Abstracts tagged "Antinuclear antibodies (ANA)"

Abstract Number: 130 • 2020 Pediatric Rheumatology Symposium
Anti-Ro/SSA Is Associated with Progression to End-Stage Renal Disease in Anti-dsDNA Positive Lupus Nephritis
Matthew Sherman¹, Amali Gunawardana ², Janine Amirault ², Asha Moudgil ³, James Bost ³ and Hemalatha Srinivasalu ¹, ¹Children's National Medical Center, Washington, ²George Washington University, Washington, ³Children's Health Center, Children's National Medical Center, Washington
Background/Purpose: Lupus nephritis (LN) is related to disease severity, morbidity, and mortality in juvenile systemic lupus erythematosus (jSLE). Cluster analysis emerged to identify autoantibody profiles…
Abstract Number: 411 • 2019 ACR/ARP Annual Meeting
Frequency and Staining Patterns of Antinuclear Antibodies in Myositis Patients Without Known Myositis-specific Autoantibodies
Maria casal-Dominguez¹, Iago Pinal-Fernandez ¹, Ana Marin ², Maria Teresa Sanz-Martinez ², Andres Baucells-de la Pena ³, Katherine Pak ⁴, Yuji Hosono ¹, Lisa Christopher-Stine ⁵ and Andrew L Mammen ⁴, ¹NIH, Bethesda, ²Vall d'Hebron Hospital, Barcelona, Spain, ³Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ⁴National Institutes of Health, Bethesda, ⁵Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Objective:To determine the frequency and staining patterns of antinuclear antibodies (ANA) in myositis patients who do not have known myositis-specific autoantibodies.Methods: Material and methods:Sera…
Abstract Number: 652 • 2019 ACR/ARP Annual Meeting
Clinical Relevance According to Staining Patterns and Titers of Antinuclear Antibody
Mi Ryoung Seo¹, Ji Na Yeo ², Hee Jung Ryu ³, Hyo-Jin Choi ³ and Han Joo Baek ³, ¹, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea, ²Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea, ³Division of Rheumatology / Department of Internal Medicine / Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea
Background/Purpose: Immunofluorescent antinuclear antibody (ANA) test using HEp-2 cells still plays an important role in the diagnosis of autoimmune diseases. The aim of this study…
Abstract Number: 963 • 2019 ACR/ARP Annual Meeting
Alterations of Memory and Naive B Cell Subsets Associate with Reduced IFNα and TNFRII in ANA+ Healthy Individuals
Aleksandra Bylinska¹, Samantha Slight-Webb ¹, Miles Smith ², Susan R. Macwana ¹, Nicolas Dominguez ¹, Eliza F. Chakravarty ³, Joan T. Merrill ⁴, Judith James ³ and Joel Guthridge ³, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, ³Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Okalahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Loss of systemic self-tolerance leading to anti-nuclear autoantibody (ANAs) by B cells is a hallmark of SLE. However, up to 20% of healthy female…
Abstract Number: 1015 • 2019 ACR/ARP Annual Meeting
Evidence for Substantial Immune Activation in Asymptomatic ANA Positive Individuals
Emma Van Lieshout¹, Dennisse Bonilla ², Zahi Touma ³, Arthur Bookman ⁴, Linda Hiraki ⁵, Zareen Ahmad ⁶, Sindhu Johnson ⁷, Earl D. Silverman ⁸ and Joan Wither ⁹, ¹University of Toronto, Toronto, ON, Canada, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³University Health Network, University of Toronto, Toronto, Canada, ⁴University Health Network - Toronto Western Hospital, Toronto, Canada, ⁵The Hospital for Sick Children, Toronto, Canada, ⁶Mount Sinai Hospital, Toronto, Canada, ⁷Toronto Scleroderma Program, Department of Medicine, Toronto Western and Mount Sinai Hospitals, University of Toronto, Toronto, Canada, Toronto, Canada, ⁸Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁹University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Systemic autoimmune rheumatic diseases (SARD) including Sjogren’s Disease (SjD), Systemic Sclerosis (SSc) and Systemic Lupus Erythematosus (SLE) are characterized by the production of anti-nuclear…
Abstract Number: 1023 • 2019 ACR/ARP Annual Meeting
Neutrophils Are an Important Source of Microparticles in Lupus and Asymptomatic ANA+ Individuals
Carolina Muñoz-Grajales¹, Dennisse Bonilla ², Earl D. Silverman ³, Sindhu Johnson ⁴, Arthur Bookman ⁵, Zahi Touma ², Zareen Ahmad ⁶, Linda Hiraki ⁷ and Joan Wither ⁸, ¹University of Toronto, Toronto, Canada, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁴Toronto Scleroderma Program, Department of Medicine, Toronto Western and Mount Sinai Hospitals, University of Toronto, Toronto, Canada, Toronto, Canada, ⁵University Health Network - Toronto Western Hospital, Toronto, Canada, ⁶Mount Sinai Hospital, Toronto, Canada, ⁷The Hospital for Sick Children, Toronto, Canada, ⁸University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Apoptotic microparticles (MPs) in the circulation of systemic lupus erythematosus (SLE) patients are enriched for nucleic acids and complexed with IgG (MP-IC), as compared…
Abstract Number: 707 • 2017 ACR/ARHP Annual Meeting
Distinctive Features of Positive Anti-Cell Antibody Tests on HEp-2 Cells (HEp-2-ANA) in Patients with Non-Autoimmune Diseases
Renan Agustinelli¹, Sílvia H. Rodrigues², Mônica Prado³, Henrique Mariz⁴ and Luis Eduardo C. Andrade^5,6, ¹Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, São Paulo, Brazil, ²Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, Sao Paulo, Brazil, ³Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ⁴Internal Medicine Department, Hospital das Clínicas - Universidade Federal de Pernambuco, Recife, Brazil, ⁵Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil, ⁶Immunology Division, Fleury Medicine and Health, São Paulo, Brazil
Background/Purpose: The indirect immunofluorescence (IIF) test for anti-cell or antinuclear (ANA) antibodies on HEp-2 cells (HEp-2-ANA) is considered the gold standard method for ANA detection.…
Abstract Number: 1096 • 2017 ACR/ARHP Annual Meeting
Clinical Significance of RNP Antibodies in Diagnosis of Systemic Autoimmune Rheumatic Disease When Detected By Multiplex Immunoassay
Heather Bukiri¹, Amish Dave², Erin Bauer², Vivian Stone², Chris Chong³ and Punam Verma⁴, ¹Graduate Medical Education, Virginia Mason Medical Center, Seattle, WA, ²Rheumatology, Virginia Mason Medical Center, Seattle, WA, ³Virginia Mason Medical Center, Seattle, WA, ⁴Microbiology/Immunology General Lab, Virginia Mason Medical Center, Seattle, WA
Background/Purpose: A large multicenter healthcare system recently adopted multiplex immunoassay as an initial screen for antinuclear antibody (ANA) with confirmatory reflex testing by immunofluorescence antibody…
Abstract Number: 2885 • 2016 ACR/ARHP Annual Meeting
Expression Levels and Function of the Inhibitory Molecule, Immunoglobulin like Transcript 7 (ILT7), Are Decreased on Circulating Plasmacytoid Dendritic Cells in SLE Patients with High ANA Titers
Mark A. Jensen¹, Jessica M. Dorschner², Danielle Vsetecka², Shreyasee Amin³, Ashima Makol³, Floranne C. Ernste⁴, Thomas Osborn³, Kevin Moder³, Vaidehi Chowdhary³ and Timothy B. Niewold⁵, ¹Department of Immunology and Division of Rheumatology, Mayo Clinic, Rochester, MN, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁵Rheumatology and Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: Systemic lupus erythematous (SLE) is a complex autoimmune disease often involving multiple organs. In SLE, immune complexes containing autoreactive antibody and nuclear material activate…
Abstract Number: 791 • 2016 ACR/ARHP Annual Meeting
The International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns (ICAP) Initiative – Update and Its Impact
Edward K.L. Chan¹, Jan Damoiseaux², Gabriel Carballo³, Karsten Conrad⁴, Wilson de Melo Cruvinel⁵, Paulo Francescantonio⁵, Marvin J. Fritzler⁶, Ignacio Garcia-De La Torre⁷, Manfred Herold⁸, Tsuneyo Mimori⁹, Minoru Satoh¹⁰, Carlos Von Muhlen¹¹, Luis E C Andrade¹² and representing committee and translation team members, ¹Dept of Oral Biology, University of Florida, Gainesville, FL, ²Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, Netherlands, ³Hospital Carlos G. Durand, Buenos Aires, Argentina, ⁴Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, ⁵Pontifícia Universidade Católica de Goiás, Goiânia, Brazil, ⁶Medicine, University of Calgary, Calgary, AB, Canada, ⁷Immunology & Rheumatology, Centro de Est. de Invest. Bas. y Clin., S.C., Guadalajara, JAL, Mexico, ⁸Medical University of Innsbruck, Innsbruck, Austria, ⁹Kyoto University Graduate School of Medicine, Kyoto, Japan, ¹⁰Department of Clinical Nursing, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan, ¹¹Rheumatology, Rheuma Clinic Dr. von Muhlen, Porto Alegre, Brazil, ¹²Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: The indirect immunofluorescence (IIF) pattern observed in the antinuclear antibody (ANA) test provides an initial assessment of autoantibody responses in candidate patients who have…
Abstract Number: 1801 • 2016 ACR/ARHP Annual Meeting
Clinical Implications of Persistent Sinus Tachycardia in Systemic Lupus Erythematous: A Retrospective Study
Santosh Bhusal¹, Bassam Alhaddad², Douglas Einstadter³ and Stanley Ballou¹, ¹Rheumatology, Case Western Reserve University/MetroHealth Medical Center, Cleveland, OH, ²Rheumatology, Premier Physicians, Westlake OH, Cleveland, OH, ³Medicine, Case Western Reserve University/MetroHealth Medical Center, Cleveland, OH
Background/Purpose: Resting Sinus Tachycardia (ST) is found in approximately 50 % of patients with SLE. Unexplained episodes of intermittent ST could be a manifestation of…
Abstract Number: 647 • 2015 ACR/ARHP Annual Meeting
Involvement of Peripheral Nervous System in Primary Sjögren Syndrome, a Gessar Analysis
M. Mayer¹, S. Velez², F. Zazzetti², J. C. Barreira², L. Galvan¹, G. Bennasar³, L. R. Carlevaris³, A. Secco³, C. Asnal⁴, P. Pucci⁴, C. Amitrano⁴, A. Nitsche⁴, M. C. Khoury⁵, F. Caeiro⁶, N. Benzaquén⁶, J.P. Pirola⁶, M. Colazo⁶, O.L. Rillo⁷, S. Papasidero⁷, J. Demarchi⁷, L. Raitti⁸, M. N. Tamborenea⁹, M. L. Santiago⁹, P. Alba¹⁰, B. Busamia¹⁰, G. Salvatierra¹¹ and A. Catalán Pellet³, ¹Rheumatology, Buenos Aires British Hospital, CABA, Argentina, ²Rheumatology, Buenos Aires British Hospital, Buenos Aires, Argentina, ³Rivadavia Hospital, CABA, Argentina, ⁴German Hospital, CABA, Argentina, ⁵Statistics, Buenos Aires British Hospital, CABA, Argentina, ⁶Private Hospital of Cordoba, Cordoba, Argentina, ⁷Tornú Hospital, CABA, Argentina, ⁸Bessone Clinic, CABA, Argentina, ⁹OMI, Buenos Aires, CABA, Argentina, ¹⁰Córdoba Hospital, Cordoba, Argentina, ¹¹IPRI, Santiago del Estero, Santiago del Estero, Argentina
Background/Purpose: Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by dysfunction of the exocrine glands. The frequency of neurological manifestations in pSS ranges from…
Abstract Number: 797 • 2015 ACR/ARHP Annual Meeting
Divergent Phenotypic Patterns Between Systemic Lupus Erythematosus and Healthy Anti-Nuclear Antibody Positive Individuals Reveal Distinct Differences in B Cell and Myeloid Populations Among Ethnicities
Samantha Slight-Webb¹, Rufei Lu², Holden T. Maecker³, Paul J. Utz⁴, Joel M. Guthridge¹ and Judith A. James⁵, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disorder that arises from genetic and environmental factors. Thus, patients with different ancestral backgrounds display differences in…
Abstract Number: 2373 • 2015 ACR/ARHP Annual Meeting
Frequency of Antinuclear (ANA), Myositis-Specific (MSA) and Myositis-Associated Antibodies (MAA) in Patients with Idiopathic Inflammatory Myopathies (IIM) from Mexico, Central and South America Centers: Data from the Panlar Myositis Study Group.
Yelitza Gonzalez-Bello^1,2, Daniel Garcia-Cerda³, Gabriel Medrano-Ramírez⁴, José E. Navarro-Zarza⁵, Lilia Andrade-Ortega⁶, Marco Maradiaga-Ceceña⁷, Alicia Cardenas-Anaya⁸, Arnulfo H. Nava-Zavala^3,9, Gerardo Orozco-Barocio⁸, Armando Rojo-Mejia¹⁰, Esthela Loyo¹¹, Paola Gottschalk¹¹, Graciela Gómez¹², Marvin J. Fritzler¹³ and Ignacio Garcia-De La Torre⁸, ¹Immunology and Rheumatlogy, Universidad de Guadalajara, Zapopan, Jalisco, Mexico, ²Immunology and Rheumatology, Hospital General de Occidente, Secretaria de Salud Jalisco, Guadalajara, Jalisco, Mexico, ³Immunology and Rheumatology, Hospital General de Occidente, Secretaria de Salud Jalisco, Zapopan, Jal., Mexico, ⁴Rheumatology, Hospital General de Mexico, Secretaria de Salud, Mexico City, Mexico, ⁵Medicine, Hospital General Raymundo Abarca Alarcón, Chilpancingo, Mexico, ⁶Rheumatology, Centro Medico Nacional 20 de Noviembre, ISSSTE, Mexico City, Mexico, ⁷Rheumatology, Hospital General de Culiacan de la Secretaría de Salud, Culiacan, Sin., Mexico, ⁸Immunology and Rheumatology, Hospital General de Occidente, Secretaria de Salud Jalisco, Zapopan, Jalisco, Mexico, ⁹UMAE, Hospital de Especialidades Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico, ¹⁰Rheumatology, Clinica San Pablo, Lima, Peru, ¹¹Rheumatology, Hospital Regional Universitario, Santiago, Dominican Republic, ¹²Rheumatology, Instituto de Investigaciones Medicas Alfredo Lanari, Buenos Aires, Argentina, ¹³Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Dermatomyositis (DM) and polymyositis (PM) are forms of IIM that involve skeletal muscle as well as many other organs. As in other systemic rheumatic…
Abstract Number: 1810 • 2014 ACR/ARHP Annual Meeting
Improper Use of Antinuclear Antibody (ANA) Test Can Result in Misdiagnosis, Increased Patient Anxiety, and Wasted Health Care Resources
Sahar Eivaz Mohammadi¹, Imam H Shaik¹, Parag Chevli¹, Fernando Gonzalez-Ibarra¹, Sohini Sarkar¹, Saurav Acharya¹, Prerna Dogra¹, Hesam Hekmatjou², Maushmi Savjani², Waheed Abdul² and Valentin Marian³, ¹Internal Medicine, Jersey City Medical Center-Barnabas Health, Jersey City, NJ, ²Internal Medicine, St. George's University SOM, St. George's, Grenada, ³Rheumatology, Jersey City Medical Center-Barnabas Health, Jersey City, NJ
Background/Purpose: Results of serologic tests for autoantibodies, including tests for Antinuclear antibodies (ANAs) and antibodies to specific nuclear antigens such as double-stranded DNA (dsDNA), play…

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