Abstracts tagged "autoantibodies"

Abstract Number: 2713 • 2013 ACR/ARHP Annual Meeting
IL-21 Inhibited Follicular Regulatory T Cells To Promote Autoreactive Germinal Center Development In Autoimmune BXD2 Mice
Yanna Ding¹, Hui-Chen Hsu^2,3, Jun Li⁴, PingAr Yang⁴, Qi Wu⁴, Allan J. Zajac⁵ and John D. Mountz^3,6, ¹University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Birmingham VA Medical Center, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Microbiology, University of Alabama at Birmingham, Birmingham, AL, ⁶Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Follicular T helper (Tfh) cells have been correlated with germinal center (GC) formation, autoantibody production and disease severity in human systemic lupus erythematosus (SLE).…
Abstract Number: 1884 • 2013 ACR/ARHP Annual Meeting
Autoantibody Specificities and Type I Interferon Pathway Activation In Idiopathic Inflammatory Myopathies
Saskia Vosslamber¹, Louise Ekholm², Anna Tjarnlund³, T.D. de Jong¹, Lenka Plestilova⁴, Martin Klein⁵, Peter J. Charles⁶, A.E. Voskuyl⁷, Irene Bultink⁸, Michiel Pegtel¹, J Vencovsky⁹, Ingrid E. Lundberg¹⁰ and Cornelis L. Verweij¹¹, ¹Pathology, VU University Medical Center, Amsterdam, Netherlands, ²Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, ³Pathology, Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Clinical and Experimental Rheumatology, Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology, Prague, Prague, Czech Republic, ⁶Oxford University, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ⁷Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ⁸Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ⁹Institute of Rheumatology, Prague, Czech Republic, ¹⁰Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ¹¹Pathology and Rheumatology, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are rare autoimmune diseases characterized by proximal muscle weakness and muscle inflammation. IIM are associated with several autoantibodies, which are…
Abstract Number: 922 • 2013 ACR/ARHP Annual Meeting
Role Of B Cells and/Or Autoantibodies In Pulmonary Manifestations Of Inflammatory Arthritis
Lisa K. Peterson¹, Jeremy Sokolove², Paul Jedlicka³, Lauren J. Lahey⁴, William H. Robinson⁵ and Leonard L. Dragone⁶, ¹Pediatrics, National Jewish Health, Denver, CO, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ³Pathology, University of Colorado Denver, Aurora, CO, ⁴Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁵VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁶Dept of Pediatrics, National Jewish Health, Denver, CO
Background/Purpose: RA is a systemic condition affecting approximately 1% of the general population leading to progressive arthritis and extra-articular manifestations (ExRA), including interstitial lung disease…
Abstract Number: 2685 • 2013 ACR/ARHP Annual Meeting
Anti-Peptidylarginine Deiminase 3/4 Cross-Reactive Antibodies Are Associated With Radiographic Interstitial Lung Disease In Rheumatoid Arthritis, An Effect Potentiated By Smoking
Jon T. Giles¹, Erika Darrah², Sonye K. Danoff³, Cheilonda Johnson⁴, Felipe Andrade⁵, Antony Rosen² and Joan M. Bathon⁶, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ³Medicine/Pulmonary, Johns Hopkins University, Baltimore, MD, ⁴Medicine/Pulmonology, Johns Hopkins University, Baltimore, MD, ⁵Division of Rheumatology, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Columbia University, New York, NY
Background/Purpose: Antibodies targeting citrullinated proteins (ACPA) are implicated in the pathogenesis of interstitial lung disease (ILD) in rheumatoid arthritis (RA). Citrullinated proteins and the enzymes…
Abstract Number: 1844 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis, Sjogren’s Syndrome and Systemic Lupus Erythematosus Patients Have a Distinct Spectrum Of Serum Anticytokine Autoantibodies
Sarthak Gupta^1,2, Ioanna P. Tatouli³, Lindsey B. Rosen², Sarfaraz A. Hasni¹, Richard M. Siegel¹, Steven M. Holland², Haralampos M. Moutsopopoulos³ and Sarah K. Browne², ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ³School of Medicine, National University of Athens, Athens, Greece
Background/Purpose: Anticytokine autoantibodies are pathogenic in many hematologic, pulmonary and infectious diseases. However, the prevalence and significance of anticytokine autoantibodies in rheumatic conditions is poorly…
Abstract Number: 923 • 2013 ACR/ARHP Annual Meeting
Redox Dependent Conformational Changes Of The Autoantigen La Are Responsible For Its Shuttling, Translocation and a Pathophysiological Role Of Anti-La Autoantibodies
Irene Michalk¹, Nicole Berndt¹, Claudia C. Bippes¹, Holger Bartsch², Stefanie Koristka³, Claudia Arndt¹, Anja Feldmann¹, Biji T. Kurien⁴, Robert Hal Scofield⁵, A. Darise Farris⁶, Judith A. James⁷, Marc Cartellieri¹ and Michael Bachmann¹, ¹Inst. Immunology, Carl Gustav Carus TU-Dresden, Dresden, Germany, ²Inst. Immunol., Carl Gustav Carus TU-Dresden, Dresden, Germany, ³Carl Gustav Carus TU-Dresden, Dresden, Germany, ⁴College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁶Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK, ⁷Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Since their detection a pathophysiological role of antibodies (abs) to extractable nuclear autoantigens including anti-La abs has been controversially discussed. Stainings of anti-La abs…
Abstract Number: 2655 • 2013 ACR/ARHP Annual Meeting
Therapeutic Effect Of β2GPI and Its Synthetic derivative Loaded Tolerogenic Dendritic Cells In Experimental Antiphospholipid Syndrome, Is Associated With miRNA 23b, 142-3p and 221 Expression and Tregs Upregulation
Miri Blank¹, Silvia S. Pierangeli², Honorio Torres-Aguilar³ and Yehuda Shoenfeld⁴, ¹Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, affiliated to Sackler Medical School, Tel Aviv University, Ramat Gan, Israel, ²Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ³National Center for Blood Transfusion, Mexico City, Mexico, ⁴Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University,Tel-Aviv, Tel-Aviv, Israel
Background/Purpose: The importance of beta-glycoprotein I (beta2GPI)-specific CD4+ T cells in the development of pathogenic processes in patients with antiphospholipid syndrome (APS) and APS mice…
Abstract Number: 1777 • 2013 ACR/ARHP Annual Meeting
Antibodies Against TIF1-Gamma In Cancer Associated Myositis May Precede Cancer Symptoms and Persist After Cancer Removal
Ingrid E. Lundberg¹, Lara Dani², Maryam Dastmalchi², Maria Angeles Martinez³, Moises Labrador-Horrillo⁴ and Albert Selva O'Callaghan⁴, ¹Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, ³Sant Pau Hospital, Barcelona, Spain, ⁴Vall d'Hebron General Hospital, Barcelona, Spain
Background/Purpose: Antibodies against TIF1-gamma have been detected in patients with cancer associated myositis (CAM) but it is not known whether the antibodies precede the diagnosis…
Abstract Number: 926 • 2013 ACR/ARHP Annual Meeting
Autoantibodies to the Th/To Complex Are the Most Common Antibodies in Systemic Sclerosis (SSc) Patients Without Other Autoantibodies
Michael Mahler¹, Jason Y.F. Chan², Edward K.L. Chan³, Minoru Satoh², Marie Hudson⁴, Murray Baron⁵, James Wick⁶ and Marvin J. Fritzler⁷, ¹Research, INOVA Diagnostics, San Diego, CA, ²Medicine, University of Florida, Gainesville, FL, ³Oral Biology, University of Florida, Gainesville, FL, ⁴Jewish General Hospital, McGill University, Montreal, QC, Canada, ⁵Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁶Department of medicine, Faculty of Medicine, University of Calgary, Calgary, AB, Canada, ⁷Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Antinuclear antibodies (ANA) play an important role in the diagnosis of systemic sclerosis (SSc) being present in about 80-90% of the patients. In the…
Abstract Number: 1764 • 2012 ACR/ARHP Annual Meeting
B Cells in Early Rheumatoid Arthritis: ZAP-70 More Than SYK Characterize Seropositive Disease
Anna Laura Fedele, Barbara Tolusso, Elisa Gremese, Silvia Laura Bosello, Angela Carbonella, Silvia Canestri and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: B cells are involved as central players in the pathogenesis of rheumatoid arthritis (RA). Our aim was to define whether a specific B cell…
Abstract Number: 1391 • 2012 ACR/ARHP Annual Meeting
Anti-Ku Autoantibodies in Systemic Lupus Erythematosus Versus Autoimmune Myositis As Measured by a Novel Chemiluminescence Assay
Michael Mahler¹, Jason Wu², Magdalena Szmyrka-Kaczmarek³, Andreas Swart⁴, Marvin J. Fritzler⁵, Jean-Luc Senécal⁶ and John G. Hanly⁷, ¹Research, INOVA Diagnostics, San Diego, CA, ²Research, INOVA Diagnostics, San Diego, ³Rheumatology, Wroclaw Medical University, Wroclaw, Poland, ⁴Rheumatology clinic Neuss, Neuss, Germany, ⁵Medicine, University of Calgary, Calgary, AB, Canada, ⁶Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ⁷Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada
Background/Purpose: Autoantibodies targeting Ku, an abundant nuclear protein with DNA helicase activity, have been reported in patients with systemic autoimmune rheumatic diseases. Little is known…
Abstract Number: 441 • 2012 ACR/ARHP Annual Meeting
Performance of Anti-Cyclic Citrullinated Peptide Assays Differs in Healthy Subjects At Elevated Risk for Future Rheumatoid Arthritis and Subjects with Established Disease
M. Kristen Demoruelle¹, Mark Parish², Lezlie A. Derber³, Michael H. Weisman⁴, William R. Gilliland⁵, Jess Edison⁶, James R. O'Dell⁷, Ted R. Mikuls⁸, Richard M. Keating⁹, Peter K. Gregersen¹⁰, Jane H. Buckner¹¹, Jill M. Norris¹², V. Michael Holers¹³ and Kevin D. Deane¹, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, ³University of Colorado School of Medicine, Division of Rheumatology, Aurora, CO, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Walter Reed National Military Medical Center, Bethesda, MD, ⁶Department of Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ⁷Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁸Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁹Rheumatology Section, The University of Chicago, Chicago, IL, ¹⁰Genomics and Human Genetics, North Shore University Hospital Research Center, Manhasset, NY, ¹¹Benaroya Research Institute at Virginia Mason, Seattle, WA, ¹²Epidemiology, Colorado School of Public Health, Aurora, CO, ¹³Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: The 2010 ACR/EULAR RA criteria include autoantibodies to cyclic citrullinated peptides (CCP) that are highly specific for RA in the setting of inflammatory arthritis…
Abstract Number: 1770 • 2012 ACR/ARHP Annual Meeting
Recognition of Citrullinated and Carbamylated Proteins by Human Antibodies: Specificity, Cross-Reactivity and the “AMC-Senshu” Method
Jing Shi¹, George Janssen², Peter van Veelen², Janwouter Drijfhout², Antony Cerami³, Tom Huizinga⁴, Leendert A. Trouw⁵ and René E.M. Toes⁴, ¹Rheumatology, LUMC, Leiden, Netherlands, ²Immunohematology and Bloodbank, LUMC, Leiden, Netherlands, ³Nephrology, LUMC, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) play an important role in the diagnosis and prognosis of Rheumatoid Arthritis (RA). The Anti-Modified Citrulline (AMC) (‘Senshu’) method is…
Abstract Number: 1195 • 2012 ACR/ARHP Annual Meeting
Identification of Follicular Helper T Cells As a Novel Cell Population Potentially Involved in the Pathogenesis of Rheumatoid Arthritis
Sharon Ing¹, Anika Alarakhia¹, Elvira Lindwall¹, Austin Fraser¹, Jerald M. Zakem¹, William E. Davis¹, Tamika A. Webb-Detiege¹, Robert Quinet¹ and Xin Zhang², ¹Rheumatology, Ochsner Medical Center, New Orleans, LA, ²Institute of Translational Research, Ochsner Medical Center, New Orleans, LA
Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovium, causing progressive joint destruction and reduction in quality of life…
Abstract Number: 423 • 2012 ACR/ARHP Annual Meeting
Sputa Autoantibodies in Patients with Established Rheumatoid Arthritis and Subjects At-Risk for Future Clinically Apparent Disease
Van C. Willis¹, M. Kristen Demoruelle², Lezlie A. Derber², Catherine J. Chartier-Logan¹, Mark Parish¹, Isabel Pedraza³, Michael H. Weisman⁴, Jill M. Norris⁵, V. Michael Holers⁶ and Kevin D. Deane², ¹Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Division of Pulmonary and Critical Care Medicine, Cedars Sinai Med Ctr, Los Angeles, CA, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Epidemiology, Colorado School of Public Health, Aurora, CO, ⁶Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Elevations of rheumatoid arthritis (RA)-related autoantibodies (Abs) prior to the symptomatic onset of inflammatory arthritis (IA) suggest that autoimmunity in RA is initiated outside…

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