Abstracts tagged "Atherosclerosis"

Abstract Number: 1381 • 2013 ACR/ARHP Annual Meeting
The ZC3HC1 rs11556924 Polymorphism Is Associated With Increased Carotid Intima-Media Thickness In Patients With Rheumatoid Arthritis
Raquel lopez Mejias¹, Fernanda Genre², Mercedes García-Bermúdez³, Alfonso Corrales⁴, Carlos González-Juanatey⁵, J. Llorca⁶, Encarnación Amigo⁷, Jose A. Miranda-Filloy⁸, Javier Rueda-Gotor¹, Ricardo Blanco¹, Santos Castañeda⁹, Javier Martin¹⁰ and Miguel A. Gonzalez-Gay¹¹, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain., Santander, Spain, ²Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ³Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁴Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁵Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁶Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁷Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁸Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ⁹Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, ¹⁰Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ¹¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a complex polygenic disease associated with chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. A recent meta-analysis has described…
Abstract Number: 358 • 2013 ACR/ARHP Annual Meeting
Inflammatory Burden Predicts Carotid Plaque Progression and Subsequent Cardiovascular Events In Rheumatoid Arthritis: The 2-Year Prospective Cohort Study
Churl Hyun Im¹, Sang Hoon Kwon², Jeong Soo Eun¹, Na Ri Kim¹, Eon Jeong Nam¹ and Young Mo Kang³, ¹Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, ²Internal medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, ³Department of Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea
Background/Purpose: Rheumatoid arthritis (RA) patients have increased prevalence of carotid atherosclerosis, especially plaque formation, which has been associated with inflammatory burden in a previous study.…
Abstract Number: 1382 • 2013 ACR/ARHP Annual Meeting
The 11q23.3 Genomic Region – rs964184- Is Associated With Cardiovascular Disease In Patients With Rheumatoid Arthritis
Raquel lopez Mejias¹, Fernanda Genre², Mercedes García-Bermúdez³, Santos Castañeda⁴, Carlos González-Juanatey⁵, J. Llorca⁶, Encarnación Amigo⁷, Alfonso Corrales⁸, Jose A. Miranda-Filloy⁹, Javier Rueda-Gotor¹, Carmen Gomez vaquero¹⁰, Luis Rodriguez Rodriguez¹¹, Benjamin Fernandez Gutierrez¹¹, Alejandro Balsa¹², Dora Pascual-Salcedo¹³, Francisco Javier López-Longo¹⁴, Patricia Carreira¹⁵, Ricardo Blanco¹, Isidoro González-Alvaro¹⁶, Javier Martin¹⁷ and Miguel A. Gonzalez-Gay¹⁸, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain., Santander, Spain, ²Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ³Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁴Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, ⁵Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁶Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁷Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁸Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁹Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ¹⁰Department of Rheumatology, Hospital Universitario Bellvitge, Barcelona, Spain, ¹¹Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹²Rheumatology unit, La Paz University Hospital, Rheumatology, Madrid, Spain, ¹³La Paz University Hospital, Rheumatology, Madrid, Spain, ¹⁴Hospital General Universitario Gregorio Marañón, Department of Rheumatology, Madrid, Spain, ¹⁵Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁶Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ¹⁷Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ¹⁸Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and high risk of cardiovascular (CV) disease. A recent meta-analysis has…
Abstract Number: 285 • 2013 ACR/ARHP Annual Meeting
Juvenile Idiopathic Arthritis Patients Demonstrate Alterations In HDL Functionality Without Accelerated Subclinical Atherosclerosis
Preethi Mani¹, Kiyoko Uno², Katherine Wolski³, Steven J. Spalding⁴, Stephen J. Nicholls⁵ and M. Elaine Husni⁶, ¹Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ²Cardiovascular medicine, Cleveland Clinic Foundation, Cleveland, OH, ³Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, ⁴Pediatric Institute, Department of Pediatric Rheumatology, The Cleveland Clinic, Cleveland, OH, ⁵Clinical Research Heart & Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH, ⁶Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Previous literature supports an increase in cardiovascular (CV) morbidity and mortality in adults with inflammatory joint disease, however it is not known whether children with…
Abstract Number: 1277 • 2013 ACR/ARHP Annual Meeting
A Pilot Study Of Young Adults With Juvenile Dermatomyositis With Decreased Nailfold Capillary End Row Loops: Brachial Artery Reactivity and Oxidized Lipids
Lauren M. Pachman^1,2, Maureen A. McMahon³, Tamar Polonsky⁴, Gabrielle A. Morgan¹, Maria Amoruso⁵ and Chiang-Ching Huang⁶, ¹Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, ²Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁴Cardiology, University of Chicago Medicine, Chicago, IL, ⁵Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Cure JM Myositis Center, Chicago, IL, ⁶Zilber School of Public Health, University of Wisconsin at Milwaukee, Milwaukee, WI
Background/Purpose: Our center previously reported increased carotid intima media thickness, and lower high-density lipoprotein (HDL) levels in young or middle-age adults with a history of…
Abstract Number: 1267 • 2013 ACR/ARHP Annual Meeting
Impact Of Disease Duration On Vascular Surrogates Of Early Atherosclerosis In Childhood-Onset Systemic Lupus Erythematosus
Julie Barsalou¹, Timothy J. Bradley², Cameron Slorach², Lawrence W.K. Ng³, Deborah M. Levy⁴ and Earl D. Silverman¹, ¹Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ²Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
Background/Purpose: Cardiovascular disease is a leading cause of morbidity and mortality in adults with systemic lupus erythematosus. Exposure to atherogenic risk factors in childhood-onset SLE…
Abstract Number: 1210 • 2013 ACR/ARHP Annual Meeting
Epicardial Adipose Tissue and Atherosclerosis In Patients With Familial Mediterranean Fever
Adem Kucuk¹, Yalcin Solak², Hakan Akilli³, Oguzhan Yildirim³, Ibrahim Guler⁴, Ramazan Ucar⁵, Alpay Aribas³, Orhan Ozbek⁶, Mehmet Kayrak³ and Recep Tunc¹, ¹Necmettin Erbakan University, Meram Medical Faculty,Division of Rheumatology, Konya, Turkey, ²Karaman State Hospital, Division of Nephrology, Karaman, Turkey, ³Necmettin Erbakan University, Division of Cardiology, Konya, Turkey, ⁴Konya Research and Education Hospital, Division of Radiology, Konya, Turkey, ⁵Konya Education and Research Hospital, Department ofInternal Medicine, Konya, Turkey, ⁶Necmettin Erbakan University, Division of Radiology, Konya, Turkey
Background/Purpose : Familial Mediterranean Fever (FMF) is a chronic autosomal recessive hereditary disease characterized by episodic attacks of fever and inflammation of serosal and synovial…
Abstract Number: 1157 • 2013 ACR/ARHP Annual Meeting
Peptidylarginine Deiminase Inhibition Prevents Neutrophil Extracellular Trap Formation, Modulates Innate Immune Responses, and Reduces Vascular Damage In Mice
Jason S. Knight¹, Wei Luo², Alexander A. O'Dell¹, Wenpu Zhao³, Venkataraman Subramanian⁴, Chiao Guo², Robert C. Grenn³, Paul Ryan Thompson⁴, Daniel T. Eitzman² and Mariana J. Kaplan⁵, ¹Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Cardiology, Ann Arbor, MI, ³University of Michigan Rheumatology, Ann Arbor, MI, ⁴The Scripps Research Institute, Jupiter, FL, ⁵Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Neutrophil extracellular trap (NET) formation promotes vascular damage, while stimulating interferon alpha (IFN-α) production in diseased arteries. Patients with rheumatoid arthritis and systemic…
Abstract Number: 1261 • 2012 ACR/ARHP Annual Meeting
Epicardial Adipose Tissue Is Associated with Cardiometabolic Risk and the Metabolic Syndrome in Patients with Rheumatoid Arthritis
Michelle J. Ormseth¹, Aliza Lipson², Nikolaos Alexopoulos³, Gregory R. Hartlage³, Annette M. Oeser⁴, Aihua Bian⁴, Tebeb Gebretsadik⁵, Ayumi Shintani⁴, Paolo Raggi⁶ and C. Michael Stein⁷, ¹Rheumatology, Vanderbilt Medical Center, Nashville, TN, ²Rheumatology, Emory University, Atlanta, GA, ³Emory University, Atlanta, GA, ⁴Vanderbilt Medical Center, Nashville, TN, ⁵Biostatistics, Vanderbilt University, Nashville, TN, ⁶University of Alberta, Edmonton, AB, Canada, ⁷School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN
Background/Purpose: Patients with rheumatoid arthritis (RA) have increased coronary atherosclerosis and this may be related to their increased prevalence of visceral adiposity, insulin resistance, and…
Abstract Number: 629 • 2012 ACR/ARHP Annual Meeting
Inflammatory Biomarkers of Atherosclerosis and Oxidative Stress Are Associated with Disease Flare in SLE
Maureen A. McMahon¹, Jennifer M. Grossman¹, Brian Skaggs², Elaine Lourenco², Cheryl Lee¹, Lori Sahakian³, John FitzGerald⁴, Christina Charles-Schoeman⁵, Alan H. Gorn⁶, George A. Karpouzas⁷, Michael H. Weisman⁸, Daniel J. Wallace⁹, Weiling Chen¹ and Bevra H. Hahn⁶, ¹Div of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ³Division of Rheumatology, Department of Medicine,, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁴Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁵University of California, Los Angeles, CA, ⁶Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁷Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, ⁸Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: Although our current serologic measures of disease activity are useful for predicting flare in some patients, other patients experience disease flare in the absence…
Abstract Number: 1262 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patients with Higher Disease Severity and Subclinical Carotid Plaque Experience More Cardiovascular Events Despite a Favorable Conventional Cadiovascular Risk Profiles
Yeon-Ah Lee¹, Somi Kim¹, Sang-Hoon Lee², Ran Song², Hyung In Yang² and Seung-Jae Hong¹, ¹Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea, ²Rheumatology, Hospital at GANGDONG, Kyung Hee University, Seoul, South Korea
Background/Purpose: It has been shown that patients with rheumatoid arthritis (RA) experience cardiovascular (CV) events more often than expected. Increased risks of CV diseases in…
Abstract Number: 596 • 2012 ACR/ARHP Annual Meeting
Evolution of Atherosclerosis in Psoriatic Arthritis: Is the Former an Independent Inflammatory Process?
Roberta Ramonda¹, Massimo Puato², Valentina Modesti³, Mariagrazia Lorenzin⁴, Paola Frallonardo⁴, Augusta Ortolan⁴, Carla Campana³, Alessandro Lo Nigro³ and Leonardo Punzi⁵, ¹Rheumatology Unit, University of Padova, Padova, Italy, ²Department of Internal Medicine, University of Padova, Padova, Italy, ³Unit of Rheumatology, University of Padova, Padova, Italy, ⁴Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ⁵Clinical and Experimental Medicine, Rheumatology Unit - University of Padova, Padova, Italy
Background/Purpose: A non-invasive study focusing on the structural and functional properties of the carotid arteries was carried out in psoriatic arthritis (PsA) patients. Increased cardiovascular…
Abstract Number: 1267 • 2012 ACR/ARHP Annual Meeting
Inflammatory Burden Predicts Progression of Carotid Plaque in Rheumatoid Arthritis: A 24-Month Longitudinal Analysis
Churl Hyun Im¹, Na Ri Kim¹, Jong Wan Kang¹, Young Ji Kim¹, Kyung Hye Kim¹, Eon Jeong Nam¹ and Young Mo Kang², ¹Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, ²Department of Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea
Background/Purpose: Carotid atherosclerosis, which is associated with the increased risk of cardiovascular (CV) disease, is increased in rheumatoid arthritis (RA) patients. In our previous study,…
Abstract Number: 2663 • 2012 ACR/ARHP Annual Meeting
A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results From a Candidate Gene Study
Cecilia P. Chung¹, Joseph F. Solus², Annette M. Oeser³, Chun Li⁴, Paolo Raggi⁵, Jeffrey R. Smith³ and C. Michael Stein³, ¹Medicine, Vanderbilt University, Nashville, TN, ²Medicine, Vanderbilt Medical Center, Nashville, TN, ³Vanderbilt University, Nashville, TN, ⁴Biostatistics, Vanderbilt University, Nashville, TN, ⁵Emory University, Atlanta, GA
Background/Purpose: Patients with rheumatoid arthritis (RA) have accelerated atherosclerosis. However, this association is not fully explained by traditional cardiovascular risk factors or markers of inflammation. Little is…
Abstract Number: 1269 • 2012 ACR/ARHP Annual Meeting
Serum Cytokines Associated with Carotid Atherosclerosis in Rheumatoid Arthritis
Inmaculada del Rincon¹, Roy W. Haas², Daniel H. O'Leary³, Joseph F. Polak³, Daniel F. Battafarano⁴ and Agustin Escalante⁵, ¹Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ²Dept. of Medicine-Rheumatology, University of Texas Health Science Center, San Antonio, TX, ³Radiology, Tufts University-Boston Campus, Boston, MA, ⁴Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX, ⁵Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX
Background/Purpose: The mechanism for the increased cardiovascular morbidity and mortality in rheumatoid arthritis (RA) is incompletely understood. In a previous analysis, we found that both…

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