Abstracts tagged "autoantibodies"

Abstract Number: 889 • 2012 ACR/ARHP Annual Meeting
Modeling Environmental and Genetic Determinants to Identify the Association of Risk Genes in Anti-Ro60-Mediated Injury: Relaxin Receptor I and Tumor Necrosis Factor
Joanne H. Reed¹, Paula S. Ramos², Jiri Zavadil³, Jill P. Buyon⁴ and Robert M. Clancy¹, ¹Medicine, New York University School of Medicine, New York, NY, ²Department of Medicine, Medical University of South Carolina, Charleston, SC, ³Pathology and Center for Health Informatics and Bioinformtics, New York University School of Medicine, New York, NY, ⁴Department of Medicine, New York University School of Medicine, New York, NY
Background/Purpose: Fetuses exposed to maternal anti-Ro60 antibodies can develop cardiac conduction abnormalities and life threatening cardiomyopathy; manifestations of neonatal lupus (NL). Recent data support an injury…
Abstract Number: 233 • 2012 ACR/ARHP Annual Meeting
IFN Signature Is Associated with Autoantibody Profiles in Patients with Idiopathic Inflammatory Myopathies
Saskia Vosslamber¹, Louise Ekholm², Anna Tjarnlund³, Clio P. Mavragani⁴, Lenka Plestilova⁵, Martin Klein⁶, Mary K. Crow⁷, Peter J. Charles⁸, Leonid Padyukov⁹, Jiri Vencovsky⁵, Ingrid E. Lundberg¹⁰ and Cornelis L. Verweij¹, ¹Pathology, VU University Medical Center, Amsterdam, Netherlands, ²Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, ³Pathology, Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, ⁵Institute of Rheumatology, Prague, Czech Republic, ⁶Institute of Rheumatology, Prague, Prague, Czech Republic, ⁷Department of Medicine, Hospital for Special Surgery, New York, NY, ⁸Oxford University, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ⁹Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ¹⁰Rheumatology Unit, Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Sweden, Stockholm, Sweden
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are rare autoimmune diseases characterized by the presence of autoantibodies, proximal muscle weakness and muscle inflammation. Recent studies showed an…
Abstract Number: 2578 • 2012 ACR/ARHP Annual Meeting
Monoclonal IgG Antibodies (ACPAs) From Synovial Fluid B Cells of Rheumatoid Arthritis Patients – Antigen-Driven Affinity Maturation and Cross Reactivity
Khaled Amara¹, Johanna Steen², Fiona Murray², Henner Morbach³, Blanca Fernandez-Rodriguez⁴, Vijay Balasingh², Marianne Engström², Omri Snir², Lena Israelsson⁵, Anca Catrina², Hedda Wardemann⁶, Davide Corti⁴, Eric Meffre Sr.³, Lars Klareskog⁷ and Vivianne Malmström⁸, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, SE-17176 Solna, Stockholm, Sweden., Stockholm, Sweden, ²Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ⁴Institute for Research in Biomedicine, Bellinzona, Switzerland, ⁵Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁶Max Planck Research Group Molecular Immunology, Max Planck Institute for Infection Biology, Berlin, Germany, ⁷Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁸Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Antibodies targeting citrullinated proteins (ACPA) are commonly found in patients with Rheumatoid Arthritis (RA), strongly associate with distinct HLA-DR alleles and predict a more…
Abstract Number: 1753 • 2012 ACR/ARHP Annual Meeting
A Rheumatoid Factor Paradox: Inhibition of Rituximab-Induced Complement Dependent Cytotoxicity of B Cells
Jonathan D. Jones¹, Irene Shyu², Marianna M. Newkirk³ and William F. C. Rigby², ¹Rheumatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, ²Rheumatology, Dartmouth-Hitchcock Med Ctr, Lebanon, NH, ³Medicine, McGill University Health Centr, Montreal, QC, Canada
Background/Purpose: Rheumatoid factor (RF) is an autoantibody directed against the Fc portion of IgG antibodies. It is found in ~80% of patients with rheumatoid…
Abstract Number: 854 • 2012 ACR/ARHP Annual Meeting
Anti-EIF2B: A Novel Interstitial Lung Disease Associated Autoantibody in Patients with Systemic Sclerosis
Zoe Betteridge¹, Felix Woodhead², Christopher Bunn³, Christopher D. Denton⁴, David J. Abraham⁵, Sujal Desai⁶, Roland du Bois⁷, Athol U. Wells⁸ and Neil McHugh⁹, ¹Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²Respiratory, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom, ³Immunology, Royal Free Hospital, London, United Kingdom, ⁴Department of Rheumatology, Royal Free and University College Medical School, London, England, ⁵UCL Medical School, London, United Kingdom, ⁶Radiology, Kings College Hosptial, London, United Kingdom, ⁷National Jewish Health, Denver, ⁸Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, London, United Kingdom, ⁹Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom
Background/Purpose: Autoantibodies occur in 75-95% of Systemic Sclerosis (SSc) patients. Studies have shown that the presence of particular SSc-specific autoantibodies (anti-centromere, anti-topoisomerase-1, anti-RNA polymerase III,…
Abstract Number: 176 • 2012 ACR/ARHP Annual Meeting
Prevalence and Associations of Hepatitis C Arthritis in Chronic Hepatitis C Virus Infection
Elizabeth D. Ferucci¹, Holly S. Ryan², Tammy L. Choromanski¹, Lisa J. Townshend-Bulson², Stephen E. Livingston², Brian J. McMahon² and Mark H. Wener³, ¹Division of Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, ²Alaska Native Tribal Health Consortium, Anchorage, AK, ³Rheumatology & Lab Med, University of Washington, Seattle, WA
Background/Purpose: Chronic infection with hepatitis C virus (HCV) has been reported to cause inflammatory arthritis and/or fibromyalgia. Case series of patients with HCV-associated arthritis have…
Abstract Number: 2579 • 2012 ACR/ARHP Annual Meeting
Novel Autoantibodies to 14-3-3 Eta Are Highly Specific for Rheumatoid Arthritis
Walter P. Maksymowych¹, Désirée van der Heijde², R. Landewe³, Vivian P. Bykerk⁴ and Anthony Marotta⁵, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁴Rheumatology, Hospital for Special Surgery, New York, NY, ⁵Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: Serum 14-3-3 eta, a protein biomarker that is differentially expressed in rheumatoid arthritis (RA), has been reported to add incrementally to rheumatoid factor (RF)…
Abstract Number: 1688 • 2012 ACR/ARHP Annual Meeting
Evolution of Preclinical Autoimmunity in Individuals At Risk for Development of Rheumatoid Arthritis
Hani S. El-Gabalawy¹, David B. Robinson¹, Irene Smolik¹, Donna M. Hart¹, Elizabeth D. Ferucci², Marianna M. Newkirk³, Marvin J. Fritzler⁴, Catriona Cramb⁵, Jeremy Sokolove⁶ and William H. Robinson⁷, ¹Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, ²Division of Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, ³Medicine, McGill University Health Centr, Montreal, QC, Canada, ⁴Medicine, University of Calgary, Calgary, AB, Canada, ⁵CCSR 4135 Immunology Rheumatol, Stanford University, Palo Alto, CA, ⁶Medicine, Stanford University, Palo Alto, CA, ⁷Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is prevalent, severe, and predominantly seropositive in many North American Native (NAN) populations. We have shown a strong tendency towards familial…
Abstract Number: 758 • 2012 ACR/ARHP Annual Meeting
Cutaneous Ulceration in Dermatomyositis: Association with MDA-5 and Interstitial Lung Disease
Neera Narang¹, Livia Casciola-Rosen², Antony Rosen², David Fiorentino³ and Lorinda Chung⁴, ¹Stanford Univ Medical Center, Stanford, CA, ²Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ³Dermatology, Stanford University School of Medicine, Redwood City, CA, ⁴Rheumatology, Stanford Univ Medical Center, Palo Alto, CA
Background/Purpose: Dermatomyositis (DM) is a multisystem autoimmune disease that affects the muscles and skin and can be associated with malignancy or interstitial lung disease (ILD). …
Abstract Number: 71 • 2012 ACR/ARHP Annual Meeting
The Association Between Preclinical Markers for Cardiovascular Disease and Rheumatoid Arthritis-Related Autoantibodies in First-Degree Relatives without Rheumatoid Arthritis
Ryan W. Gan¹, Jan M. Hughes-Austin², Kevin D. Deane³, Elaine M. Urbina⁴, Peter K. Gregersen⁵, Michael H. Weisman⁶, V. Michael Holers⁷ and Jill M. Norris¹, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Epidemiology, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ³Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁴Preventive Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Rheumatoid arthritis (RA) is characterized by systemic inflammation and immune dysregulation, including the presence of autoantibodies and elevated inflammatory markers in subjects with…
Abstract Number: 2530 • 2012 ACR/ARHP Annual Meeting
Anti-Ribosomal P Antibodies in a Large Cohort of Autoimmune Hepatitis with No Evidence of Lupus: A Common Underlying Mechanism Targeting Liver?
Ana Luisa Calich¹, Vilma S. T. Viana¹, Eduardo L. Cançado², Débora R. Terrabuio², Francisco Tustumi¹, Elaine P. Leon¹, Clovis Artur Silva³, Eduardo F. Borba Neto¹ and Eloisa Bonfa¹, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Gastroenterology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy
Background/Purpose: Anti-ribosomal P proteins antibody (anti-rib P) is a highly specific marker for systemic lupus erythematosus (SLE) and it is associated with liver involvement in…
Abstract Number: 1689 • 2012 ACR/ARHP Annual Meeting
Anti-Peptidylarginine Deiminase 3/4 Cross-Reactive Antibodies: A Novel Biomarker with Clinical and Mechanistic Implications in Rheumatoid Arthritis
Erika Darrah¹, Jon T. Giles², Herbert Bull³, Felipe Andrade⁴ and Antony Rosen¹, ¹Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ³Consultant, Westfield, NJ, ⁴Division of Rheumatology, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Peptidylarginine deiminases (PADs) have emerged as key participants in the pathogenesis of rheumatoid arthritis (RA) due to their expression in inflamed RA synovium and…
Abstract Number: 765 • 2012 ACR/ARHP Annual Meeting
A Prediction Rule for the Development of Rheumatoid Arthritis: A Prospective Cohort Study of Seropositive Arthralgia Patients
Lotte van de Stadt¹, B. I. Witte², W.H. Bos¹ and Dirkjan van Schaardenburg¹, ¹Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ²Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Patients presenting with arthralgia and a positive test for anti-cyclic citrullinated peptide antibodies (aCCP) and/or IgM rheumatoid factor (IgM-RF) (seropositive) are at risk for…
Abstract Number: 72 • 2012 ACR/ARHP Annual Meeting
Relationships Between Air Pollution and Presence of Rheumatoid Arthritis-Related Autoantibodies in Individuals without Rheumatoid Arthritis: Studies of the Etiology of Rheumatoid Arthritis
Ryan W. Gan¹, Kevin D. Deane², Gary O. Zerbe³, Michael H. Weisman⁴, Jane H. Buckner⁵, P. K. Gregersen⁶, Ted R. Mikuls⁷, James R. O'Dell⁸, Richard M. Keating⁹, V. Michael Holers¹⁰ and Jill M. Norris¹, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Biostatistics and Informatics, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁶Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY, ⁷Internal Medicine, Omaha VA and University of Nebraska Medical Center, Omaha, NE, ⁸Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, ⁹Rheumatology Section, The University of Chicago, Chicago, IL, ¹⁰Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the presence of circulating autoantibodies, which can be predictive of future RA development in currently unaffected individuals. …
Abstract Number: 2380 • 2012 ACR/ARHP Annual Meeting
High Frequency of Ferritin Autoantibodies in Takayasu Arteritis
Niklas T. Baerlecken¹, Katherina Große², Frank Moosig³, Wolfgang L. Gross⁴, Reinhold E. Schmidt¹ and Torsten Witte⁵, ¹Clinical Immunology and Rheumatology, Medical University Hannover, Hannover, Germany, ²Department of Immunology and Rheumatology, Student, Hannover, Germany, ³University of Luebeck, Stormarnzing 156, Bad Bramstedt, Germany, ⁴Dept of Clinical Rheumatology, Medical University at Lubeck, Lubeck, Germany, ⁵Hannover Medical School, Hanover, Germany
Background/Purpose: Takayasu arteritis (TA) may be difficult to diagnose since diagnostic biomarkers have not been established so far. In a previous study, we could show…

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