Abstracts tagged "autoantibodies"

Abstract Number: 1779 • 2015 ACR/ARHP Annual Meeting
Characterization of Anti-Nuclear Antibody (ANA) Signatures in Murine Models of Lupus Using Genalyte Maverick Technology
Jacqueline Loud¹, Stuart Perper², Rachel Twomey² and Stephen Clarke², ¹Immunology Pharmacology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ²Immunology Pharmacology, Abbvie Bioresearch Center Inc., Worcester, MA
Background/Purpose: Systemic lupus erythematosus (SLE) and lupus nephritis (LN) are autoimmune diseases characterized by circulating antibodies to nuclear self-antigens, including reactivities to double-stranded DNA, RNP…
Abstract Number: 2570 • 2015 ACR/ARHP Annual Meeting
Comparative Analysis of Collagen-Antibody Induced Arthritis and the Arthritis Inhibitory Potential of Specific ACPA in Two Mouse Subspecies Genetically Separated about One Million Years Ago
Christina Grimm¹, Bianka Marklein¹, Zoltan Konthur², Gerd Burmester¹ and Karl Skriner¹, ¹Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
Background/Purpose: Rheumatoid arthritis (RA) is believed to be induced by environmental, genetic and immunological factors. Monoclonal Anti-citrullinated protein/peptide autoantibodies (ACPA) target different citrullinated proteins years…
Abstract Number: 947 • 2015 ACR/ARHP Annual Meeting
Cohesin Complex Is a New Myositis Autoantigen
Shin Tanaka¹, S. John Calise², Yurie Satoh³, Yoshiya Tanaka⁴, Monica Vazquez-Del Mercado⁵, Gabriel Medrano-Ramírez⁶, Eric S. Sobel⁷, Westley H. Reeves⁸, Edward K.L. Chan⁹ and Minoru Satoh¹⁰, ¹Human, Information and Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²Department of Oral Biology, University of Florida, Miami, FL, ³First Department of Internal Medicine, University of Occupational and Environmental Health, KItakyushu, Japan, ⁴The First Dept. of Internal Medicine, University of Occupational & Environmental Health, Kitakyusyu, Japan, ⁵Servicio de Reumatología, División de Medicina Interna, Hospital Civil Dr. Juan I. Menchaca, Guadalajara, Mexico, ⁶Rheumatology, Hospital General de Mexico, Secretaria de Salud, Mexico City, Mexico, ⁷Medicine/Div of Rheumatology, University of Florida, Gainesville, FL, ⁸Medicine, University of Florida, Gainesville, FL, ⁹Dept of Oral Biology, University of Florida, Gainesville, FL, ¹⁰Department of Clinical Nursing, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: Each myositis specific autoantibodies (MSA) are associated with unique clinical subset and useful biomarkers in polymyositis/dermatomyositis (PM/DM). Identifying new MSA will help in monitoring…
Abstract Number: 1851 • 2015 ACR/ARHP Annual Meeting
Antibody Against Ribonuclease-H Is a Novel Autoantibody Specifically Recognized in Systemic Lupus Erhythematosus
Kazuhisa Nozawa¹, Kentaro Doe², Kaori Hiruma³, Yusuke Yamada⁴ and Yoshinari Takasaki⁵, ¹2-1-1 Hongo Bunkyo-ku, Juntendo University, Tokyo, Japan, ²2-1-1 Hongo, Bunkyo-Ku, Juntendo University School of Medicine, Tokyo, Japan, ³Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁵Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Proliferating cell nuclear antigen (PCNA) is known to be an autoantigen specifically recognized in patients with SLE. PCNA constitutes PCNA-complex along with several PCNA-binding…
Abstract Number: 2592 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patients with Many Autoantibodies Have Different Characteristics at Presentation Compared to Patients with Few Autoantibodies
Veerle F.A.M. Derksen¹, Sofia Ajeganova², Annette H.M. van der Helm- van Mil¹, Ingiäld Hafström³, T. W. J. Huizinga¹, René E. M. Toes¹, Leendert A. Trouw¹, Björn Svensson⁴ and Diane van der Woude¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology unit, Department of Medicine,, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden, ³Unit of Rheumatology, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden, ⁴Section of Rheumatology, Institution of Clinical Science, Lund University, Lund, Sweden
Background/Purpose: Patients with rheumatoid arthritis (RA) are frequently positive for one or several autoantibodies like rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein…
Abstract Number: 966 • 2015 ACR/ARHP Annual Meeting
In Rheumatoid Arthritis, Smoking Is Not Associated with Anti-Citrullinated Protein Antibodies per Se, but with the Concurrent Presence of Rheumatoid Factor, Anti-Citrullinated Protein Antibodies and Anti-Carbamylated Protein Antibodies
Tineke van Wesemael¹, Ammar Muhammad¹, Sofia ajeganova^2,3, Jennifer Humphreys⁴, Deborah P.M. Symmons^5,6, Alex J Macgregor⁷, Ingiäld Hafström², Leendert Trouw¹, T. W. J. Huizinga¹, Björn Svensson⁸, René E. M. Toes¹, Suzanne M. Verstappen⁹ and Diane van der Woude¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Department of Medicine Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden, ³Rheumatology, Leiden University Medical Center, LEIDEN, Netherlands, ⁴Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit,, Manchester, United Kingdom, ⁵Centre for Musculoskeletal Research, University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ⁶NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ⁷Rheumatology, Norfolk and Norwich University Hospital, Norwich, United Kingdom, ⁸Section of Rheumatology, Department of Clinical Sciences,, University of Lund, Lund, Sweden, ⁹Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
Background/Purpose : In rheumatoid arthritis (RA) a biological hypothesis has been proposed linking smoking with citrullination, the development of anti-citrulline autoimmunity and anti-citrullinated protein antibodies…
Abstract Number: 1859 • 2015 ACR/ARHP Annual Meeting
Anti-Interferon Autoantibodies in Systemic Lupus Erythematosus Are Biologically Active and Have Distinct Functions
Sarthak Gupta^1,2, Ioanna P. Tatouli³, Lindsey B. Rosen¹, Sarfaraz Hasni², Illias Alevizos⁴, Zerai G. Manna², Juan Rivera², Chao Jiang^2,5, Richard M. Siegel⁶, Steven M. Holland¹, Haralampos M. Moutsopoulos³ and Sarah K. Browne^1,7, ¹Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece, ⁴National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ⁵National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD, ⁶NIAMS, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, ⁷Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD
Background/Purpose: Anticytokine autoantibodies are pathogenic in many hematologic, pulmonary and infectious diseases. However, a systematic investigation of their presence and significance in autoimmune diseases is…
Abstract Number: 2602 • 2015 ACR/ARHP Annual Meeting
CCP Antibody Negativity Is Associated with Higher Fatigue in Rheumatoid Arthritis
Laura Cappelli¹, Susan J. Bartlett^2,3, Michelle Jones⁴ and Clifton Bingham⁴, ¹Ste 4500, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, ³Medicine , Divisions of Clinical Epidemiology, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, ⁴Johns Hopkins University, Baltimore, MD
Background/Purpose: Fatigue in rheumatoid arthritis (RA) is common and highly debilitating. Emerging evidence suggests that seronegative RA patients differ from their seropositive peers in…
Abstract Number: 1016 • 2015 ACR/ARHP Annual Meeting
Collagen Antibodies Induce Pain-like Behavior in Mice Independent of Inflammation and Complement Activation but Requires FcÎ³rs
Gustaf Wigerblad¹, Katalin Sandor¹, Kutty Selva Nandakumar², Rikard Holmdahl³ and Camilla Svensson¹, ¹Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, ²Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, ³Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Collagen Antibody Induced Arthritis (CAIA) is an acute mouse model of rheumatoid arthritis (RA). It is induced by an intravenous injection of a cocktail…
Abstract Number: 1860 • 2015 ACR/ARHP Annual Meeting
Autoantibodies Utilizing the Immunoglobulin Heavy Chain Variable Region Gene 4-34 (VH4-34) Exhibit Autoreactivity Towards, and Potential Competition with Galectins within Systemic Lupus Erythematosus (SLE)
Kevin Cashman¹, Asiya Chida² and Ignacio Sanz², ¹Department of Medicine- Division of Rheumatology, Emory University, Atlanta, GA, ²Medicine, Emory University, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the propagation of autoreactive B cell populations leading to the production of pathogenic antibodies…
Abstract Number: 2698 • 2015 ACR/ARHP Annual Meeting
Follicular Helper T Cells in Peripheral Blood of Patients with Rheumatoid Arthritis
Alicia Beatriz Costantino¹, Laura Onetti², Melina del Valle Cloquell³, Cristina del Valle Acosta¹, Eduardo Mussano², Isaac Ignacio Cadile², Cecilia María Rodriguez³, Stefania Santo¹ and Paola Virginia Ferrero¹, ¹Córdoba, Laboratorio de Inmunología. Hospital Nacional de Clínicas. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba, Córdoba, Argentina, ²Córdoba, Servicio de Reumatología. Hospital Nacional de Clínicas. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba, Córdoba, Argentina, ³Córdoba, Laboratorio de Oncohematología, Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
Background/Purpose: RA is an autoimmune, inflammatory and chronic disease which aetiology is unknown. It presents different autoantibodies such as RF and ACPA. A population of…
Abstract Number: 13 • 2015 ACR/ARHP Annual Meeting
Altered Soluble Mediators, Autoantibodies, and Lupus-Specific Connective Tissue Disease Questionnaire Scores Distinguish Blood Relatives with Incomplete Lupus from Unaffected Relatives and Relatives with Classified SLE
Melissa E. Munroe¹, Kendra A. Young², Jill M. Norris³, Teresa Aberle¹, Virginia C. Roberts¹, Joel M. Guthridge¹, Diane L. Kamen⁴, Gary S. Gilkeson⁵, Michael H. Weisman⁶, Mariko L. Ishimori⁶, Daniel J Wallace⁷, David R. Karp⁸, Kathy L. Sivils⁹, John B. Harley¹⁰ and Judith A. James¹¹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Epidemiology, University of Colorado Denver, Aurora, CO, ³University of Colorado Denver, Aurora, CO, ⁴Medicine, Medical University of South Carolina, Charleston, SC, ⁵Department of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, ⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹¹Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Blood relatives (Rel) of lupus patients have increased risk of SLE. Some have autoantibodies and SLE clinical features, but do not meet ≥ 4…
Abstract Number: 1101 • 2015 ACR/ARHP Annual Meeting
Matrix Metalloproteinase-10 (Stromelysin 2) Is a Target of Robust Autoimmune T and B Cell Responses in Antibiotic-Refractory Lyme Arthritis, but Not in Rheumatoid Arthritis
Jameson T. Crowley¹, Elise E. Drouin², Annalisa Pianta¹, Klemen Strle¹, Qi Wang³, Catherine E. Costello³ and Allen C. Steere⁴, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, ⁴Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Infection-induced autoimmunity has been hypothesized to have a pathogenic role in antibiotic-refractory Lyme arthritis (LA). We previously identified 3 autoantigens, endothelial cell growth factor,…
Abstract Number: 1862 • 2015 ACR/ARHP Annual Meeting
Identification of Homogeneous Systemic Lupus Erythematosus (SLE) Patient Groups Using Clustered Autoantibody Reactivities
Petra Budde¹, Hans-Dieter Zucht¹, Daniel Chamrad¹, Anna Telaar¹, Johannes Schulte-Pelkum¹, Stefan Vordenbäumen², Peter Schulz-Knappe¹ and Matthias Schneider³, ¹Protagen AG, Dortmund, Germany, ²Department of Rheumatology, Univ. Duesseldorf, Düsseldorf, Germany, ³Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany
Background/Purpose: In SLE, early diagnosis, differentiation to other autoimmune diseases and prognostic stratification are still great challenges. Hence, SLE represents an enormous challenge for the…
Abstract Number: 2713 • 2015 ACR/ARHP Annual Meeting
A Novel Paradigm in the Clinical Context of Rheumatoid Arthritis: Role of Tfh and Th17 Cells in Autoimmunity
Magdalena Budziakowska¹, Arif Shahzad¹, Jerry Pounds¹, Shikha Singla¹, Jerald M. Zakem^1,2, Kismet Collins¹, Tamika Webb-Detiege¹, William E. Davis^1,2, Zongbing You³, Robert Quinet^1,2 and Xin Zhang⁴, ¹Rheumatology, Ochsner Medical Center, New Orleans, LA, ²University of Queensland School of Medicine, Brisbane, Australia, ³Tulane University Health Science Center, New Orleans, LA, ⁴Laboratory of Cellular Immunology, Institution of Translational Research, Ochsner Medical Center, New Orleans, LA
Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovium, which causes progressive joint destruction and reduction in quality of life…

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