Abstracts tagged "B cells"

Abstract Number: 2453 • 2012 ACR/ARHP Annual Meeting
The Role of Bob1 in Rheumatoid Arthritis: Potential Implications for Autoimmunity
Nataliya Yeremenko¹, Tineke Cantaert¹, Melissa N. van Tok², Ioana Gofita¹, Juan D. Canete³, Paul P. Tak⁴, Hergen Spits⁵ and Dominique L. Baeten⁴, ¹Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Arthritis Unit. Rheumatology Department, Hospital Clínic, Barcelona, Spain, ⁴Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁵Tytgat Institute for Liver and Intestinal Research, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a prototypic autoimmune disease characterized by a prominent humoral autoimmunity. Of particular relevance is the local production of autoantibodies such…
Abstract Number: 1774 • 2012 ACR/ARHP Annual Meeting
Identification of Target Antigens of Anti-Endothelial Cell Antibodies in Patients with ANCA-Associated Systemic Vasculitis: A Proteomic Approach
Alexis Régent¹, Hanadi Dib², Guillaume Bussone¹, Mathieu C. Tamby¹, Nicolas Tamas², Christian Federici³, Cédric Broussard³, Loic Guillevin⁴ and Luc Mouthon¹, ¹Internal Medicine, Hopital Cochin, Paris, France, ²Université Paris Descartes, Paris, France, ³Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, ⁴Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France
Background/Purpose: Anti-endothelial cell antibodies (AECA) are frequently detected in anti-neutrophil cytoplasm antibodies (ANCA)-associated systemic vasculitis (AAV) and are considered to play pathological roles but their…
Abstract Number: 860 • 2012 ACR/ARHP Annual Meeting
Interleukin-21, B Cell Activating Factor and Unmethylated CpG Oligodeoxynucleotides Synergize in Promoting Anti-Proteinase 3 Autoantibody Production in Vitro
Nikola Lepse¹, Judith Land², Abraham Rutgers², Cees G.M. Kallenberg², Coen A. Stegeman³, Peter Heeringa¹ and Wayel H. Abdulahad², ¹Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Nephrology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are characterized by the presence of circulating autoantibodies that are often directed against proteinase 3 (PR3). Although the…
Abstract Number: 201 • 2012 ACR/ARHP Annual Meeting
High Rate of Autoimmune Manifestations During Idiopathic CD4 Lymphocytopenia
Alexis Régent¹, Brigitte Autran², Guislaine Carcelain², Benjamin Terrier³, Alain Krivitzky⁴, Eric Oksenhendler⁵, Nathalie Costedoat-Chalumeau⁶, Pascale Hubert², Olivier Lortholary⁷, Nicolas Dupin⁸, Patrice Debré², Loic Guillevin⁹ and Luc Mouthon¹, ¹Internal Medicine, Hopital Cochin, Paris, France, ²INSERM, UMR945, AP-HP, Hôpital Pitié-Salpêtrière, Laboratoire d'Immunologie Cellulaire Et Tissulaire, Paris, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, ⁴Département de médecine interne, Hôpital Avicenne, AP-HP, Bobigny, France, ⁵Département d'Immunologie Clinique, Hôpital Saint-Louis, AP-HP, Paris, France, ⁶Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, ⁷Service de maladies infectieuses, Hôpital Necker-Enfants malades, AP-HP, Paris, France, ⁸Service de Dermatologie, Hôpital Cochin, AP-HP, Paris, France, ⁹Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France
Background/Purpose: When first described by the Center for Disease Control, idiopathic CD4 lymphocytopenia (ICL) was characterized by opportunistic infections in patients with a CD4 count≤300/mm3…
Abstract Number: 2333 • 2012 ACR/ARHP Annual Meeting
A Novel Subset of CD4 T Cells That Provides Help for Human Memory B Cell Responses
Sang T. Kim, Jin Young Choi, Begona Lainez and Joseph E. Craft, Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT
Background/Purpose: Follicular helper T (Tfh) cells provide help to B cells in germinal centers (GCs) of secondary lymphoid organs (SLOs) following primary antigen (Ag) challenge,…
Abstract Number: 1742 • 2012 ACR/ARHP Annual Meeting
A Novel Murine Model of B Cell-Mediated Proteinuria Suggests Cytokines Mediate Podocyte Injury
Alfred Kim¹ and Andrey S. Shaw², ¹IM/Div of Rheumatology, Washington Univ School of Med, St. Louis, MO, ²Pathology & Immunology/HHMI, Washington University School of Medicine, Saint Louis, MO
Background/Purpose: B cell depletion therapies have been efficacious in several glomerulopathies. The contributions of B cells to proteinuria and foot process effacement remain unknown. The…
Abstract Number: 835 • 2012 ACR/ARHP Annual Meeting
Low Doses of Ocaratuzumab, a Fc- and Fab-Engineered Anti-CD20 Antibody, Result in Rapid and Sustained Depletion of Circulating B-Cells in Rheumatoid Arthritis Patients
Adrienne O'Reilly, Tracy Davis and Vinay Jain, Mentrik Biotech, Dallas, TX
Background/Purpose: B-cell depletion provides therapeutic benefits for patients with rheumatoid arthritis (RA). Ocaratuzumab, previously known as AME-133v, is a Fc- and Fab-engineered, humanized, anti-CD20…
Abstract Number: 2316 • 2012 ACR/ARHP Annual Meeting
Generation of CD4⁺ Follicular Helper Tcells by Complement and Immune Complexes
Anil K. Chauhan¹, Richard DiPaolo² and Terry L. Moore³, ¹Rheumatology, Saint Louis University, St. Louis, MO, ²Molecular Microbiology and Immunology, Saint Louis, MO, ³Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose: Complement opsonized immune complexes (ICs) are key players of disease pathology. We showed in systemic lupus erythematosus (SLE), ICs and complement (C’) drive activation…
Abstract Number: 1743 • 2012 ACR/ARHP Annual Meeting
IL-5-Induced FasL⁺ Regulatory B Cells Are Inhibited by IL-4 and Cyclosporine
Matthew W. Klinker¹, Brian R. Alzua¹, Tamra J. Reed², David A. Fox³ and Steven K. Lundy⁴, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ³Rheumatology/Int Medicine, Univ of Michigan Med Ctr, Ann Arbor, MI, ⁴Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: We previously identified a subset of regulatory B cells that express the apoptosis-inducing molecule Fas ligand (FasL), and reported that these B cells were…
Abstract Number: 674 • 2012 ACR/ARHP Annual Meeting
Altered Response to B Cell Receptor (BCR) Crosslinking in SLE: Correlation with Genetic Risk Variants Predicted to Impact BCR Signaling
Nan-Hua Chang¹, Timothy Li², Paul R. Fortin³, Dafna D. Gladman⁴, Carolina Landolt-Marticorena⁵, Jorge Sanchez-Guerrero⁶, Murray B. Urowitz⁷ and Joan E. Wither⁸, ¹Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ²Genetics and developmental biology, Toronto Western Hospital, Toronto, ON, Canada, ³University of Laval, Quebec, QC, Canada, ⁴Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, University Health Network, Toronto, ON, Canada, ⁵Rheumatology, University Health Network, University of Toronto, Toronto, ON, Canada, ⁶UHN Toronto Western Hospital, Toronto, ON, Canada, ⁷Division of Rheumatology, University Health Network, University of Toronto, Toronto, ON, Canada, ⁸1E420/Div of Rheumatology, Toronto Western Research Institute, University of Toronto, University Health Network, Toronto, ON, Canada
Background/Purpose: Altered B cell signaling has been proposed to play an important role in susceptibility to SLE. In mice, genetic manipulations or polymorphisms that attenuate…
Abstract Number: 2666 • 2012 ACR/ARHP Annual Meeting
A Link Between B Cells and Bone Erosion in RA: RANKL Production by Memory B Cells
Nida Meednu¹, Teresa Owen², Hengwei Zhang³, Christopher A. Cistrone¹, Lianping Xing⁴ and Jennifer H. Anolik⁵, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Allergy, Immununolgy and Rheumatology,, University of Rochester, Rochester, NY, ³Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, ⁴Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁵Medicine- Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disorder that often leads to joint damage. Several lines of evidence suggests the role of B cells…
Abstract Number: 2319 • 2012 ACR/ARHP Annual Meeting
T Follicular Helper Cell and Regulatory T Cell Frequencies Are Affected by B Cell Depletion in Patients with Granulomatosis with Polyangiitis
Yuan Zhao¹, Jessica Thomas¹, Shirish Sangle², Pamela M.K Lutalo³, Lee Meng Choong⁴, Jennifer R. Tyler¹, Jo Spencer⁵, Timothy Tree⁶ and David P. D'Cruz², ¹Peter Gorer Department of Immunobiology, School of Medicine, King's College London, London, United Kingdom, ²Louise Coote Lupus Unit, Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ³Louise Coote Lupus Unit, St Thomas Hospital, London, United Kingdom, ⁴Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ⁵Peter Gorer Department of Immunobiology, King's College London, School of Medicine, London, United Kingdom, ⁶national Institute of Health Research Centre at Guy's and St Thomas' NHS Trust, School of Medicine, King's College London, London, United Kingdom
Background/Purpose: Granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis) is a rare and sometimes fatal systemic autoimmune disease. Anti-neutrophil cytoplasmic antibodies (ANCAs) specific for…
Abstract Number: 1744 • 2012 ACR/ARHP Annual Meeting
Regulatory B Cells Supress the Progression of Fatal Autoimmunity in Lupus-Prone Mice
Yuriy Baglaenko¹, Nan-Hua Chang², Evelyn Pau³ and Joan E. Wither⁴, ¹Immunology, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁴1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disorder characterized by the production of anti-nuclear antibodies (ANA) which form immune complexes and promote…
Abstract Number: 679 • 2012 ACR/ARHP Annual Meeting
ZAP70+ B Cells and Plasmablasts As Markers of Disease Activity and Remission in Systemic LUPUS Erythematosus Nephritis
Elisa Gremese, Barbara Tolusso, Laura Messuti, Marcin Nowik, Silvia Canestri, Luca Petricca, Maria Rita Gigante and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: To analyze differences in B cells subsets distribution in patients with renal systemic lupus erythematosus (SLE). To define possible cellular biomarkers of active nephritis…
Abstract Number: 2668 • 2012 ACR/ARHP Annual Meeting
Interferon and B-Cell Gene Signatures Contribute to Diagnosis of pre-Clinical Rheumatoid Arthritis
Joyce Lubbers¹, Lotte A. van de Stadt², Saskia Vosslamber¹, John G. Wesseling¹, Dirkjan van Schaardenburg² and Cornelis L. Verweij³, ¹Pathology, VU University Medical Center, Amsterdam, Netherlands, ²Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Pathology and Rheumatology, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Diagnosis of the preclinical phase of rheumatoid arthritis (pre-RA) allows timely start of treatment with the potential to prevent disease progression. It is known…

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