1, Akihiko Tanaka2, Masafumi Moriyama2, Isao Matsumoto1, Seiji Nakamura2 and Takayuki Sumida1, 1Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Faculty of Dental Science, Kyushu University, Fukuoka, Japan

    Background/Purpose: IgG4-related disease (IgG4-RD) is a new disease entity characterized by high serum IgG4 levels, IgG4-positive plasmacytic infiltration and fibrosis in various organs. Although the…
  • Abstract Number: 1767 • 2012 ACR/ARHP Annual Meeting

    Circulating Plasmablasts As a Source of Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis

    Priscilla Kerkman, Ellen I.H. van der Voort, Leendert A. Trouw, Tom W.J. Huizinga, René E.M. Toes and Hans Ulrich Scherer, Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA) and predict disease onset and severity. Accumulating evidence indicates that ACPA could…
  • Abstract Number: 1207 • 2012 ACR/ARHP Annual Meeting

    Impact of Anti Tumor Necrosis Factor-Alpha Therapy in Rheumatoid Arthritis On Osteoclast Activation and B Cells

    Ezinma Ezealah1, Jennifer Hossler1, Jamie Biear1, Christopher A. Cistrone1, Teresa Owen1, Nida Meednu1, Kelly Callahan1, Arumugam Palanichamy1, Ignacio Sanz2, Allen P. Anandarajah1, Ralf G. Thiele1, Darren Tabechian3, R. John Looney1 and Jennifer H. Anolik1, 1Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 2Rheumatology, Emory University, Atlanta, GA, 3Allergy/Immun/Rheumatology, Univ of Rochester Schl of Med, Rochester, NY

    Background/Purpose:  Serum receptor activator of NFkB ligand (RANKL) and its natural decoy receptor, osteoprotegerin (OPG), play key roles in osteoclast activation. In a group of…
  • Abstract Number: 316 • 2012 ACR/ARHP Annual Meeting

    The Interleukin-10 (IL-10) Producing Regulatory B Cell (“B10 cell”) Compartment Expands with Disease Activity in Juvenile Dermatomyositis (JDM) and Pediatric-Onset Systemic Lupus Erythematosus (pSLE)

    Ioannis Kalampokis1, Jeffrey A. Dvergsten2 and Thomas Tedder3, 1Immunology and Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 2Pediatrics Division of Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 3Department of Immunology, Duke University Medical Center, Durham, NC

    Background/Purpose: pSLE and JDM are multisystem inflammatory diseases, whereas juvenile idiopathic arthritis (JIA) is typically an organ-limited disease. “B10 cells”, a rare subset of human…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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