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Abstracts tagged "axial spondyloarthritis"

  • Abstract Number: 659 • 2018 ACR/ARHP Annual Meeting

    Comparison of MRI and Conventional Radiography for Detection of Structural Changes Typical for Spa – Data from the Assessment of Spondyloarthritis International Society Cohort

    Mikhail Protopopov1, Denis Poddubnyy2,3, Fabian Proft1, Stephanie Wichuk4, Pedro Machado5, Robert G. Lambert6, Ulrich Weber7,8, Susanne J Pedersen9,10, Mikkel Østergaard9,10, Joachim Sieper3, Martin Rudwaleit3,11, Xenofon Baraliakos12 and Walter P. Maksymowych13, 1Charité Universitätsmedizin Berlin, Berlin, Germany, 2German Rheumatism Research Centre, Berlin, Germany, 3Charité Universitätsmeidzin Berlin, Berlin, Germany, 4Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, 5Centre for Rheumatology Research & MRC Centre for Neuromuscular Diseases, University College London, London, United Kingdom, 6Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, 7University of Southern Denmark, Odense, Denmark, 8Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, Graasten, Denmark, 9Copenhagen Center for Arthritis Research, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark, 10Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 11Internal Medicine and Rheumatology, Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany, 12Rheumatology, Rheumazentrum Ruhrgebiet, Herne, and Ruhr University Bochum, Herne, Germany, 13University of Alberta, Edmonton, AB, Canada

    Background/Purpose: The objective of the study was to compare magnetic resonance imaging (MRI) and conventional radiography of the sacroiliac joints (SIJs) for detection of structural…
  • Abstract Number: 1656 • 2018 ACR/ARHP Annual Meeting

    Is a Positive Family History of Spondyloarthritis Relevant for Diagnosing Axial Spondyloarthritis Once HLA-B27 Status Is Known? Data from the ASAS, DESIR, and SPACE Cohorts

    Miranda van Lunteren1, Désirée van der Heijde1, Alexandre Sepriano1,2, Inger Berg3, Maxime Dougados4,5, Laure Gossec6,7, Lennart Jacobsson8, Roberta Ramonda9, Martin Rudwaleit10,11, Joachim Sieper11,12, Robert B.M. Landewé13,14 and Floris van Gaalen1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal, 3Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, 5Rheumatology, Paris Descartes University, Cochin Hospital, Paris, France, 6Rheumatology, Sorbonne Université, Paris, France, 7Rheumatology, Pitié Salpêtrière Hospital, Paris, France, 8Rheumatology, University of Gothenburg, Gothenburg, Sweden, 9Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, 10Internal Medicine and Rheumatology, Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany, 11Rheumatology, Charité Campus Benjamin Franklin, Berlin, Germany, 12German Rheumatism Research Centre, Berlin, Germany, 13Rheumatology, Zuyderland Hospital, Heerlen, Netherlands, 14Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands

    Background/Purpose: A positive family history (PFH) of spondyloarthritis (SpA), in particular a PFH of ankylosing spondylitis (AS) or acute anterior uveitis (AAU), can be used…
  • Abstract Number: 660 • 2018 ACR/ARHP Annual Meeting

    Progression of Radiographic Sacroiliitis in Patients with Axial Spondyloarthritis from the Assessment of Spondyloarthritis International Society Cohort on Central Reading – Five-Year Data

    Mikhail Protopopov1, Fabian Proft1, Alexandre Sepriano2,3, Robert B.M. Landewé4,5, Désirée van der Heijde2, Joachim Sieper1, Martin Rudwaleit6,7 and Denis Poddubnyy1,8, 1Charité Universitätsmedizin Berlin, Berlin, Germany, 2Leiden University Medical Center, Leiden, Netherlands, 3Rheumatology, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal, 4Zuyderland Medical Center, Heerlen, Netherlands, 5Amsterdam Rheumatology & Clinical Immunology Center, Amsterdam, Netherlands, 6Charité Universitätsmeidzin Berlin, Berlin, Germany, 7Rheumatology, Klinikum Bielefeld Rosenhöhe, Berlin, Germany, 8German Rheumatism Research Centre, Berlin, Germany

    Background/Purpose: It is known that radiographic progression of sacroiliitis in axial spondyloarthritis (axSpA) is quite slow, with only few predictors of such progression identified. An…
  • Abstract Number: 1658 • 2018 ACR/ARHP Annual Meeting

    Which Factors Influence the Diagnostic Delay in Patients with Axial Spondyloarthritis?

    Imke Redeker1, Johanna Callhoff1, Falk Hoffmann2, Hildrun Haibel3, Joachim Sieper4, Angela Zink5 and Denis Poddubnyy4, 1Epidemiology Unit, German Rheumatism Research Centre, Berlin, Germany, 2Department of Health Services Research, Carl von Ossietzky University, Oldenburg, Germany, 3Charité Universitätmedizin Berlin, Berlin, Germany, 4Rheumatology, Charité Universitätsmeidzin Berlin, Berlin, Germany, 5Epidemiology Unit / Rheumatology and Clinical Immunology, German Rheumatism Research Centre (DRFZ) / Charité University Hospital, Berlin, Germany

    Background/Purpose: The interval from symptom onset till diagnosis in axial spondyloarthritis (axSpA) was reported a decade ago to be between five and ten years. The…
  • Abstract Number: 661 • 2018 ACR/ARHP Annual Meeting

    Bridging the Gap between Symptom Onset and Diagnosis in Axial Spondyloarthritis

    Laura Passalent1,2,3, Kala Sundararajan4, Anthony V. Perruccio5, Christopher Hawke6,7, Nigil Haroon8,9,10, Robert D Inman3,11,12 and Y. Raja Rampersaud5,6,13, 1Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, Toronto, ON, Canada, 2Department of Physical Therapy, University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, 3Arthritis Program, Krembil Research Institute, Toronto, ON, Canada, 4Orthopaedic Research Department, Toronto Western Hospital, Toronto, ON, Canada, 5Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 6Orthopaedics, Toronto Western Hospital, Toronto, ON, Canada, 7Department of Physical Therapy, University of Toronto, Toronto, ON, Canada, 8Arthrits Program, Krembil Research Institute, Toronto, ON, Canada, 9Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, 10Medicine, Rheumatology, University of Toronto, Toronto, ON, Canada, 11Department of Medicine, University of Toronto, Toronto, ON, Canada, 12Toronto Western Hospital, Toronto, ON, Canada, 13University of Toronto, Toronto, ON, Canada

    Background/Purpose:   Axial spondyloarthritis (axSpA) is diagnosed an average of 9 years after symptom onset (1), partly because inflammatory back pain (IBP) can be difficult…
  • Abstract Number: 1864 • 2018 ACR/ARHP Annual Meeting

    Ixekizumab Significantly Improves Signs, Symptoms, and Spinal Inflammation of Active Ankylosing Spondylitis/Radiographic Axial Spondyloarthritis: 16-Week Results of a Phase 3 Randomized, Active and Placebo-Controlled Trial

    Désirée van der Heijde1, James Cheng-Chung Wei2, Maxime Dougados3, Philip J. Mease4, Atul A. Deodhar5, Walter P. Maksymowych6, Filip van Den Bosch7, Joachim Sieper8, Tetsuya Tomita9, Robert B.M. Landewé10, Lotus Mallbris11, Fangyi Zhao11, David Adams11, Beth Pangallo11 and Hilde Carlier11, 1Leiden University Medical Centre, Leiden, Netherlands, 2Allergy/Immunology/Rheumatology, Chung Shan Med Univ Hospital, Taichung, Taiwan, 3Rheumatology Department, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France, Paris, France, 4Swedish Medical Center and University of Washington, Seattle, WA, 5Oregon Health & Science U, Portland, OR, 6University of Alberta, Edmonton, AB, Canada, 7Ghent University Hospital, Ghent, Belgium, Ghent, Belgium, 8Charité University Hospital, Berlin, Germany, 9Department of Orthopedics, Osaka University Graduate School of Medicine, Suita Osaka, Japan, 10Amsterdam Rheumatology & Clinical Immunology Center and Zuyderland Medical Center, Amsterdam; Heerlen, Netherlands, 11Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: COAST-V (NCT02696785) is the first phase 3 study of ixekizumab (IXE), a high-affinity anti-IL-17A monoclonal antibody, in patients (pts) with active radiographic axial SpA…
  • Abstract Number: 666 • 2018 ACR/ARHP Annual Meeting

    Inflammation on MRI of the Sacroiliac Joints Is Highly Associated with Structural Damage in Axial Spondyloarthritis Patients in Clinical Practice: Data from the ASAS and DESIR Cohorts

    Alexandre Sepriano1, Sofia Ramiro1,2, Robert B.M. Landewé3,4, Maxime Dougados5, Désirée van der Heijde6 and Martin Rudwaleit7, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Zuyderland Medical Center, Heerlen & Leiden University Medical Center, Leiden, Netherlands, 3Zuyderland Medical Center, Heerlen, Netherlands, 4Amsterdam Rheumatology & Immunology Center, Amsterdam, the Netherlands, Amsterdam, Netherlands, 5Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, 6Leiden University Medical Centre, Leiden, Netherlands, 7Internal Medicine and Rheumatology, Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany

    Background/Purpose: The effect of MRI-detected inflammation on the development of radiographic damage at the sacroiliac joints (SIJ) level in patients (pts) with axial SpA (axSpA)…
  • Abstract Number: 1867 • 2018 ACR/ARHP Annual Meeting

    Drug Retention and Response Rates of TNFi Treatment in 21,470 Patients with Axial Spondyloarthritis Treated in Clinical Practice– Pooled Data from the Eurospa Research Network Collaboration

    Cecilie Heegaard Brahe1, Lykke Midtbøll Ørnbjerg1, Johan Askling2, Adrian Ciurea3, Eirik K Kristianslund4, Fatos Onen5, Dan Nordström6, Maria José Santos7, Catalin Codreanu8, Ziga Rotar9, Björn Gudbjornsson10, Daniela Di Giuseppe2, Michael J. Nissen11, Tore Kvien4, Merih Birlik5, Nina Trokovic6, Anabela Barcelos7, Ruxandra Ionescu8, Matija Tomšič9, Arni Jon Geirsson10, Anne Gitte Loft1, Herman F Mann12, Tamara Rusman13, Juan J. Gomez-Reino14, Gareth T. Jones15, Florenzo Iannone16, Karel Pavelka12, Irene van der Horst-Bruinsma17, Lise Hyldstrup1, Niels Steen Krogh18, Merete Lund Hetland1 and Mikkel Østergaard1, 1DANBIO, EuroSpA Research Collaboration Network, Coordinating Centre, Copenhagen, Denmark, 2ARTIS, EuroSpA Research Collaboration Network, Stockholm, Sweden, 3SCQM, EuroSpA Research Collaboration Network, Zurich, Switzerland, 4NOR-DMARD, EuroSpA Research Collaboration Network, Oslo, Norway, 5TURKBIO, EuroSpA Research Collaboration Network, Izmir, Turkey, 6ROB-FIN, EuroSpA Research Collaboration Network, Helsinki, Finland, 7Reuma.pt, EuroSpA Research Collaboration Network, Lisbon, Portugal, 8RRBR, EuroSpA Research Collaboration Network, Bucharest, Romania, 9biorx.si, EuroSpA Research Collaboration Network, Ljubljana, Slovenia, 10ICEBIO, EuroSpA Research Collaboration Network, Reykjavik, Iceland, 11SCQM, EuroSpA Research Collaboration Network, Geneva, Switzerland, 12ATTRA, EuroSpA Research Collaboration Network, Prague, Czech Republic, 13ARC, EuroSpA Research Collaboration Network, Haarlem, Netherlands, 14BIOBADASER, EuroSpA Research Collaboration Network, Santiago, Spain, 15BSRBR-AS, EuroSpA Research Collaboration Network, Aberdeen, United Kingdom, 16GISEA, EuroSpA Research Collaboration Network, Bari, Italy, 17ARC, EuroSpA Research Collaboration Network, Harleem, Netherlands, 18Zitelab, EuroSpA Research Collaboration Network, Copenhagen, Denmark

    Drug retention and response rates of TNFi treatment in 21,470 patients with axial spondyloarthritis treated in clinical practice– pooled data from the EuroSpA Research Network…
  • Abstract Number: 675 • 2018 ACR/ARHP Annual Meeting

    Quantitative Ultrasound of the Calcaneus Has a Role to Play in Detecting Low Bone Mineral Density in Axial Spondyloarthropathy Patients

    Gillian Fitzgerald1,2, Tochukwu Anachebe3, Ronan Mullan4, David Kane5, Kevin McCarroll6 and Finbar O' Shea2, 1School of Medicine, Trinity College Dublin, Dublin 2, Ireland, 2Rheumatology, St. James's Hospital, Dublin 8, Ireland, 3Department of Rheumatology, St. James's Hospital, Dublin 8, Ireland, 4Department of Rheumatology,, Tallaght Hospital, Dublin, Ireland, 5Department of Rheumatology, Tallaght Hospital, Dublin 24, Ireland, 6Department of Medicine for the Elderly, St. James's Hospital, Dublin 8, Ireland

    Background/Purpose: Axial spondyloarthropathy (axSpA) patients have an increased risk of developing osteoporosis compared to matched controls. Dual energy x-ray absorptiometry (DXA) is the technique of…
  • Abstract Number: 1868 • 2018 ACR/ARHP Annual Meeting

    Efficacy and Safety Outcomes in Patients with Non-Radiographic Axial Spondyloarthritis Treated with Certolizumab Pegol: Results from the First 52-Week Randomized Placebo-Controlled Study (NCT02552212)

    Atul A. Deodhar1, Lianne S. Gensler2, Jonathan Kay3, Walter P. Maksymowych4, Nigil Haroon5, Robert B.M. Landewé6, Martin Rudwaleit7, Stephen Hall8, Lars Bauer9, Bengt Hoepken9, Natasha de Peyrecave10, Brian Kilgallen11 and Désirée van der Heijde12, 1Oregon Health and Science University, Portland, OR, 2University of California San Francisco, San Francisco, CA, 3Division of Rheumatology, University of Massachusetts Medical School and UMass Memorial Medical Center, Worcester, MA, 4Department of Medicine, University of Alberta, Edmonton, AB, Canada, 5University Health Network, University of Toronto, Toronto, ON, Canada, 6Amsterdam Rheumatology & Clinical Immunology Center and Zuyderland Medical Center, Amsterdam; Heerlen, Netherlands, 7Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Bielefeld, Germany, 8Cabrini Medical Centre, Cabrini Private Hospital, Malvern, Australia, 9UCB Pharma, Monheim, Germany, 10UCB Pharma, Brussels, Belgium, 11UCB Pharma, Raleigh, NC, 12Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: In the USA, certolizumab pegol (CZP) is approved for treatment of adults with active ankylosing spondylitis (AS) and not for non-radiographic axial spondyloarthritis (nr-axSpA).…
  • Abstract Number: 678 • 2018 ACR/ARHP Annual Meeting

    Ultrasonographic Evaluation of Achilles Tendon in Early Axial Spondyloarthropathy: Is There Any Difference between Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthropathy?

    Shahla Vahidfar1, Ismihan Sunar2, Sebnem Ataman3, Gürkan Yılmaz4, Javid M. AZARABADI5 and Ayşe Bölükbaşı1, 1Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, 2Department of Physical Medicine and Rehabilitation, Division of Rheumatology,, Ankara University, Faculty of Medicine, Ankara, Turkey, 3Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey, 4Physical Medicine and Rehabilitation, Rheumatology Division, Ankara University Faculty of Medicine, Ankara, Turkey, 5ORTHOPEDICS AND TRAUMATOLOGY, Başkent University Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Along with emergence of the term of ‘non-radiographic axial SpA’ (nr-AxSpA), studies comparing AS and nr-AxSpA in terms of genetic, epidemiologic, and clinical issues…
  • Abstract Number: 2062 • 2018 ACR/ARHP Annual Meeting

    Omentin-1: Potential Biomarker of Cardiovascular Risk in Axial Spondyloarthritis? a Serological and Genetic Study

    Fernanda Genre1, Javier Rueda-Gotor1, Sara Remuzgo-Martínez1, Verónica Pulito-Cueto1, Alfonso Corrales1, Verónica Mijares1, Leticia Lera-Gómez1, Virginia Portilla1, Rosa Expósito2, Cristina Mata2, Iván Ferraz-Amaro3, M. Vanesa Hernandez-Hernandez4, Santos Castañeda5, Esther Vicente5, Cristina Fernández-Carballido6, María Paz Martínez-Vidal7, David Castro-Corredor8, Joaquín Anino-Fernández8, Ricardo Blanco1, Oreste Gualillo9, Javier Martin10, Javier Llorca11, Raquel Lopez-Mejías1 and Miguel Angel González-Gay1,12, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, 2Rheumatology Division, Hospital Comarcal de Laredo, Laredo, Spain, 3Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 4Rheumatology Division, Hospital Universitario de Canarias, La Laguna, Spain, 5Rheumatology Division, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, 6Rheumatology Division, Hospital General Universitario de Elda, Elda, Spain, 7Rheumatology Division, Hospital General Universitario de Alicante, Alicante, Spain, 8Rheumatology Division, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, 9SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), The NEIRID Group (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Santiago de Compostela, Spain, Santiago de Compostela, Spain, 10Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain., Granada, Spain, 11Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, 12School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain

    Background/Purpose: Cardiovascular (CV) disease (mainly due to accelerated atherosclerosis) is one of the main causes of mortality in axial spondyloarthritis (axSpA). The higher incidence of…
  • Abstract Number: 691 • 2018 ACR/ARHP Annual Meeting

    A Service Evaluation of Reporting Standards of Computer Tomography Defined Sacroiliitis Suggestive of Axial Spondyloarthritis in Inflammatory Bowel Disease Patients Imaged for Non-Musculoskeletal Indications

    Chong Seng Edwin Lim1, Samantha Bee Lian Low2, Baljeet Dhillon2, Shin Azegami2, Andoni Paul Toms2 and Karl Gaffney1, 1Rheumatology, Norfolk and Norwich University Hospital, Norwich, United Kingdom, 2Radiology, Norfolk and Norwich University Hospital, Norwich, United Kingdom

    Background/Purpose: A combined service evaluation by the rheumatology and radiology department was undertaken to understand the frequency and reporting standards of Computer Tomography-defined Sacroiliitis (CTSI)…
  • Abstract Number: 2076 • 2018 ACR/ARHP Annual Meeting

    Transmembrane TNF (tmTNF) Transgenic Mice Exhibit Enlarged Lymph Nodes and Elevated Numbers of High Endothelial Cells Associated with Increased Lymphocyte Recruitment

    Kim Jeucken1, Jan Piet van Hamburg2, Merlijn Kaaij3, Leonie van Duivenvoorde3, Dominique Baeten3 and Sander W. Tas2, 12Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: The NF-κB family of transcription factors plays a crucial role in chronic inflammatory diseases and can be activated via two distinct pathways. Non-canonical NF-κB…
  • Abstract Number: 692 • 2018 ACR/ARHP Annual Meeting

    TNF Inhibitor Dose Tapering in Axial Spondyloarthritis: A Systematic Review and Meta-Analysis

    Daeria O. Lawson1,2, Maria Eraso3, Lawrence Mbuagbaw4, Theresa Aves5, Alvin Leenus4, Marianinha Joanes6, Ahmed Omar1,7 and Robert D Inman8,9, 1Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, Toronto, ON, Canada, 2Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Hamilton, ON, Canada, 3Toronto Western Hospital, Toronto, ON, Canada, Tornoto, ON, Canada, 4McMaster University, Hamilton, ON, Canada, Hamilton, ON, Canada, 5St. Michael's Hospital, Toronto, ON, Canada, Toronto, ON, Canada, 6Boston University School of Medicine, Boston, MA, United States, Boston, MA, 7Rheumatology, University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, 8Toronto Western Hospital, Toronto, ON, Canada, Toronto, ON, Canada, 9University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada

    Background/Purpose: Patients with axial spondyloarthritis (axSpA) who have achieved a stable disease state and are undergoing treatment with tumour necrosis factor inhibitor (TNFi) therapy may…
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