ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "autoantigens"

  • Abstract Number: 0045 • ACR Convergence 2022

    Rheumatoid Arthritis Patient-derived Anti-citrullinated Protein Antibodies (ACPAs) Ameliorate Joint Inflammation in Early Collagen-antibody Induced Arthritis (CAIA)

    Alejandro Gomez1, Camille Brewer1, Jae-Seung Moon2, Suman Acharya1, Tobias V. Lanz1, Qian Wang1, Gundula Min-Oo3, Anita Niedziela-Majka3 and William Robinson4, 1Stanford University, Stanford, CA, 2Stanford University, Palo Alto, CA, 3Gilead Sciences, Foster City, CA, 4Stanford University School of Medicine, Palo Alto, CA

    Background/Purpose: ACPAs are present in two-thirds of patients with rheumatoid arthritis (RA) and are associated with higher risks for severe bone erosions. The pathogenic role…
  • Abstract Number: 2026 • ACR Convergence 2022

    Serum and Tear Autoantibodies from nor Mice as Potential Diagnostic Indicators of Local and Systemic Inflammation in Sjögren’s Syndrome

    Shruti Singh Kakan1, Yaping Ju2, Maria Edman2 and Sarah Hamm-Alvarez3, 1Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California; Department of Ophthalmology, Keck School of Medicine, Roski Eye Institute, University of Southern California, Los Angeles, CA, 2Department of Ophthalmology, Keck School of Medicine, Roski Eye Institute, University of Southern California, Los Angeles, CA, 3Department of Ophthalmology, Keck School of Medicine, Roski Eye Institute, University of Southern California; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA

    Background/Purpose: Sjögren's Syndrome (SS) is an autoimmune disease characterized by infiltration of lymphocytes into lacrimal (LG) and salivary (SG) glands and their concurrent loss of…
  • Abstract Number: 0048 • ACR Convergence 2022

    Combination of Repetitive Inhalant Endotoxin Exposure and Collagen-induced Arthritis Interact in a Testosterone-dependent Manner to Drive Inflammatory Lung Disease Processes and Arthritis Severity in Mice

    Elizabeth Ramler1, Ted Mikuls2, Geoffrey Thiele3, Amy Nelson3, Michael Duryee3, Rohit Gaurav3, Todd Wyatt1, Aaron Schwabb3, carlos hunter3, Bryant England3 and Jill Poole3, 1University of Nebraska Medical Center, Omaha, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Respiratory-related diseases are among the most common causes of death in rheumatoid arthritis (RA). Although autoimmune diseases are reported in higher frequency in females,…
  • Abstract Number: 2185 • ACR Convergence 2022

    Development of a Novel Regulatory T Cell-Based Therapy for Patients with Rheumatoid Arthritis

    Anne-Renee van der Vuurst de Vries1, Kathryn Hooper1, Jonathan Graf2, Katie Tuckwell1 and Joshua Beilke1, 1Sonoma Biotherapeutics, South San Francisco, CA, 2Ucsf, San Francisco, CA

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory condition with persistent unmet medical need despite significant treatment advances. The pathogenesis of RA is initiated…
  • Abstract Number: 0256 • ACR Convergence 2022

    Patients with ACPA-positive and ACPA-negative Rheumatoid Arthritis Show Different Circulating Auto-antibody Repertoires

    Kevin Cunningham1, Benjamin Hur2, John Davis2 and Jaeyun Sung2, 1University of Minnesota, Rochester, MN, 2Mayo Clinic, Rochester, MN

    Background/Purpose: RA is commonly diagnosed through a serological test for the presence of ACPA, and RA patients who test positive are collectively known as 'ACPA-positive…
  • Abstract Number: 0326 • ACR Convergence 2022

    Mapping Anti-Mitochondrial Antibodies over Time in a Lupus Inception Cohort

    Yann Becker1, Éric Boilard1, Emmanuelle Rollet-Labelle1, Christian Lood2, Anne-Sophie Julien3, Joannie Leclerc1, Tania Lévesque1, Murray Urowitz4, John Hanly5, Caroline Gordon6, Sang-Cheol Bae7, Juanita Romero-Diaz8, Jorge Sanchez-Guerrero9, Ann E Clarke10, Sasha Bernatsky11, Daniel Wallace12, David Isenberg13, Anisur Rahman14, Joan Merrill15, Dafna Gladman16, Ian N. Bruce17, Michelle Petri18, Ellen M. Ginzler19, Mary Anne Dooley20, Rosalind Ramsey-Goldman21, Susan Manzi22, Andreas Jönsen23, Graciela Alarcón24, Ronald van Vollenhoven25, Cynthia Aranow26, Guillermo Ruiz-Irastorza27, S. Sam Lim28, Murat Inanc29, Kenneth Kalunian30, Soren Jacobsen31, Christine Peschken32, Diane Kamen33, Anca Askanase34, Jill Buyon35 and Paul R Fortin36, 1Centre de Recherche ARThrite, CHU de Québec - Université Laval, Québec, QC, Canada, 2Division of Rheumatology, University of Washington, Seattle, WA, 3Université Laval, Québec, QC, Canada, 4University of Toronto, University Health Network, Schroeder Arthritis Institute, Toronto, ON, Canada, 5Division of Rheumatology, Queen Elizabeth II Health Sciences Center (Nova Scotia Rehabilitation Site) and Dalhousie University, Halifax, NS, Canada, 6Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 7Hanyang University Medical Center, Seoul, Republic of Korea, 8Instituto Nacional de Ciencias Medicas y Nutricion SZ, Ciudad de México, Mexico, 9Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, ON, Canada, 10University of Calgary, Division of Rheumatology, Cumming School of Medicine, Calgary, AB, Canada, 11Research Institute of the McGill University Health Centre, Montréal, QC, Canada, 12Cedars-Sinai Medical Center, Los Angeles, CA, 13University College London, London, United Kingdom, 14Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, 15Oklahoma Medical Research Foundation, Oklahoma City, OK, 16Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada, 17Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, 18Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, 19SUNY Downstate Health Sciences University, Department of Medicine, Brooklyn, NY, 20Raleigh Neurology Associates, Chapel Hill, NC, 21Northwestern University Feinberg School of Medicine, Chicago, USA, Chicago, IL, 22Allegheny Health Network, Lupus Center of Excellence, Wexford, PA, 23Department of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Lund and Skåne University Hospital, Lund, Sweden, 24The University of Alabama at Birmingham, Oakland, 25Amsterdam University Medical Centers, Amsterdam, Netherlands, 26Feinstein Institutes for Medical Research, Manhasset, NY, 27Autoimmune Diseases Research Unit, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, UPV/EHU, Barakaldo, Spain, 28Emory University, Atlanta, GA, 29Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istambul, Turkey, 30University of California San Diego, La Jolla, CA, 31Rigshospitalet, Copenhagen, Denmark, 32University of Manitoba, Winnipeg, MB, Canada, 33Medical University of South Carolina, Charleston, SC, 34Columbia University Medical Center, New York, NY, 35NYU Grossman School of Medicine, New York, NY, 36Centre ARThrite - CHU de Québec - Université Laval, Québec, QC, Canada

    Background/Purpose: Mitochondria can be both pro-inflammatory and antigenic. We hypothesize (1) that anti-mitochondrial antibodies (AMA) are present in lupus and (2) can predict outcomes. Our…
  • Abstract Number: 0385 • ACR Convergence 2022

    T Cell Receptor Sequencing Identifies Two Classes of T Cells Enriched in HLA-B27-associated Inflammation

    Michael Paley1, Lynn Hassman2, Grace Paley2, Nicole Linskey2, Philip Ruzycki2, Jennifer Laurent2, Lacey Feigl2, Luke Springer2 and Wayne Yokoyama2, 1Washington University in St. Louis, Saint Louis, MO, 2Washington University School of Medicine, St. Louis, MO

    Background/Purpose: HLA-B27 is genetically linked to Axial Spondyloarthritis (axSpA) and anterior uveitis (AU), an inflammatory ocular disease that can lead to cataract, glaucoma, and permanent…
  • Abstract Number: 0609 • ACR Convergence 2022

    Macrophage Response to MAA Modified Fibrinogen in the Presence of Peptidyl Arginine Deiminase Inhibitor

    nozima Aripova1, Michael Duryee1, carlos hunter1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The formation of citrullinated (CIT) proteins is catalyzed by a calcium-dependent peptidyl arginine deiminase (PAD). In rheumatoid arthritis (RA), synovial macrophages are main contributors…
  • Abstract Number: 0631 • ACR Convergence 2022

    Perfluoroalkyl Substances and Community Vulnerability: Associations with Lupus-Related Autoantibodies and Disease

    Emily Vara, Dulaney Wilson, John Pearce, Jim Oates and Diane Kamen, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Perfluoroalkyl substances (PFAS) are a class of persistent organic pollutants found in nonstick products, water repellant fabrics, fire-retardant foams, and food packaging. Highly stable,…
  • Abstract Number: 1681 • ACR Convergence 2022

    Supernatants from Activated Macrophages Contain Citrullinated Vimentin and Induce Extracellular Matrix Deposition from Fibroblasts

    nozima Aripova1, Michael Duryee1, Eric Daubach1, carlos hunter1, Bryant England1, James O'Dell1, Ted Mikuls2 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Studies have shown that activated macrophages secrete several factors that promote human fibroblast-like synoviocyte (HFLS) activation, resulting in an invasive phenotype, that contributes to…
  • Abstract Number: 1682 • ACR Convergence 2022

    Peptidyl Arginine Deiminase Expression and Macrophage Polarization Following Stimulation with Citrullinated and Malondialdehyde-acetaldehyde Modified Fibrinogen

    nozima Aripova1, Michael Duryee1, carlos hunter1, Bryant England1, Debra Romberger1, James O'Dell1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Post-translational modifications (PTM) of extracellular matrix proteins, such as fibrinogen, have been implicated in the pathogenesis of rheumatoid arthritis (RA). Citrullination, a type of…
  • Abstract Number: 1686 • ACR Convergence 2022

    Post-translational Modification of Matrix-gla Protein with Malondialdehyde-Acetaldehyde Alters Cellular Responses by Human Fibroblasts

    Austin Ragland1, Michael Duryee1, nozima Aripova1, Spencer Jones1, Ted Mikuls2 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Post-translational modifications with malondialdehyde-acetaldehyde (MAA) alter protein structure and function, inducing pro-inflammatory and pro-fibrotic responses characteristic of rheumatoid arthritis (RA). Matrix-gla protein (MGP) chelates…
  • Abstract Number: 1734 • ACR Convergence 2022

    Identification of Sjögren’s Disease-Associated T Cell Receptors Through Deep Sequencing and Single-Cell Transcriptomics

    Ananth Aditya Jupudi1, Michelle Joachims1, Christina Lawrence1, Charmaine Lopez-Davis1, Bhuwan Khatri1, Astrid Rasmussen1, Lida Radfar2, Kiely Grundahl1, R. Hal Scofield2, Judith James1, Joel Guthridge1, Christopher Lessard1, Linda F. Thompson1 and A. Darise Farris1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren's disease (SjD) is a chronic rheumatic autoimmune disorder that primarily targets the lacrimal and salivary glands (SG) resulting in dry eyes and dry…
  • Abstract Number: 1735 • ACR Convergence 2022

    Clonally Expanded Cytotoxic CD8+ T Cells Recognize Citrullinated Antigens in ACPA+ Rheumatoid Arthritis

    Jae-Seung Moon1, Shady Younis2, Orr Sharpe2, Navin Rao3, Julie Carman3, Eddie James4, Jane Buckner4, Kevin D Deane5, Michael Holers6, Laura Donlin7, Mark Davis2 and William Robinson8, 1Stanford University, Palo Alto, CA, 2Stanford University, Stanford, CA, 3Janssen Research and Development, LLC, Spring House, PA, 4Benaroya Research Institute at Virginia Mason, Seattle, WA, 5University of Colorado Denver Anschutz Medical Campus, Denver, CO, 6Department of Medicine Division of Rheumatology, Aurora, CO, 7Hospital for Special Surgery, New York, NY, 8Stanford University School of Medicine, Palo Alto, CA

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease associated with MHC polymorphisms. The shared epitope polymorphism in MHC class II genes is by far…
  • Abstract Number: 1741 • ACR Convergence 2022

    Mutated Nod2 Controls T Cell Function and Promotes Uveitis in a Blau Syndrome Mouse Model

    Leah Huey1, Kylie Koney1, Emily Vance1, Chia-Feng Tsai2, Rosalie K. Chu2, Marina A. Gritsenko2, Ellen Lee1, Holly Rosenzweig1 and Ruth Napier1, 1Oregon Health & Science University and VA Portland Health Care System, Portland, OR, 2Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA

    Background/Purpose: Mutations in the microbial signaling molecule NOD2 cause granulomatous uveitis, arthritis, and dermatitis in Blau Syndrome. We previously showed a novel role for Nod2…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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