Abstracts tagged "Arthritis"

Abstract Number: 2172 • 2014 ACR/ARHP Annual Meeting
PTPN22 Promotes TLR-Induced Amelioration of Arthritis
David Ewart¹, Erik J. Peterson¹ and Yaya Wang², ¹University of Minnesota, Minneapolis, MN, ²Center for Immunology, University of Minnesota, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) synovial fluid exhibits high levels of type 1 interferons (IFN). Type 1 IFN may exert potent anti-inflammatory effects, since a TLR3…
Abstract Number: 848 • 2014 ACR/ARHP Annual Meeting
Malignant Progression of Precancerous Lesions of the Uterine Cervix Following DMARD Therapy in Female Arthritis Patients
René Cordtz¹, Lene Mellemkjær², Bente Glintborg¹, Merete Lund Hetland³ and Lene Dreyer¹, ¹Department of Rheumatology, Copenhagen University Hospital Gentofte, Hellerup, Denmark, ²Virus, Lifestyle and Genes, The Danish Cancer Society, Copenhagen, Denmark, ³DANBIO Registry and Department of Rheumatology., Copenhagen University Hospital Glostrup. On behalf of all departments of Rheumatology in Denmark., Glostrup, Denmark
Background/Purpose Recent studies have found that a high proportion of female rheumatoid arthritis (RA) patients are chronic carriers of high-risk HPV-strains and that these patients…
Abstract Number: 2187 • 2014 ACR/ARHP Annual Meeting
Revisiting RS3PE after Twenty Five Years: A Systematic Review of 250 Cases
Paras Karmacharya¹, Anthony Donato², Madan Aryal³, Sushil Ghimire⁴, Ranjan Pathak³, Kalpana Shah⁵, Pragya Shrestha⁶, Ananta Subedi⁷, Smith Giri⁸, Leena Jalota³, Dilli Poudel⁴ and David George⁹, ¹Internal MEdicine, Reading Health System, West Reading, PA, ²Internal medicine, Reading Health System, Reading, PA, ³Internal medicine, Reading Health System, West Reading, PA, ⁴Reading Health System, West Reading, PA, ⁵Internal medicine, Mymensingh Medical College, Mymensingh, Bangladesh, ⁶Internal medicine, Nanjing Medical University, Nanjing, China, ⁷Suite 511 Russell Morgan Build, Good Samaritan Hospital, Baltimore, MD, ⁸Internal medicine, University of Tennessee Health Science Center, Memphis, TN, ⁹Internal Medicine, Reading Health System, Reading, PA
Background/Purpose Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome is a rare inflammatory arthritis, first described by McCarty et al in 1985 characterised by…
Abstract Number: 830 • 2014 ACR/ARHP Annual Meeting
Profound Hypouricemia Induced in Human Subjects By Novel Bifunctional Inhibitors of Xanthine Oxidase and URAT1
Raymond P. Warrell Jr.¹, Anna Klukovits², Keith Barnes³, Chitkala Satyanarayana⁴, Chris Cheeseman⁵ and John Piwinski¹, ¹Relburn-Metabolomics, Inc., Westfield, NJ, ²SOLVO Biotechnology, Budapest, Hungary, ³AMRI, Albany, NY, ⁴AMRI, Singapore, Singapore, ⁵University of Alberta, Alberta, AB, Canada
Background/Purpose: A prototype anticancer drug (RLBN1001) induced marked hypouricemia in studies of > 350 human subjects. Preliminary exploration suggested dual effects on uric acid (UA)…
Abstract Number: 2162 • 2014 ACR/ARHP Annual Meeting
Immunological Abnormalities in Adult Patients with Parvovirus B19 Infection : A study of 23 Cases
Edouard Pertuiset, Farid Kemiche, Mehdi Yahia and Isabelle Cerf-Payrastre, Rheumatology, Centre Hospitalier René Dubos, Pontoise, France
Background/Purpose In adults, parvovirus B19 infection can induce joint symptoms and cutaneous manifestations which are known to be transient most of the time. It has…
Abstract Number: 346 • 2014 ACR/ARHP Annual Meeting
Treatment of Collagen Induced Artritis with Human Embrionic Stem Cell-Derived Multipotent Mesenchymal Stromal Cells (hESC-MSC)
Gabriel Criado¹, María J. Pérez-Lorenzo¹, María Galindo², Jose L. Pablos², Pablo Menéndez³ and Elena Gonzalo-Gil⁴, ¹Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Josep Carreras Leukemia Research Insitute, Barcelona, Spain, ⁴Grupo de Investigación en Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain
Background/Purpose Inhibition of TGFβ signaling in human Embryonic Stem Cells (hESC) generates mesenchymal stromal cells (hESC-MSC) with osteogenic, adipogenic and chondrogenic potential. These cells have…
Abstract Number: 2050 • 2014 ACR/ARHP Annual Meeting
Knee Arthritis Is Positively Associated with Physical Impairment: Conclusion Based on Physical Examinations from a Cross-Sectional Study of 17708 Chinese Residents
Qiang Liu¹, Xu Tang Sr.², Xu Wu³, Zhengming Cao² and Jianhao Lin², ¹Arthritis Clinical and Reserch Center, Peking University People's Hospital, Peking University Health Science Center, Beijing, China, ²Peking University Health Science Center, Beijing, China, ³Peking University People's Hospital Arthritis Clinic & Research Center, Peking University Health Science Center, Beijing, China
Background/Purpose The prevalence of knee arthritis is high in both urban and rural China. Although the association between knee arthritis and limitation of daily activity…
Abstract Number: 67 • 2014 ACR/ARHP Annual Meeting
Effects of Exercise on Depressive Symptoms in Adults with Arthritis: A Systematic Review with Meta-Analysis
George A. Kelley¹, Kristi S. Kelley¹ and Jennifer Hootman², ¹Biostatistics, West Virginia University, Morgantown, WV, ²Population Health, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Previous randomized controlled trials have led to conflicting findings regarding the effects of exercise on depressive symptoms in adults with arthritis and other rheumatic…
Abstract Number: 1974 • 2014 ACR/ARHP Annual Meeting
Sex Steroids, Interleukin-1, and Interleukin-10 Inhibit interferon–gamma (IFN-γ) Induced B Cell Activating Factor of the Tumor Necrosis Factor Family (BAFF) in Human Synovial Fibroblasts
Georg Pongratz¹, Marina Bäuml², Tanja Späth², Rainer Straub³ and Torsten Lowin², ¹Internal Medicine I, University Hospital Regensburg, Regensburg, Germany, ²University Hospital Regensburg, Regensburg, Germany, ³Internal Medicine, University Hospital Regensburg, Regensburg, Germany
Background/Purpose B cell activating factor of the tumor necrosis factor family (BAFF) is a cytokine important for the stimulation and survival of autoreactive B cells…
Abstract Number: 1970 • 2014 ACR/ARHP Annual Meeting
T_H17 Inflammatory Responses Occur in a Subset of Patients with Erythema Migrans or Lyme Arthritis, but Are Not Predominant Responses in Joints
Klemen Strle¹, Elise E. Drouin¹ and Allen C. Steere², ¹Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Medicine, Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose Lyme disease usually begins with an expanding skin lesion, erythema migrans (EM), whereas arthritis is a late disease manifestation. The infection usually resolves with…
Abstract Number: 1961 • 2014 ACR/ARHP Annual Meeting
Chemokine-like Receptor 1 (CMKLR1) is Expressed on Synoviocytes and Proinflammatory Monocytes in Arthritis and is Predominantly Regulated By β arrestin 2 and G Protein Coupled Receptor Kinase (GRK) 6
D. Stephen Serafin¹, Maria F. Sassano², Daniel Mattox¹, Roman Timoshchenko¹, Matthew J. Billard¹, David P. Siderovski³, Bryan Roth⁴ and Teresa K. Tarrant⁵, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Pharmacology, Dept. of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, ⁴Dept. of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Medicine/Rheumatology, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose Chemokine-like receptor 1 (CMKLR1) is a G protein-coupled receptor (GPCR) expressed by inflammatory monocytes and up-regulated in fibroblast-like synoviocytes (FLSs), both of which are…
Abstract Number: 2942 • 2014 ACR/ARHP Annual Meeting
A Longitudinal Population-Based Study 1994-2010 of Age, Period, and Cohort Effects in the Prevalence of Arthritis: The Effect of Improving Socioeconomic Status and Increasing Obesity over Time
Elizabeth M. Badley^1,2, Mayilee Canizares^3,4, Anthony V. Perruccio^5,6, Sheilah. Hogg-Johnson^6,7 and Monique A.M. Gignac^6,7, ¹Division Health Care and Outcomes Research,, Toronto Western Research Institute, Toronto, ON, Canada, ²Dalla Lana School of Public Health,, University of Toronto, Toronto, ON, Canada, ³Division of Health Care and Outcome Research, Toronto Western Research Institute, Toronto, ON, Canada, ⁴Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, ⁵Arthritis Program, Toronto Western Hospital, Toronto, ON, Canada, ⁶Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁷Institute for Work and Health, Toronto, ON, Canada
Background/Purpose: To examine birth cohort and period effects in the age-trajectories of reported arthritis from 1994 to 2010 in a representative sample of Canadians; and…
Abstract Number: 1959 • 2014 ACR/ARHP Annual Meeting
Interaction of PDE4 and β-Arrestin Reverses Anti-Inflammatory Effects of Catecholamine-Producing Cells in Chronic Arthritis Via Adrenoceptor Switching from Gαs to GαI Signalling
Zsuzsa Jenei-Lanzl¹, Janika Zwingenberg², Torsten Lowin³ and Rainer Straub², ¹Department of Internal Medicine, University Hospital Regensburg, 1Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Regensburg, Germany, ²Internal Medicine, University Hospital Regensburg, Regensburg, Germany, ³Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose In recent studies, we confirmed the anti-inflammatory effects of tyrosine-hydroxylase (TH)-positive catecholamine producing synovial cells in chronic arthritis. Other studies described that inhibitors of…
Abstract Number: 2906 • 2014 ACR/ARHP Annual Meeting
Systemic Delivery of Short Hairpin RNA Targeting Calcium Release-Activated Calcium Channel 3 Down-Regulates Severity of Collagen-Induced Arthritis
Shuang Liu¹, Takeshi Kiyoi², Shohei Watanabe³ and Kazutaka Maeyama¹, ¹Department of Pharmacology, Informational Biomedicine, Ehime University Graduate School of Medicine, Toon-shi, Ehime, Japan, ²Bioscience, Integrated Center for Sciences, Ehime University, Ehime, Japan, ³Japan Community Health Care Organization Uwajima Hospital, Ehime, Japan
Background/Purpose: In recent years, one widespread and potentially important Ca2+ channel, store-operated Ca2+-release-activated Ca2+ (CRAC) channel is raised in drug discovery for rheumatoid arthritis (RA).…
Abstract Number: 1794 • 2014 ACR/ARHP Annual Meeting
The Sting Pathway Regulates Bone Remodeling in a Model of Autoimmune Disease
Rebecca Baum¹, Jason M. Organ², David B. Burr³, Ann Marshak-Rothstein⁴, Katherine A. Fitzgerald⁵ and Ellen M. Gravallese⁶, ¹Cell Biology, University of Massachusetts Medical School, Worcester, MA, ²Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, ³Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, ⁴Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ⁵Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁶Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Cytosolic DNA sensors detect viral and bacterial DNA, inducing inflammatory cytokines and type I IFNs via the adaptor stimulator of interferon genes (STING) to…

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