ACR Meeting Abstracts

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Abstracts tagged "autoantibodies"

  • Abstract Number: 2713 • 2015 ACR/ARHP Annual Meeting

    A Novel Paradigm in the Clinical Context of Rheumatoid Arthritis: Role of Tfh and Th17 Cells in Autoimmunity

    Magdalena Budziakowska1, Arif Shahzad1, Jerry Pounds1, Shikha Singla1, Jerald M. Zakem1,2, Kismet Collins1, Tamika Webb-Detiege1, William E. Davis1,2, Zongbing You3, Robert Quinet1,2 and Xin Zhang4, 1Rheumatology, Ochsner Medical Center, New Orleans, LA, 2University of Queensland School of Medicine, Brisbane, Australia, 3Tulane University Health Science Center, New Orleans, LA, 4Laboratory of Cellular Immunology, Institution of Translational Research, Ochsner Medical Center, New Orleans, LA

    Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovium, which causes progressive joint destruction and reduction in quality of life…
  • Abstract Number: 209 • 2015 ACR/ARHP Annual Meeting

    Different Autoimmune Rheumatic Diease IgG Have Differential Effects upon Neutrophil Binding, Activation and Neutrophil Extracellular Trap Formation

    Akif A. Khawaja1,2, Charis Pericleous3, Vera M. Ripoll2, Joanna C. Porter4 and Ian Giles5, 1Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 2Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 3Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 4Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 5Rayne Intitiute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom

    Background/Purpose: Dysregulation of neutrophil activation and function is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs). Neutrophil dysfunction is well recognised…
  • Abstract Number: 1111 • 2015 ACR/ARHP Annual Meeting

    Relapse of Lupus after B-Cell Depletion Therapy Is Associated with Loss of Apoptotic Cell Clearance and Elevated Type I Interferon Responses in Lupus Prone BXD2

    Hui-Chen Hsu1,2, Zhaoqi Yan3, PingAr Yang2, Qi Wu1,2, Jennie Hamilton4, Jun Li5, Hao Li6, Bao Luo6, Laurie Harrington3 and John Mountz7, 1Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Cell, Developmntl & Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, 4University of Alabama at Birmingham, Birmingham, AL, 5Medicine, University of Alabama at Birmingham, Birmingham, AL, 6Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 7Dept of Med/Rheumatology Div, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL

    Background/Purpose: B-cell depletion therapy (BCDT) is a promising therapy for autoimmune diseases but relapse can occur.  In rheumatoid arthritis, patients who did not respond well…
  • Abstract Number: 1870 • 2015 ACR/ARHP Annual Meeting

    A Lupus-Associated Variant in Purine Nucleoside Phosphorylase (PNP) Causes Cell Cycle Abnormalities

    Yogita Ghodke-Puranik1, Jessica M. Dorschner1, Danielle Vsetecka1, Shreyasee Amin2, Ashima Makol3, Floranne C. Ernste2, Thomas Osborn2, Kevin Moder2, Vaidehi Chowdhary4, Mark A. Jensen5 and Timothy B. Niewold1, 1Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 2Division of Rheumatology, Mayo Clinic, Rochester, MN, 3Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, 4Rheumatology, Mayo Clinic, Rochester, MN, 5Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN

    Background/Purpose:  Systemic lupus erythematosus (SLE) is a multi-system, autoimmune disease characterized by autoantibodies to nucleic acids and nucleosomal proteins. The type I interferon pathway is…
  • Abstract Number: 2785 • 2015 ACR/ARHP Annual Meeting

    Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome

    Yoshiyuki Arinuma1,2, Yuko Sakuma3, Eisuke Ogawa2, Tatsuhiko Wada4, Tatsuo Nagai2, Sumiaki Tanaka2 and Shunsei Hirohata2, 1Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, 2Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 3Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 4Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan

    Background/Purpose: Sjögren syndrome (SjS) is one of the autoimmune disease characterized by the production of autoantibodies. Patients with SjS frequently observe psychiatric manifestation such as…
  • Abstract Number: 285 • 2015 ACR/ARHP Annual Meeting

    Tobacco Smoking in Different Racial Groups Is Differentially Associated with the Development of Myositis Autoantibodies and Interstitial Lung Disease in the Idiopathic Inflammatory Myopathies

    Adam Schiffenbauer1, Natalie Smith2, Lisa G Rider1 and Frederick W. Miller3, 1Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 2Statistics, Purdue University, Allison Park, PA, 3Clinical Research Branch / Environmental Autoimmunity Group, NIH, Bethesda, MD

    Background/Purpose: Smoking has been found to be a risk or protective factor in certain autoimmune diseases. Yet, its role in the idiopathic inflammatory myopathies (IIM)…
  • Abstract Number: 1114 • 2015 ACR/ARHP Annual Meeting

    Profiling Circulating Plasmablasts from Anti-Ro Positive Mothers of Children with Congenital Heart Block to Identify Antigenic Targets Conferring Pathogenicity

    Sarah Kongpachith1, WH Robinson1, Sara Rasmussen2, Robert Clancy3 and Jill P. Buyon3, 1Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 2Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 3Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY

    Background/Purpose: Neonatal lupus (NL) is an uncommon autoimmune disease classically manifest as permanent complete heart block and/or transient cutaneous lesions. By definition of NL, there…
  • Abstract Number: 1885 • 2015 ACR/ARHP Annual Meeting

    Identification and Clinical Correlations of Rare Autoantibodies in Systemic Sclerosis and Poly/Dermatomyositis Patients

    Angela Ceribelli1,2, Natasa Isailovic3, Maria De Santis4, Elena Generali1, Marco Massarotti5, Minoru Satoh6 and Carlo Selmi7,8, 1Internal Medicine- Unit of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Rozzano (MI), Italy, 2BIOMETRA, University of Milan, Milan, Italy, 3Internal Medicine; Unit of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Rozzano (MI), Italy, 4Internal Medicine, Unit of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Rozzano (MI), Italy, 5Internal Medicine- Unit of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Rozzano (Milan), Italy, 6Department of Clinical Nursing, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan, 7Internal Medicine- Unit of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Rozzano, Italy, 8BIOMETRA Department, University of Milan, Milan, Italy

    Background/Purpose: Systemic Sclerosis (SSc), Polymyositis (PM) and Dermatomyositis (DM) are characterized by the presence of serum autoantibodies (autoAbs) which are central in the diagnosis, predicting…
  • Abstract Number: 2947 • 2015 ACR/ARHP Annual Meeting

    Association of Anti-NR2 and U1RNP Antibodies with Neurotoxic Inflammatory Mediators in Cerebrospinal Fluid from Patients with Neuropsychiatric Systemic Lupus Erythematosus

    Seiko Kondo-Ishikawa1, Takao Fujii2, Nozomi Ishigooka1, Kosaku Murakami1, Ran Nakashima1, Yoshitaka Imura1, Motomu Hashimoto2, Naoichiro Yukawa1, Hajime Yoshifuji1, Koichiro Ohmura1 and Tsuneyo Mimori1, 1Department of Rheumatology and Clinical Immunology, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Department of the Control for Rheumatic Diseases, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Background/Purpose: Autoantibodies (auto Abs) in cerebrospinal fluid (CSF) and inflammatory mediators (IMs) may be involved in the pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE). Previous…
  • Abstract Number: 290 • 2015 ACR/ARHP Annual Meeting

    Cancer and Necrotizing Immune Mopathy: High Incidence in Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase Positive and Seronegative Patients but Not in Anti-Single Recognition Particle Positive Patients

    Yves Allenbach1, Jeremy Kaeren1, Nicolas Champtiaux1, Yoland Schoindre1, Kuberaka Mariampillai1, Aude Rigolet1, Lucile Musset2, Jean- Luc Charuel2, Anthony Behin3, Bruno Eymard4, Pascal Laforet5, Tanya Stojkovic5, Olivier Boyer6, Baptiste Hervier7 and Olivier Benveniste1, 1Department de Internal Medicine and Clinical Immunology, Hôpital Pitié-Salpêtrière, AP-PH, UPMC, Paris, France, 2Laboratoire d'immunochimie, Pitié- Salpêtrière, Paris, France, 3Institute of Myology, Pitie-Salpetriere Hospital, Paris, France, 4Department of Neurology, Hôpital Pitié-Salpêtrière, AP-PH, UPMC, Paris, France, 5Department of Neurology, Myology Institute, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, 6Immunology, Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France, 7Department de Internal Medicine and Clinical Immunology, Hôpital Pitié-Salpêtrière, AP-PH, UPMC, Paris, Paris, France

    Background/Purpose: Twenty percent of inflammatory myopathy are associated with a synchronous cancer occurring ±3 years around the diagnosis. Malignancy is a major cause of mortality…
  • Abstract Number: 1115 • 2015 ACR/ARHP Annual Meeting

    B Cell-Intrinsic Interferon Gamma Signals Promote the Development of Systemic Lupus Erythematosus By Enhancing the Formation of Spontaneous Autoimmune Germinal Centers

    Shaun Jackson, Nicole Scharping, Holly Jacobs, Tanvi Arkatkar, Socheath Khim and David Rawlings, Seattle Children's Research Institute, Seattle, WA

    Background/Purpose: Type 1 interferon (IFN) is strongly implicated in lupus pathogenesis, and SLE patients frequently express a “type 1 IFN gene signature”. The type 2…
  • Abstract Number: 1896 • 2015 ACR/ARHP Annual Meeting

    Early Signs, Symptoms and Auto-Antibodies to Predict Diffuse Cutaneous or Limited Cutaneous Systemic Sclerosis at First Presentation

    WMT van den Hombergh1, HKA Knaapen-Hans1, Patricia E. Carreira2,3, FHJ van den Hoogen1, Jaap Fransen1 and MC Vonk1, 1Rheumatology, Radboud University Medical Centre, Nijmegen, Netherlands, 2Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 3Rheumatology Unit, Hospital 12 de Octubre, Hospital 12 de Octubre, Madrid, Spain

    ABSTRACT Background/Purpose: Diffuse cutaneous systemic sclerosis (dcSSc) is associated with a poorer prognosis compared to limited cutaneous SSc (lcSSc), due to earlier and more severe…
  • Abstract Number: 2995 • 2015 ACR/ARHP Annual Meeting

    Genome Wide Analysis in Scleroderma Renal Crisis: Defining Genetic Risk in Patients with RNA Polymerase III Auto-Antibodies

    Maria C Fonseca1, Sandra Guerra1, Edward Stern1,2, Svetlana I. Nihtyanova1, David Abraham3, Aine Burns2, Mark Harber2 and Christopher P. Denton4, 1Rheumatology, UCL Division of Medicine, London, United Kingdom, 2Nephrology, Royal Free Hospital, London, United Kingdom, 3Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, 4Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom

    Background/Purpose: Scleroderma renal crisis (SRC) is a severe complication of systemic sclerosis (SSc). Most SSc cases demonstrate a disease-specific antinuclear antibody including anti-RNA polymerase III…
  • Abstract Number: 398 • 2015 ACR/ARHP Annual Meeting

    Clinical and Serological Profile of Children with Positive SSA-Ro/SSB-La Antibodies

    Juan G. Ovalles-Bonilla1, Juan C. Nieto1, Francisco Javier López Longo1, Julia Martínez-Barrio2, Iustina Janta1, Esperanza Naredo1, Carlos M. Gonzalez1, Michelle Hinojosa1, Natalia Bello1, Belen Serrano1, Carmen Mata1, Claudia Sáenz Tenorio1, Diana C. Hernández1, Lara Valor1, Indalecio Monteagudo1 and Luis Carreño1, 1Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 2Servicio de Reumatologia, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    Background/Purpose: Several studies have shown the relationship between anti-SSA-Ro/SSB-La antibodies and Systemic Lupus Erythematosus (SLE), Sjögren Syndrome (SS) and other autoimmune diseases in adult population.…
  • Abstract Number: 1119 • 2015 ACR/ARHP Annual Meeting

    High Resolution Motif Mapping of in Situ Anti-Native-Vimentin Antibodies in Lupus Tubulointerstitial Nephritis

    Andrew Kinloch1, Yuta Asano2, Balazs Banfai3, Gregor Dernick3, Carole Henry Dunand4, Nirit Mor-Vaknin5, Maureen Legendre5, David Markovitz5, Thomas Schindler6 and Marcus R. Clark7, 1University of Chicago, Chicago, IL, 2Committee of immunology, University of Chicago, Chicago, IL, 3Translational Technologies and Bioinformatics, Roche, Basel, Switzerland, 4Rheumatology and Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, 5University of Michigan, Ann Arbor, MI, 6Roche Innovation Center Basel, Roche, Basel, Switzerland, 7Rheumatology and Knapp Center for Lupus Research, University of Chicago, Chicago, IL

    Background/Purpose: Severe lupus tubulointerstitial nephritis (TIN) is prognostic of renal failure and characterized by an in situ autoantibody response. By characterizing monoclonal antibodies engineered from…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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