Abstracts tagged "Arthritis"

Abstract Number: 984 • 2019 ACR/ARP Annual Meeting
Important Role of CD11c+ Cells in Inflammatory Arthritis
Antonia Puchner¹, Elisabeth Simader ¹, Victoria Saferding ², Gerhard Kroenke ³, Rene Pfeifle ⁴, Daniel Aletaha ¹, Josef Smolen ¹ and Stephan Blueml ¹, ¹Medical University of Vienna, Vienna, Austria, ²Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Austria, ⁴University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Dendritic cells (DCs) are important antigen presenting cells (APCs) and therefore they play an important role in bridging the innate and the adaptive immune…
Abstract Number: 990 • 2019 ACR/ARP Annual Meeting
Development of a Novel Anti TNF-Steroid Antibody Drug Conjugate That Shows Promising Efficacy at Doses That Avoid Steroid Side Effects in a Mouse Model of Rheumatoid Arthritis
Wendy Waegell¹, Christian Goess ², Robert Stoffel ¹, Michael McPherson ¹, Adrian Hobson ¹, Suzanne Mathieu ², Lucy Phillips ¹ and Shaughn Bryant ¹, ¹AbbVie, Worcester, ²Abbvie bioresearch Center, Worcester, MA
Background/Purpose: TNF-inhibitors are a well established therapy for autoimmune diseases including rheumatoid arthritis, Crohn’s disease, psoriasis and ankylosing spondylitis but they have limited efficacy in…
Abstract Number: 998 • 2019 ACR/ARP Annual Meeting
Stimulation of Splenic Neurovascular Bundle Protect Mice from Developing Collagen-induced Arthritis
Thomas Simon¹, Clara Panzolini ², Julien Lavergne ², Arun Srihar ³, Margriet Vervoordeldonk ³, nicolas Glaichenhaus ² and Philippe Blancou ², ¹CNRS/IPMC, Valbonne, France, ²IPMC/CNRS, VALBONNE, France, ³Galvani Bioelectronics, Stevenage, United Kingdom
Background/Purpose: Vagus nerve (VN) stimulation has shown the potential to improve the disease development in animal models of arthritis and in patients with RA. However,…
Abstract Number: 1001 • 2019 ACR/ARP Annual Meeting
Oral Collagen Type V Supplementation Inhibits Cartilage Degeneration in Experimental Arthritis
Lizandre Keren Silveira ¹, José Eduardo Rodrigues ¹, Silvana Atayde ¹, Sergio Catanozi ¹, Antonio dos Santos Filho ², Vera Luiza Capelozzi ¹, Ricardo Fuller ², Ana Paula Velosa ² and Walcy Teodoro¹, ¹Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ²Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil
Background/Purpose: It is known that collagen V (col V) can generate autoimmunity when exposed. In contrast, induction of tolerance with col V supplementation is able…
Abstract Number: 1185 • 2019 ACR/ARP Annual Meeting
New Imaging Modality to Evaluate Arthritis in Lupus Based on Frequency-domain Optical Transmission
Anca Askanase¹, Fiamma Van Biema ², Alessandro Marone ², Youngwan Kim ², Tommy Chen ², Teja Kapoor ², Laura Geraldino ², Yevgeniya Gartshteyn ³ and Andreas Hielscher ², ¹Columbia University Medical Center, New York, NY, ²Columbia University School of Medicine, New York, NY, ³Columbia University School of Medicine, Glen Rock, NJ
Background/Purpose: 95% of the people with SLE experience joint pain, stiffness and swelling at some time during their illness. It is currently difficult to both…
Abstract Number: 1186 • 2019 ACR/ARP Annual Meeting
How Accurate Is Physical Joint Inflammation of the MTP-joints and What Can We Learn from Additional MRI on Forefoot Involvement in Early Arthritis?
Yousra Dakkak¹, Aleid Boer ¹, Debbie Boeters ¹, Annette van der Helm-van Mil ² and Monique Reijnierse ¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²LUMC, Leiden, Zuid-Holland, Netherlands
Background/Purpose: Magnetic resonance imaging (MRI) is more sensitive than physical examination in detecting inflammation. This has predominantly been studied in metacarpophalangeal-(MCP) and wrist-joints. Data on…
Abstract Number: 1263 • 2019 ACR/ARP Annual Meeting
The Prevalence and Patterns of Celiac Disease Associated Arthropathy and Coexistence of Celiac Disease with Rheumatic Disorders in a Single Tertiary Medical Center
Anita Moudgal¹, Pooja Bhadbhade ¹, Ammar Haikal ¹ and Mehrdad Maz ¹, ¹The University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically predisposed individuals. Arthropathy has been reported as an extra-intestinal manifestation of CD. The…
Abstract Number: 1771 • 2019 ACR/ARP Annual Meeting
MyD88 S209R Enhances Inflammation in Mouse Models of Arthritis
Sufia Bakshi¹, Anders Lindstedt ², Malika Waschmann ³, Wanxia Tsai ¹, Robert Colbert ⁴ and Keith Sikora ¹, ¹National Institutes of Health, Bethesda, MD, ²NIH, Bethesda, MD, ³Oregon Health and Science University, Portland, OR, ⁴Pediatric Clinical Trials Unit, Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD
Background/Purpose: MyD88 is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-kB. We previously reported a heterozygous de novo gain-of-function mutation in MYD88 (S222R)…
Abstract Number: 2062 • 2019 ACR/ARP Annual Meeting
Arthritis, Physical Function, and Disability Among Older Mexican Americans over 20-Years of Follow-up
Martin A Rodriguez¹, Lin-Na Chou ¹, Jaspreet K Sodhi ¹, Kyriakos S Markides ¹, Kenneth J Ottenbacher ¹ and Soham Al Snih ¹, ¹The University of Texas Medical Branch, Galveston
Background/Purpose: Hispanics are the fastest growing group of older adults in the US, with older Mexican Americans the largest segment of US Hispanics (65%), a…
Abstract Number: 2063 • 2019 ACR/ARP Annual Meeting
Arthritis, Upper-Lower Extremity Functional Limitations, and Disability in American Older Adults: Findings from the National Health and Aging Trends Study (NHATS)
Martin A Rodriguez¹, Jaspreet K Sodhi ¹ and Soham Al Snih ¹, ¹The University of Texas Medical Branch, Galveston
Background/Purpose: To examine the effect of arthritis on upper-lower extremity (UE-LE) functional limitations and disability over 6-years of follow-up among American older adults.Methods: Data are…
Abstract Number: 2119 • 2019 ACR/ARP Annual Meeting
Impact of Day of Admission and Time to Diagnostic Arthrocentesis on Mortality and Other Outcomes in Septic Arthritis: A Nationwide Analysis
Gustavo Contreras¹, Ana B Arevalo ¹, Shane Murray ¹, Faris Haddadin ¹ and Yiming Luo ¹, ¹Mount Sinai St. Luke's - West/ Icahn School of Medicine, New York, NY
Background/Purpose: Multiple studies have been done assessing the “weekend effect” and outcomes for hospitalized patients 1,2,3,4, however, there is no data evaluating the outcome of…
Abstract Number: 136 • 2018 ACR/ARHP Annual Meeting
Alpn-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Disease in Multiple Mouse Models of Autoimmunity
Stacey Dillon¹, Katherine Lewis¹, Lawrence Evans², Ryan Swanson², Jing Yang³, Martin Wolfson⁴, Michelle Seaberg¹, Kayla Susmilch⁵, Sherri Mudri¹, Mark Rixon⁴, Stanford Peng⁶ and Kristine Swiderek⁷, ¹Translational Sciences, Alpine Immune Sciences, Seattle, WA, ²Immunology, Alpine Immune Sciences, Seattle, WA, ³Clinical, R&D, Alpine Immune Sciences, SEATTLE, WA, ⁴Protein Therapeutics, Alpine Immune Sciences, Seattle, WA, ⁵Translational Sciences, Alpine Immune Sciences, SEATTLE, WA, ⁶Clinical, R&D, Alpine Immune Sciences, Seattle, WA, ⁷Research, Alpine Immune Sciences, SEATTLE, WA
Background/Purpose: CD28 and Inducible T-cell Costimulator (ICOS) are two related costimulatory molecules within the immunoglobulin superfamily (IgSF) expressed on T cells and interacting with CD80/CD86…
Abstract Number: 1237 • 2018 ACR/ARHP Annual Meeting
What Is the Value of Synovial Biopsies for the Diagnosis of Septic Arthritis?
Bastien Ouvrard^1,2, Géraldine Bart¹, Christelle Darrieutort¹, Aurélie Najm¹ and Benoit Le Goff¹, ¹CHU Nantes, Nantes, France, ²INSERM UMR1238, nantes, France
Background/Purpose: Synovial biopsies are increasingly performed for research purposes but also in clinical practice. The development of US guided procedure has made this procedure simpler.…
Abstract Number: 2972 • 2018 ACR/ARHP Annual Meeting
Multicentric Reticulohistiocytosis (1980-2017): A Rare Disease, Commonly Associated with Malignancy and Autoimmunity
Avneek Singh Sandhu¹, Cynthia S. Crowson², David Wetter³, Gavin McKenzie⁴ and Ashima Makol¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, ³Dermatology, Mayo Clinic, Rochester, MN, ⁴Radiology, Mayo Clinic, Rochester, MN
Background/Purpose: Multicentric reticulohistiocytosis (MRH) is a systemic disease characterized by papulo-nodular skin eruptions and progressive, deforming arthritis. We aimed to examine the clinical correlates and…
Abstract Number: 359 • 2018 ACR/ARHP Annual Meeting
Characterization of Lymphoid Cells in Synovial Fluid from Cancer Patients with Immunotherapy-Induced Arthritis
Sang Kim¹, Jean Tayar¹, Huifang Lu¹, Jennifer Wang², Don Gibbons³, Guillermo Garcia-Manero⁴, Patrick Hwu⁵, Adi Diab⁵ and Roza Nurieva⁶, ¹General Internal Medicine (Rheumatology), MD Anderson Cancer Center, Houston, TX, ²Genitourinary Medical Oncology, MD Anderson Cancer Center, Houston, TX, ³Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, ⁴Leukemia, MD Anderson Cancer Center, Houston, TX, ⁵Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, ⁶Immunology, MD Anderson Cancer Center, Houston, TX
Background/Purpose: Checkpoint inhibitors (ICIs) are revolutionizing cancer treatment; however, ICI therapy is associated with immune-related adverse events (irAEs). irAEs can be life-threatening and/or severely impair…

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