Abstracts tagged "autoantibodies"

Abstract Number: 1606 • 2014 ACR/ARHP Annual Meeting
Profiling a Broad Range of Autoantibodies in Healthy and Systemic Lupus Erythematosis Revealed Autoantibody Patterns Associated with Autoantibody Transition and Disease Activity
Quan-Zhen Li Li¹, Edward Wakeland², Prithvi Raj³, Honglin Zhu², Xiaoxia Zuo⁴, Mei Yan⁵ and Indu Raman⁶, ¹Immunology and internal medicine, University of Texas Southwestern Medical Center, Dallas, TX, ²Immunology, University of Texas Southwestern Medical Center, Dallas, TX, ³Immunology, University of Texas Southwestern Medical Center, dallas, TX, ⁴Rheumatology, Xiangya Hospital of Hunan Medical Univ, Changsha, China, ⁵Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, ⁶Department of Immunology and Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Autoantibodies targeting to nuclear antigens are serological hallmarks of SLE, however, the processing of autoantibody production during the transition from normal to autoimmunity and…
Abstract Number: 780 • 2014 ACR/ARHP Annual Meeting
Novel Roles for Zyxin in the Pathogenesis of Giant Cell Arteritis
Rie Karasawa¹, Paul A. Monach², Mayumi Tamaki¹, Takahiro Okazaki³, Masamichi Oh-Ishi⁴, Yoshio Kodera⁴, Toshiko Sato¹, Shoichi Ozaki⁵, Kaiyu Jiang⁶, Kazuo Yudoh¹, James N. Jarvis⁷ and Peter A. Merkel⁸, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ²Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, ³Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁴School of Science, Kitasato University, Sagamihara, Japan, ⁵Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁶415 Carmen Road, Apt. 1, The University at Buffalo, Buffalo, NY, ⁷Pediatrics, The University at Buffalo, Buffalo, NY, ⁸Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose �:The mechanisms of the blood vessel injury in giant cell arteritis (GCA), a systemic vasculitis characterized by inflammation of large- and medium-sized vessels, remain…
Abstract Number: 2874 • 2014 ACR/ARHP Annual Meeting
Pro-Inflammatory FcRL4+ Memory B Cells in Joints of RA Patients: Immunoglobulin Gene Characteristics and Antigen Specificity
Khaled Amara¹, Lorraine Yeo², Natalie Sippl¹, Philip Titcombe¹, Andrew Filer³, Karim Raza³, Dagmar Scheel-Toellner² and Vivianne Malmström⁴, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, SE-17176 Solna, Stockholm, Sweden., Stockholm, Sweden, ²Rheumatology Research Group, Centre for Translational Inflammation Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK, Birmingham, United Kingdom, ³Rheumatology Research Group, MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, ⁴Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Our recent findings identified a subset of pro-inflammatory memory B cells in the RA synovium characterized by the expression of the surface protein…
Abstract Number: 1328 • 2014 ACR/ARHP Annual Meeting
Modulation of Natural IgM-Autoantibodies to Oxidative Stress-Related Neo-Epitopes on Apoptotic Cells in Newborns of Mothers with Anti-Ro Autoimmunity
Caroline Grönwall¹, Robert M. Clancy², Lelise Getu³, Don L. Siegel⁴, Joanne Reed³, Jill P. Buyon² and Gregg J. Silverman¹, ¹Medicine, New York University School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³New York University School of Medicine, New York, NY, ⁴Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose At birth, the human immune system expresses substantial circulating levels of polymeric IgM that include autoantibodies to oxidation-associated epitopes on apoptotic cells. This study…
Abstract Number: 773 • 2014 ACR/ARHP Annual Meeting
Functional Autoantibodies from Patients with Systemic Sclerosis Reactive to Angiotensin II Type 1and Endothelin-1 Type a Receptor Induce Inflammatory Lymphocyte Infiltration into Lungs of Mice
Angela Kill¹, Clement Braesch¹, Anja Kühl², Jeannine Guenther³, Mike O. Becker⁴, Gerd Burmester⁵, Thomas Walther⁶ and Gabriela Riemekasten⁷, ¹Rheumatology and clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, ²Department of Internal Medicine, Charité University Hospital, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, ⁴Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, ⁵Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁶Pharmacology & Therapeutics, University College Cork, Cork, Ireland, ⁷Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany
Background/Purpose Functional autoantibodies reactive to the angiotensin II type 1 receptor (AT1R) and endothelin 1 type A receptor (ETAR) were found in elevated levels in…
Abstract Number: 2700 • 2014 ACR/ARHP Annual Meeting
Clinical Phenotype of Systemic Sclerosis Patients with Anti-RNA Polymerase III Antibodies: A New French Cohort, Systematic Review and Meta-Analysis
Vincent Sobanski^1,2, Luc Dauchet^3,4, Guillaume Lefèvre², Marc Lambert⁵, Sandrine Morell-Dubois⁶, Thierno Sy⁶, Eric Hachulla¹, Pierre-Yves Hatron⁷, Sylvain Dubucquoi^8,9 and David Launay^1,9, ¹Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, ²EA 2686, Lille, LILLE, France, ³Service d'Epidémiologie Régionale, CHRU Lille, LILLE, France, ⁴INSERM U744, LILLE, France, ⁵Faculté de Médecine Henri Warembourg, Université Lille Nord de France, Lille, France, ⁶Internal Medicine, CHRU Lille, LILLE, France, ⁷Internal Medicine, Lille, France, ⁸Institut d’Immunologie, Centre de Biologie-Pathologie-Génétique, CHRU Lille, Lille, France, ⁹EA 2686, Lille, Lille, France
Background/Purpose: Anti-RNA polymerase III antibodies (anti-RNAP III) are one of the most frequent antinuclear antibodies identified in systemic sclerosis (SSc), with an estimated prevalence of…
Abstract Number: 1317 • 2014 ACR/ARHP Annual Meeting
Anti-p155/140 Autoantibodies and Selected Features at Illness Onset Are Associated with a Chronic Course of Illness in the Juvenile Idiopathic Inflammatory Myopathies
G. Esther A. Habers¹, Adam M. Huber², Gulnara Mamyrova³, Ira Targoff⁴, Chantal Boonacker⁵, Marco van Brussel¹, Frederick W. Miller⁶, Lisa G. Rider⁶ and Annet van Royen-Kerkhof⁷, ¹Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands, ²IWK Health Centre, Halifax, NS, Canada, ³Rheumatology, George Washington University, Washington, DC, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁷Paediatric Immunology and Rheumatology, University Medical Centre Utrecht - Wilhelmina Children's Hospital, Utrecht, Netherlands
Background/Purpose : Three types of disease courses can be distinguished in patients with juvenile idiopathic inflammatory myopathies (JIIM), namely monocyclic (M), polycyclic (P), and chronic…
Abstract Number: 761 • 2014 ACR/ARHP Annual Meeting
Specific Autoantibody Profiles and Disease Subgroups Correlate with Circulating Micro-RNA in Systemic Sclerosis
Dirk Wuttge¹, Anting L. Carlsen², Gabriel Teku³, Samantha Steen⁴, Marie Wildt¹, Mauno Vihinen³, Roger Hesselstrand¹ and Niels H. H. Heegaard^4,5, ¹Rheumatology, Lund University, Lund, Sweden, ²Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ³Experimental Medical Science, Lund University, Lund, Sweden, ⁴Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁵Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark
Background/Purpose: Systemic sclerosis (SSc) is a serious autoimmune disease with clinical phenotypes of different prognosis, progression rate, and different extent of involvement of internal organs.…
Abstract Number: 2698 • 2014 ACR/ARHP Annual Meeting
Survival in Systemic Sclerosis-Pulmonary Arterial Hypertension By Serum Autoantibody Status
Monique Hinchcliff^1,2, Saira Khanna³, Jungwha Lee^4,5, Orit Almagor⁶, Rowland W. Chang^2,7, Virginia D. Steen⁸ and Lorinda Chung⁹, ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Preventive Medicine, Northwestern University Medical School, Chicago, IL, ⁶Northwestern University, Chicago, IL, ⁷Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ⁹Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA
Background/Purpose: Previous studies have shown that anticentromere (AC) and isolated nucleolar (NUC) antibodies are the most common autoantibodies in patients with systemic sclerosis (SSc) and…
Abstract Number: 1262 • 2014 ACR/ARHP Annual Meeting
Mechanisms of Muscular Necrosis in Auto-Immune Myopathies Associated with Anti-Signal Recognition Particle and Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase Antibodies: Pathogenic Role of Auto-Antibodies
Yves Allenbach^1,2,3, Aude Rigolet³, Bruno Eymard⁴, Tanya Stojkovic⁴, Anthony. Behin⁴, Pascal Laforet⁴, Peter Hufnagl⁵, Norman Zerbe⁶, Thierry Maisonobe⁷, Kuberaka Mariampillai⁸, Serge Herson⁸, Olivier Benveniste^2,3 and Werner Stenzel⁹, ¹Neuropathology, Charite Hospital, Berlin, Germany, ²UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, ³Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France, ⁴Department of Neurology, Myology Institute, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ⁵Pathology departmen, Charite Hospital, Berlin, Germany, ⁶Department of Pathology, Charite Hospital, Berlin, Germany, ⁷Neuropathology, Pitie-Salpetriere Hospital, Paris, France, ⁸Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ⁹Department of Neuropathology, Charite Hospital, Berlin, Germany
Background/Purpose: Necrotizing auto-immune myopathies (NAM) are a group of acquired idiopathic inflammatory myopathies characterized by severe muscle weakness and no or mild extra-muscular involvement. Definition of…
Abstract Number: 638 • 2014 ACR/ARHP Annual Meeting
Commensal Microbiota Influence Systemic Autoimmune Responses
Jens Van Praet¹, Erin Donovan², Michael Drennan¹, Fons Van de Loo³, Sylvie Rabot⁴, Jeroen Raes⁵, Tom Van De Wiele⁶, Carl Ware⁷ and Dirk Elewaut⁸, ¹Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ²department of Rheumatology, Ghent University Hospital, ghent, Belgium, ³Rheumatology, Raboud University Medical Center, Utrecht, Netherlands, ⁴AgroParisTech, Micalis,, Jouy-en-Josas, France, ⁵Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium, ⁶Laboratory of Microbial Ecology and Technology, Ghent University Hospital, Ghent, Belgium, ⁷Infectious and Inflammatory Disease Center,, Sanford-Burnham Medical Research Institute, La Jolla, CA, ⁸Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium
Background/Purpose Antinuclear antibodies are a hallmark feature of generalized autoimmune diseases, including systemic lupus erythematosus and systemic sclerosis. However, the processes underlying the loss of…
Abstract Number: 2530 • 2014 ACR/ARHP Annual Meeting
PRE.MARK-TNF Test Based on Iga-Specific Autoantigens Predicts Therapy Response in Rheumatoid Arthritis Patients Treated with TNFα Inhibitors
Karl Skriner¹, Jörg Hollidt², Gerd Burmester³ and Zoltan Konthur⁴, ¹Department of Rheumatology and Clinical Immunology, Germany, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Drug Response DX GmbH, Berlin, Germany, ³Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Drug Response DX GmbH, Hennigsdorf, Germany
Background/Purpose One third of rheumatoid arthritis patients treated with biologicals targeting TNFα are therapy non-responders. We have earlier investigated the difference in seroreactivity of patients…
Abstract Number: 1272 • 2014 ACR/ARHP Annual Meeting
Myositis-Specific and Myositis Associated Autoantibodies in Indian Patients with Inflammatory Myositis
Puja Srivastava, Ramnath Misra, Able Lawrence, Amita Aggarwal and Vikas Agarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose Recently, idiopathic inflammatory myositis (IIM) has been categorised into distinct subsets based on myositis specific autoantibodies (MSA) and myositis associated autoantibodies (MAA). However, there is…
Abstract Number: 442 • 2014 ACR/ARHP Annual Meeting
Anti-Carbamylated Protein Antibody Levels Are Elevated in Seropositive Rheumatoid Arthritis and Correlate with Anti-Sa/Citrullinated Vimentin Antibody Levels
Gregory J. Challener¹, Jonathan D. Jones², B. JoNell Hamilton¹, Gilles Boire³, Artur José de Brum-Fernandes⁴, Pierre Cossette⁵, Patrick Liang³, Ariel Masetto⁶, Nathalie Carrier⁷, Henri A. Ménard⁸ and William F.C. Rigby⁹, ¹Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, ²Rheumatology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, ³Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴Médecine, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Internal Medicine Departement, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Rheumatology, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁷Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸Rheumatology, Research Institute of the McGill University Health Center, Montreal, QC, Canada, ⁹Rheumatology; Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH
Background/Purpose: Recent studies indicate that the breach of immune tolerance that occurs in rheumatoid arthritis (RA) extends beyond the citrullination of arginines (as recognized by…
Abstract Number: 2457 • 2014 ACR/ARHP Annual Meeting
Anti-Major Histocompatibility Complex Class I-Related Chain a (MICA) Antibodies in Rheumatoid Arthritis Patients with Interstitial Lung Disease
Hiroshi Furukawa¹, Shomi Oka¹, Kota Shimada², Akiko Komiya¹, Naoshi Fukui¹, Naoyuki Tsuchiya³ and Shigeto Tohma¹, ¹Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ²Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ³Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Interstitial lung disease (ILD) is frequently associated with rheumatoid arthritis (RA), and is designated RA-associated ILD (RA-ILD) that influences the prognosis of the disease.…

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