Abstracts tagged "Arthritis"

Abstract Number: 153 • 2017 Pediatric Rheumatology Symposium
Training pediatric rheumatology fellows intra-articular injection techniques and skills using a cadaver based musculoskeletal curriculum
Baruch Goldberg¹, Amanda Brown² and Monica Marcus³, ¹Pediatric Rheumatology, Texas Children's Hospital, Houston, TX, ²Allergy, Immunology and Rheumatology, Texas Children's Hospital, houston, TX, ³Pediatric Immunology, Allergy and Rheumatology, Texas Children's Hospital, Houston, TX
Background/Purpose: Intra-articular injections are important to treat children with arthritis. Practice differences, comfort levels, and reimbursement can decrease fellow exposure to this skill. The purpose…
Abstract Number: 481 • 2016 ACR/ARHP Annual Meeting
Dual Effect of 3-Bromopyruvate on Both Th17 and Treg Cell Differentiation and Dendritic Cell Activation Ameliorates Autoimmune Arthritis in Mice
Takaichi Okano¹, Jun Saegusa², Keisuke Nishimura³, Yo Ueda⁴, Sho Sendo², Soshi Takahashi⁵, Kengo Akashi³, Akira Onishi⁶ and Akio Morinobu², ¹Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Rheumatology, Kobe University Hospital, Kobe, Japan, ⁴Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁶Department for Rheumatology, Kobe University Hospital, Kobe, Japan
Background/Purpose: Recent studies have shown that cellular metabolism plays an important role in regulating immune cell function. In the process of cell differentiation, both interleukin-17-producing…
Abstract Number: 1915 • 2016 ACR/ARHP Annual Meeting
Partial Elimination of Intestinal Microbiota Dampens T Helper 17 Cell Differentiation and Established Collagen-Induced Arthritis in Mice
Rebecca Rogier¹, Heather Evans-Marin², Birgitte Walgreen¹, Monique M. Helsen¹, Liduine van den Bersselaar¹, Peter M. van der Kraan¹, Fons A.J. van de Loo³, Peter L. van Lent¹, Jose U. Scher⁴, Wim B. van den Berg¹, Marije I. Koenders¹ and Shahla Abdolahi-Roodsaz¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Division of Rheumatology, New York University School of Medicine, New York, NY, ³Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴New York University School of Medicine, New York, NY
Background/Purpose: High-throughput sequencing of intestinal microbiota recently revealed that the composition of intestinal microbiota is perturbed in patients with new onset untreated rheumatoid arthritis (RA).…
Abstract Number: 925 • 2016 ACR/ARHP Annual Meeting
Complement C5a Receptor Is the Key Initiator of Neutrophil Adhesion and Inflammation in Immune Complex-Induced Arthritis
Yoshishige Miyabe¹, Chie Miyabe¹, Thomas Murooka², Edward Kim³, Nancy Kim³, Thorsten R. Mempel⁴ and Andrew D. Luster¹, ¹Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²University of Manitoba, Winnipeg, MB, Canada, ³Massachusetts General Hospital, Boston, MA, ⁴Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Inflammatory arthritis, including rheumatoid arthritis, is characterized by neutrophil (PMN) recruitment into the joint in a highly regulated process controlled by chemoattractants (CAs). Four…
Abstract Number: 2157 • 2016 ACR/ARHP Annual Meeting
Share the Fate: Fibroblast-like Synoviocyte Cell-to-Cell Organelle Transfer Is Directed By the Inflammatory Microenvironment
Ruth Byrne¹, Isabel Olmos Calvo², Thomas Karonitsch³, Felix Kartnig⁴, Johannes Holinka⁵, Günter Steiner⁶, Peter Ertl⁷, Josef Smolen⁸ and Hans Peter Kiener⁹, ¹Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, ²Nanotechnology, Austrian Institute for Technology, Vienna, Austria, ³Internal Medicine III, Vienna Medical University, Vienna, Austria, ⁴Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁵Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, ⁶Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁷Vienna University of Technology, Vienna, Austria, ⁸Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ⁹Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Fibroblast-like synoviocytes (FLS) form a complex tissue network via long-distance intercellular connections with wide intercellular matrix spaces. The adaptive synovial tissue response to inflammation…
Abstract Number: 1008 • 2016 ACR/ARHP Annual Meeting
Advantageous Effect of an Endogenous Retroviral Envelope Protein in Systemic Lupus Erythematosus with Ex Vivo and In Vivo Anti-Inflammatory Potential
Anne Troldborg^1,2, Magdalena Janina Laska³, Ellen-Margrethe Hauge^4,5, Shervin Bahrami⁶ and Kristian Stengaard-Pedersen^7,8, ¹clinical medicine, Aarhus University, Aarhus, Denmark, ²Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Biomedicine, Aarhus University, Aarhus, Denmark, ⁴Dept. of Anatomy, Aarhus University, Aarhus, Denmark, ⁵Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁶Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁷Clinical medicine, Aarhus University, Aarhus, Denmark, ⁸Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Human Endogenous Retroviruses (HERVs) are remnants of retroviral infections in the human germline. Most, but not all, HERV genes have become inactive by accumulation…
Abstract Number: 2190 • 2016 ACR/ARHP Annual Meeting
Prevalence of Severe Joint Pain Among Adults with Doctor-Diagnosed Arthritis— United States, 2002–2014
Kamil E. Barbour¹, Michael Boring¹, Charles Hemlick², Louise Murphy¹ and Jin Qin¹, ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Severe joint pain (SJP) from arthritis may reflect insufficiently managed pain, and SJP can limit an individual’s ability to perform basic functions. We…
Abstract Number: 1030 • 2016 ACR/ARHP Annual Meeting
Synovial Tissue Resident Macrophages Play the Protective Role in the Development of Inflammatory Arthritis in CD11c-Flip-KO Mice
Qi Quan Huang¹, Renee E. Doyle², Robert Birkett³ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL
Synovial Tissue Resident Macrophages Play the protective role in the Development of Inflammatory Arthritis in CD11c-Flip-KO MiceQi-Quan Huang1, Renee Doyle1, Robert Birkett1 and Richard M.…
Abstract Number: 2195 • 2016 ACR/ARHP Annual Meeting
Conceptualizing the Life Course in the Employment Experiences of Working-Aged Adults with Arthritis: A Qualitative Study
Arif Jetha^1,2, Julie Bowring¹, Catherine Connelly², Sean Tucker³, Kathleen Martin Ginis⁴ and Monique A.M. Gignac^5,6, ¹Institute for Work & Health, Toronto, ON, Canada, ²DeGroote School of Business, McMaster University, Hamilton, ON, Canada, ³University of Regina, Regina, SK, Canada, ⁴Department of Kinesiology, McMaster University, Hamilton, ON, Canada, ⁵Instititue for Work and Health, Toronto, ON, Canada, ⁶Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Background/Purpose: Research consistently finds that arthritis contributes to work disability. Yet, few studies have examined how employment experiences differ across the life course. This study…
Abstract Number: 1031 • 2016 ACR/ARHP Annual Meeting
Glucocorticoid Receptor Dimerization in Stromal Cells Modulates Macrophage Polarization during Serum Transfer-Induced Arthritis
Mascha Koenen¹, Ulrike Baschant^2,3, Stephan Culemann^3,4, Tobias Kockmann⁵, Hans-Michael Kaltenbach⁶, Sabine Vettorazzi^1,3, Paolo Nanni⁷, Bernd Roschitzki⁸, Ulrich Auf dem Keller⁹ and Jan P. Tuckermann^1,3, ¹Institute for Comparative Molecular Endocrinology, University of Ulm, Ulm, Germany, ²Dep. of Medicine III, TU Dresden, Dresden, Germany, ³Leibniz Institute on Aging, FLI Jena, Jena, Germany, ⁴Dep. of Internal Medicine 3, Universitätsklinikum Erlangen, Erlangen, Germany, ⁵Institute for Molecular Health Sciences, ETH Zürich, Zürich, Switzerland, ⁶Dep. of Biosystems Science and Engineering, ETH Zürich, Zürich, Germany, ⁷Functional Genomics Center Zurich, University and ETH Zurich, Zürich, Switzerland, ⁸Functional Genomics Center Zurich, University and ETH Zurich, Zurich, Switzerland, ⁹Institute for Molecular Health Sciences, ETH Zürich, Zürich, Germany
Background/Purpose: Rheumatoid arthritis is commonly treated with potent anti-inflammatory glucocorticoids (GC), despite severe side effects such as osteoporosis and insulin resistance associated with chronic dosing…
Abstract Number: 2405 • 2016 ACR/ARHP Annual Meeting
Musculoskeletal Manifestations As Presenting Symptoms of Inflammatory Bowel Disease in Children and Adolescents
Rachel Levy¹, Gil Amarilyo^2,3, Jacob Amir⁴, Rotem Tal^2,3, Amit Assa^3,5, Firas Rinawi⁵ and Liora Harel^2,3, ¹The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel, ²Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel, ³Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Tel Aviv, Israel, ⁴Mayanei Hayeshua Medical Center, Bnei Brak, Israel, ⁵Institute of Gastroenterology Hepatology and Liver diseases, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel
Background/Purpose: Extra intestinal manifestations occur in 40-50% of patients with inflammatory bowel disease (IBD), with musculoskeletal involvement in 25%. Data regarding musculoskeletal manifestations in…
Abstract Number: 1122 • 2016 ACR/ARHP Annual Meeting
Infliximab Suppresses the Monocyte Chemotaxis in Human TNF-Transgenic Mice
Qi Quan Huang¹, Robert Birkett¹, Elyssa L Roberts² and Richard M. Pope³, ¹Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²northwestern University, Chicago, IL, ³Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Macrophages in rheumatoid arthritis (RA) synovium produce high levels of inflammatory cytokines/chemokines and play the pivotal role in promoting inflammation and joint destruction. Treatment…
Abstract Number: 2703 • 2016 ACR/ARHP Annual Meeting
Apremilast May Improve Atherosclerosis By Promoting Cholesterol Efflux and Inhibiting Foam Cell Formation in Atherosclerotic Plaques
Hailing Liu¹, Tuere Wilder², Aranzazu Mediero³, Zhimin Wei¹, Carmen Corciulo² and Bruce Cronstein³, ¹Medicine, NYU School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Atherosclerosis is characterized by the accumulation of lipid-laden macrophages in the arterial walls. Patients with inflammatory arthritis and psoriasis are at greater risk of…
Abstract Number: 1295 • 2016 ACR/ARHP Annual Meeting
The Prevalence of Inflammatory and Structural Lesions on MRI of the Sacroiliac Joints in Patients with Very Early Peripheral Spondyloarthritis
Gaëlle Varkas¹, Philippe Carron², Heleen Cypers¹, Dirk Elewaut¹, Lennart Jans³ and Filip van Den Bosch⁴, ¹Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ²Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ³Department of Radiology, Ghent University Hospital, Ghent, Belgium, ⁴Rheumatology, Ghent University Hospital, Ghent, Belgium
Background/Purpose: To assess the prevalence of inflammatory and structural lesions on MRI of the sacroiliac joints (SIJ) in patients with peripheral spondyloarthritis (PSpA) in a…
Abstract Number: 2739 • 2016 ACR/ARHP Annual Meeting
Subclinical Ungueal Distrophy in Patients with Psoriasis without Joint Involvement: Is There Any Role for Nail Ultrasound?
Barbara Nascimento de Carvalho Klemz¹, Karine Luz², Eugenia Maria Damasio Ohe³, Adriana Maria Porro⁴, Polianna de Oliveira Matos Soares⁵, Helder Henrique da Costa Pinheiro⁶ and Marcelo Pinheiro⁷, ¹Rheumatology Division, Federal University of Sao Paulo (Unifesp/ EPM), Sao Paulo, Brazil, ²Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil, ³Dermatology Division, Federal University of Sao Paulo, (UNIFESP/EPM), Sao Paulo, Brazil, ⁴Dermatology Division, Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo, Brazil, ⁵Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo, Brazil, ⁶Federal University of Para (UFPA), Belem, Brazil, ⁷Federal University of São Paulo, São Paulo, Brazil
Background/Purpose: The joint involvement is observed in approximately 30% of patients with psoriasis (Ps). However, no clinical, lab or by imaging strategy is well established…

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