Abstracts tagged "Arthritis"

Abstract Number: 1974 • 2014 ACR/ARHP Annual Meeting
Sex Steroids, Interleukin-1, and Interleukin-10 Inhibit interferon–gamma (IFN-γ) Induced B Cell Activating Factor of the Tumor Necrosis Factor Family (BAFF) in Human Synovial Fibroblasts
Georg Pongratz¹, Marina Bäuml², Tanja Späth², Rainer Straub³ and Torsten Lowin², ¹Internal Medicine I, University Hospital Regensburg, Regensburg, Germany, ²University Hospital Regensburg, Regensburg, Germany, ³Internal Medicine, University Hospital Regensburg, Regensburg, Germany
Background/Purpose B cell activating factor of the tumor necrosis factor family (BAFF) is a cytokine important for the stimulation and survival of autoreactive B cells…
Abstract Number: 1970 • 2014 ACR/ARHP Annual Meeting
T_H17 Inflammatory Responses Occur in a Subset of Patients with Erythema Migrans or Lyme Arthritis, but Are Not Predominant Responses in Joints
Klemen Strle¹, Elise E. Drouin¹ and Allen C. Steere², ¹Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Medicine, Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose Lyme disease usually begins with an expanding skin lesion, erythema migrans (EM), whereas arthritis is a late disease manifestation. The infection usually resolves with…
Abstract Number: 1961 • 2014 ACR/ARHP Annual Meeting
Chemokine-like Receptor 1 (CMKLR1) is Expressed on Synoviocytes and Proinflammatory Monocytes in Arthritis and is Predominantly Regulated By β arrestin 2 and G Protein Coupled Receptor Kinase (GRK) 6
D. Stephen Serafin¹, Maria F. Sassano², Daniel Mattox¹, Roman Timoshchenko¹, Matthew J. Billard¹, David P. Siderovski³, Bryan Roth⁴ and Teresa K. Tarrant⁵, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Pharmacology, Dept. of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, ⁴Dept. of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Medicine/Rheumatology, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose Chemokine-like receptor 1 (CMKLR1) is a G protein-coupled receptor (GPCR) expressed by inflammatory monocytes and up-regulated in fibroblast-like synoviocytes (FLSs), both of which are…
Abstract Number: 2942 • 2014 ACR/ARHP Annual Meeting
A Longitudinal Population-Based Study 1994-2010 of Age, Period, and Cohort Effects in the Prevalence of Arthritis: The Effect of Improving Socioeconomic Status and Increasing Obesity over Time
Elizabeth M. Badley^1,2, Mayilee Canizares^3,4, Anthony V. Perruccio^5,6, Sheilah. Hogg-Johnson^6,7 and Monique A.M. Gignac^6,7, ¹Division Health Care and Outcomes Research,, Toronto Western Research Institute, Toronto, ON, Canada, ²Dalla Lana School of Public Health,, University of Toronto, Toronto, ON, Canada, ³Division of Health Care and Outcome Research, Toronto Western Research Institute, Toronto, ON, Canada, ⁴Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, ⁵Arthritis Program, Toronto Western Hospital, Toronto, ON, Canada, ⁶Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁷Institute for Work and Health, Toronto, ON, Canada
Background/Purpose: To examine birth cohort and period effects in the age-trajectories of reported arthritis from 1994 to 2010 in a representative sample of Canadians; and…
Abstract Number: 1959 • 2014 ACR/ARHP Annual Meeting
Interaction of PDE4 and β-Arrestin Reverses Anti-Inflammatory Effects of Catecholamine-Producing Cells in Chronic Arthritis Via Adrenoceptor Switching from Gαs to GαI Signalling
Zsuzsa Jenei-Lanzl¹, Janika Zwingenberg², Torsten Lowin³ and Rainer Straub², ¹Department of Internal Medicine, University Hospital Regensburg, 1Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Regensburg, Germany, ²Internal Medicine, University Hospital Regensburg, Regensburg, Germany, ³Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose In recent studies, we confirmed the anti-inflammatory effects of tyrosine-hydroxylase (TH)-positive catecholamine producing synovial cells in chronic arthritis. Other studies described that inhibitors of…
Abstract Number: 2906 • 2014 ACR/ARHP Annual Meeting
Systemic Delivery of Short Hairpin RNA Targeting Calcium Release-Activated Calcium Channel 3 Down-Regulates Severity of Collagen-Induced Arthritis
Shuang Liu¹, Takeshi Kiyoi², Shohei Watanabe³ and Kazutaka Maeyama¹, ¹Department of Pharmacology, Informational Biomedicine, Ehime University Graduate School of Medicine, Toon-shi, Ehime, Japan, ²Bioscience, Integrated Center for Sciences, Ehime University, Ehime, Japan, ³Japan Community Health Care Organization Uwajima Hospital, Ehime, Japan
Background/Purpose: In recent years, one widespread and potentially important Ca2+ channel, store-operated Ca2+-release-activated Ca2+ (CRAC) channel is raised in drug discovery for rheumatoid arthritis (RA).…
Abstract Number: 1794 • 2014 ACR/ARHP Annual Meeting
The Sting Pathway Regulates Bone Remodeling in a Model of Autoimmune Disease
Rebecca Baum¹, Jason M. Organ², David B. Burr³, Ann Marshak-Rothstein⁴, Katherine A. Fitzgerald⁵ and Ellen M. Gravallese⁶, ¹Cell Biology, University of Massachusetts Medical School, Worcester, MA, ²Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, ³Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, ⁴Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ⁵Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁶Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Cytosolic DNA sensors detect viral and bacterial DNA, inducing inflammatory cytokines and type I IFNs via the adaptor stimulator of interferon genes (STING) to…
Abstract Number: 2908 • 2014 ACR/ARHP Annual Meeting
Flip Deficiency in Dendritic Cells Promotes Spontaneous Arthritis Mediated By Reduced Treg and Increased Autoreactive CD4⁺t Cells
Qiquan Huang¹, Harris R. Perlman², Robert Birkett³, Renee E. Doyle⁴, Deyu Fang⁵, G Kenneth.Haines⁶, William H. Robinson⁷, Syamal K. Datta⁸, Hyewon Phee⁹ and Richard M. Pope¹⁰, ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Mount Sinai Hospital School of Medicine, New York, New York, NY, ⁷VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁸Rheumatology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁹Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁰Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose Flip (CFLAR) has been identified as a rheumatoid arthritis (RA) risk allele and is important in preventing death receptor mediated apoptosis of dendritic cells…
Abstract Number: 1792 • 2014 ACR/ARHP Annual Meeting
Clinical-Biological and Pathological Spectrum and Outcome of IgA Vasculitis in Adults: A French Study
Alexandra Audemard¹, Evangeline Pillebout², Patrice Cacoub³, Noémie Jourde-Chiche Sr.⁴, Zahir Amoura⁵, Noemie Le Gouellec⁶, Francois Maurier⁷, Boris Bienvenu⁸, Geoffrey Urbanski⁹, Sébastien Sanges¹⁰, Aurélie Hummel¹¹, Alban Deroux¹², Loic Raffray¹³, Luc Mouthon¹⁴, Loïc Guillevin for the French Vasculitis Study Group¹⁴, Eric Thervet¹⁵ and Benjamin Terrier¹⁶, ¹Internal Medicine, Centre Hospitalier Universitaire de Caen, Caen, France, ²Nephrology, Saint Louis, Paris, France, ³Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ⁴Nephrology, CHU, Marseille, France, ⁵Internal medicine 2, French National Reference Center for Systemic Lupus and Antiphospholipid Syndrome, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, ⁶Internal Medicine, Lille, France, ⁷HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ⁸Médecine interne, CHU Côte de Nacre, CAEN, France, ⁹Internal Medicine, CHRU, Lille, France, ¹⁰Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, ¹¹Nephrology, Necker Hospital, Paris, France, ¹²Internal Medicine, CHU Grenoble, Grenoble, France, ¹³INTERNAL MEDICINE, bordeaux, France, ¹⁴National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ¹⁵Nephrology, Hopital Européen Georges Pompidou, APHP, PARIS, France, ¹⁶National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France
Background/Purpose IgA vasculitis is an immune-complex small-vessel vasculitis that mainly affects children and, more rarely, adults, in whom it seems to be more severe, because…
Abstract Number: 2801 • 2014 ACR/ARHP Annual Meeting
IL-38: A New Factor in Rheumatoid Arthritis
Shinjiro Kaieda¹, Katsuya Kanezaki², Naomi Yoshida³, Yukiko Kunitake³, Hiroaki Ida³ and Tomoaki Hoshino³, ¹67 Asahi-machi, Kurume, Fukuoka, Kurume University School of Medicine, Kurume, Japan, ²Nagata orthopedic hospital, Omuta, Japan, ³Kurume University School of Medicine, Kurume, Japan
Background/Purpose: IL-38 (IL-1F10) was originally described as an IL-1 family cytokine, and named IL-1HY2. The IL-38 gene is located in the IL-1 family cluster on…
Abstract Number: 1739 • 2014 ACR/ARHP Annual Meeting
Immunomodulatory Properties of CD271+ and CD271- Synovial Mesenchymal Cells
Alicia Usategui¹, Manuel J. Del Rey¹, Regina Faré¹, Gabriel Criado², Vanessa Miranda¹, Juan D. Cañete³ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain
Background/Purpose Mesenchymal stem cells (MSC) have been isolated from synovium and represent a fraction of synovial fibroblast (SF) cultures. CD271+ is considered a MSC surface…
Abstract Number: 2807 • 2014 ACR/ARHP Annual Meeting
Comparison of Outcomes in Septic Arthritis Caused By MRSA and MSSA
Deepa Panikkath¹, Sian Yik Lim², Swetha Gadwala³, Ragesh Panikkath³ and Kenneth Nugent⁴, ¹INTERNAL MEDICINE, Texas Tech University of Health Sciences, Lubbock, LUBBOCK, TX, ²Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, ³Internal Medicine, Texas Tech University of Health Sciences, Lubbock, TX, ⁴3601, Texas Tech University Health Sciences Center, Lubbock, TX
Background/Purpose: Staphylococcus aureus is the most common cause of adult septic arthritis and the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infections continues to rise. There…
Abstract Number: 1600 • 2014 ACR/ARHP Annual Meeting
Is There a Role for Inflammasome Activation in PsA Pathogenesis and Its Comorbidities?
Rodolfo Perez Alamino¹, Raquel Cuchacovich², Arnold Zea³ and Luis R. Espinoza⁴, ¹internal Medicine, LSUHSC, New Orleans, LA, ²Rheumatology, LSU Medical Center, New Orleans, LA, ³Stanley Scott Cancer Center, New Orleans, LA, ⁴Medicine-Section of Rheum, LSU Medical Center, New Orleans, LA
Background/Purpose . New data has emerged about the role of the inflammasome in psoriasis and psoriatic arthritis (PsA). The assembly of the inflammasome components in…
Abstract Number: 2352 • 2014 ACR/ARHP Annual Meeting
RORγt Expressing Foxp3⁺ Regulatory T Cells Regulates the Development of Autoimmune Arthritis in Mice
Yuya Kondo¹, Masahiro Tahara¹, Mana Iizuka¹, Masahiro Yokosawa¹, Shunta Kaneko¹, Hiroto Tsuboi¹, Satoru Takahashi², Isao Matsumoto³ and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Japan, ³Department of Interenal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: To determine the effect of RORγt overexpression in T cells on the development of collagen induced arthritis (CIA). Methods: Arthritis was induced with chicken…
Abstract Number: 1404 • 2014 ACR/ARHP Annual Meeting
Presence and Significance of Anti-CCP Antibody in Patients with Interstitial Lung Disease with and without Clinically Apparent Rheumatoid Arthritis
Muhammad Imran¹, Shanley O'brien², Mark Hamblin³ and Mehrdad Maz⁴, ¹Rheumatology, University of Kansas Medical Center, Kansas City, KS, ²Internal Medicine, Kansas University Medical Center, Kansas city, MO, ³Pulmonary and Critical Care Medicine, ILD Clinic, Kansas University Medical Center, Kansas city, MO, ⁴Division of Rheumatology, University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Interstitial lung disease (ILD) can be idiopathic or associated with underlying etiologies including rheumatoid arthritis (RA). The purpose of this study is to determine…

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