Abstract Number: 2453 • 2012 ACR/ARHP Annual Meeting
The Role of Bob1 in Rheumatoid Arthritis: Potential Implications for Autoimmunity
Background/Purpose: Rheumatoid arthritis (RA) is a prototypic autoimmune disease characterized by a prominent humoral autoimmunity. Of particular relevance is the local production of autoantibodies such…Abstract Number: 1774 • 2012 ACR/ARHP Annual Meeting
Identification of Target Antigens of Anti-Endothelial Cell Antibodies in Patients with ANCA-Associated Systemic Vasculitis: A Proteomic Approach
Background/Purpose: Anti-endothelial cell antibodies (AECA) are frequently detected in anti-neutrophil cytoplasm antibodies (ANCA)-associated systemic vasculitis (AAV) and are considered to play pathological roles but their…Abstract Number: 860 • 2012 ACR/ARHP Annual Meeting
Interleukin-21, B Cell Activating Factor and Unmethylated CpG Oligodeoxynucleotides Synergize in Promoting Anti-Proteinase 3 Autoantibody Production in Vitro
Background/Purpose: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are characterized by the presence of circulating autoantibodies that are often directed against proteinase 3 (PR3). Although the…Abstract Number: 201 • 2012 ACR/ARHP Annual Meeting
High Rate of Autoimmune Manifestations During Idiopathic CD4 Lymphocytopenia
Background/Purpose: When first described by the Center for Disease Control, idiopathic CD4 lymphocytopenia (ICL) was characterized by opportunistic infections in patients with a CD4 count≤300/mm3…Abstract Number: 2333 • 2012 ACR/ARHP Annual Meeting
A Novel Subset of CD4 T Cells That Provides Help for Human Memory B Cell Responses
Background/Purpose: Follicular helper T (Tfh) cells provide help to B cells in germinal centers (GCs) of secondary lymphoid organs (SLOs) following primary antigen (Ag) challenge,…Abstract Number: 1742 • 2012 ACR/ARHP Annual Meeting
A Novel Murine Model of B Cell-Mediated Proteinuria Suggests Cytokines Mediate Podocyte Injury
Background/Purpose: B cell depletion therapies have been efficacious in several glomerulopathies. The contributions of B cells to proteinuria and foot process effacement remain unknown. The…Abstract Number: 835 • 2012 ACR/ARHP Annual Meeting
Low Doses of Ocaratuzumab, a Fc- and Fab-Engineered Anti-CD20 Antibody, Result in Rapid and Sustained Depletion of Circulating B-Cells in Rheumatoid Arthritis Patients
Background/Purpose: B-cell depletion provides therapeutic benefits for patients with rheumatoid arthritis (RA). Ocaratuzumab, previously known as AME-133v, is a Fc- and Fab-engineered, humanized, anti-CD20…Abstract Number: 2316 • 2012 ACR/ARHP Annual Meeting
Generation of CD4+ Follicular Helper T cells by Complement and Immune Complexes
Background/Purpose: Complement opsonized immune complexes (ICs) are key players of disease pathology. We showed in systemic lupus erythematosus (SLE), ICs and complement (C’) drive activation…Abstract Number: 1743 • 2012 ACR/ARHP Annual Meeting
IL-5-Induced FasL+ Regulatory B Cells Are Inhibited by IL-4 and Cyclosporine
Background/Purpose: We previously identified a subset of regulatory B cells that express the apoptosis-inducing molecule Fas ligand (FasL), and reported that these B cells were…Abstract Number: 674 • 2012 ACR/ARHP Annual Meeting
Altered Response to B Cell Receptor (BCR) Crosslinking in SLE: Correlation with Genetic Risk Variants Predicted to Impact BCR Signaling
Background/Purpose: Altered B cell signaling has been proposed to play an important role in susceptibility to SLE. In mice, genetic manipulations or polymorphisms that attenuate…Abstract Number: 2666 • 2012 ACR/ARHP Annual Meeting
A Link Between B Cells and Bone Erosion in RA: RANKL Production by Memory B Cells
Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disorder that often leads to joint damage. Several lines of evidence suggests the role of B cells…Abstract Number: 2319 • 2012 ACR/ARHP Annual Meeting
T Follicular Helper Cell and Regulatory T Cell Frequencies Are Affected by B Cell Depletion in Patients with Granulomatosis with Polyangiitis
Background/Purpose: Granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis) is a rare and sometimes fatal systemic autoimmune disease. Anti-neutrophil cytoplasmic antibodies (ANCAs) specific for…Abstract Number: 1744 • 2012 ACR/ARHP Annual Meeting
Regulatory B Cells Supress the Progression of Fatal Autoimmunity in Lupus-Prone Mice
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disorder characterized by the production of anti-nuclear antibodies (ANA) which form immune complexes and promote…Abstract Number: 679 • 2012 ACR/ARHP Annual Meeting
ZAP70+ B Cells and Plasmablasts As Markers of Disease Activity and Remission in Systemic LUPUS Erythematosus Nephritis
Background/Purpose: To analyze differences in B cells subsets distribution in patients with renal systemic lupus erythematosus (SLE). To define possible cellular biomarkers of active nephritis…Abstract Number: 2668 • 2012 ACR/ARHP Annual Meeting
Interferon and B-Cell Gene Signatures Contribute to Diagnosis of pre-Clinical Rheumatoid Arthritis
Background/Purpose: Diagnosis of the preclinical phase of rheumatoid arthritis (pre-RA) allows timely start of treatment with the potential to prevent disease progression. It is known…