Abstracts tagged "autoimmune diseases"

Abstract Number: 2972 • 2018 ACR/ARHP Annual Meeting
Multicentric Reticulohistiocytosis (1980-2017): A Rare Disease, Commonly Associated with Malignancy and Autoimmunity
Avneek Singh Sandhu¹, Cynthia S. Crowson², David Wetter³, Gavin McKenzie⁴ and Ashima Makol¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, ³Dermatology, Mayo Clinic, Rochester, MN, ⁴Radiology, Mayo Clinic, Rochester, MN
Background/Purpose: Multicentric reticulohistiocytosis (MRH) is a systemic disease characterized by papulo-nodular skin eruptions and progressive, deforming arthritis. We aimed to examine the clinical correlates and…
Abstract Number: PP09 • 2018 ACR/ARHP Annual Meeting
Improved Quality of Life and Decreased Symptoms of Lupus with Diet, Exercise, and Functional Medicine
Marisa Zeppieri-Caruana, Lupus Chick, New York, NY
Background/Diagnosis: Like most people who live with a chronic illness and/or autoimmune disease, my story started long before I realized. Symptoms came and went throughout…
Abstract Number: PP10 • 2018 ACR/ARHP Annual Meeting
Using a Mobile App to Facilitate Patient-Doctor Discussions to Make Informed Decisions Regarding ‘Painsomnia’
Shelley Fritz¹, Kristine Carandang² and Dawn Gibson³, ¹ArthritisPower Patient Partner: CreakyJoints/Global Healthy Living Foundation, Tampa, FL, ²Chan Division of Occupational Science & Occupational Therapy, University of Southern California, Los Angeles, CA, ³Founder #SpoonieChat; CreakyJoints/Global Healthy Living Foundation Patient Partner, Upper Nyack, NY
Background/Diagnosis: As a patient with AS, Dawn founded #SpoonieChat to provide a space on twitter for people living with chronic diseases to support each other.…
Abstract Number: 9 • 2018 ACR/ARHP Annual Meeting
Integration of Cytokine Profiles with Distinct B-Cell Functions Reveals a Specific Micro-Environmental Framework in Autoimmune Diseases
Quentin Simon¹, Alexis Grasseau², Bénédicte Rouvière², Laetitia Le Pottier², Divi Cornec³, Maria Orietta Borghi⁴, Rocio Aguilar Quesada⁵, Yves Renaudineau^2,6, Marta Alarcón-Riquelme⁷, Jacques-Olivier Pers¹ and Sophie Hillion^2,6, ¹U1227, Université de Brest, Inserm, Labex IGO, CHU de Brest, Brest, France, ²U1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, Brest, France, ³Hopital La Cavale Blanche, Brest, France, ⁴University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy, ⁵Biobanco Del Sistema Sanitario Publico de Andalucía, Sevilla, Spain, ⁶CHU de Brest, Brest, France, ⁷Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain
Background/Purpose: The functional duality of B cells is central to balance immune homeostasis by regulating or promoting the immune response. However, the mechanisms by which…
Abstract Number: 126 • 2018 ACR/ARHP Annual Meeting
Direct Interaction between Autoreactive B Cells and Endothelial Colony Forming Cells Induces Cytokine Production from B Cells through B Cell Receptor and IL-6-JAK2-STAT3 Signaling Pathway, Suppressing Proliferation of Endothelial Colony Forming Cells in Systemic Sclerosis
Takemichi Fukasawa¹, Ayumi Yoshizaki¹, Satoshi Ebata¹, Kouki Nakamura¹, Yoshihide Asano¹, Yutaka Kazoe², Kazuma Mawatari², Takehiko Kitamori² and Shinichi Sato¹, ¹Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disorder that is characterized by fibrosis and vascular damage in the skin and other visceral organs, with…
Abstract Number: 843 • 2018 ACR/ARHP Annual Meeting
Localization of the Voltage-Gated Sodium Channel 1.7 in Peripheral Monocytes Contributes to Activation of BAFF Signaling in Monocytes of Patients with Primary Sjögren’s Syndrome
Keiko Yoshimoto, Yumi Ikeda, Katsuya Suzuki and Tsutomu Takeuchi, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: In our previous study, we have reported that IL-6 production was robustly increased in BAFF-stimulated peripheral monocytes of patients with primary Sjögren’s syndrome (pSS)…
Abstract Number: 1182 • 2018 ACR/ARHP Annual Meeting
The Disproportionate High Risk of Re-Fracture after Osteoporotic Treatment in Patients with Autoimmune Diseases
Wen-Nan Huang¹, Yi-Ming Chen¹, Wei-Ting Hung², Yu-Wan Liao³ and Yi-Hsing Chen¹, ¹Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan, ²Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ³Taichung Veterans General Hospital, Taichung, Taiwan
Background/Purpose: Patients with autoimmune diseases are associated with an increased risk of osteoporotic fracture. Anti-osteoporotic treatment could diminish re-fracture rates in post-menopause women. However, treatment…
Abstract Number: 1584 • 2018 ACR/ARHP Annual Meeting
Evaluation of the Performance of the 2016 American College of Rheumatology-European League Against Rheumatism (Acr-Eular) Classification Criteria for Primary Sjogren`S Syndrome in Different Centers of Argentina
Hugo Najera¹, Marta Mamani², Anastasia Secco¹, Fernando Melo³, Cristian Troitiño⁴, Felix Romanini Sr.², Emmanuel Guerra², Antonio Catalan Pellet⁵, Silvia Beatriz Papasidero⁶, Rodrigo Aguila Maldonado⁷, Mercedes Garcia⁷, Mariano Rivero⁸, Juan Carlos Barreira⁹, ivan remolina¹⁰, A. perdomo¹¹, quevedo mayorga¹⁰, M.J. santacruz¹² and j demarchi¹⁰, ¹Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, ²Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ³Rheumatology Department, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁴Reumatologia, Hospital Bernardino Rivadavia, CAPITAL FEDERAL, Argentina, ⁵Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁶Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, Buenos Aires, Argentina, ⁷Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, ⁸Rheumatology, Consultorios Externos Vacarezza,Alberdi,Pcia Buenos Aires, Pcia Buenos Aires, Argentina, ⁹Rheumatology Unit, Hospital Británico, Buenos Aires, Buenos Aires, Argentina, ¹⁰hospital britanico, Buenos Aires, Argentina, ¹¹hospital nuestra señora de la merced, alberti, Argentina, ¹²hospital tornu, Buenos Aires, Argentina
Background/Purpose: Primary Sjögren`s Syndrome (pSS) is a multisystemic, autoimmunity disease, characterized mainly by the hypofunction of the salivary and lacrimal glands, however the clinical spectrum…
Abstract Number: 1771 • 2018 ACR/ARHP Annual Meeting
Long-Term Survival of Renal Transplantation in Rapidly Progressive Glomerulonephritis (RPGN). Study of 43 Cases from a Single Center
Belén Atienza-Mateo¹, Lara Sánchez-Bilbao¹, José Luis Martín-Varillas¹, Marina de Cos-Gómez², Íñigo González-Mazón¹, Diana Prieto Peña³, Monica Calderón Goercke³, Emilio Rodrigo Calabia², Juan Carlos Ruiz San Millán², Miguel Angel González-Gay¹ and Ricardo Blanco⁴, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ²Nephrology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ³Rheumatology, Rheumatology. Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ⁴Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain
Background/Purpose: Rapidly Progressive Glomerulonephritis (RPGN) is characterized histology by presence of crescents and clinically by rapid and severe decline in kidney function. Thus, it may…
Abstract Number: 1915 • 2018 ACR/ARHP Annual Meeting
Big Data Analysis of Autoimmune Diseases Induced By Cancer Immunotherapies: Identifying Pharmacological Patterns of Organ-Specific Involvement
Soledad Retamozo^1,2,3, Alejandra Flores-Chavez^4,5,6, Belchin Kostov⁷, Antoni Sisó-Almirall⁸, Marta Pérez-de-Lis⁹, Roberto Pérez-Alvarez¹⁰, Pilar Brito-Zerón^11,12, Munther A Khamashta¹³ and Manuel Ramos-Casals¹⁴, ¹Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, ²Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, ³Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, ⁴Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Spain., Barcelona, Spain, ⁵Unidad de Investigación Biomédica 02 (Unidad de Investigación en Epidemiología Clínica), UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Jalisco, Mexico, ⁶Programa de Doctorado en Ciencias Médicas, Centro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, Mexico, Mexico, Mexico, ⁷ABS Les Corts, CAPSE, Research Group in Primary Care, IDIBAPS, ABS Les Corts, CAPSE, Barcelona, Spain, ⁸Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC, Barcelona, Barcelona, Spain, ⁹Department of Anesthesia, Complexo Hospitalario Universitario A Coruña (CHUAC), A Coruña, Spain, ¹⁰Department of Internal Medicine, Hospital Alvaro Cunqueiro, Vigo, Vigo, Spain, ¹¹Autoimmune Diseases Unit, Department of Internal Medicine, Hospital CIMA-Sanitas, Barcelona, Barcelona, Spain, ¹²Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Barcelona, Spain, ¹³Lupus Research Unit, The Rayne Institute, Lupus Research Unit, The Rayne Institute, Kings' College London School of Medicine, St Thomas' Hospital, London, United Kingdom, ¹⁴Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona., Barcelona, Spain
Background/Purpose: The scenario of biological-triggered autoimmune diseases has dramatically changed in recent years due to the increasing use of biologics in patients with solid cancers. Methods:…
Abstract Number: 2167 • 2018 ACR/ARHP Annual Meeting
Incidence and Baseline Characteristics of Exacerbation in Patients with Interstitial Pneumonia with Autoimmune Features: A Single Center Large-Scale Cross-Sectional Cohort Study
Okinori Murata, Nobuhito Sasaki and Makoto Maemondo, Division of Pulmonary medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan
Background/Purpose: Patients with idiopathic interstitial pneumonia (IIP) may have features of connective tissue diseases (CTDs). The term interstitial pneumonia with autoimmune features (IPAF) has been…
Abstract Number: 2256 • 2018 ACR/ARHP Annual Meeting
Rheumatic Diseases Associated with Neuromyelitis Optica Spectrum Disorders (NMOSD): Prevalence, Clinical, Laboratory and Imaging Characteristics
Milena Rodriguez Alvarez¹, Su Zhaz Leon¹, Fernando Cuascut², Naureen Kabani³, Joshy Pathiparampil³, Kristaq Koci⁴, Manjeet Bhamra⁵, Latoya Freeman⁴, Alexandra Kreps⁶, Justin Levinson⁶, Sophia Francis⁶, Vinodkumar Velayndhan⁶, Steve Xie⁷, Abhimanyu Amarnani⁶, Helen Valsamis⁸, Yaacov Anziska⁶, Ellen M. Ginzler⁹ and Isabel M. McFarlane⁹, ¹Rheumatology, SUNY Downstate, Brooklyn, NY, ²Neurology, SUNY Downstate, Brooklyn, NY, ³Internal Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ⁴Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ⁵Medicine, SUNY Downstate, Brooklyn, NY, ⁶SUNY Downstate, Brooklyn, NY, ⁷NYC Health + Hospitals Kings County, Brooklyn, NY, ⁸Neurology, NYC Health + Hospitals Kings County, Brooklyn, NY, ⁹Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY
Background/Purpose: NMOSD are autoimmune disorders characterized by optic neuritis (ON), longitudinal extensive transverse myelitis (LETM), and other clinical features. Aquaporin 4 antibodies (AQP4 Ab) have…
Abstract Number: 2257 • 2018 ACR/ARHP Annual Meeting
Prevalence and Distinct Clinical Phenotype of Concomitant Sarcoidosis in Other Autoimmune Rheumatic Diseases
Kristina E.N. Clark¹, Huw Beynon², Christopher P. Denton³ and Voon H. Ong⁴, ¹Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ²Department of Rheumatology, Royal Free Hospital, London, United Kingdom, ³UCL Division of Medicine, Royal Free Campus, London, United Kingdom, ⁴Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Lung involvement is common in both sarcoidosis (up to 90%) and autoimmune rheumatic diseases (ARDs). Case reports have suggested distinct clinical manifestations when sarcoidosis…
Abstract Number: 1171 • 2017 ACR/ARHP Annual Meeting
Mycophenolate Mofetil May Improve Interstitial Pneumonia with Autoimmune Features
Sara S. McCoy¹, Zubin Mukadam², Keith C. Meyer³, Emmanuel Sampene⁴, Jeffrey P. Kanne⁵, Christopher A. Meyer⁵, Maria D. Martin⁵, Scott W. Aesif⁶, Laurie Rice⁷ and Christie M. Bartels⁸, ¹Department of Medicine, Rheumatology Division, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²PULMONARY & CRITICAL CARE, University of Wisconsin School of Medicine and Public Health, madison, WI, ³PULMONARY & CRITICAL CARE, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁴Biostatistics, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁵Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁶Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, madison, WI, ⁷Critical Care Medicine, SSM Health Dean Medical Group, madison, WI, ⁸Rheumatology/Medicine, University of Wisconsin - Madison, Madison, WI
Background/Purpose: To assess the efficacy of mycophenolate mofetil (MMF) in treatment of adult patients with interstitial pneumonia with autoimmune features (IPAF). Methods: A retrospective medical…
Abstract Number: 2601 • 2017 ACR/ARHP Annual Meeting
Novel Anti-Malarial Drug Derivative Inhibited Type I Interferon Production and Autoimmune Inflammation in SLE Patient PBMC and in Trex1-/- Mouse Spleen and Heart
Jie An¹, Weinan Lai^2,3, Joshua Woodward⁴, Xizhang Sun¹, Lena Tanaka¹, Tomikazu Sasaki⁵ and Keith B. Elkon⁶, ¹Division of Rheumatology, University of Washington, Seattle, WA, ²Department of Medicine/Division of Rheumatology, University of Washington, Seattle, WA, ³Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁴Department of Microbiology, University of Washington, Seattle, WA, ⁵Department of Chemistry, University of Washington, Seattle, WA, ⁶Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA
Background/Purpose: Type I interferon (IFN-I) is strongly implicated in the pathogenesis of Systemic Lupus Erythematosus (SLE) as well as rare monogenic ‘interferonopathies’ such as Aicardi-Goutieres…

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