ACR Meeting Abstracts

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Abstracts tagged "autoantibodies"

  • Abstract Number: 209 • 2015 ACR/ARHP Annual Meeting

    Different Autoimmune Rheumatic Diease IgG Have Differential Effects upon Neutrophil Binding, Activation and Neutrophil Extracellular Trap Formation

    Akif A. Khawaja1,2, Charis Pericleous3, Vera M. Ripoll2, Joanna C. Porter4 and Ian Giles5, 1Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 2Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 3Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 4Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 5Rayne Intitiute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom

    Background/Purpose: Dysregulation of neutrophil activation and function is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs). Neutrophil dysfunction is well recognised…
  • Abstract Number: 1111 • 2015 ACR/ARHP Annual Meeting

    Relapse of Lupus after B-Cell Depletion Therapy Is Associated with Loss of Apoptotic Cell Clearance and Elevated Type I Interferon Responses in Lupus Prone BXD2

    Hui-Chen Hsu1,2, Zhaoqi Yan3, PingAr Yang2, Qi Wu1,2, Jennie Hamilton4, Jun Li5, Hao Li6, Bao Luo6, Laurie Harrington3 and John Mountz7, 1Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Cell, Developmntl & Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, 4University of Alabama at Birmingham, Birmingham, AL, 5Medicine, University of Alabama at Birmingham, Birmingham, AL, 6Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 7Dept of Med/Rheumatology Div, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL

    Background/Purpose: B-cell depletion therapy (BCDT) is a promising therapy for autoimmune diseases but relapse can occur.  In rheumatoid arthritis, patients who did not respond well…
  • Abstract Number: 1870 • 2015 ACR/ARHP Annual Meeting

    A Lupus-Associated Variant in Purine Nucleoside Phosphorylase (PNP) Causes Cell Cycle Abnormalities

    Yogita Ghodke-Puranik1, Jessica M. Dorschner1, Danielle Vsetecka1, Shreyasee Amin2, Ashima Makol3, Floranne C. Ernste2, Thomas Osborn2, Kevin Moder2, Vaidehi Chowdhary4, Mark A. Jensen5 and Timothy B. Niewold1, 1Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 2Division of Rheumatology, Mayo Clinic, Rochester, MN, 3Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, 4Rheumatology, Mayo Clinic, Rochester, MN, 5Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN

    Background/Purpose:  Systemic lupus erythematosus (SLE) is a multi-system, autoimmune disease characterized by autoantibodies to nucleic acids and nucleosomal proteins. The type I interferon pathway is…
  • Abstract Number: 2785 • 2015 ACR/ARHP Annual Meeting

    Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome

    Yoshiyuki Arinuma1,2, Yuko Sakuma3, Eisuke Ogawa2, Tatsuhiko Wada4, Tatsuo Nagai2, Sumiaki Tanaka2 and Shunsei Hirohata2, 1Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, 2Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 3Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 4Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan

    Background/Purpose: Sjögren syndrome (SjS) is one of the autoimmune disease characterized by the production of autoantibodies. Patients with SjS frequently observe psychiatric manifestation such as…
  • Abstract Number: 3000 • 2014 ACR/ARHP Annual Meeting

    Comparison of Systemic Sclerosis Subsets As Predictors of Mortality and Morbidity

    Hebah Alhajeri1, Marie Hudson2,3, Canadian Scleroderma Research Group CSRG4 and Murray Baron5, 1Rheumatology, McGill University, Montreal, QC, Canada, 2Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, 3Division of Rheumatology, McGill University, Montreal, QC, Canada, 4McGill University, Montreal, QC, Canada, 5Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada

    Background/Purpose: Identifying systemic sclerosis (SSc) subsets that predict mortality and morbidity could provide useful prognostic information. We undertook this study to compare the predictive ability…
  • Abstract Number: 1730 • 2014 ACR/ARHP Annual Meeting

    Identification of Novel Scleroderma –associated Antigens and Development of an Autoantibody Assay Panel Enabling Their Subsequent Validation

    Hans-Dieter Zucht1, Petra Budde1, Peter Schulz-Knappe1, Nicolas Hunzelmann2, Karsten Conrad3 and Prof. Dr. Matthias Schneider4, 1Protagen AG, Dortmund, Germany, 2Department of Dermatology, University of Cologne, Cologne, Germany, 3Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, 4Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany

    Background/Purpose: Scleroderma (systemic sclerosis or SSc) has a highly variable clinical presentation and course resulting in difficulties for disease management. When SSc is suspected, autoantibodies…
  • Abstract Number: 984 • 2014 ACR/ARHP Annual Meeting

    Apolipoprotein B Is a Target of T and B Cell Responses in a Subgroup of Patients with Lyme Disease

    Jameson T. Crowley1, Elise E. Drouin2, Qi Wang3, Gail McHugh4, Catherine E. Costello3 and Allen C. Steere5, 1Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, 4Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, 5Medicine, Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose Borrelia burgdorferi-induced autoimmunity in affected joints has been hypothesized to be a contributing factor to antibiotic-refractory Lyme arthritis (ARLA).  Our prior study, which combined…
  • Abstract Number: 2985 • 2014 ACR/ARHP Annual Meeting

    Autoantibodies to 14-3-3η Are Novel Biomarkers Associated with Inflammation and  Radiographic Progression in Ankylosing Spondylitis

    Walter P. Maksymowych1, Stephanie Wichuk1, RG Lambert2, Mairead Murphy3 and Anthony Marotta4, 1Medicine, University of Alberta, Edmonton, AB, Canada, 2Radiology, University of Alberta, Edmonton, AB, Canada, 3Augurex Life Sciences Corp., North Vancouver, BC, Canada, 41423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada

    Background/Purpose 14-3-3η is a ubiquitous intracellular chaperone protein that is expressed extracellularly in rheumatoid arthritis and mediates inflammatory cascades that result in expression of inflammatory…
  • Abstract Number: 1708 • 2014 ACR/ARHP Annual Meeting

    The Pathogenic Role of Immune Complexes Containing Scleroderma-Specific Autoantibodies in the Inductor Phase of the Disease

    Cecilia B. Chighizola1, Elena Raschi2, Laura Cesana2, Silvana Zeni3, Maria Orietta Borghi4 and Pier Luigi Meroni5,6, 1Rheumatology, Istituto Auxologico Italiano, University of Milan, Cusano Milanino, Italy, 2Istituto Auxologico Italiano, Milan, Italy, 3Division of Rheumatology, Istituto G. Pini, Milano, Italy, 4Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, 5Department of Clinical Sciences and Community Health, Division of Rheumatology, Istituto G. Pini, Milan, Italy, 6Chair and Division of Rheumatology, Gaetano Pini Institute, University of Milan, Milan, Italy

    Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune condition characterized by excessive tissue fibrosis, microvascular alterations and immune dysfunction with the production of peculiar autoantibodies.…
  • Abstract Number: 982 • 2014 ACR/ARHP Annual Meeting

    Identification of Potential SERUM Autoantibody Biomarkers in Rheumatic Diseases Using a New Generation of Protein Arrays

    Lucia Lourido1, Juan Fernandez-Tajes1, Valentina Calamia1, Carolina Fernandez-Costa1,2, Beatriz Rocha1, Patricia Fernandez-Puente1, Jesus Mateos1, Carlos Fernandez-Lopez1, Natividad Oreiro-Villar1, Manuel Fuentes3, Francisco J. Blanco Garcia1 and Cristina Ruiz-Romero1, 1Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, 2Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A coruña, Spain, 3Centro de Investigación del Cáncer/IBMCC (USAL/CIC), IBSAL, Departamento de Medicina, Unidad de Proteomica Servicio general de Citometría, Universidad de Salamanca, Salamanca, SPAIN., Salamanca, Spain

    Background/Purpose Osteoarthritis (OA) is characterized by the loss of structural components from the extracelullar matrix (ECM) of articular cartilage. The progressive release of proteins from…
  • Abstract Number: 2991 • 2014 ACR/ARHP Annual Meeting

    Anti-Ribosomal P Antibody Is a Key Autoantibody Associated with Complications of NP-SLE with High-Levels of CSF IL-8

    Hidenaga Kawasumi1, Takahisa Gono1, Yasushi Kawaguchi1, Yasuhiro Katsumata1, Hisae Ichida1, Akiko Tochimoto1, Masanori Hanaoka1, Yuko Okamoto1, Sayuri Kataoka1 and Hisashi Yamanaka2, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan

    Background/Purpose: Complications of neuropsychiatric systemic lupus erythematosus (NP-SLE) are associated with the morbidity and mortality of patients with SLE. Although the detailed pathophysiology of NP-SLE…
  • Abstract Number: 1692 • 2014 ACR/ARHP Annual Meeting

    The Additive Value of Nailfold Videocapillaroscopy Patterns to Disease-Specific Autoantibodies in Discrimination of Patients with Systemic Sclerosis at Risk for Severe Organ Involvement

    I.M. Markusse1, J. Meijs2, B. de Boer2, A. a. Schouffoer1, N. Ajmone Marsan3, L. J. M. Kroft4, M. K. Ninaber5, T. W. J. Huizinga2 and J.K. de Vries-Bouwstra6, 1Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Cardiology, Leiden University Medical Center, Leiden, Netherlands, 4Deparment of Radiology, Leiden University Medical Center, Leiden, Netherlands, 5Pulmonology, Leiden University Medical Center, Leiden, Netherlands, 6Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Severe nailfold videocapillaroscopy (NVC) patterns in patients with systemic sclerosis (SSc) are associated with a high risk of organ involvement. SSc-specific autoantibodies seem to…
  • Abstract Number: 914 • 2014 ACR/ARHP Annual Meeting

    A Predictive Model of Disease Outcome in Rituximab-Treated Myositis Patients Using Clinical Features, Autoantibodies, and Serum Biomarkers

    Jeannette Olazagasti1, Cynthia S. Crowson2, Molly S. Hein1, Consuelo Lopez de Padilla1, Rohit Aggarwal3, Chester V. Oddis4 and Ann M. Reed1, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic, Rochester, MN, 3Medicine, University of Pittsburgh, Pittsburgh, PA, 4Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Develop predictive models of early (8 week) and late (24 week) disease outcomes using clinical features, autoantibodies, and serum biomarkers in patients with refractory…
  • Abstract Number: 2908 • 2014 ACR/ARHP Annual Meeting

    Flip Deficiency in Dendritic Cells Promotes Spontaneous Arthritis Mediated By Reduced Treg and Increased Autoreactive CD4+t Cells

    Qiquan Huang1, Harris R. Perlman2, Robert Birkett3, Renee E. Doyle4, Deyu Fang5, G Kenneth.Haines6, William H. Robinson7, Syamal K. Datta8, Hyewon Phee9 and Richard M. Pope10, 1Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University Feinberg School of Medicine, Chicago, IL, 3Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, 6Mount Sinai Hospital School of Medicine, New York, New York, NY, 7VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 8Rheumatology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, 9Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 10Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL

    Background/Purpose Flip (CFLAR) has been identified as a rheumatoid arthritis (RA) risk allele and is important in preventing death receptor mediated apoptosis of dendritic cells…
  • Abstract Number: 1645 • 2014 ACR/ARHP Annual Meeting

    Interferon Gene Signature Expression and Serological Differences in Japanese and Non-Japanese SLE Patients

    Hitoshi Kohsaka1, Kosuke Kotani2, Tomonori Ishii3, Tomoya Miyamura4, Masato Okada5, Toshihiko Aranishi2, R. Maciuca6, William P. Kennedy6 and Junko Ohata2, 1Department of Rheumatology, Graduate School of Medical and Dental Sciences,, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 2Chugai Pharmaceutical co., ltd, Tokyo, Japan, 3Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, 4Department of Internal Medicine and Rheumatology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan, 5Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 6Genentech, Inc, South San Francisco, CA

    Background/Purpose: Elevated expression of interferon(IFN)-regulated genes in peripheral blood cells has been reported in systemic lupus erythematosus (SLE) patients and is known as the IFN…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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