Abstracts tagged "Atherosclerosis"

Abstract Number: 2780 • 2013 ACR/ARHP Annual Meeting
Cumulative Exposure To Elevated Inflammatory Markers Is Associated With Increased Burden Of Atherosclerosis In Psoriatic Arthritis Patients: A Cohort Study
Lihi Eder¹, Arane Thavaneswaran², Vinod Chandran³, Richard J. Cook⁴ and Dafna D. Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
Background/Purpose: Cardiovascular morbidity is increased in patients with psoriatic arthritis (PsA). Traditional cardiovascular risk factors do not fully explain this excessive risk. It is unclear…
Abstract Number: 402 • 2013 ACR/ARHP Annual Meeting
Can Modulators Of Inflammation Serve As Biomarkers For Subclinical Atherosclerosis In Rheumatoid Arthritis?
Kimberly P. Liang¹, Douglas P. Landsittel², Suresh R. Mulukutla³, Steven E. Reis⁴, Marc C. Levesque⁵, Donald M. Jones⁶, Rachel Gartland⁷, Ali Shoushtari⁸, Flordeliza S. Villanueva³, Hunter C. Champion⁸ and Larry W. Moreland⁵, ¹Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Medicine, Biostatistics and Clinical and Translational Science, University of Pittsburgh, Center for Health Care Research Data Center, Pittsburgh, PA, ³Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, ⁴Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Rheumatoid arthritis (RA) is independently associated with a higher risk of cardiovascular disease (CVD) and premature atherosclerosis. Mechanisms of atherosclerosis include (1) Endothelial dysfunction/activation mediated…
Abstract Number: 2763 • 2013 ACR/ARHP Annual Meeting
Carotid Atherosclerosis As a Predictor Of Mortality In Rheumatoid Arthritis
Inmaculada del Rincon¹, Roy W. Haas², Jose Felix Restrepo³, Daniel F. Battafarano⁴, Daniel H. O'Leary⁵, Emily Molina¹ and Agustin Escalante⁶, ¹Rheumatology, University of Texas Health Science Center, San Antonio, TX, ²Dept. of Medicine-Rheumatology, University of Texas Health Science Center, San Antonio, TX, ³Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ⁴Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX, ⁵Radiology, Tufts University-Boston Campus, Boston, MA, ⁶Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX
Background/Purpose: Patients with rheumatoid arthritis (RA) have higher mortality than do persons of the same age and sex without RA. This is due in part…
Abstract Number: 384 • 2013 ACR/ARHP Annual Meeting
Carotid Artery Plaques Are Associated With Coronary Atherosclerosis In Patients With Inflammatory Joint Diseases Independent Of Several Cardiovascular Risk Calculators
Silvia Rollefstad¹, Eirik Ikdahl², Inge C. Olsen³, Tore K. Kvien^4,5, Anne S. Eirheim², Terje R. Pedersen^4,6 and Anne G. Semb², ¹Rhuematology, Diakonhjemmet Hospital, Oslo, Norway, ²Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Faculty of Medicine, University of Oslo, Oslo, Norway, ⁵Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁶Centre of Preventive Medicine, Oslo University Hospital-Ullevaal, Oslo, Norway
Background/Purpose: Patients with rheumatoid arthritis (RA) and carotid plaque (CP) have been shown to have increased risk of future acute coronary syndrome. We have established…
Abstract Number: 2343 • 2013 ACR/ARHP Annual Meeting
Assessment Of Subclinical Atherosclerosis (Flow Mediated Dilatation and arterial stiffness) After 24 Weeks Of a Tocilizumab Therapy In 22 Patients With Rheumatoid Arthritis
Martin Soubrier¹, Thomas Frayssac², Bruno Pereira³, Marion Couderc Sr.⁴, Coline Daron², Jean Jacques Dubost⁵, Sandrine Malochet-Guinamand⁴, Anne Tournadre⁴ and Sylvain Mathieu⁴, ¹Rheumatology, CHU CLERMONT-FERRAND, Clermont-Ferrand, France, ²CHU CLERMONT-FERRAND, Clermont-ferrand, France, ³Clinical research department, Clermont-Ferrand, France, ⁴Rheumatology CHU Gabriel Montpied, Clermont-Ferrand, France, ⁵Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France
Background/Purpose: Increased incidence of cardiovascular diseases and sub-clinical atherosclerosis have been observed in rheumatoid arthritis (RA). Inflammation and traditional risk factors could be involved in…
Abstract Number: 386 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Is Associated With Systemic Inflammation In Coronary Vessels
Inge A.M. van den Oever¹, Alper M. van Sijl¹, Umit Baylan², Michael. T. Nurmohamed¹, Alexandre E. Voskuyl¹, Hans W. Niessen² and Suat Simsek³, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Pathology, VU University Medical Center, Amsterdam, Netherlands, ³Internal Medicine, Medical Center Alkmaar (MCA), Alkmaar, Netherlands
Background/Purpose: Patients with a chronic inflammatory disease (CID), particularly rheumatoid arthritis (RA), have an increased risk of fatal myocardial infarction (MI), as compared to the…
Abstract Number: 1975 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Risk Stratification In Rheumatic Diseases : Carotid Ultrasound Is More Sensitive Than Coronary Artery Calcification Score To Detect Subclinical atherosclerosis In Patients With Rheumatoid Arthritis
Francisco Ortiz-Sanjuán¹, Alfonso Corrales², José Antonio Parra³, Carlos González-Juanatey⁴, Montserrat Santos⁵, Javier Rueda⁶, Ricardo Blanco⁷, Vanesa Calvo-Río⁸, Javier Loricera⁸, Javier Llorca⁹ and Miguel A González-Gay¹⁰, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ²Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ³Radiology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁴Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁵Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ⁶Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁷Hospital Marques de Valdecilla, Santander, Spain, ⁸Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁹Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ¹⁰Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a disease associated to accelerated atherogenesis leading to increased incidence of cardiovascular (CV) mortality. Adequate stratification of the CV risk…
Abstract Number: 387 • 2013 ACR/ARHP Annual Meeting
Left Ventricular Myocardial Tissue In Rheumatoid Arthritis Shows Systemic Inflammation After Fatal Myocardial Infarction
Inge A.M. van Den Oever¹, Alper M. van Sijl¹, Umit Baylan², Michael. T. Nurmohamed¹, Alexandre E. Voskuyl¹, Hans W. Niessen² and Suat Simsek³, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Pathology, VU University Medical Center, Amsterdam, Netherlands, ³Internal Medicine, Medical Center Alkmaar (MCA), Alkmaar, Netherlands
Background/Purpose: Patients with a chronic inflammatory disease (CID), particularly rheumatoid arthritis (RA), have an increased risk of fatal myocardial infarction (MI) and a diminished survival…
Abstract Number: 2272 • 2012 ACR/ARHP Annual Meeting
Gene Expression Signatures in Monocytes From Primary Antiphospholipd Syndrome, Systemic Lupus Erythematosus and Lupus with Antiphospholipid Syndrome Identify Specific Pathways Involved in the Pathogenesis of Atherosclerosis and Cardiovascular Disease
Chary Lopez-Pedrera¹, Sebastiano Messineo², Carlos Perez-Sanchez¹, Patricia Ruiz-Limon¹, Mª Angeles Aguirre³, Rosario M. Carretero-Prieto⁴, Antonio Rodriguez-Ariza¹, Nuria Barbarroja⁴, Francisco Velasco¹, Munther A. Khamashta⁵, Eduardo Collantes-Estevez¹ and Mª Jose Cuadrado⁶, ¹IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ²Dipartimento di Scienze della Salute, Universitá Magna Graecia di Catanzaro, Dipartimento di Scienze della Salute, Universitá Magna Graecia di Catanzaro, Italy., Catanzaro, Italy, ³Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ⁴Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, ⁵Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, ⁶Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by immune-mediated inflammation in multiple organ systems. SLE, primary Antiphospholipid syndrome (APS) and secondary APS (SAPS) share several…
Abstract Number: 1211 • 2012 ACR/ARHP Annual Meeting
ANTI-Cyclic Citrullinated Protein Antibodies Induce Inflammation and Oxidative Stress in WHITE Blood CELLS of Rheumatoid Arthritis Patients
Chary Lopez-Pedrera¹, Carlos Perez-Sanchez¹, Patricia Ruiz-Limon¹, Mª Angeles Aguirre², Rosario M. Carretero-Prieto¹, Antonio Rodriguez-Ariza³, Nuria Barbarroja¹, Pilar Font¹, Francisco Martinez², Inmaculada Gomez-Gracia², Mª Jose Cuadrado⁴ and Eduardo Collantes-Estevez², ¹Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, ²Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ³Oncology Service and Research Unit, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ⁴Lupus Research Unit, The Rayne Institute, London, United Kingdom
Background/Purpose: Anti-cyclic citrulinated protein antibodies (anti-CCP) are the most specific autoantibody markers in rheumatoid arthritis (RA) patients. However no previous studies have evaluated their role…
Abstract Number: 2078 • 2012 ACR/ARHP Annual Meeting
Low-Density Lipoprotein Receptor Deficiency Ameliorates the Development of Inflammatory Arthritis
Shawn Rose¹ and Harris R. Perlman², ¹Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Patients with rheumatoid arthritis (RA) carry a higher risk of cardiovascular disease compared to the general population. The low-density lipoprotein receptor (LDLR) and Apolipoprotein…
Abstract Number: 1038 • 2012 ACR/ARHP Annual Meeting
Assessment of Aortic Stiffness by Cardiac Magnetic Resonance Imaging in Systemic Autoimmune Rheumatic Diseases
Galia Karp¹, Arik Wolak², Nina Baram³, Victor Novack⁴, Philip Rosen³, Yael Perl⁵, Talia Wolak⁶, Ilan Shelef³ and Mahmoud Abu-Shakra⁷, ¹Medicine and Rheumatology, Department of Medicine, Soroka Medical Centre and Ben Gurion University, Beer-Sheva, Israel, ²Cardiology and and MRI Unit, Dept. of Cardiology, Cardiac MRI unit, Soroka University Medical Center, and Ben Gurion University, Beer-Sheva, Israel, ³Radiology division, Soroka University Medical Center and Ben Gurion University, Radiology division, Soroka University Medical Center and Ben Gurion University, ⁴Department of Medicine and Clinical Research center, Department of Medicine, Clinical Research center, Soroka University Medical Center and Ben Gurion University, ⁵Department of Medicine and Clinical Research center, Clinical Research center, Soroka University Medical Center and Ben Gurion University, ⁶Department of Medicine and Hypertension unit, Soroka University Medical Center and Ben-Gurion University, Department of Medicine and Hypertension unit, Soroka University Medical Center and Ben-Gurion University, ⁷Medicine and Rheumatology, Department of Medicine and Rheumatology, Soroka Medical Centre and Ben Gurion University, Beer-Sheva, Israel
Background/Purpose: Systemic Lupus Erythematosus (SLE) and rheumatoid arthritis (RA) are known to cause premature arterial aging and early atherosclerosis hence leading to increased stiffness of…
Abstract Number: 1707 • 2012 ACR/ARHP Annual Meeting
The Association of Serum Biomarkers and Metabolic Syndrome with Subclinical Atherosclerosis in Systemic Lupus Erythematosus: A Controlled Analysis in Patients with No Clinical Disease Activity
Semra Ertan-Demir¹, Ahmet Yasar Cizgici², Gaye Erten³, Bahar Artim-Esen⁴, Yasemin Sahinkaya⁴, Özlem Pehlivan⁴, Nilüfer Alpay-Kanitez⁴, Kadri Atay¹, Huseyin Oflaz², Gunnur Deniz³ and Murat Inanc⁴, ¹Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Cardiology Department, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ³Department of Immunology, Istanbul University, Institute of Experimental Medicine (DETAE), Istanbul, Turkey, ⁴Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing atherosclerotic cardiovascular disease (CVD). In addition to traditional CVD risk factors or…
Abstract Number: 991 • 2012 ACR/ARHP Annual Meeting
MTHFR Polymorphisms in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Associations with Intima Media Thickness Scores
Clio P. Mavragani¹, Maira Giannelou², Ioanna Papadaki³, Eleni Antypa⁴, Dimitrios Ioakeimidis⁵, Haralampos M. Moutsopoulos² and Michael Koutsilieris⁶, ¹Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, ²Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece, ³Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Athens, Greece, ⁴Department of Radiology, General Hospital of Athens, Greece, ⁵Department of Rheumatology, General Hospital, Greece, ⁶Department of Physiology, Athens University Medical School, Athens, Greece
Background/Purpose: Previous studies identified polymorphisms in the gene coding for the Methylenetetrahydrofolatereductase (MTHFR) enzyme as genetic contributors for cardiovascular disease in the general population. The…
Abstract Number: 1664 • 2012 ACR/ARHP Annual Meeting
Autoantibodies Are Associated with Subclinical Atherosclerosis and Cardiovascular Endpoints in Caucasian and African American Women in a Prospective Study: the Multi-Ethnic Study of Atherosclerosis (MESA)
Darcy S. Majka¹, Rowland W. Chang², Richard M. Pope³, Marius C. Teodorescu⁴, Elizabeth W. Karlson⁵, Thanh Huyen T. Vu⁶, Joseph Kang⁶ and Kiang Liu⁷, ¹Division of Rheumatology, Northwestern University, Chicago, IL, ²Dept Preventive Med, Northwestern University, Chicago, IL, ³Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ⁴Microbiology, TheraTest Laboratories Inc, Lombard, IL, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁷Preventive Medicine, Northwestern University, Chicago, IL
Background/Purpose: Although the association between rheumatoid arthritis (RA) and cardiovascular disease (CVD) is established, the exact mechanism is not known. Subjects who later develop RA…

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