Abstracts tagged "autoantibodies"

Abstract Number: 447 • 2015 ACR/ARHP Annual Meeting
Components of Treatment Delay in Rheumatoid Arthritis Differ According to Autoantibody Status
Arthur G Pratt¹, Ben Hargreaves², Dennis W Lendrem², Osman Aslam² and John D Isaacs², ¹Institute of Cellular Medicine (Musculoskeletal Research Group), National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ²Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom
Background/Purpose: Despite a proliferation of early arthritis (EA) clinics intended to expedite the diagnosis of rheumatoid arthritis (RA), patients continue to experience substantial and multifactorial…
Abstract Number: 1121 • 2015 ACR/ARHP Annual Meeting
Breach of B Cell Anergy in New Zealand Black Congenic Mice
Kieran Manion^1,2, Yuriy Baglaenko^1,2, Nan-Hua Chang³ and Joan Wither³, ¹Immunology, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ³University Health Network, Toronto, ON, Canada
Background/Purpose: Anti-DNA B cells are a primary cause of pathology in individuals with systemic lupus erythematosus (SLE), producing autoantibodies that deposit in diverse tissues and…
Abstract Number: 2021 • 2015 ACR/ARHP Annual Meeting
Omega-3 Fatty Acids Are Associated with a Lower Prevalence of Autoantibody Positivity in HLA-DR Shared Epitope Positive Subjects Who Are at Increased Risk for Future RA
Ryan W. Gan¹, M. Kristen Demoruelle², Kevin D. Deane³, Michael H. Weisman⁴, Jane H. Buckner⁵, Peter K. Gregersen⁶, Ted R. Mikuls⁷, James R. O'Dell⁷, Richard M. Keating⁸, Tasha Fingerlin⁹, Gary O. Zerbe¹⁰, Michael J. Clare-Salzler¹¹, V. Michael Holers¹² and Jill M. Norris¹³, ¹Colorado School of Public Health, University of Colorado Denver, Aurora, CO, ²Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Division of Rheumatology, U Colo Denver, Aurora, CO, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁶Feinstein Insititute for Medical Research, Manhasset, NY, ⁷University of Nebraska Medical Center, Omaha, NE, ⁸Division of Rheumatology, Scripps Health, La Jolla, CA, ⁹National Jewish Health, Denver, CO, ¹⁰Biostatistics and Informatics, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ¹¹Experimental Pathology, University of Florida, College of Medicine, Gainesville, FL, ¹²Rheumatology Division, Univ of Colorado School of Med, Aurora, CO, ¹³University of Colorado Denver, Aurora, CO
Background/Purpose: Studies of fish intake suggest that omega-3 fatty acids (n-3 FAs) could be protective against the development of RA. Previously, we found n-3 FAs…
Abstract Number: 3115 • 2015 ACR/ARHP Annual Meeting
Autoantibodies of the IgA Type a Link Between the Gut and the Anti-TNF Therapy Response in Rheumatoid Arthritis Patients Analysed in Two Clinical Trials
Zoltan Konthur¹, Ute Nonhof², Melvin Michael Wiemkes³, Jacqueline Detert³, Tanja Braun⁴, Jörg Hollidt², Gerd Burmester⁵ and Karl Skriner⁵, ¹Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, ²Drug Response DX GmbH, Berlin, Germany, ³Department of Rheumatology and Clinical Immunology, Germany, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁵Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: So far no mechanism for non response to biologicals targeting TNFα has been described despite one third of rheumatoid arthritis patients treated are non-responders.…
Abstract Number: 2891 • 2014 ACR/ARHP Annual Meeting
Inflammatory Genes Are Associated with Autoantibodies in Rheumatoid Arthritis-Free Individuals Who Are at-Risk for Future Disease
Ryan W. Gan¹, Kendra A. Young¹, M. Kristen Demoruelle², Michael H. Weisman³, Jane H. Buckner⁴, P. K. Gregersen⁵, Ted R. Mikuls⁶, James R. O'Dell⁶, Richard M. Keating⁷, Elizabeth W. Karlson⁸, Kevin D. Deane², V. Michael Holers⁹ and Jill M. Norris¹, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁵Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY, ⁶Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁷Division of Rheumatology, Scripps Clinic, La Jolla, CA, ⁸Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁹Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: We previously found that presence of rheumatoid arthritis(RA)-related autoantibodies is associated with systemic inflammation, and that decreased consumption of anti-inflammatory omega-3 fatty acids (n-3…
Abstract Number: 1644 • 2014 ACR/ARHP Annual Meeting
Mycophenolic Acid and Ribavirin Induces Cytoplasmic Autoimmunogenic Rods and Rings Structures in Vivo
Gerson D Keppeke Sr.¹, Eunice Nunes², Maria Lucia Ferraz³, Sandro F. Perazzio¹, Mônica Prado¹, Edward K.L. Chan⁴ and Luis Eduardo C. Andrade⁵, ¹Rheumatology, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Gastroenterology Division, Universidade Federal de São Paulo, Sao Paulo, Brazil, ³Gastroenterology Division, Universidade Federal de São Paulo, São Paulo, Brazil, ⁴Oral Biology, University of Florida, Gainesville, FL, ⁵Fleury Laboratories, Sao Paulo, Brazil
Background/Purpose Autoantibodies to IMPDH2 occur in Hepatitis C patients receiving ribavirin (RBV) & interferon-α (IFN-α). Anti-IMPDH2 antibodies recognize “rods and rings” (RR) cytoplasmic structures in…
Abstract Number: 861 • 2014 ACR/ARHP Annual Meeting
Ultraviolet B Generates Type 1 Interferon and Induces Autoantibody-Mediated Disease in a Mouse Model of Cutaneous Lupus
Clayton Sontheimer¹ and Keith B. Elkon², ¹Pediatric Rheumatology, University of Washington, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose Photosensitivity is a common symptom in patients with systemic lupus erythematosus (SLE) and lupus skin lesions often contain plasmacytoid dendritic cells (pDC). The mechanisms…
Abstract Number: 2872 • 2014 ACR/ARHP Annual Meeting
B-Cell Autoepitope and Tetramer Analysis Reveals Expansion of Apoptotic Autoantigen La and snRNP Reactive B Cells in BXD2 Mice
Jennie Hamilton¹, Jun Li², Qi Wu³, PingAr Yang³, Bao Luo³, Hao Li⁴, Troy Randall⁵, John Edwin Bradley⁵, Justin J. Taylor⁶, John D. Mountz^7,8 and Hui-Chen Hsu^3,4, ¹University of Alabama at Birmingham, Birmingham, AL, ²Med - Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, ⁷Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL, ⁸Birmingham VA Medical Center, Birmingham, AL
Background/Purpose Systemic lupus erythematous (SLE) is characterized by production of highly pathogenic IgG autoantibodies (autoAbs). While serum autoAb profiling is standard, it remains challenging to…
Abstract Number: 1606 • 2014 ACR/ARHP Annual Meeting
Profiling a Broad Range of Autoantibodies in Healthy and Systemic Lupus Erythematosis Revealed Autoantibody Patterns Associated with Autoantibody Transition and Disease Activity
Quan-Zhen Li Li¹, Edward Wakeland², Prithvi Raj³, Honglin Zhu², Xiaoxia Zuo⁴, Mei Yan⁵ and Indu Raman⁶, ¹Immunology and internal medicine, University of Texas Southwestern Medical Center, Dallas, TX, ²Immunology, University of Texas Southwestern Medical Center, Dallas, TX, ³Immunology, University of Texas Southwestern Medical Center, dallas, TX, ⁴Rheumatology, Xiangya Hospital of Hunan Medical Univ, Changsha, China, ⁵Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, ⁶Department of Immunology and Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Autoantibodies targeting to nuclear antigens are serological hallmarks of SLE, however, the processing of autoantibody production during the transition from normal to autoimmunity and…
Abstract Number: 780 • 2014 ACR/ARHP Annual Meeting
Novel Roles for Zyxin in the Pathogenesis of Giant Cell Arteritis
Rie Karasawa¹, Paul A. Monach², Mayumi Tamaki¹, Takahiro Okazaki³, Masamichi Oh-Ishi⁴, Yoshio Kodera⁴, Toshiko Sato¹, Shoichi Ozaki⁵, Kaiyu Jiang⁶, Kazuo Yudoh¹, James N. Jarvis⁷ and Peter A. Merkel⁸, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ²Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, ³Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁴School of Science, Kitasato University, Sagamihara, Japan, ⁵Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁶415 Carmen Road, Apt. 1, The University at Buffalo, Buffalo, NY, ⁷Pediatrics, The University at Buffalo, Buffalo, NY, ⁸Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose �:The mechanisms of the blood vessel injury in giant cell arteritis (GCA), a systemic vasculitis characterized by inflammation of large- and medium-sized vessels, remain…
Abstract Number: 2874 • 2014 ACR/ARHP Annual Meeting
Pro-Inflammatory FcRL4+ Memory B Cells in Joints of RA Patients: Immunoglobulin Gene Characteristics and Antigen Specificity
Khaled Amara¹, Lorraine Yeo², Natalie Sippl¹, Philip Titcombe¹, Andrew Filer³, Karim Raza³, Dagmar Scheel-Toellner² and Vivianne Malmström⁴, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, SE-17176 Solna, Stockholm, Sweden., Stockholm, Sweden, ²Rheumatology Research Group, Centre for Translational Inflammation Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK, Birmingham, United Kingdom, ³Rheumatology Research Group, MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, ⁴Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Our recent findings identified a subset of pro-inflammatory memory B cells in the RA synovium characterized by the expression of the surface protein…
Abstract Number: 1328 • 2014 ACR/ARHP Annual Meeting
Modulation of Natural IgM-Autoantibodies to Oxidative Stress-Related Neo-Epitopes on Apoptotic Cells in Newborns of Mothers with Anti-Ro Autoimmunity
Caroline Grönwall¹, Robert M. Clancy², Lelise Getu³, Don L. Siegel⁴, Joanne Reed³, Jill P. Buyon² and Gregg J. Silverman¹, ¹Medicine, New York University School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³New York University School of Medicine, New York, NY, ⁴Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose At birth, the human immune system expresses substantial circulating levels of polymeric IgM that include autoantibodies to oxidation-associated epitopes on apoptotic cells. This study…
Abstract Number: 773 • 2014 ACR/ARHP Annual Meeting
Functional Autoantibodies from Patients with Systemic Sclerosis Reactive to Angiotensin II Type 1and Endothelin-1 Type a Receptor Induce Inflammatory Lymphocyte Infiltration into Lungs of Mice
Angela Kill¹, Clement Braesch¹, Anja Kühl², Jeannine Guenther³, Mike O. Becker⁴, Gerd Burmester⁵, Thomas Walther⁶ and Gabriela Riemekasten⁷, ¹Rheumatology and clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, ²Department of Internal Medicine, Charité University Hospital, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, ⁴Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, ⁵Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁶Pharmacology & Therapeutics, University College Cork, Cork, Ireland, ⁷Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany
Background/Purpose Functional autoantibodies reactive to the angiotensin II type 1 receptor (AT1R) and endothelin 1 type A receptor (ETAR) were found in elevated levels in…
Abstract Number: 2700 • 2014 ACR/ARHP Annual Meeting
Clinical Phenotype of Systemic Sclerosis Patients with Anti-RNA Polymerase III Antibodies: A New French Cohort, Systematic Review and Meta-Analysis
Vincent Sobanski^1,2, Luc Dauchet^3,4, Guillaume Lefèvre², Marc Lambert⁵, Sandrine Morell-Dubois⁶, Thierno Sy⁶, Eric Hachulla¹, Pierre-Yves Hatron⁷, Sylvain Dubucquoi^8,9 and David Launay^1,9, ¹Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, ²EA 2686, Lille, LILLE, France, ³Service d'Epidémiologie Régionale, CHRU Lille, LILLE, France, ⁴INSERM U744, LILLE, France, ⁵Faculté de Médecine Henri Warembourg, Université Lille Nord de France, Lille, France, ⁶Internal Medicine, CHRU Lille, LILLE, France, ⁷Internal Medicine, Lille, France, ⁸Institut d’Immunologie, Centre de Biologie-Pathologie-Génétique, CHRU Lille, Lille, France, ⁹EA 2686, Lille, Lille, France
Background/Purpose: Anti-RNA polymerase III antibodies (anti-RNAP III) are one of the most frequent antinuclear antibodies identified in systemic sclerosis (SSc), with an estimated prevalence of…
Abstract Number: 1317 • 2014 ACR/ARHP Annual Meeting
Anti-p155/140 Autoantibodies and Selected Features at Illness Onset Are Associated with a Chronic Course of Illness in the Juvenile Idiopathic Inflammatory Myopathies
G. Esther A. Habers¹, Adam M. Huber², Gulnara Mamyrova³, Ira Targoff⁴, Chantal Boonacker⁵, Marco van Brussel¹, Frederick W. Miller⁶, Lisa G. Rider⁶ and Annet van Royen-Kerkhof⁷, ¹Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands, ²IWK Health Centre, Halifax, NS, Canada, ³Rheumatology, George Washington University, Washington, DC, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁷Paediatric Immunology and Rheumatology, University Medical Centre Utrecht - Wilhelmina Children's Hospital, Utrecht, Netherlands
Background/Purpose : Three types of disease courses can be distinguished in patients with juvenile idiopathic inflammatory myopathies (JIIM), namely monocyclic (M), polycyclic (P), and chronic…

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