Abstracts tagged "Arthritis"

Abstract Number: 58 • 2017 Pediatric Rheumatology Symposium
Analysis and Implications of Non-Invasive Knee Acoustical Emissions in Juvenile Idiopathic Arthritis
Daniel Whittingslow^1,2, Beren Semiz³, Lori Ponders⁴, Andrew Wiens⁵, Omer Inan^3,6 and Sampath Prahalad⁷, ¹Emory University School of Medicine, Atlanta, GA, ²Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, ³Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, ⁴Emory University, Atlanta, GA, ⁵Computer Science, Cornell University, Ithaca, NY, ⁶Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, ⁷Pediatrics, Emory Children's Center, Atlanta, GA
Background/Purpose: Juvenile Idiopathic Arthritis (JIA), the most common chronic rheumatic disease occurring in childhood, is an important cause of disability. Despite the persistence of disease…
Abstract Number: 1440 • 2016 ACR/ARHP Annual Meeting
Anti-TNF Vaccination Protects from Experimental Arthritis without Affecting Resistance to Mycobacterium Tuberculosis or Listeria Monocytogenes infection
Eric Assier^1,2, Nadia Belmellat^1,2, Luca Semerano^1,2,3, Bernhard Ryffel⁴, Patrice Decker^1,5, Valérie Quesniaux⁴ and Marie-Christophe Boissier^1,5,6, ¹UMR 1125, Inserm, Bobigny, France, ²EA4222, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ³Service de Rhumatologie, Assistance Publique – Hôpitaux de Paris (AP-HP) Groupe hospitalier Avicenne - Jean Verdier – René Muret, Bobigny, France, ⁴INEM, CNRS UMR7355, Orléans, France, ⁵Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ⁶Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France
Background/Purpose: Anti-TNF-alpha therapy has been a successful treatment strategy for rheumatoid arthritis (RA), but is associated with reduced resistance to infection. In mice, TNF is…
Abstract Number: 2927 • 2016 ACR/ARHP Annual Meeting
Mechanisms Regulating the Loss of Tregs in CD11c-Flip-KO Mice That Contribute to the Spontaneous Development of Inflammatory Arthritis
Qi Quan Huang¹, Renee E. Doyle², Robert Birkett¹, Deyu Fang³ and Richard M. Pope², ¹Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: CD11c-Flip-KO (HUPO) mice spontaneously develop inflammatory, erosive arthritis. We previously demonstrated that T regulatory cells (Tregs) were reduced in HUPO mice and that the…
Abstract Number: 1441 • 2016 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Knockout Attenuates Arthritis Progression and Systemic Inflammation in TNF-Tg Arthritis Mouse Models
Yahui Grace Chiu¹, Richard Bell², Dongge Li³, Edward Schwarz⁴ and Christopher T. Ritchlin⁵, ¹Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Pathology, University of Rochester, Rochester, NY, ³Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁴Orthopedeatrics, University of Rochester, Rochester, NY, ⁵Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Tumor necrosis factor-transgenic (TNF-Tg) mice develop systemic inflammatory polyarthritis. DC-STAMP, a multi-pass transmembrane protein, was originally identified from a dendritic cell library and required…
Abstract Number: 3049 • 2016 ACR/ARHP Annual Meeting
Prevalence of Doctor-Diagnosed Arthritis Among Adults with Clinically Measured Pre-Diabetes— United States, 2009–2014
Kamil E. Barbour¹, Michael Boring¹, Charles Hemlick², Jennifer M. Hootman³, Louise Murphy¹ and Giuseppina Imperatore⁴, ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²Centers for Disease Control and Prevention, Atlanta, GA, ³Centers for Disease Control and Prevention, Kennesaw, GA, ⁴Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA
Background/Purpose: In the US, over 86 million adults have pre-diabetes; physical activity is recommended to reduce the high risk of developing diabetes. Arthritis is…
Abstract Number: 1442 • 2016 ACR/ARHP Annual Meeting
Suppression of Acute Arthritis By N-Methyl-3,4-Dichloropropionaniline (N-MeDCPA), a Reversible Orai Calcium Channel Inhibitor
John Barnett¹, Lisa Robinson², Jonathan Soboloff³, Rosana Schafer⁴, Ida Holaskova⁵, Meenal Elliott¹, Michelle Witt², Raphael Hirsch⁶ and Harry Blair⁷, ¹Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, ²Pathology, West Virginia University, Morgantown, WV, ³Dept of Medical Genetics and Molecular Biochemistry, Temple University, Philadelphia, PA, ⁴Dept Micro, Immun & Cell Biol, West Virginia University, Morgantown, WV, ⁵West Virginia University, Morgantown, WV, ⁶Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ⁷pathology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Bone maintenance is a balance between the removal of old bone by osteoclasts (OCL) and the production of new bone by osteoblasts. In the…
Abstract Number: 3146 • 2016 ACR/ARHP Annual Meeting
Selective Deletion of a Pathogenic Subset Synovial Fibroblasts Attenuates Synovial Inflammation
Adam Paul Croft, Joana Campos, Andrew Filer, Francesca Barone and Chris Buckley, Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Despite their role as key effector cells driving synovial inflammation and joint damage, fibroblast like synoviocytes (FLS) have yet to be targeted therapeutically. Fibroblast…
Abstract Number: 1443 • 2016 ACR/ARHP Annual Meeting
A Therapeutic Peptide Vaccine Reduces Pro-Inflammatory Responses and Suppresses Arthritis in the Cartilage Proteoglycan G1 Domain-Induced Mouse Model of Rheumatoid Arthritis
Daniel Zimmerman¹, Harold Steiner III¹, Roy Carambula¹, Adrienn Markovics², Alison Finnegan³, Katalin Mikecz² and Tibor Glant⁴, ¹Research and Development, Cellular Immunology, CEL-SCI Corporation, VIENNA, VA, ²Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ³Dept of Medicine, Rush University Med Ctr, Chicago, IL, ⁴Orthopedic Surgery, Rush Med Ctr Cohn Bldg Rm 708, Chicago, IL
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease leading to inflammatory destruction of the peripheral joints. Although pro-inflammatory T helper 1 (Th1) and/or Th17 cell…
Abstract Number: 3147 • 2016 ACR/ARHP Annual Meeting
Remote Inflammation Triggers Autoimmune Arthritis through Th17 Distribution
Nina Chevalier¹, Jian Tan², Linda Mason², Remy Robert², Craig McKenzie², Seth Masters³ and Charles Mackay², ¹University Freiburg Medical Center, Freiburg, Germany, ²Monash University, Melbourne, Australia, ³WEHI, Melbourne, Australia
Background/Purpose: Autoimmune diseases, such as autoimmune inflammatory arthritis, result through breakdown of immune tolerance and development of self-reactive T cells, or autoantibody-producing B cells. Tolerance…
Abstract Number: 173 • 2016 ACR/ARHP Annual Meeting
S100A8/A9, a Potent Serum and Molecular Imaging Biomarker for Synovial Inflammation and Joint Destruction in Seronegative Experimental Arthritis
Edwin J. W. Geven¹, Martijn H. J. van den Bosch¹, Shahla Abdolahi-Roodsaz¹, Annet W. Sloetjes¹, Sven Hermann², Michael Schäfers², Marije I. Koenders¹, Dirk Föll³, Johannes Roth⁴, Thomas Vogl⁴ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²European Institute for Molecular Imaging, University of Münster, Münster, Germany, ³Department of Pediatric Rheumatology and Immunology, University of Münster, Münster, Germany, ⁴Institute of Immunology, University of Münster, Münster, Germany
Background/Purpose: Seronegative joint diseases, including psoriatic arthritis and juvenile idiopathic arthritis, are characterized by the lack of autoantibodies, which are relevant biomarkers for predicting disease…
Abstract Number: 1450 • 2016 ACR/ARHP Annual Meeting
Regulatory Mechanisms of Mesenchymal Stem Cell Transplantation on Systemic Osteoporosis in Collagen-Induced Arthritis Mice
Chang Liu, Huayong Zhang, Xiaojun Tang, Ruihai Feng, Genhong Yao, Weiwei Chen, Wenchao Li and Lingyun Sun, Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: To investigate the effects of umbilical cord-mesenchymal stem cell (UC-MSC) transplantation on joint damage and systemic osteoporosis in collagen induced arthritis (CIA) mice. Methods:…
Abstract Number: 3165 • 2016 ACR/ARHP Annual Meeting
HLA-B27 Expression Is Accompanied By a Profoundly Altered IgA Response to the Intestinal Microbiota and Microbial Translocation to the Joint
Mark Asquith¹, Sean Davin¹, Patrick Stauffer¹, Claire Mitchell² and James T. Rosenbaum¹, ¹Oregon Health & Science University, Portland, OR, ²Division of Arthritis and Rheumatology, Oregon Health & Science University, Portland, OR
Background/Purpose: HLA-B27 is the strongest known genetic risk factor for ankylosing spondylitis and other spondyloarthropathies (SpAs). We have shown previously that Fisher 344 rats that…
Abstract Number: 459 • 2016 ACR/ARHP Annual Meeting
Resident Non-Classical Monocytes Are Critically Important for Tissue Destruction in Arthritis
Antonia Puchner¹, Victoria Saferding², Michael Bonelli³, Carl-Walter Steiner², Eliana Goncalves-Alves³, Silvia Hayer⁴, Yohei Mikami⁵, Marije M. Koenders⁶, Birgit Niederreiter⁷, Josef S. Smolen⁸, Kurt Redlich³, Stephan Blüml⁹ and Michael Bonelli and Stephan blueml, ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Waehringer Guertel 18-20 A-A09, Medical University of Vienna, Vienna, Austria, ⁵Molecular Immunology and Inflammation Branch, NIAMS, Bethesda, MD, ⁶Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ⁷Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, ⁸Medical University of Vienna, Vienna, Austria, ⁹Internal Medicine 3; Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Bone destruction in rheumatoid arthritis is mediated by osteoclasts, which are derived from precursor cells of the myeloid lineage. Although there is much known…
Abstract Number: 1452 • 2016 ACR/ARHP Annual Meeting
18 F-FDG PET Imaging: An In Vivo quantitative Drug Screening Tool for Novel Antiinflammatory Therapies
Siba P. Raychaudhuri¹, Smriti K. Raychaudhuri², Anupam Mitra³ and Abhijit Chaudhari⁴, ¹Davis, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA, ³Dermatology, UC Davis School of Medicine, Davis, CA, ⁴Radiology, UC Davis School of Medicine, Sacramento, CA
Background/Purpose: Collagen induced arthritis (CIA) mouse model is used for screening of new drugs for autoimmune arthritis. The conventional read outs of this model are…
Abstract Number: 462 • 2016 ACR/ARHP Annual Meeting
Selective Inhibition of MMP9 Using a Monoclonal Antibody As a Therapeutic Strategy for Rheumatoid Arthritis
Sunhwa Kim¹, Brian Carr¹, Leah Tong¹, Debi Jin¹, Ruth Wang¹, Derrek Marshall¹, David Gossage² and Victoria Smith¹, ¹Biology, Gilead Sciences, Inc., Foster city, CA, ²Biology, Gilead Sciences, Inc., foster city, CA
Background/Purpose: Matrix metalloproteinase-9 (MMP9), highly expressed by infiltrating inflammatory cells, pannus tissue, and multinucleated cells in the synovium and subchondral bone tissue, including osteoclasts, participates…

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