Abstracts tagged "Arthritis"

Abstract Number: 2190 • 2016 ACR/ARHP Annual Meeting
Prevalence of Severe Joint Pain Among Adults with Doctor-Diagnosed Arthritis— United States, 2002–2014
Kamil E. Barbour¹, Michael Boring¹, Charles Hemlick², Louise Murphy¹ and Jin Qin¹, ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Severe joint pain (SJP) from arthritis may reflect insufficiently managed pain, and SJP can limit an individual’s ability to perform basic functions. We…
Abstract Number: 1030 • 2016 ACR/ARHP Annual Meeting
Synovial Tissue Resident Macrophages Play the Protective Role in the Development of Inflammatory Arthritis in CD11c-Flip-KO Mice
Qi Quan Huang¹, Renee E. Doyle², Robert Birkett³ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL
Synovial Tissue Resident Macrophages Play the protective role in the Development of Inflammatory Arthritis in CD11c-Flip-KO MiceQi-Quan Huang1, Renee Doyle1, Robert Birkett1 and Richard M.…
Abstract Number: 2195 • 2016 ACR/ARHP Annual Meeting
Conceptualizing the Life Course in the Employment Experiences of Working-Aged Adults with Arthritis: A Qualitative Study
Arif Jetha^1,2, Julie Bowring¹, Catherine Connelly², Sean Tucker³, Kathleen Martin Ginis⁴ and Monique A.M. Gignac^5,6, ¹Institute for Work & Health, Toronto, ON, Canada, ²DeGroote School of Business, McMaster University, Hamilton, ON, Canada, ³University of Regina, Regina, SK, Canada, ⁴Department of Kinesiology, McMaster University, Hamilton, ON, Canada, ⁵Instititue for Work and Health, Toronto, ON, Canada, ⁶Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Background/Purpose: Research consistently finds that arthritis contributes to work disability. Yet, few studies have examined how employment experiences differ across the life course. This study…
Abstract Number: 1031 • 2016 ACR/ARHP Annual Meeting
Glucocorticoid Receptor Dimerization in Stromal Cells Modulates Macrophage Polarization during Serum Transfer-Induced Arthritis
Mascha Koenen¹, Ulrike Baschant^2,3, Stephan Culemann^3,4, Tobias Kockmann⁵, Hans-Michael Kaltenbach⁶, Sabine Vettorazzi^1,3, Paolo Nanni⁷, Bernd Roschitzki⁸, Ulrich Auf dem Keller⁹ and Jan P. Tuckermann^1,3, ¹Institute for Comparative Molecular Endocrinology, University of Ulm, Ulm, Germany, ²Dep. of Medicine III, TU Dresden, Dresden, Germany, ³Leibniz Institute on Aging, FLI Jena, Jena, Germany, ⁴Dep. of Internal Medicine 3, Universitätsklinikum Erlangen, Erlangen, Germany, ⁵Institute for Molecular Health Sciences, ETH Zürich, Zürich, Switzerland, ⁶Dep. of Biosystems Science and Engineering, ETH Zürich, Zürich, Germany, ⁷Functional Genomics Center Zurich, University and ETH Zurich, Zürich, Switzerland, ⁸Functional Genomics Center Zurich, University and ETH Zurich, Zurich, Switzerland, ⁹Institute for Molecular Health Sciences, ETH Zürich, Zürich, Germany
Background/Purpose: Rheumatoid arthritis is commonly treated with potent anti-inflammatory glucocorticoids (GC), despite severe side effects such as osteoporosis and insulin resistance associated with chronic dosing…
Abstract Number: 2405 • 2016 ACR/ARHP Annual Meeting
Musculoskeletal Manifestations As Presenting Symptoms of Inflammatory Bowel Disease in Children and Adolescents
Rachel Levy¹, Gil Amarilyo^2,3, Jacob Amir⁴, Rotem Tal^2,3, Amit Assa^3,5, Firas Rinawi⁵ and Liora Harel^2,3, ¹The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel, ²Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel, ³Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Tel Aviv, Israel, ⁴Mayanei Hayeshua Medical Center, Bnei Brak, Israel, ⁵Institute of Gastroenterology Hepatology and Liver diseases, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel
Background/Purpose: Extra intestinal manifestations occur in 40-50% of patients with inflammatory bowel disease (IBD), with musculoskeletal involvement in 25%. Data regarding musculoskeletal manifestations in…
Abstract Number: 1122 • 2016 ACR/ARHP Annual Meeting
Infliximab Suppresses the Monocyte Chemotaxis in Human TNF-Transgenic Mice
Qi Quan Huang¹, Robert Birkett¹, Elyssa L Roberts² and Richard M. Pope³, ¹Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²northwestern University, Chicago, IL, ³Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Macrophages in rheumatoid arthritis (RA) synovium produce high levels of inflammatory cytokines/chemokines and play the pivotal role in promoting inflammation and joint destruction. Treatment…
Abstract Number: 2703 • 2016 ACR/ARHP Annual Meeting
Apremilast May Improve Atherosclerosis By Promoting Cholesterol Efflux and Inhibiting Foam Cell Formation in Atherosclerotic Plaques
Hailing Liu¹, Tuere Wilder², Aranzazu Mediero³, Zhimin Wei¹, Carmen Corciulo² and Bruce Cronstein³, ¹Medicine, NYU School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Atherosclerosis is characterized by the accumulation of lipid-laden macrophages in the arterial walls. Patients with inflammatory arthritis and psoriasis are at greater risk of…
Abstract Number: 1295 • 2016 ACR/ARHP Annual Meeting
The Prevalence of Inflammatory and Structural Lesions on MRI of the Sacroiliac Joints in Patients with Very Early Peripheral Spondyloarthritis
Gaëlle Varkas¹, Philippe Carron², Heleen Cypers¹, Dirk Elewaut¹, Lennart Jans³ and Filip van Den Bosch⁴, ¹Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ²Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ³Department of Radiology, Ghent University Hospital, Ghent, Belgium, ⁴Rheumatology, Ghent University Hospital, Ghent, Belgium
Background/Purpose: To assess the prevalence of inflammatory and structural lesions on MRI of the sacroiliac joints (SIJ) in patients with peripheral spondyloarthritis (PSpA) in a…
Abstract Number: 2739 • 2016 ACR/ARHP Annual Meeting
Subclinical Ungueal Distrophy in Patients with Psoriasis without Joint Involvement: Is There Any Role for Nail Ultrasound?
Barbara Nascimento de Carvalho Klemz¹, Karine Luz², Eugenia Maria Damasio Ohe³, Adriana Maria Porro⁴, Polianna de Oliveira Matos Soares⁵, Helder Henrique da Costa Pinheiro⁶ and Marcelo Pinheiro⁷, ¹Rheumatology Division, Federal University of Sao Paulo (Unifesp/ EPM), Sao Paulo, Brazil, ²Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil, ³Dermatology Division, Federal University of Sao Paulo, (UNIFESP/EPM), Sao Paulo, Brazil, ⁴Dermatology Division, Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo, Brazil, ⁵Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo, Brazil, ⁶Federal University of Para (UFPA), Belem, Brazil, ⁷Federal University of São Paulo, São Paulo, Brazil
Background/Purpose: The joint involvement is observed in approximately 30% of patients with psoriasis (Ps). However, no clinical, lab or by imaging strategy is well established…
Abstract Number: 1318 • 2016 ACR/ARHP Annual Meeting
Profile of Macrophage-Derived Cytokines and Chemokines of Patients with Chikungunya-Induced Chronic Arthralgia/Arthritis
Idali Martinez¹, Edwin Lopez¹, Zelma L. Rios¹ and Luis M. Vilá², ¹Department of Microbiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, ²Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
Background/Purpose: Chikungunya virus (CHIKV) caused a large epidemic in Puerto Rico in 2014 with more than 30,000 reported cases. Many of the affected individuals developed…
Abstract Number: 2923 • 2016 ACR/ARHP Annual Meeting
T-Cell Receptor Signaling Inhibition By CC-90005, a Selective Protein Kinase C Theta Antagonist, Reduces Antigen Mediated T-Cell Activation and Arthritis Pathology in the Mouse CIA Model
Garth Ringheim¹, Jolanta Kosek¹, Lori Capone², Eun Mi Hur¹ and Peter H. Schafer³, ¹Inflammation and Immunology Translational Development, Celgene Corporation, Summit, NJ, ²Celgene Corporation, Summit, NJ, ³Department of Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: PKC-θ is a member of the Ca2+-independent novel PKC subfamily, most abundantly expressed in T-cells, and mediates early antigen recognition signal transduction and cell…
Abstract Number: 1440 • 2016 ACR/ARHP Annual Meeting
Anti-TNF Vaccination Protects from Experimental Arthritis without Affecting Resistance to Mycobacterium Tuberculosis or Listeria Monocytogenes infection
Eric Assier^1,2, Nadia Belmellat^1,2, Luca Semerano^1,2,3, Bernhard Ryffel⁴, Patrice Decker^1,5, Valérie Quesniaux⁴ and Marie-Christophe Boissier^1,5,6, ¹UMR 1125, Inserm, Bobigny, France, ²EA4222, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ³Service de Rhumatologie, Assistance Publique – Hôpitaux de Paris (AP-HP) Groupe hospitalier Avicenne - Jean Verdier – René Muret, Bobigny, France, ⁴INEM, CNRS UMR7355, Orléans, France, ⁵Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ⁶Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France
Background/Purpose: Anti-TNF-alpha therapy has been a successful treatment strategy for rheumatoid arthritis (RA), but is associated with reduced resistance to infection. In mice, TNF is…
Abstract Number: 2927 • 2016 ACR/ARHP Annual Meeting
Mechanisms Regulating the Loss of Tregs in CD11c-Flip-KO Mice That Contribute to the Spontaneous Development of Inflammatory Arthritis
Qi Quan Huang¹, Renee E. Doyle², Robert Birkett¹, Deyu Fang³ and Richard M. Pope², ¹Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: CD11c-Flip-KO (HUPO) mice spontaneously develop inflammatory, erosive arthritis. We previously demonstrated that T regulatory cells (Tregs) were reduced in HUPO mice and that the…
Abstract Number: 1441 • 2016 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Knockout Attenuates Arthritis Progression and Systemic Inflammation in TNF-Tg Arthritis Mouse Models
Yahui Grace Chiu¹, Richard Bell², Dongge Li³, Edward Schwarz⁴ and Christopher T. Ritchlin⁵, ¹Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Pathology, University of Rochester, Rochester, NY, ³Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁴Orthopedeatrics, University of Rochester, Rochester, NY, ⁵Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Tumor necrosis factor-transgenic (TNF-Tg) mice develop systemic inflammatory polyarthritis. DC-STAMP, a multi-pass transmembrane protein, was originally identified from a dendritic cell library and required…
Abstract Number: 3049 • 2016 ACR/ARHP Annual Meeting
Prevalence of Doctor-Diagnosed Arthritis Among Adults with Clinically Measured Pre-Diabetes— United States, 2009–2014
Kamil E. Barbour¹, Michael Boring¹, Charles Hemlick², Jennifer M. Hootman³, Louise Murphy¹ and Giuseppina Imperatore⁴, ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²Centers for Disease Control and Prevention, Atlanta, GA, ³Centers for Disease Control and Prevention, Kennesaw, GA, ⁴Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA
Background/Purpose: In the US, over 86 million adults have pre-diabetes; physical activity is recommended to reduce the high risk of developing diabetes. Arthritis is…

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