Abstracts tagged "axial spondyloarthritis"

Abstract Number: 1006 • 2019 ACR/ARP Annual Meeting
Vaspin rs35262691 Is Associated with Atherosclerotic Disease in Axial Spondyloarthritis Patients
Fernanda Genre¹, Javier Rueda-Gotor ¹, Sara Remuzgo-Martinez ¹, Veronica Pulito-Cueto ¹, Alfonso Corrales ¹, Veronica Mijares ¹, Leticia Lera-Gomez ¹, Virginia Portilla ¹, Rosa Expósito ², Cristina Mata ², Iván Ferraz-Amaro ³, Vanesa Hernández-Hernández ³, Santos Castañeda ⁴, Esther Vicente-Rabaneda ⁵, Cristina Fernández-Carballido ⁶, M. Paz Martínez-Vidal ⁷, David Castro-Corredor ⁸, Joaquín Anino-Fernández ⁸, Juan Quevedo-Abeledo ⁹, Carlos Rodríguez-Lozano ⁹, Ricardo Blanco ¹⁰, María Luz García-Vivar ¹¹, Eva Galíndez-Agirregoikoa ¹¹, Javier Llorca ¹², Raquel López-Mejías ¹ and Miguel Angel González-Gay ¹³, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Rheumatology Division, Hospital Comarcal de Laredo, Laredo, Spain, Laredo, Spain, ³Rheumatology Division, Hospital Universitario de Canarias, Tenerife, Spain, Tenerife, Spain, ⁴Rheumatology Department, Hospital Universitario de la Princesa, IIS-Princesa, Madrid, Spain, Madrid, Spain, ⁵Rheumatology Department, Hospital Universitario La Princesa, Madrid, Spain, ⁶Rheumatology Division, Hospital Universitario San Juan de Alicante, Alicante, Spain, Alicante, Spain, ⁷Rheumatology Division, Hospital General Universitario de Alicante, Alicante, Spain, Alicante, Spain, ⁸Rheumatology Division, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, Ciudad Real, Spain, ⁹Rheumatology Division, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain, Las Palmas de Gran Canaria, Spain, ¹⁰Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ¹¹Rheumatology Unit, Basurto University Hospital, Bilbao, Spain, Bilbao, Spain, ¹²School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, Santander, Spain, ¹³Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Background/Purpose: Vaspin is a novel adipokine with insulin-sensitizing functions that exerts anti-inflammatory actions1,2. It has been associated with cardiovascular (CV) disease, CV risk factors and…
Abstract Number: 1509 • 2019 ACR/ARP Annual Meeting
Impact of Age and Disease Duration on the Response to IL-17A Inhibitor (Secukinumab) Treatment in Ankylosing Spondylitis: Pooled Results from the Phase 3 MEASURE Studies
Atul Deodhar¹, Philip Mease ², Paula Machado ³, Xiangyi Meng ³, Vibeke Strand ⁴ and Marina Magrey ⁵, ¹Oregon Health & Science University, Portland, OR, ²Swedish Medical Center/Providence St Joseph Health, and University of Washington, Seattle, WA, ³Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁴Division of Immunology/Rheumatology, Stanford University, Stanford, CA, ⁵Division of Rheumatology, The MetroHealth System and School of Medicine, Case Western Reserve University, Cleveland, OH
Background/Purpose: Ankylosing spondylitis (AS), a chronic inflammatory disease involving the sacroiliac joints and spine, is associated with pain, stiffness, disability, and reduced quality of life.1,2…
Abstract Number: 2212 • 2019 ACR/ARP Annual Meeting
Patients with Axial Spondyloarthritis Have Abnormal Microarchitecture Despite Normal Areal Bone Mineral Density and Trabecular Bone Score by DXA
Dalit Ashany¹, Susan Goodman ², Haley Tornberg ¹, Donald McMahon ³, Douglas Mintz ⁴, Linda Russell ⁵ and Emily Stein ¹, ¹Hospital for Special Surgery, New York, NY, ²Hospital For Special Surgery/Weill Cornell Medicine, New York, NY, ³Donald J.McMahon Statistical Consulting, South Nyack, NY, ⁴Hospital for Special Surgery, Division of Radiology and Imaging, New York, ⁵Hospital for Special Surgery, New York
Background/Purpose: Axial Spondyloarthritis (axSpA) is characterized by abnormal bone formation that produces syndesmophytes, while paradoxically, inflammation causes increased bone resorption and skeletal fragility. Detection of…
Abstract Number: 418 • 2019 ACR/ARP Annual Meeting
Work Productivity Is Associated with Disease Activity and Functional Ability in Chinese Patients with Axial Spondyloarthritis Using a Smart-Phone Management System: A Prospective Cohort Study
Xiaofei Liu ¹, Yanyan Wang ², Wenji Chen ¹, Shiyan Mo ³, Xiaojian Ji ⁴ and Feng Huang², ¹Department of Rheumatology,Hainan Hospital of PLA General Hospital,, sanya, Hainan, China (People's Republic), ²Department of Rheumatology, Chinese PLA General Hospital, beijing, China (People's Republic), ³Department of Rheumatology,Hainan Hospital of PLA General Hospital,, sanya, ⁴Department of Rheumatology, Chinese PLA GeneralHospital,, Beijing, Beijing, China (People's Republic)
Background/Purpose: Axial spondyloarthritis (axSpA) usually affects young people and may lead to work disability(WD). We used the "Smart-phone SpondyloArthritis Management System”, an interactive mobile health…
Abstract Number: 591 • 2019 ACR/ARP Annual Meeting
Longitudinal Assessment of MRI of the Sacroiliac Joints in the ASAS Classification Cohort: Evolution of Diagnostic Features and Predictive Utility for Axial Spondyloarthritis
Walter P. Maksymowych¹, Xenofon Baraliakos ², Manouk de Hooge ³, Iris Eshed ⁴, Susanne Juhl Pedersen ⁵, Ulrich Weber ⁶, Joachim Sieper ⁷, Stephanie Wichuk ⁸, Denis Poddubnyy ⁹, Martin Rudwaleit ¹⁰, Désirée van der Heijde ¹¹, Robert B.M. Landewé ¹², Joel Paschke ¹³, Robert Lambert ⁸ and Mikkel Østergaard ¹⁴, ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ³Ghent University Hospital, Ghent, Belgium, ⁴Sheba Medical Center, Tel Aviv, Israel, ⁵Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark, ⁶Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sonderborg, Denmark, ⁷Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ⁸University of Alberta, Edmonton, Canada, ⁹Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany, ¹⁰Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, ¹¹Leiden University Medical Center, Leiden, Netherlands, ¹²Amsterdam University Medical Center, Amsterdam, Netherlands, ¹³CARE Arthritis, Edmonton, Canada, ¹⁴Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark
Background/Purpose: Follow up of the ASAS Classification Cohort (CC) indicated a high positive predictive value for the ASAS classification criteria derived from baseline patient and…
Abstract Number: 617 • 2019 ACR/ARP Annual Meeting
Peripheral Involvement Is Associated with Less Radiographic Spinal Progression in Patients with Early Axial Spondyloarthritis: Results from the German Spondyloarthritis Inception Cohort
Murat Torgutalp ¹, Mikhail Protopopov², Fabian Proft ³, Joachim Sieper ³, Hildrun Haibel ³, Martin Rudwaleit ⁴ and Denis Poddubnyy ⁵, ¹Charité Universitätsmedizin Berlin, Germany and Ankara University Faculty of Medicine, Ankara, Turkey., Berlin, Germany, ²Charité Universitätsmedizin Berlin, Germany, Berlin, Berlin, Germany, ³Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ⁴Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, ⁵Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany
Background/Purpose: Peripheral involvement (PI), such as arthritis, enthesitis, and dactylitis, is common in patients with axial spondyloarthritis (axSpA); data showing the influence of PI on…
Abstract Number: 1013 • 2019 ACR/ARP Annual Meeting
Effects of Anti-TNF on MiR Expression in Monocytes and CD4+ T-Lymphocytes in Spondyloarthritis
Olivier Fogel¹, Maud Fagny ², Elodie Roche ³, Nelly Sigrist ³, Jean-François Deleuze ⁴, Maxime Dougados ⁵, Corinne Miceli-Richard ¹ and Jorg Tost ³, ¹Paris Descartes University, Department of Rheumatology - Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, ²CEA-CNRGH-Institut François Jacob- Laboratoire Epigenetique et Envrironnement, Evry, Ile-de-France, France, ³CEA-CNRGH-Institut François Jacob- Laboratoire Epigenetique et Envrironnement, Evry, France, ⁴CEA-CNRGH-Institut François Jacob, Evry, France, ⁵Cochin Hospital, Paris, France
Background/Purpose: TNFα inhibitors are an effective treatment for many inflammatory diseases. However, their mechanism of action is more complicated than just blocking the targeted cytokine.…
Abstract Number: 1510 • 2019 ACR/ARP Annual Meeting
Ixekizumab Improves Fatigue, Pain, and Sleep up to 52 Weeks in Patients with Radiographic Axial Spondyloarthritis
Atul Deodhar¹, Philip Mease ², Proton Rahman ³, Victoria Navarro-Compán ⁴, Vibeke Strand ⁵, Theresa Hunter ⁶, David Sandoval ⁷, Jeffrey Lisse ⁷, Fangyi Zhao ⁷ and Helena Marzo-Ortega ⁸, ¹Oregon Health & Science University, Portland, OR, ²Swedish Medical Center/Providence St Joseph Health, and University of Washington, Seattle, WA, ³Memorial University, Newfoundland, NL, Canada, ⁴University Hospital La Paz, IdiPaz, Madrid, Spain, ⁵Division of Immunology/Rheumatology, Stanford University, Stanford, CA, ⁶Eli Lilly and Company, Indianapolis, ⁷Eli Lilly and Company, Indianapolis, IN, ⁸NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, Leeds, United Kingdom
Background/Purpose: Axial spondyloarthritis (axSpA) is an inflammatory condition affecting sacroiliac joints and axial skeleton, characterized by fatigue, spinal pain, and sleep disturbances that negatively affect…
Abstract Number: 2266 • 2019 ACR/ARP Annual Meeting
Treatment Preferences in Patients with Axial Spondyloarthritis
Dafne Capelusnik¹, Emilce Schneeberger ², Leonela Lysseth Macias Oviedo ¹, Juan Manuel Sevillano Gutierrez ³ and Gustavo Citera ⁴, ¹Instituto de Rehabilitacion Psicofisica, CABA, Ciudad Autonoma de Buenos Aires, Argentina, ²Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ³Instituto de Rehabilitacion Psicofisica, CABA, Argentina, ⁴Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Due to the increasing tendency of involving patients in decisions regarding their health care and knowing the need for further research on patients' preferences…
Abstract Number: 430 • 2019 ACR/ARP Annual Meeting
Axial Spondyloarthritis Patients Report Important Impairments in Daily Life and Work Ability – a Web Survey in 472 Patients
Sebastian Ibanez¹, Rianne van Bentum ², Omar Valenzuela ³ and Irene van der Horst-Bruinsma ², ¹Facultad de Medicina Clinica Alemana - UDD, Santiago, Region Metropolitana, Chile, ²Amsterdam University Medical Center, Amsterdam, Netherlands, ³Facultad de Medicina Clinica Alemana -UDD, Santiago, Region Metropolitana, Chile
Background/Purpose: Axial spondyloarthritis (axSpA) can be associated with significant burden and impaired work activity. In Chile, several barriers impede adequate treatment, such as insufficient access…
Abstract Number: 592 • 2019 ACR/ARP Annual Meeting
Replacement of Radiographic Sacroilitis by MRI Structural Lesions: What Is the Impact on Classification of Axial Spondyloarthritis in the ASAS Classification Cohort?
Walter P. Maksymowych¹, Pedro Machado ², Robert Lambert ³, Xenofon Baraliakos ⁴, Mikkel Østergaard ⁵, Joachim Sieper ⁶, Stephanie Wichuk ³, Denis Poddubnyy ⁷, Martin Rudwaleit ⁸, Désirée van der Heijde ⁹, Robert B.M. Landewé ¹⁰, Joel Paschke ¹¹, Susanne Juhl Pedersen ¹² and Ulrich Weber ¹³, ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²University College London, London, United Kingdom, ³University of Alberta, Edmonton, Canada, ⁴Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ⁵Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ⁶Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ⁷Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany, ⁸Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, ⁹Leiden University Medical Center, Leiden, Netherlands, ¹⁰Amsterdam University Medical Center, Amsterdam, Netherlands, ¹¹CARE Arthritis, Edmonton, Canada, ¹²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark, ¹³Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sonderborg, Denmark
Background/Purpose: xClassification of axial spondyloarthritis is based on the application of either an imaging or clinical arm. Radiographic or MRI evidence of sacroiliitis can be…
Abstract Number: 621 • 2019 ACR/ARP Annual Meeting
The Use of Microbial Flow Cytometry to Analyze the Intestinal and Oral Microbiota
Patrick Stauffer¹, Mark Klick ¹, Tammy Martin ¹, James T. Rosenbaum ² and Mark Asquith ¹, ¹Oregon Health and Science University, Portland, OR, ²Devers Eye Institute and Oregon Health & Science University, Portland, OR
Background/Purpose: The role of the microbiome in the pathogenesis of autoimmune disorders such as axial spondyloarthritis (SpA) has been well-established through means of describing gross…
Abstract Number: 1081 • 2019 ACR/ARP Annual Meeting
Characteristics of Patients with Seropositive or Seronegative Rheumatoid Arthritis, Psoriatic Arthritis, or Axial Spondyloarthritis: Data from the US-Based Corrona Rheumatoid Arthritis and Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registries
Alexis Ogdie¹, Mei Liu ², Sabrina Rebello ², Angel Cronin ², Blessing Dube ², Robert McLean ², Esther Yi ³, Peter Hur ³ and Philip Mease ⁴, ¹Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²Corrona, LLC, Waltham, MA, ³Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁴Swedish Medical Center/Providence St Joseph Health, and University of Washington, Seattle, WA
Background/Purpose: Rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA) share many clinical features but are differentiated by key clinical and molecular characteristics. Patients…
Abstract Number: 1515 • 2019 ACR/ARP Annual Meeting
Infections in Patients with Active Radiographic Axial Spondyloarthritis Treated with Ixekizumab in 2 Phase 3 Clinical Trials
Marina Magrey¹, Victoria Navarro-Compán ², Sandra Garces ³, Xenofon Baraliakos ⁴, David Sandoval ³, Jeffrey Lisse ³, Silvia Santisteban ³, David Adams ³, Fangyi Zhao ³ and Robert Inman ⁵, ¹Division of Rheumatology, The MetroHealth System and School of Medicine, Case Western Reserve University, Cleveland, OH, ²University Hospital La Paz, IdiPaz, Madrid, Spain, ³Eli Lilly and Company, Indianapolis, IN, ⁴Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, Herne, Germany, ⁵University of Toronto, University Health Network, Toronto, ON, Canada
Background/Purpose: Ixekizumab (IXE) is a high-affinity monoclonal antibody that selectively targets IL-17A. IL-17 inhibitors have shown efficacy for radiographic axial spondyloarthritis (r-axSpA), with IXE currently…
Abstract Number: 2497 • 2019 ACR/ARP Annual Meeting
Description and Prevalence of Spondyloarthritis in Unselected Patients with Psoriasis, Acute Anterior Uveitis, and Inflammatory Bowel Disease Presenting with Undiagnosed Back Pain
Walter P. Maksymowych¹, Raj Carmona ², Jonathan Chan ³, James Yeung ⁴, Sibel Zehra Aydin ⁵, Liam Martin ⁶, Ariel Masetto ⁷, Dianne Mosher ⁸, Olga Ziouzina ⁶, Stephanie Keeling ⁹, Sherry Rohekar ¹⁰, Rana Dadashova ¹¹, Joel Paschke ¹¹, Amanda Carapellucci ¹¹ and Robert Lambert ¹², ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²McMaster University, Hamilton, Canada, ³Artus Health Clinic, Vancouver, BC, Canada, ⁴Yeung Rheumatology, Vancouver, Canada, ⁵University of Ottawa Faculty of Medicine, Rheumatology,Ottawa Hospital Research Institute, 1967 Riverside Drive, Ottawa, ON, K1H 7W9, CANADA, Ottawa, Canada, ⁶University of Calgary, Calgary, Canada, ⁷Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸University of Calgary, Calgary, AB, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Western University, London, ON, Canada, ¹¹CARE Arthritis, Edmonton, Canada, ¹²University of Alberta, Edmonton, Canada
Background/Purpose: There is limited prospective data as to the frequency of axial spondyloarthritis (axSpA) in unselected patients referred to rheumatologists with undiagnosed back pain who…

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