Abstracts tagged "autoantibodies"

Abstract Number: 2301 • 2012 ACR/ARHP Annual Meeting
The Interferon Type I Signature Is Increased in Monocytes From Systemic Sclerosis Patients
Zana Brkic¹, Lenny van Bon², Cornelia G. van Helden-Meeuwsen³, Madelon C. Vonk⁴, Hanneke Knaapen⁵, Wim van den Berg⁵, Paul L. Van Daele³, Virgil A. Dalm¹, Timothy Radstake² and Marjan A. Versnel¹, ¹Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht/Radboud University Nijmegen Medical Center, Utrecht/Nijmegen, Netherlands, ³Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ⁵Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
Background/Purpose: Systemic sclerosis (SSc) is a complex fibrosing disease of unknown etiology. The past decade clear indications for an aberrant immune system have been revealed.…
Abstract Number: 1671 • 2012 ACR/ARHP Annual Meeting
Characterization of Jo-1 Autoantibodies in Patients with Inflammatory Myopathy and Interstitial Lung Disease
Kyle P. Chiang¹, Varun Gauba¹, Darin Lee¹, Minh-Ha T. Do¹, Jie J. Zhou², Feng Wang², Ying Buechler¹, Leslie Nangle¹, Zhiwen Xu², John Mendlein¹, Melissa Ashlock¹ and Jeffrey M. Greve¹, ¹aTyr Pharma, San Diego, CA, ²Scripps Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong
Background/Purpose: Anti-Jo-1 autoantibodies (Jo-1 Abs), directed against histidine tRNA synthetase (HisRS1), are detected in a high proportion of patients with both autoimmune inflammatory myopathy (IM)…
Abstract Number: 671 • 2012 ACR/ARHP Annual Meeting
Differences in the SLE Clinical Phenotype by Age of Diagnosis
T. Clark Powell¹, Elizabeth E. Brown on behalf of PROFILE², Gerald McGwin Jr.³, Luis M. Vila⁴, Yesenia C. Santiago-Casas⁴, Michelle Petri⁵, Rosalind Ramsey-Goldman⁶, John D. Reveille⁷, Sergio Duran⁸, Sergio M.A. Toloza⁹, Robin L. Brey¹⁰, Agustin Escalante¹¹, Randy Q. Cron¹², Robert P. Kimberly on behalf of PROFILE investigators¹³ and Graciela S. Alarcon¹⁴, ¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ⁵Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁸UIECD, Guadalajara, Mexico, Guadalajara, Mexico, ⁹Medicine, Hospital San Juan Bautista, Catamarca, Argentina, ¹⁰Medicine/Neurology, UTHSCSA, San Antonio, TX, ¹¹Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ¹²Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹³Clinical Immun & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹⁴Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that is characterized by the presence of antinuclear autoantibodies, complement activation and the formation and…
Abstract Number: 2684 • 2012 ACR/ARHP Annual Meeting
Cerebrospinal Fluid IL-6 and Anti-NMDA Receptor NR2 Antibodies As Surrogate Markers for CNS Disease Severity in SLE
Shunsei Hirohata, Yoshiyuki Arinuma and Eisuke Ogawa, Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Neuropsychiatric manifestations occur in approximately one-half of patients with SLE and may cause substantial impairment of quality of life as well as disability. Among…
Abstract Number: 2126 • 2012 ACR/ARHP Annual Meeting
Changes of Serological Markers in the Course of Traditional and Biological Disease Modifying Therapy of Rheumatoid Arthritis
Christoph Böhler¹, Helga Radner², Josef S. Smolen³ and Daniel Aletaha⁴, ¹Department of Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Internal Medicine III; Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ⁴Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Rheumatoid factor (RF) and antibodies against citrullinated peptides (ACPA) are established markers in the diagnostic approach to rheumatoid arthritis (RA). Both auto-antibodies (AAB) also…
Abstract Number: 1673 • 2012 ACR/ARHP Annual Meeting
Clinical Phenotypes of Caucasian Adult and Juvenile Dermatomyositis Patients with Anti-MDA5 Autoantibodies
Zoe Betteridge¹, Sarah Tansley¹, Harsha Gunawardena², Lucy R. Wedderburn³, Hector Chinoy⁴, Robert G. Cooper⁵, Jiri Vencovsky⁶, Lenka Plestilova⁷, Ingrid E. Lundberg⁸, Katalin Danko⁹, Melinda Vincze¹⁰, Neil McHugh¹¹, UK JDRG¹² and EuMyoNet¹³, ¹Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²Rheumatology, North Bristol NHS Trust, Bristol, United Kingdom, ³Rheumatology Unit , Institute of Child Health, University College London (UCL), London, United Kingdom, ⁴Rheumatic Diseases Centre, The University of Manchester, Manchester, United Kingdom, ⁵Rheumatic Diseaes Center, Salford Royal Foundation Trust, Salford, United Kingdom, ⁶Institute of Rheumatology, Prague, Czech Republic, ⁷Institute of Rheumatology, Prague 2, Czech Republic, ⁸Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁹University of Debrecen, University of Debrecen, Debrecan, Hungary, ¹⁰University of Debrecen, University of Debrecen, Debrecen, Hungary, Debrecan, Hungary, ¹¹Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ¹²Institute of Child Health, London, United Kingdom, ¹³Rheumatology Unit, Stockholm, Sweden
Background/Purpose: Autoantibodies to MDA5 have been previously reported in Japanese patients with dermatomyositis (DM) and are associated with clinically-amyopathic DM and rapidly progressing interstitial lung…
Abstract Number: 685 • 2012 ACR/ARHP Annual Meeting
Using a Library of Synthetic Autoantigen Mimics to Discover Biomarkers of Systemic Lupus Erythematosus
Akshai Lakhanpal¹, Jiexia Quan², Sayed Zaman¹, Nancy J. Olsen³ and David R. Karp², ¹Rheumatic Diseases Divsion, UT Southwestern Medical Center, Dallas, TX, ²Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ³Medicine, Penn State MS Hershey Medical Center, Hershey, PA
Background/Purpose: The natural history of systemic lupus erythematosus (SLE) is felt to evolve from a state of normal immunity to serologic autoimmunity and then…
Abstract Number: 2097 • 2012 ACR/ARHP Annual Meeting
Adiponectin Is Associated with Pro-Inflammatory Cytokines in Autoantibody Positive First-Degree Relatives (FDRs) of Patients with Rheumatoid Arthritis
Jan M. Hughes-Austin¹, Kevin D. Deane², Lezlie A. Derber³, Gary O. Zerbe⁴, Dana M. Dabelea¹, Jeremy Sokolove⁵, William H. Robinson⁶, V. Michael Holers⁷ and Jill M. Norris⁸, ¹Epidemiology, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³University of Colorado School of Medicine, Division of Rheumatology, Aurora, CO, ⁴Biostatistics and Informatics, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁶Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁷Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁸Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: While adiponectin is generally considered an anti-inflammatory adipokine, it has also been shown to participate in active RA in inflammatory, matrix-destructive and fibrotic processes…
Abstract Number: 1440 • 2012 ACR/ARHP Annual Meeting
Lupus-Prone Mice Demonstrate Enhanced Neutrophil Extracellular Trap Formation: Implications for Autoantibody Formation and Organ Damage
Jason S. Knight¹, Alexander A. O'Dell¹, Wenpu Zhao², Ritika Khandpur², Srilakshmi Yalavarthi² and Mariana J. Kaplan³, ¹Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Rheumatology, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation—the programmed release of chromatin fibers decorated with granular antimicrobial peptides—is as an important activator…
Abstract Number: 689 • 2012 ACR/ARHP Annual Meeting
Activation of the Interferon Pathway Is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients
Kichul Ko¹, Yelena Koldobskaya¹, Elizabeth Rosenzweig² and Timothy B. Niewold¹, ¹Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, ²Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL
Background/Purpose: Gene expression studies have been instrumental in defining important aspects of the complex immunological pathogenesis in systemic lupus erythematosus (SLE) which is a heterogeneous…
Abstract Number: 1956 • 2012 ACR/ARHP Annual Meeting
A New Linked Set of Autoantibodies in Dermatomyositis: Anti-Mi-2 and Anti-Transcription Intermediary Factor (TIF) 1alpha
Minoru Satoh¹, Jason YF Chan¹, Yi Li¹, Monica Vázquez-Del Mercado², Marcelo Petri³, Luis J. Jara⁴, Miguel A. Saavedra⁵, Claudia Cruz-Reyes⁶, Eric S. Sobel⁷, Westley H. Reeves⁸, Angela Ceribelli⁹ and Edward K.L. Chan⁹, ¹Medicine, University of Florida, Gainesville, FL, ²Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Hospital Civil JIM, Universidad de Guadalajara, Guadalajara, Jalisco, México, Mexico, ³Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara, Guadalajara, Mexico, ⁴Research and Education, Hospital de Especialidades Centro Medico La Raza, México City, Mexico, ⁵Centro Medico La Raza Instituto Mexicano del Seguro Social Mexico D.F., México D.F., Mexico, ⁶Centro Medico La Raza Instituto Mexicano del Seguro Social Mexico D.F., Mexico D. F., Mexico, ⁷Medicine/Div of Rheumatology, University of Florida, Gainesville, FL, ⁸Rheumatology & Clinical Imm, University of Florida, Gainesville, FL, ⁹Oral Biology, University of Florida, Gainesville, FL
Background/Purpose: Myositis specific autoantibodies (MSA) produced in patients with polymyositis/dermatomyositis (PM/DM) are clinically useful biomarkers in diagnosis and management. Anti-Mi-2 antibodies that recognize nucleosome remodeling…
Abstract Number: 1449 • 2012 ACR/ARHP Annual Meeting
Numbers of Splenic Long-Lived Plasma Cells in Autoimmune and Pre-Autoimmune Lupus Mice Are Linked to a Hyper-Responsive Variant of the Thrombopoietin Receptor and Enhanced Megakaryopoiesis
Oliver Winter¹, Katrin Moser², Rudolf A. Manz³ and Falk Hiepe⁴, ¹Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ²German Arthritis Research Center (DRFZ Berlin), Berlin, Germany, ³Institute for Systemic Inflammation Research (ISEF), University of Lübeck, Lübeck, Germany, ⁴Med. Klinik m. Sp. Rheumatologie und klin. Immunologie, Charité University Hospital Berlin, Berlin, Germany
Background/Purpose: Autoantibodies contribute to the pathogenesis of the autoimmune disease Systemic Lupus Erythematosus (SLE) by stimulating the immune response. Further, deposits of immune complexes in…
Abstract Number: 661 • 2012 ACR/ARHP Annual Meeting
Co-Localization of C-Reactive Protein, Immunoglobulin G and Complement in Renal Subendothelial Immune Deposits of Proliferative Lupus Nephritis Detected Using Immunogold Electron Microscopy
Christopher Sjöwall¹, Anders I. Olin², Thomas Skogh³, Jonas Wetterö⁴, Mattias Mörgelin², Ola Nived⁵, Gunnar Sturfelt⁶ and Anders A. Bengtsson⁷, ¹Deparment of clinical and experimental medicine, Linkoping University, Linkoping, Sweden, ²Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden, Lund, Sweden, ³Deparment of clinical and experimental medicine, Linköping University, Linköping, Sweden, ⁴Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden, ⁵Department of Rheumatology, University Hospital Lund, Lund, Sweden, ⁶Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Lund, Sweden, ⁷Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden
Background/Purpose: The pattern recognition molecules C-reactive protein (CRP) and complement protein 1q (C1q) are pivotal parts of the innate immune system and display relevant biological…
Abstract Number: 1929 • 2012 ACR/ARHP Annual Meeting
Pernicious Anemia and Vitamin B-12 Deficiency in Autoimmune Disease: Neglecting the Feet Will Lead You Astray
Michael R. Lovy, Desert Oasis Healthcare, Palm Springs, CA
Background/Purpose: The occurrence of multiple autoimmune disorders in individual patients is commonly observed. Rarely, this is explained by recently recognized genetically based autoimmune polyendocrine syndromes.…
Abstract Number: 1403 • 2012 ACR/ARHP Annual Meeting
Anti-Nucleosome Antibodies Are Associated with Disease Activity and Hydroxychloroquine Use in Patients with Lupus: A Longitudinal, Multivariate Analysis of 398 Samples
Sara Croca¹, Ian Giles², David A. Isenberg³, Yiannis Ioannou⁴ and Anisur Rahman², ¹Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ²Centre for Rheumatology Research,Rayne Institute, 4th Floor, University College London, London, United Kingdom, ³Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ⁴Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom
Background/Purpose: Impaired apoptotic clearance appears to play a pivotal role in the pathogenesis of SLE leading to the accumulation of nuclear debris, such as nucleosomes,…

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