Abstracts tagged "axial spondyloarthritis"

Abstract Number: 1626 • 2018 ACR/ARHP Annual Meeting
The Disease Expression in Familial and Sporadic Axial Spondyloarthritis Patients
Dilek Solmaz¹, Onay Gercik², Gökhan Kabadayı¹ and Servet Akar³, ¹Rheumatology, Izmir Katip Celebi University, Faculty of Medicine, Izmir, Turkey, ²Rheumatology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey, ³Faculty of Medicine, Department of Rheumatology, Izmir Katip Celebi University, Izmir, Turkey
Background/Purpose: Familial aggregation of the SpA in particular AS has long been known and up to 40% of AS patients have a positive family history…
Abstract Number: 2862 • 2018 ACR/ARHP Annual Meeting
Magnitude of Response to TNF Inhibitors in Children with Spondyloarthritis and Sacroiliitis
Rosemary Peterson¹, Rui Xiao², Timothy G. Brandon³, David M. Biko⁴, Michael Francavilla⁴, Nancy A. Chauvin⁵ and Pamela F. Weiss⁶, ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ³Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁵Radiology, Penn State Hershey Medical Center, Hershey, PA, ⁶Pediatrics, Children's Hospital Philadelphia, Philadelphia, PA
Background/Purpose: We aimed to quantify the magnitude of biologic effect on sacroiliitis in juvenile SpA by comparing the change in the Spondyloarthritis Research Consortium of…
Abstract Number: 646 • 2018 ACR/ARHP Annual Meeting
Do Ethnicity, Degree of Family Relationship, and the Spondyloarthritis Subtype in Affected Relatives Influence the Association between a Positive Family History for Spondyloarthritis and HLA-B27 Carriership? Results from the Worldwide ASAS Cohort
Miranda van Lunteren¹, Alexandre Sepriano^1,2, Robert B.M. Landewé^3,4, Joachim Sieper^5,6, Martin Rudwaleit^6,7, Désirée van der Heijde¹ and Floris van Gaalen¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal, ³Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, ⁴Rheumatology, Zuyderland Hospital, Heerlen, Netherlands, ⁵German Rheumatism Research Centre, Berlin, Germany, ⁶Rheumatology, Charité Campus Benjamin Franklin, Berlin, Germany, ⁷Internal Medicine and Rheumatology, Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany
Background/Purpose: The Assessment of SpondyloArthritis international Society (ASAS) defines a positive family history (PFH) of spondyloarthritis (SpA) as presence of ankylosing spondylitis (AS), acute anterior…
Abstract Number: 1645 • 2018 ACR/ARHP Annual Meeting
Clinical Features of Axial Spondyloarthritis Patients Diagnosed in Secondary Versus a Tertiary Hospital
Ann-Sophie De Craemer^1,2, Thomas Renson^1,2, Philippe Carron^1,2, Peggy Jacques^1,2, Rik Joos^1,3,4, Jan Lenaerts^5,6, Lieve Gyselbrecht⁷, Filip van Den Bosch^1,2 and Dirk Elewaut^1,2, ¹Department of Rheumatology, Ghent University Hospital, Ghent, 9000, Belgium, ²VIB Inflammation Research Center, Ghent, 9000, Belgium, ³Department of Rheumatology, Antwerp University Hospital, Edegem, 2650, Belgium, ⁴Department of Rheumatology, ZNA Jan Palfijn, Merksen, 2170, Belgium, ⁵Reuma Institute Hasselt, Hasselt, 3500, Belgium, ⁶Department of Rheumatology, Leuven University Hospital, Leuven, 3000, Belgium, ⁷Department of Rheumatology, ASZ Aalst, Aalst, 9300, Belgium
Background/Purpose: Diagnosis of axial spondyloarthritis (axSpA) often relies on a positive MRI of the SI joints. However, pitfalls in interpretation of MRI images were recently…
Abstract Number: 2891 • 2018 ACR/ARHP Annual Meeting
Eligibility Criteria for TNFi Therapy in Axial Spa: Going Beyond Basdai
José Marona^1,2, Alexandre Sepriano^2,3, Santiago Rodrigues Manica^1,2, Fernando Pimentel-Santos^1,2, Ana Filipa Mourão^1,2, Nélia Gouveia², Jaime Cunha Branco^1,2, Filipe Vinagre⁴, Raquel Roque⁴, João Rovisco⁵, Mary Lucy Marques⁵, José Tavares Costa⁶, Joana Leite Silva⁶, Helena Santos⁷, Nathalie Madeira⁷, Elsa Vieira-Sousa^8,9, Ana Rita Machado¹⁰, Miguel Bernardes¹¹, Raquel Ferreira¹¹ and Sofia Ramiro^2,12,13, ¹Rheumatology, Hospital de Egas Moniz - Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal, ²CEDOC, NOVA Medical School, Lisbon, Portugal, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ⁵Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ⁶Rheumatology, Unidade Local de Saúde do Alto Minho, Ponte de Lima, Portugal, ⁷Rheumatology, Instituto Português de Reumatologia, Lisbon, Portugal, ⁸Rheumatology and Metabolic Bone Diseases, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, ⁹Rheumatology Research Unit, Instituto de Medicina Molecular - Faculty of Medicine, University of Lisbon, Lisbon Academic Medical Centre, Lisbon, Portugal, ¹⁰Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal, Lisboa, Portugal, ¹¹Rheumatology, Centro Hospitalar de São João, Oporto, Portugal, ¹²Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, ¹³Department of Rheumatology, Zuyderland Medical Center, Heerlen, Netherlands
Background/Purpose: A BASDAI ≥4 has often been required to start TNF inhibitors (TNFi) therapy in patients with axial SpA (axSpA). However, this cut-off of high…
Abstract Number: 651 • 2018 ACR/ARHP Annual Meeting
Analysis of the Different Value of Magnetic Resonance Imaging Changes in the Sacroiliac Joints for a Diagnosis of Axial Spondyloarthritis As Judged By Rheumatologists and Radiologists
Xenofon Baraliakos¹, Ana Ghadir², Martin Fruth², Uta Kiltz³ and Jürgen Braun¹, ¹Ruhr-University Bochum, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Rheumatology, Rheumazentrum Ruhrgebiet, Herne, and Ruhr University Bochum, Herne, Germany
Background/Purpose: Classification of axial spondyloarthritis (axSpA) by the imaging arm of the ASAS criteria relies partly on the detection of a bone marrow edema (BME)…
Abstract Number: 1652 • 2018 ACR/ARHP Annual Meeting
Musculoskeletal Involvement in Inflammatory Bowel Disease’S Patients: A Mono Centric Experience
Andrea Delle Sedie¹, Linda Ceccarelli², Linda Carli¹, Francesco Costa³, Santino Marchi³ and Marta Mosca¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²University Gastroenterology Unit, University of Pisa, Pisa, Italy, ³University Gastroenterology Unit, University of Pisa,, Pisa, Italy
Background/Purpose: Musculoskeletal symptoms are frequently reported by patients with inflammatory bowel diseases (IBD). Those symptoms may vary from arthralgia to arthritis, involving peripheral or axial…
Abstract Number: 2944 • 2018 ACR/ARHP Annual Meeting
Longitudinal Outcomes and Predictors of E-Learning Effectiveness in Patients with Axial Spondyloarthritis: A Randomized Controlled Trial
Daeria O. Lawson¹, Ahmed Omar^1,2, Rita Kang³, Nigil Haroon^1,2, Robert D Inman^1,4 and Laura Passalent^1,5, ¹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ³Patient and Family Education, Toronto Western Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ⁵Department of Physical Therapy, University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada
Background/Purpose: There is evidence that education programs are effective (e.g. improved disease activity and quality of life) for patients with arthritis, but little is known…
Abstract Number: 659 • 2018 ACR/ARHP Annual Meeting
Comparison of MRI and Conventional Radiography for Detection of Structural Changes Typical for Spa – Data from the Assessment of Spondyloarthritis International Society Cohort
Mikhail Protopopov¹, Denis Poddubnyy^2,3, Fabian Proft¹, Stephanie Wichuk⁴, Pedro Machado⁵, Robert G. Lambert⁶, Ulrich Weber^7,8, Susanne J Pedersen^9,10, Mikkel Østergaard^9,10, Joachim Sieper³, Martin Rudwaleit^3,11, Xenofon Baraliakos¹² and Walter P. Maksymowych¹³, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²German Rheumatism Research Centre, Berlin, Germany, ³Charité Universitätsmeidzin Berlin, Berlin, Germany, ⁴Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Centre for Rheumatology Research & MRC Centre for Neuromuscular Diseases, University College London, London, United Kingdom, ⁶Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, ⁷University of Southern Denmark, Odense, Denmark, ⁸Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, Graasten, Denmark, ⁹Copenhagen Center for Arthritis Research, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark, ¹⁰Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, ¹¹Internal Medicine and Rheumatology, Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany, ¹²Rheumatology, Rheumazentrum Ruhrgebiet, Herne, and Ruhr University Bochum, Herne, Germany, ¹³University of Alberta, Edmonton, AB, Canada
Background/Purpose: The objective of the study was to compare magnetic resonance imaging (MRI) and conventional radiography of the sacroiliac joints (SIJs) for detection of structural…
Abstract Number: 1656 • 2018 ACR/ARHP Annual Meeting
Is a Positive Family History of Spondyloarthritis Relevant for Diagnosing Axial Spondyloarthritis Once HLA-B27 Status Is Known? Data from the ASAS, DESIR, and SPACE Cohorts
Miranda van Lunteren¹, Désirée van der Heijde¹, Alexandre Sepriano^1,2, Inger Berg³, Maxime Dougados^4,5, Laure Gossec^6,7, Lennart Jacobsson⁸, Roberta Ramonda⁹, Martin Rudwaleit^10,11, Joachim Sieper^11,12, Robert B.M. Landewé^13,14 and Floris van Gaalen¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, ⁵Rheumatology, Paris Descartes University, Cochin Hospital, Paris, France, ⁶Rheumatology, Sorbonne Université, Paris, France, ⁷Rheumatology, Pitié Salpêtrière Hospital, Paris, France, ⁸Rheumatology, University of Gothenburg, Gothenburg, Sweden, ⁹Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ¹⁰Internal Medicine and Rheumatology, Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany, ¹¹Rheumatology, Charité Campus Benjamin Franklin, Berlin, Germany, ¹²German Rheumatism Research Centre, Berlin, Germany, ¹³Rheumatology, Zuyderland Hospital, Heerlen, Netherlands, ¹⁴Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands
Background/Purpose: A positive family history (PFH) of spondyloarthritis (SpA), in particular a PFH of ankylosing spondylitis (AS) or acute anterior uveitis (AAU), can be used…
Abstract Number: 660 • 2018 ACR/ARHP Annual Meeting
Progression of Radiographic Sacroiliitis in Patients with Axial Spondyloarthritis from the Assessment of Spondyloarthritis International Society Cohort on Central Reading – Five-Year Data
Mikhail Protopopov¹, Fabian Proft¹, Alexandre Sepriano^2,3, Robert B.M. Landewé^4,5, Désirée van der Heijde², Joachim Sieper¹, Martin Rudwaleit^6,7 and Denis Poddubnyy^1,8, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal, ⁴Zuyderland Medical Center, Heerlen, Netherlands, ⁵Amsterdam Rheumatology & Clinical Immunology Center, Amsterdam, Netherlands, ⁶Charité Universitätsmeidzin Berlin, Berlin, Germany, ⁷Rheumatology, Klinikum Bielefeld Rosenhöhe, Berlin, Germany, ⁸German Rheumatism Research Centre, Berlin, Germany
Background/Purpose: It is known that radiographic progression of sacroiliitis in axial spondyloarthritis (axSpA) is quite slow, with only few predictors of such progression identified. An…
Abstract Number: 1658 • 2018 ACR/ARHP Annual Meeting
Which Factors Influence the Diagnostic Delay in Patients with Axial Spondyloarthritis?
Imke Redeker¹, Johanna Callhoff¹, Falk Hoffmann², Hildrun Haibel³, Joachim Sieper⁴, Angela Zink⁵ and Denis Poddubnyy⁴, ¹Epidemiology Unit, German Rheumatism Research Centre, Berlin, Germany, ²Department of Health Services Research, Carl von Ossietzky University, Oldenburg, Germany, ³Charité Universitätmedizin Berlin, Berlin, Germany, ⁴Rheumatology, Charité Universitätsmeidzin Berlin, Berlin, Germany, ⁵Epidemiology Unit / Rheumatology and Clinical Immunology, German Rheumatism Research Centre (DRFZ) / Charité University Hospital, Berlin, Germany
Background/Purpose: The interval from symptom onset till diagnosis in axial spondyloarthritis (axSpA) was reported a decade ago to be between five and ten years. The…
Abstract Number: 661 • 2018 ACR/ARHP Annual Meeting
Bridging the Gap between Symptom Onset and Diagnosis in Axial Spondyloarthritis
Laura Passalent^1,2,3, Kala Sundararajan⁴, Anthony V. Perruccio⁵, Christopher Hawke^6,7, Nigil Haroon^8,9,10, Robert D Inman^3,11,12 and Y. Raja Rampersaud^5,6,13, ¹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ²Department of Physical Therapy, University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ³Arthritis Program, Krembil Research Institute, Toronto, ON, Canada, ⁴Orthopaedic Research Department, Toronto Western Hospital, Toronto, ON, Canada, ⁵Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁶Orthopaedics, Toronto Western Hospital, Toronto, ON, Canada, ⁷Department of Physical Therapy, University of Toronto, Toronto, ON, Canada, ⁸Arthrits Program, Krembil Research Institute, Toronto, ON, Canada, ⁹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ¹⁰Medicine, Rheumatology, University of Toronto, Toronto, ON, Canada, ¹¹Department of Medicine, University of Toronto, Toronto, ON, Canada, ¹²Toronto Western Hospital, Toronto, ON, Canada, ¹³University of Toronto, Toronto, ON, Canada
Background/Purpose: Axial spondyloarthritis (axSpA) is diagnosed an average of 9 years after symptom onset (1), partly because inflammatory back pain (IBP) can be difficult…
Abstract Number: 1864 • 2018 ACR/ARHP Annual Meeting
Ixekizumab Significantly Improves Signs, Symptoms, and Spinal Inflammation of Active Ankylosing Spondylitis/Radiographic Axial Spondyloarthritis: 16-Week Results of a Phase 3 Randomized, Active and Placebo-Controlled Trial
Désirée van der Heijde¹, James Cheng-Chung Wei², Maxime Dougados³, Philip J. Mease⁴, Atul A. Deodhar⁵, Walter P. Maksymowych⁶, Filip van Den Bosch⁷, Joachim Sieper⁸, Tetsuya Tomita⁹, Robert B.M. Landewé¹⁰, Lotus Mallbris¹¹, Fangyi Zhao¹¹, David Adams¹¹, Beth Pangallo¹¹ and Hilde Carlier¹¹, ¹Leiden University Medical Centre, Leiden, Netherlands, ²Allergy/Immunology/Rheumatology, Chung Shan Med Univ Hospital, Taichung, Taiwan, ³Rheumatology Department, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France, Paris, France, ⁴Swedish Medical Center and University of Washington, Seattle, WA, ⁵Oregon Health & Science U, Portland, OR, ⁶University of Alberta, Edmonton, AB, Canada, ⁷Ghent University Hospital, Ghent, Belgium, Ghent, Belgium, ⁸Charité University Hospital, Berlin, Germany, ⁹Department of Orthopedics, Osaka University Graduate School of Medicine, Suita Osaka, Japan, ¹⁰Amsterdam Rheumatology & Clinical Immunology Center and Zuyderland Medical Center, Amsterdam; Heerlen, Netherlands, ¹¹Eli Lilly and Company, Indianapolis, IN
Background/Purpose: COAST-V (NCT02696785) is the first phase 3 study of ixekizumab (IXE), a high-affinity anti-IL-17A monoclonal antibody, in patients (pts) with active radiographic axial SpA…
Abstract Number: 666 • 2018 ACR/ARHP Annual Meeting
Inflammation on MRI of the Sacroiliac Joints Is Highly Associated with Structural Damage in Axial Spondyloarthritis Patients in Clinical Practice: Data from the ASAS and DESIR Cohorts
Alexandre Sepriano¹, Sofia Ramiro^1,2, Robert B.M. Landewé^3,4, Maxime Dougados⁵, Désirée van der Heijde⁶ and Martin Rudwaleit⁷, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Zuyderland Medical Center, Heerlen & Leiden University Medical Center, Leiden, Netherlands, ³Zuyderland Medical Center, Heerlen, Netherlands, ⁴Amsterdam Rheumatology & Immunology Center, Amsterdam, the Netherlands, Amsterdam, Netherlands, ⁵Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, ⁶Leiden University Medical Centre, Leiden, Netherlands, ⁷Internal Medicine and Rheumatology, Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany
Background/Purpose: The effect of MRI-detected inflammation on the development of radiographic damage at the sacroiliac joints (SIJ) level in patients (pts) with axial SpA (axSpA)…

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